The World Journal of Men's Health  2013;31(2):141-149

doi:10.5534/wjmh.2013.31.2.141

Effects of Sesame Oil on the Reproductive Parameters of Diabetes Mellitus-Induced Male Rats.

Zahra ABBASI 1 ; Seyed Reza Fatemi TABATABAEI ; Yazdan MAZAHERI ; Farid BARATI ; Hasan MOROVVATI

Affiliations

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Keywords

Rats; Diabetes mellitus; Spermatozoa; Testis; Testosterone; Sesame oil

Country

Republic of Korea

Language

English

Abstract

PURPOSE: The purpose of the present study was to investigate the effect of sesame oil on the reproductive parameters of diabetic male Wistar rats. MATERIALS AND METHODS: The adult male rats in a split plot design were divided into normal (n=10), normal 5% (n=5; 5% sesame oil enriched diet), diabetic (Streptozocin induced diabetes; n=9), diabetic 5% (n=9; 5% sesame oil enriched diet), and diabetic 10% (n=9; 10% sesame oil enriched diet) groups. Diet supplementation continued for 56 days. RESULTS: Sesame oil supplementation did not reduce the plasma glucose concentration of rats in the diabetic groups (p>0.05). The total spermatogonia, spermatocytes, Leydig cells/tubule, and the germ cell to Sertoli cell ratio were lower in the diabetic rats than the normal ones (p<0.05), and with the exception of spermatogonia counts, these values improved by the addition of sesame oil to the diet (p<0.05). The sperm progressive motility and viability were lower in the diabetic rats (p<0.05) and sesame oil supplementation did not improve them. Incorporation of sesame oil into the diet improved the plasma testosterone concentration of the diabetic rats in a dose-dependent manner (p<0.05). CONCLUSIONS: In summary, sesame oil supplementation improved the reproductive parameters of diabetic rats at the levels of the testicular microstructure and function, but was not effective in protecting the epididymal sperm.