Yonsei Medical Journal  2014;55(6):1562-1567

doi:10.3349/ymj.2014.55.6.1562

Coxsackievirus B Infection Is Highly Related with Missed Abortion in Korea.

Jung Hye HWANG 1 ; Jeong Wook KIM ; Ji Young HWANG ; Kyung Min LEE ; Hye Min SHIM ; Young Kyung BAE ; Seung Sam PAIK ; Hosun PARK

Affiliations

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Keywords

Coxsackievirus; missed abortion; fetal anomaly

Country

Republic of Korea

Language

English

Abstract

PURPOSE: This study investigated the possible relationship between viral infection and first trimester pregnancy loss. MATERIALS AND METHODS: A prospective study was performed on 51 gravidas with missed abortion, fetal anomaly, pre-term delivery, and full-tem delivery at Hanyang University Hospital. Enteroviruses were detected by semi-nested reverse transcription-polymerase chain reaction (RT-PCR) and immunohistochemistry in abortive tissues and placentas. Enterovirus serotypes were confirmed by genome sequencing. Herpesviruses were detected by PCR. RESULTS: Coxsackievirus B3 (CVB3) was detected in 8 of 14 missed abortion cases, 1 of 27 full-term cases, and none of the 9 pre-term cases. Coxsackievirus B1 (CVB1) was detected in an encephalocele case. Herpes simplex virus type 1 was found in 4 full-term cases, 3 pre-term cases, and none of the missed abortion cases. CONCLUSION: The prevalence of CVB3 was significantly higher in missed abortion cases compared to full-term or pre-term delivery cases. CVB infection may therefore be an important etiological agent of missed abortion.