Korean Journal of Nosocomial Infection Control  2013;18(2):44-50

doi:10.14192/kjnic.2013.18.2.44

Trends in Antibiotic Use in a Single University Hospital.

Kang Il JUN ; Hei Lim KOO ; Min Kyung KIM ; Chang Kyung KANG ; Min Jae KIM ; Shin Hye CHUN ; Jung Sook SONG ; Hyang Sook KIM ; Nam Joong KIM ; Eui Chong KIM ; Myoung Don OH

Keywords

Anti-bacterial agents; University hospitals; Utilization

Country

Republic of Korea

Language

Korean

Abstract

BACKGROUND: The aim of this study was to evaluate antibiotic consumption by adult patients at a single university hospital in Korea between 2001 and 2012. METHODS: We used the 2004 World Health Organization Anatomical Therapeutic Chemical Classification System definition of defined daily doses (DDD) per 1,000 patient-days to calculate the annual antibiotic consumption for 18 antibiotic groups. Chi-square linear-by-linear analysis was performed to evaluate antibiotic consumption trends for each group. RESULTS: Average annual antibiotic consumption during 2001-2012 was 644.6 DDD/1,000 patient-days (standard deviation, 33.3 DDD/1,000 patient-days). Although no statistically significant change was observed during the study period, consumption of first- and second-generation cephalosporins, and aminoglycosides was significantly decreased, while that of beta-lactam/beta-lactamase inhibitors, fourth-generation cephalosporins, carbapenem, glycopeptide, linezolid, colistin, and quinolone increased significantly. CONCLUSION: The total amount of prescribed antibiotics did not change, but the use of broad-spectrum antibiotics increased during the study period.