Study was carried out on 22 patients with chronic renal failure at B¹ch Mai Hospital from 5/1999-7/2000, these had clearance creatinine <30ml/min and creatinine 300-900mmol/l. 22 patients received a very low protein dietary (VLPD) 0.4g protein/kg body weight/24h and supplemented with Ketosteril 1 tablet/5kg/24h. The results: VLPD supplemented with Ketoanalogues can slow the progression of chronic renal failure without malnutritional status, metabolism disorder status of some substances associated with high uremia can be improved. Proteinuria decreased, drug is safe with renal failure patients.