Journal of Pharmaceutical Analysis 2015;(6):378-382
doi:10.1016/j.jpha.2014.11.002
Antimicrobial and antiproliferative prospective of kosinostatin-a secondary metabolite isolated from Streptomyces sp.
Vinayagam RAMBABU ; Subramaniyan SUBA ; Suburamaniyan VIJAYAKUMAR
Keywords
Kosinostatin; Secondary metabolite; Streptomyces sp.; Cytotoxic activity; MCF-7
Country
China
Language
Chinese
Abstract
Cancer is a communal health hazard worldwide. The present investigation attempts to evaluate anti-microbial and anticancer potential of kosinostatin on mammary carcinoma cell line (MCF-7). The an-ticancer and antiproliferative activities of kosinostatin were analyzed on MCF cell line by MTT assay and cytotoxicity assays like lactate dehydrogenase (LDH) and glutathione (GSH). The secondary metabolite kosinostatin exhibited its apoptotic nature by expressing p53 protein. Collectively, the results acquired from this study promise that kosinostatin shows the potent anticancer activity.
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