Journal of Pharmaceutical Practice 2020;38(1):14-17

doi:10.3969/j.issn.1006-0111.201906018

Research progress of valproic acid genomics

Xun ZHOU 1 ; Luojiao TAN 2 ; Hongyu ZHAO 3 ; Shouhong GAO 4 5

Affiliations

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Keywords

valproic acid; genomics; population pharmacokinetic; individual treatment

Country

China

Language

Chinese

Abstract

Valproic acid is a commonly used and broad-spectrum antiepileptic drug in clinical practice with a narrow therapeutic window. Valproic acid has a great individual difference in its metabolism which is influenced by many factors. The gene polymorphism of drug metabolic enzymes is one of the critical factors. Through consulting relevant articles, the affection of genomics and clinical treatment on valproic acid clinical application were reviewed in this paper, which provided a reference for clinical individualized treatment.