Chinese Journal of Zoonoses 2014;(7):743-746,752

doi:10.3969/cjz.j.issn.1002-2694.2014.07.016

Progress of Listeria monocy togenes as tumor vaccine vector

Feifei DUAN ; Yuelan YIN ; Meiqin KANG ; Weijun TAN ; Chengwu TAO ; Zhiming PAN ; Jinlin HUANG ; Xinan JIAO

Keywords

Listeria monocytogenes; vaccine vector; tumor

Country

China

Language

Chinese

Abstract

Listeriamonocytogenes is a facultative intracellular bacterium that enters professional antigen presenting cells , presents passenger antigens to the major histocompatibility complex class I and II pathways ,then elicits CD+4 and CD+8 T-cell-mediated immune responses .It was demonstrated that attenuated Listeriamonocytogenes as a novel live vaccine vector in deliv-ering tumor antigens of cervical cancer and melanoma etc .,could induce strong protective immune response ,and shows effec-tive antitumor immunotherapeutics .This review discussed the characteristics of immune responses elicited by Listeria monocy-togenes ,and the progress of its antitumor immunotherapeutics as delivery vaccine vector .