Yonsei Medical Journal  1994;35(1):91-96

doi:10.3349/ymj.1994.35.1.91

GM-CSF and low-dose araC treatment of AML in prolonged hypoplasia with residual leukemic cells after induction chemotherapy.

Yoo Hong MIN 1 ; Sung Eun KIM ; Seung Tae LEE ; Sun Ju LEE ; Jee Sook HAHN ; Yun Woong KO

Affiliations

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Keywords

Acute myelogenous leukemia GM-CSF; low-dose Ara-C

Country

Republic of Korea

Language

English

Abstract

We describe a case with acute myelogenous leukemia (AML; M2) who developed prolonged marrow hypoplasia with residual leukemic blasts and recurrent infections after induction chemotherapy. He was treated successfully with a sequential treatment of recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) and low-dose cytosine arabinoside (LD AraC). To the best of our knowledge this is the first reported case of a successful treatment of a patient with AML, who showed prolonged markedly hypocellular bone marrow with significant residual leukemic cells after induction chemotherapy, with a sequential treatment of GM-CSF and LD AraC.