Journal of Gynecologic Oncology.2009;20(3):200-200. doi:10.3802/jgo.2009.20.3.200
No abstract available.
Journal of Gynecologic Oncology
to Present ISSN: 2005-0380
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Journal of Gynecologic Oncology.2009;20(3):199-199. doi:10.3802/jgo.2009.20.3.199
No abstract available.
Journal of Gynecologic Oncology.2009;20(3):198-198. doi:10.3802/jgo.2009.20.3.198
A single horn endometrial carcinoma of a uterus bicornis unicollis.
Journal of Gynecologic Oncology.2009;20(3):195-197. doi:10.3802/jgo.2009.20.3.195
In this report, we describe a case of endometrial carcinoma arising in one horn of a bicornuate uterus. The diagnosis of this rare combination can be missed unless an unrecognized postmenopausal bleeding alerts the gynecologist to make a careful search for both endometrial cavities that may be curetted. Physicians should remember the possible existence of a separate uterine cavity when endometrial cancer is clinically suspected but histology fails to confirm the diagnosis.
Animals ; Endometrial Neoplasms ; Female ; Hemorrhage ; Horns ; Uterus
Animals ; Endometrial Neoplasms ; Female ; Hemorrhage ; Horns ; Uterus
A case of non-gestational choriocarcinoma arising in the ovary of a postmenopausal woman.
Journal of Gynecologic Oncology.2009;20(3):192-194. doi:10.3802/jgo.2009.20.3.192
Primary ovarian choriocarcinoma arising from a germ cell is an extremely rare occurrence, especially in postmenopausal women, and the prognosis is poor. Non-gestational choriocarcinoma of the ovary (NGCO) accounts for 0.6% or less of all ovarian neoplasms. It is important to distinguish gestational choriocarcinomas of the ovary (GCO) from other carcinomas because of the poor prognosis of NGCO. We describe a case of NGCO with lung metastasis in a 55 year old woman, which we present together with a brief review of the literature.
Choriocarcinoma ; Choriocarcinoma, Non-gestational ; Female ; Germ Cells ; Humans ; Lung ; Neoplasm Metastasis ; Ovarian Neoplasms ; Ovary ; Postmenopause ; Pregnancy ; Prognosis
Choriocarcinoma ; Choriocarcinoma, Non-gestational ; Female ; Germ Cells ; Humans ; Lung ; Neoplasm Metastasis ; Ovarian Neoplasms ; Ovary ; Postmenopause ; Pregnancy ; Prognosis
Journal of Gynecologic Oncology.2009;20(3):187-191. doi:10.3802/jgo.2009.20.3.187
Paraneoplastic neutrophilia caused by a squamous cell carcinoma of the uterine cervix has been seen rarely. We report a case of relapsed squamous cell carcinoma of the uterine cervix with severe neutrophilia, rapid tumor growth and aggressive clinical course, possibly due to autocrine stimulation of cell growth by G-CSF and IL-6 without other possible causes of neutrophilia.
Carcinoma, Squamous Cell ; Cervix Uteri ; Female ; Granulocyte Colony-Stimulating Factor ; Interleukin-6 ; Paraneoplastic Syndromes
Carcinoma, Squamous Cell ; Cervix Uteri ; Female ; Granulocyte Colony-Stimulating Factor ; Interleukin-6 ; Paraneoplastic Syndromes
Journal of Gynecologic Oncology.2009;20(3):181-186. doi:10.3802/jgo.2009.20.3.181
OBJECTIVE: The purpose of this study was to determine the possible predicting factors of coexisting adnexal malignancies, and to evaluate the safety of ovary-saving surgery for early-stage endometrial carcinoma in premenopausal patients. METHODS: A retrospective review of 107 patients with endometrial carcinoma who underwent surgical treatment at our institution was conducted. All patients were younger than 50 years of age and premenopausal status. Statistical analysis was performed. RESULTS: Of the 107 patients, 78 patients had stage I to II disease and both preoperative CA-125 levels were measured and tumor grades evaluated. On multivariate analysis, preoperative CA-125 levels (p=0.018) and preoperative tumor grade (p=0.029) were independent predicting factors of adnexal diseases. The risk of coexisting ovarian malignancy was 1.8% in patients with preoperative CA-125 levels less than or equal to 34.5 U/ml and preoperative tumor grade 1 or 2. The risk increases to 20% for low CA-125 and grade 3, 13.3% for high CA-125 and grade 1 or 2, and 100% for high CA-125 and grade 3. Between patients who underwent unilateral salpingo-oophorectomy and those who underwent bilateral salpingo-oophorectomy, there was no statistically significant difference in terms of BMI, preoperative CA-125 levels, FIGO stage, histology, tumor grade, lymphadenectomy, and adjuvant treatment. CONCLUSION: Ovary-saving surgery for premenopausal, early-stage endometrial cancer patients may be considered as a treatment option in those with low preoperative CA-125 and low tumor grade.
Adnexal Diseases ; Endometrial Neoplasms ; Female ; Humans ; Lymph Node Excision ; Multivariate Analysis ; Retrospective Studies
Adnexal Diseases ; Endometrial Neoplasms ; Female ; Humans ; Lymph Node Excision ; Multivariate Analysis ; Retrospective Studies
Clinical analysis of intra-operative frozen section proven borderline tumors of the ovary.
Journal of Gynecologic Oncology.2009;20(3):176-180. doi:10.3802/jgo.2009.20.3.176
OBJECTIVE: We have assessed the accuracy of frozen section diagnosis and the outcomes of misdiagnosis in borderline tumors of the ovary (BTO) according to frozen section. METHODS: All pathology reports with BTO in both frozen and permanent section analyses between 1994 and 2008 at Seoul St. Mary's Hospital were reviewed. Frozen section diagnosis and permanent section histology reports were compared. Logistic regression models were conducted to evaluate the correlation of patient and tumor characteristics with diagnostic accuracy. The clinical outcomes of misdiagnosis were evaluated. RESULTS: Agreement between frozen section diagnosis and permanent histology was observed in 63 of 101 patients (62.4%). Among the 76 patients with frozen section proven BTO, under-diagnosis and over-diagnosis occurred in 8 of 76 (10.5%) and 5 of 76 patients (6.6%), respectively. Mean diameter of under-diagnosed tumor was larger than matched BTO (21.0+/-11.4 vs. 13.7+/-7.1; p=0.021). Tumor size 20 cm was determined as the optimal cut-off for under-diagnosis (50% sensitivity, 87.3% specificity). Among 8 under-diagnosed patients, no patient relapsed. Among 5 over-diagnosed patients, 2 patients < 35 years of age had fertility-preserving surgery. CONCLUSION: Although frozen section diagnosis is an important and reliable tool in the clinical management of patients with ovarian tumors, over-diagnosis and under-diagnosis are relatively frequent in frozen proven BTO. Surgical decision-making for BTO based on frozen section diagnosis should be done carefully, especially in large tumors.
Diagnostic Errors ; Female ; Frozen Sections ; Humans ; Logistic Models ; Ovary
Diagnostic Errors ; Female ; Frozen Sections ; Humans ; Logistic Models ; Ovary
Journal of Gynecologic Oncology.2009;20(3):169-175. doi:10.3802/jgo.2009.20.3.169
OBJECTIVE: To examine the correlation among the preoperative serum levels of five biomarkers presumed to be useful for early detection of epithelial ovarian cancer and evaluate the relationships between serum levels of these five biomarkers and epithelial ovarian cancer stage. METHODS: We analyzed 56 newly diagnosed epithelial ovarian cancer patients. Preoperative serum levels of leptin, prolactin, osteopontin (OPN), insulin-like growth factor-II, and CA-125 were determined by ELISA. We also examined the correlation between the serum levels of the biomarkers and ovarian cancer stage. Significant differences in the mean serum levels of two proteins, leptin and CA-125, were observed between stage subsets. RESULTS: There was a significant negative correlation between prolactin and leptin and a significant positive correlation between prolactin and OPN. Of the five biomarkers, only the mean serum CA-125 level showed a significant positive correlation with cancer stage (Spearman rho=0.24, p<0.01). OPN showed a marginally significant positive correlation with stage (Spearman rho=0.14, p=0.07). CONCLUSION: We demonstrated the relationship between five biomarkers in epithelial ovarian cancer. These tumor markers may be useful in screening for ovarian cancer, in characterizing disease states, and in developing therapeutic interventions targeting these marker proteins. Large-scale studies that include potential confounding factors and modifiers are necessary to more accurately define the value of these novel biomarkers in ovarian cancer.
Biomarkers ; Enzyme-Linked Immunosorbent Assay ; Humans ; Leptin ; Mass Screening ; Neoplasms, Glandular and Epithelial ; Osteopontin ; Ovarian Neoplasms ; Prolactin ; Proteins ; Biomarkers, Tumor
Biomarkers ; Enzyme-Linked Immunosorbent Assay ; Humans ; Leptin ; Mass Screening ; Neoplasms, Glandular and Epithelial ; Osteopontin ; Ovarian Neoplasms ; Prolactin ; Proteins ; Biomarkers, Tumor
Journal of Gynecologic Oncology.2009;20(3):164-168. doi:10.3802/jgo.2009.20.3.164
OBJECTIVE: To examine the correlation between cervical cytology and final histological results in patients who have undergone loop electrosurgical excision procedure (LEEP) with or without colposcopy-directed biopsy. METHODS: A retrospective review was performed of 829 patients who underwent LEEP for abnormal cervical cytology at Gangnam Severance Hospital between January 2004 and December 2008. Patients were classified to three groups according to cervical cytology and also divided into two groups based on the treatment they received: see-and-treat group and the standard three-step group. Final histological results were compared for the each study group. RESULTS: There were no differences in the final histological results between see-and-treat and three-step group in patients with high-grade squamous intraepithelial lesions (HSIL) cytology (N=523) (p=0.71). However, in patients with low-grade squamous intraepithelial lesions (LSIL)/atypical squamous cells of undetermined significance (ASCUS) (N=257) or normal cytology (N=49), the final histological results were significantly different between see-and-treat and three-step group (p<0.001) and the rate of overtreatment was significantly higher in the see-and-treat group (p<0.001). CONCLUSION: A see-and-treat protocol may be a viable alternative only in patients with HSIL cytology if colposcopic impression is suggestive of cervical intraepithelial neoplasia (CIN) 2 or 3 lesions.
Biopsy ; Cervical Intraepithelial Neoplasia ; Humans ; Retrospective Studies
Biopsy ; Cervical Intraepithelial Neoplasia ; Humans ; Retrospective Studies
Country
Republic of Korea
Publisher
Asian Society of Gynecologic Oncology; Korean Society of Gynecologic Oncology
ElectronicLinks
http://synapse.koreamed.org/LinkX.php?code=1114JGOEditor-in-chief
Abbreviation
J Gynecol Oncol
Vernacular Journal Title
부인종양
ISSN
2005-0380
EISSN
2005-0399
Year Approved
2007
Current Indexing Status
Currently Indexed
Start Year
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