Philippine Journal of Reproductive Endocrinology and Infertility 2019;16(1):15-21

Fertility-sparing surgery for a prepubertal female with malignant ovarian germ cell tumor.

Sharon L. PEÑARUBIA 1 ; Stella Marie L. JOSE 1 ; Ina S. Irabon 1

Affiliations

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Keywords

Malignant Ovarian Germ Cell Tumor; Pre-pubertal Female; Fertility-sparing Surgery; Platinum-based Chemotherapy

Country

Philippines

Language

English

Abstract

Malignant ovarian germ cell tumors are rare ovarian malignancies accounting for 3 to 5% of all ovarian malignancies. They are mostly seen in adolescents and young women and are usually unilateral making fertility preservation imperative. Raised alpha-feto protein level is the hallmark of this tumor. Presented is a case of a premenarcheal 13 year old female diagnosed with yolk sac tumor and who underwent fertility-sparing surgery and adjuvant platinum-based chemotherapy post-operatively, with good outcome. In young patients, conservative surgery with adjuvant chemotherapy has made the preservation of fertility possible, even in patients with advanced disease. The increase in cure rates has shifted the focus of recent studies to the long term menstrual, reproductive, and gynecologic outcomes in these patients.