Natural Product Sciences  2016;22(2):140-145

doi:10.20307/nps.2016.22.2.140

Phenolic Constituents and Their Anti-inflammatory Activity from Echinochloa utilis Grains.

Duc Hung NGUYEN 1 ; Bing Tian ZHAO ; Duc Dat LE ; Ki Yun KIM ; Young Ho KIM ; Young Ho YOON ; Jee Youn KO ; Koan Sik WOO ; Mi Hee WOO

Affiliations

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Keywords

Echinochloa utilis; Phenolic compounds; NO production

Country

Republic of Korea

Language

English

Abstract

Seven phenolic compounds including p-coumaric acid (1), 4-hydroxybenzoic acid (2), 4-hydroxybenzaldehyde (3), vanillic acid (4), luteolin (5), acacetin (6), and tricin (7), were isolated from the methylene chloride and ethyl acetate fractions of Echinochloa utilis grains. Compounds (1 - 4, 6) were isolated for the first time from this plant. These compounds were tested for inhibitory activities against LPS-induced NO production in RAW 264.7 cells. Compounds 5 and 6 displayed significant inhibitory effects, with IC₅₀ values of 27.9 ± 2.6 and 14.0 ± 1.1 µM, respectively. The results suggested that E. utilis ethanolic extract may be used as a potential source of anti-inflammatory agents and functional foods for the treatment of allergic diseases.