The Medical Journal of Malaysia 2019;74(1):97-98

Paraneoplastic relapsing minimal change disease associated with type A thymoma in an elderly patient: A case report and literature review

Clara Lee Ying Ngoh 1 ; Giap Hean Shaun Goh 2 ; Weng Kin Wong 1

Affiliations

+expand

Country

Malaysia

Language

English

Abstract

Thymoma is a rare mediastinal tumour that can be accompanied by different paraneoplastic syndromes. Here we report a case of Type A thymoma associated with relapsing minimal change disease (MCD). This case highlights: (1) The need to balance rapid prednisolone weaning against risk for relapse in an elderly patient at risk for steroid-induced complications. (2) The addition of calcineurin inhibitor in relapsed thymoma-related MCD, to achieve steroid sparing effects. Resection of the offending tumour and prompt immunosuppressive therapy are critical in getting best renal and overall outcomes in this rare entity