Cancer Research and Treatment  2003;35(5):373-382

Combined Modality Therapy for Locally Advanced Non-Small Cell Lung Cancer.

L Chinsoo CHO 1 ; J Michael DIMAIO ; Randall HUGHES ; Phuc NGUYEN ; Paula ANDERSON ; Hak CHOY

Affiliations

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Keywords

Non-small cell lung cancer; Neoadjuvant chemotherapy; Radiotherapy

Country

Republic of Korea

Language

English

Abstract

The majority of non-small cell lung cancer patients present with locally advanced disease that may not be resectable. A single modality treatment such as thoracic radiotherapy often results in an inferior outcome when compared to combined modality treatment. Various combinations of radiotherapy, chemotherapy, and surgery have been tested in patients with locally advanced non-small-celllung cancer with promising results. The favorable results of the combined modality treatment are accompanied by a corresponding increase in treatment related morbidity. In this article, the results of the application of combined modality treatments in the management of locally advanced non-small cell lung cancer are reviewed.