Chinese Journal of Virology 2013;29(4):437-441

Research progress in the structure and fuction of Orthopoxvirus host range genes.

Zheng LIU 1 ; Ying LIU ; Yi-Ming SHAO

Affiliations

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Country

China

Language

Chinese

MeSH

Abstract

Orthopoxvirus vector has a broad prospect in recombinant vaccine research, but the rarely severe side-effect impedes its development. Vaccinia virus and Cowpox virus of Orthopoxvirus have broad host range, and they have typical host range genes as K1L, CP77 and C7L. These three genes affect host range of Vaccinia virus, disturb the cell signaling pathways, suppress immune response and are related to virulence.