Korean Journal of Clinical Neurophysiology  2016;18(1):18-20

doi:10.14253/kjcn.2016.18.1.18

Myelin Water Fraction MRI in a Case of Clinically Probable Amyotrophic Lateral Sclerosis.

Jiwon YANG 1 ; Jongho LEE ; Eungyeop KIM ; Dong Hoon SHIN

Affiliations

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Keywords

Amyotrophic lateral sclerosis; Magnetic resonance imaging; Pathology

Country

Republic of Korea

Language

English

Abstract

Amyotrophic lateral sclerosis (ALS) is a progressive motor neuron degenerative disease that clinically manifests both upper and lower motor neuron signs. However, it is unknown where and how the motor neuron degeneration begins, and conflicting hypotheses have been suggested. Recent advanced radiological techniques enable us to look into ALS neuropathology in vivo. Herein, we report a case with upper motor neuron-predominant ALS in whom the results of brain magnetic resonance imaging (MRI) and myelin water fraction MRI suggest axonal degeneration.