Chinese Journal of Marine Drugs 1994;0(01):-

CARBOXYLIC DERIVATIVES OF SUBERGORGIC ACID AND THEIR TOXICOLOGY

Yingcai PENG ; Zhongde WU ; Kanghou LONG

Keywords

Coral neurotoxin; subergorgic acid; derivatives; toxicology

Country

China

Language

Chinese

Abstract

Six new sesquiterpenoid compounds of nerve-activity were synthesized from a gorgonian neurotoxin -subergorgic acid (1). Toxicological studies and structural correlation with toxicity reveal that subergorgic acid may act on cholinesterase and make a reversible inhibition of its activity of hydrolysis.