Objective: To investigate the teaching effect of information teaching mode based on “ketangpai” network learning platform in teaching clinical nutrition and to provide guidance and method for information teaching. Method: By the random sampling method, 296 students from 2017 nursing undergraduate students of Wannan Medical College were selected and divided into two groups. The experimental group (n=148) was taught by information teaching mode based on "ketangpai" network learning platform. The control group (n=148) was taught by traditional teaching method. Both groups received the same teaching process，content and teacher. The experimental test, theory test and teaching effects were compared between the two groups. Results: The scores of experimental test and theory test in experimented group were significantly higher than those in control group (P<0.01). The abilities of self-learning, theory-practice, independent thinking, analysis, and knowledge mastery degree in experimental group were significantly better than those in control group (P<0.05). The students in the experimental group were more satisfied with the information teaching mode. Conclusion: Application of information teaching mode based on “ketangpai" network learning platform can improve the teaching effects, the students' comprehensive ability and self-learning ability.