Nephrosclerosis is a chronic kidney disease that gradually aggravates. Many elderly patients eventually require dialysis due to nephrosclerosis, which is the third-greatest cause of dialysis initiation. Past studies have shown that Chinese herbal medicines such as shinbuto may be effective for treatment. We evaluated the effect of concomitant shinbuto and boiogito extract administration to slow the progression of renal failure in patients with chronic kidney disease suspected to have nephrosclerosis. Our study included 20 patients with nephrosclerosis (12 male ; 8 female ; mean age, 76.2 years) treated at the Nephrology Department of Kagawaken Saiseikai Hospital on an outpatient basis. Shinbuto extract granules 5 g and boiogito extract granules 5 g were divided into two doses and given to the patients before breakfast and dinner. Laboratory tests were performed at baseline, 3 months, and 6 months. Serum creatinine levels decreased from 2.04 mg/dL at baseline to 1.72 mg/dL at 3 months and 1.59 mg/dL at 6 months, while eGFR increased from 26.8 mL/min at baseline to 32.2 mL/min at 3 months and 35.3 mL/min at 6 months (p < 0.01). Other laboratory tests showed no change. Shinbuto-boiogito may improve the renal function in patients with chronic kidney disease suspected with nephrosclerosis based on these data.