Protein & Cell.2020;11(10):703-706. doi:10.1007/s13238-020-00782-y
Protein & Cell
2002 (v1, n1) to Present ISSN: 1671-8925
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Potential treatment of COVID-19 by inhibitors of human dihydroorotate dehydrogenase.
Protein & Cell.2020;11(10):699-702. doi:10.1007/s13238-020-00769-9
Animals ; Betacoronavirus ; Coronavirus Infections ; drug therapy ; Drug Discovery ; Drug Evaluation, Preclinical ; Enzyme Inhibitors ; therapeutic use ; Humans ; Mice ; Molecular Structure ; Orthomyxoviridae Infections ; drug therapy ; Oseltamivir ; therapeutic use ; Oxidoreductases ; antagonists & inhibitors ; Pandemics ; Pneumonia, Viral ; drug therapy ; Pyrimidines ; biosynthesis
Protein & Cell.2020;11(10):776-782. doi:10.1007/s13238-020-00767-x
Adaptation, Physiological ; Adenosine Monophosphate ; administration & dosage ; analogs & derivatives ; pharmacology ; therapeutic use ; Administration, Intranasal ; Alanine ; administration & dosage ; analogs & derivatives ; pharmacology ; therapeutic use ; Animals ; Betacoronavirus ; genetics ; physiology ; Chlorocebus aethiops ; Coronavirus Infections ; drug therapy ; virology ; Disease Models, Animal ; Female ; Host Specificity ; genetics ; Lung ; pathology ; virology ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mutation, Missense ; Nasal Mucosa ; virology ; Pandemics ; Pneumonia, Viral ; drug therapy ; virology ; RNA, Viral ; administration & dosage ; genetics ; Turbinates ; virology ; Vero Cells ; Viral Load ; Virus Replication
Single-cell analysis reveals bronchoalveolar epithelial dysfunction in COVID-19 patients.
Protein & Cell.2020;11(9):680-687. doi:10.1007/s13238-020-00752-4
ALKBH1 deficiency leads to loss of homeostasis in human diploid somatic cells.
Protein & Cell.2020;11(9):688-695. doi:10.1007/s13238-020-00744-4
Recapitulation of SARS-CoV-2 infection and cholangiocyte damage with human liver ductal organoids.
Protein & Cell.2020;11(10):771-775. doi:10.1007/s13238-020-00718-6
Betacoronavirus ; isolation & purification ; pathogenicity ; Bile Acids and Salts ; metabolism ; Bile Ducts, Intrahepatic ; pathology ; virology ; Cell Culture Techniques ; Coronavirus Infections ; complications ; pathology ; Cytokine Release Syndrome ; etiology ; physiopathology ; Cytopathogenic Effect, Viral ; Epithelial Cells ; enzymology ; pathology ; virology ; Humans ; Hyperbilirubinemia ; etiology ; Liver ; pathology ; Organoids ; pathology ; virology ; Pandemics ; Peptidyl-Dipeptidase A ; analysis ; Pneumonia, Viral ; complications ; pathology ; Receptors, Virus ; analysis ; Serine Endopeptidases ; analysis ; Viral Load
The expanded development and application of CRISPR system for sensitive nucleotide detection.
Protein & Cell.2020;11(9):624-629. doi:10.1007/s13238-020-00708-8
Pioneer of burn medicine in China: Professor Li Ao and "Li Ao spirit".
Protein & Cell.2020;11(9):621-623. doi:10.1007/s13238-020-00703-z
Correction to: Core transcriptional signatures of phase change in the migratory locust.
Protein & Cell.2020;11(9):696-697. doi:10.1007/s13238-019-00688-4
In the original publication the photo of the gregarious adult locust in Fig. 1A is incorrect. The correct photo of adult migratory locust is provided in this correction.
High-throughput screening of SARS-CoV-2 main and papain-like protease inhibitors.
Protein & Cell.2023;14(1):17-27. doi:10.1093/procel/pwac016
The global COVID-19 coronavirus pandemic has infected over 109 million people, leading to over 2 million deaths up to date and still lacking of effective drugs for patient treatment. Here, we screened about 1.8 million small molecules against the main protease (Mpro) and papain like protease (PLpro), two major proteases in severe acute respiratory syndrome-coronavirus 2 genome, and identified 1851Mpro inhibitors and 205 PLpro inhibitors with low nmol/l activity of the best hits. Among these inhibitors, eight small molecules showed dual inhibition effects on both Mpro and PLpro, exhibiting potential as better candidates for COVID-19 treatment. The best inhibitors of each protease were tested in antiviral assay, with over 40% of Mpro inhibitors and over 20% of PLpro inhibitors showing high potency in viral inhibition with low cytotoxicity. The X-ray crystal structure of SARS-CoV-2 Mpro in complex with its potent inhibitor 4a was determined at 1.8 Å resolution. Together with docking assays, our results provide a comprehensive resource for future research on anti-SARS-CoV-2 drug development.
Humans ; Antiviral Agents/chemistry* ; COVID-19 ; COVID-19 Drug Treatment ; High-Throughput Screening Assays ; Molecular Docking Simulation ; Protease Inhibitors/chemistry* ; SARS-CoV-2/enzymology* ; Viral Nonstructural Proteins
Humans ; Antiviral Agents/chemistry* ; COVID-19 ; COVID-19 Drug Treatment ; High-Throughput Screening Assays ; Molecular Docking Simulation ; Protease Inhibitors/chemistry* ; SARS-CoV-2/enzymology* ; Viral Nonstructural Proteins
Country
China
Publisher
Institute of Biophysics, Chinese Academy of Sciences
ElectronicLinks
http://www.protein-cell.net/Editor-in-chief
Zihe Rao
protein_cell@biols.ac.cn
Abbreviation
Vernacular Journal Title
ISSN
1674-800X
EISSN
1674-8018
Year Approved
2013
Current Indexing Status
Currently Indexed
Start Year
2010
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