Tropical Biomedicine  2019;36(2):373-378

Effects of some natural leads on Trypanosoma and Leishmania strains

Alkhaldi, A.A.M. 1 ; De Koning, H.P 2 ; Bukhari, S.N.A 3

Affiliations

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Country

Malaysia

Language

English

Abstract

Well-known medical herbal compounds including apigenin, daidzein, phyllanthin and tyramine were assessed against Trypanosoma and Leishmania protozoans. Two strains of the bloodstream forms of Trypanosoma brucei: s427-WT and TbAT1-B48, and Leishmania major and Leishmania mexicana promastigotes were utilised. Among selected natural compounds, apigenin and daidzein displayed moderate activity against African trypanosomes with EC50 16 μM for wild-type sensitive control strain. Tyramine was not found to be very active for trypanosomes strains while all compounds were found to have trivial activity for the inhibition of Leishmania mexicana strains.