The reform of public hospital in prefecture-level cities is an important subject which is worth to discuss.The Regional Medical Group of Mindong Hospital in Ningde City,Fujian Province is taken as an example.On the base of the experience of Zhouning and Shouning medical alliance,the system and mechanism are continuously improved.Through improving corporate governance structure,the construction of the six integration,two-way referral mechanism and information construction,the system of public hospital which is goal-oriented,rational layout,refined frameworks,and functionally impeccable is established.Finally,the brand effect and influence of the regional medical group is attempted to be constructed.