Activated leukocyte cell adhesion(ALCAM),also known as CD166/MEMD,is a transmembrane glycoprotein,which belongs to one of the members of the immunoglobulin superfamily and is one of cell adhesion molecules.In vivo,ALCAM is divided into three subtypes including membrane ALCAM,cytoplasmic ALCAM and soluble ALCAM,which mediate a variety of pathophysiological processes involved in the body by regulating cell-to-cell tropism or heterophonic adhesion.The abnormal expression of ALCAM is closely related to the invasion and metastasis of various tumor cells,and has a certain effect on the sensitivity of radiotherapy and chemotherapy.The article reviews the latest advances in ALCAM of gynecological malignancies.