Chinese Journal of Cancer Biotherapy 2000;7(4):273-274

Cytotoxicity of GS and IL-2 Activated PBMC to Malignant Glioma Cells

Junsheng LUO ; Lixue GU ; Huanjiu XI ; Bingjie WEI ; Xingbo LIU ; Jianwu QIU ; Pengfei ZHANG ; Hongren SHAN

Keywords

ginsenoside; IL-2; BT325; eytotoxicity

Country

China

Language

Chinese

Abstract

Objective: To investigate a new method for improving the therapeutic effect on malignant glioma. Methods: A new type of killer cells, named GS-LAK, was induced by means of costimulating the peripheral ginsenoside(GS) and interleukin-2 (IL-2). Comparing with control group-LAK cells, cytotoxicity of GS-LAK cells against malignant glioma cells(BT325) was examined with MTI method. Results: It showed that GS-LAK cells exhibited some advantages over LAKcells in proliferation, cytotoxicity, as well as the utilizing of IL-2. Conclusion: The application of GS-LAK cells mightopen a new prospect to clinical therapeutic approach to malignant glioma.