Chinese Journal of Natural Medicines (English Ed.) 2017;15(12):944-949

doi:10.1016/S1875-5364(18)30011-6

Three new anthraquinone derivatives isolated from Symplocos racemosa and their antibiofilm activity.

Umar FAROOQ 1 ; Sara KHAN 2 ; Sadia NAZ 2 ; Ajmal KHAN 3 ; Afsar KHAN 4 ; Ayaz AHMED 5 ; Abdur RAUF 6 ; Syed Majid BUKHARI 2 ; Shujaat Ali KHAN 7 ; Arfa KAMIL 8 ; Nadia RIAZ 9 ; Abdur Rahman KHAN 2

Affiliations

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Keywords

Antibiofilm activity; Substituted anthraquinone; Symplocos racemosa

Country

China

Language

English

MeSH

Abstract

Three new alkyl substituted anthraquinone derivatives, trivially named as symploquinones A-C (Compounds 1-3) were isolated from Symplocos racemosa. The structures of these compounds were determined on the basis of extensive spectroscopic analyses (UV, IR, Mass, H- and C-NMR, and two-dimensional (2D) NMR techniques). The resulting data were also compared with the reported literature. These compounds were then subjected to antibacterial or antibiofilm testing. Compounds 1 and 3 exhibited good antibacterial activity in the concentration range of 160-83 μg·mL against Streptococcus mutans, methicillin resistant Staphylococcus aureus and Proteus mirabilis. Both compounds were further screened for anti-biofilm activity, which revealed promising activities at sub-MIC concentrations. None of the compounds were found to be active against Klebsiella pneumoniae.