Annals of Dentistry 2020;27(1):11-21

doi:10.22452/adum.vol27no3

Micro RNAs In Periodontal Disease – A Review

Mekha Grace Varghese 1 ; Thomas George Valliaveettil 1 ; Annie Kitty George 1 ; Saranya Rajan 1

Affiliations

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Keywords

microRNA; biogenesis; profiling; innate immunity; acquired immunity; bone remodelling

Country

Malaysia

Language

English

Abstract

microRNAs (miRNAs) constitute a family of small, non-coding RNA molecules that regulate gene expression and protein expression. microRNAs have influence on a broad range of physiologic and pathologic conditions. They are also considered as promising biomarkers especially when they are secreted extracellularly. In the inflammatory pathways, they dysregulate the molecular processes and contribute to the development of chronic inflammatory diseases including periodontitis. In this review, we provide an overview of miRNA characteristics, biogenesis, mechanisms of action and profiling methods. In addition, the role of miRNAs in the pathobiology of periodontitis, especially those pertaining to the cellular and molecular pathways of inflammation has been considered to enhance our understanding of the pathobiology of periodontitis.