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Effect of electro-acupuncture intervention on cognition attention bias in heroin addiction abstinence-a dot-probe-based event-related potential study.

Ying-Ping JIANG ; Hao LIU ; Ping XU ; Yan WANG ; Guang-Hua LU

Chinese journal of integrative medicine.2011;17(4):267-271. doi:10.1007/s11655-011-0698-y

OBJECTIVETo study the changes of cognitive attention-related brain function in the heroin addicts before and after electro-acupuncture (EA) intervention for exploring the concerned neuro-mechanism of addictive relapse and the central action role of EA intervention.

METHODSAdopting event-related potential (ERP) technique, the ERP at 64 electrode spots in 10 heroin addicts (test group) were recorded before and after EA intervention with dot-probe experimental form during implementing cognitive task on positive emotional clue (PEC), negative emotional clues (NEC), and heroin-related clue (HRC). The P200 amplitude components on the selected observation points (Fz, Cz, and Pz) were analyzed and compared with those obtained from 10 healthy subjects as the control.

RESULTSBefore EA, the ERP of attention on HRC in the test group was higher than that on PEC and NEC (P<0.05) and significantly higher than that in the control group (P<0.05); after EA, the P200 amplitude of attention on HRC at Cz and Pz was significantly lowered (P<0.05) and that on PEC at Fz was significantly elevated (P<0.05). After EA, the P200 amplitude at Pz was ranked as NEC > PEC > HRC, but in the control group, it showed PEC > HRC at all three observation points and PEC > NEC at Pz.

CONCLUSIONHeroin addicts show attention bias to HRC, which could be significantly reduced by EA intervention, illustrating that EA could effectively inhibit the attention bias to heroin and so might have potential for lowering the relapse rate.

Adult ; Attention ; Case-Control Studies ; Cognition ; Electroacupuncture ; Evoked Potentials ; Heroin Dependence ; physiopathology ; therapy ; Humans ; Male ; Substance Withdrawal Syndrome ; physiopathology ; therapy

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Effects of external application of Chinese medicine on diabetic ulcers and the expressions of β-catenin, c-myc and K6.

Fu-Lun LI ; Hui DENG ; Hong-Wei WANG ; Rong XU ; Jie CHEN ; Yi-Fei WANG ; Xin LI ; Bin FAN ; Bin LI

Chinese journal of integrative medicine.2011;17(4):261-266. doi:10.1007/s11655-011-0703-5

OBJECTIVETo observe the clinical efficacy of Chinese medicine (CM) treatment of Hongyou Ointment and Shengji Powder on diabetic ulcers, and to observe the influence of CM treatment on the expressions of proteins associated with the Wnt signaling pathway, such as β-catenin, c-myc and K6.

METHODSsixty-two patients fitting the registration standards were randomly divided into the CM group (31 patients) and the Western medicine (WM) group (31 patients) by a random number table. The patients in the CM group were treated with Hongyou Ointment and Shengji Powder externally. The patients in the WM group were treated with mupirocin ointment, growth factor (bFGF), and Vaseline gauze for external use and with basic therapies. Wound-healing time and four-week healing rate were recorded. The wounds were measured by digital photography and ImageJ software. Skin biopsies were obtained from 24 patients before CM treatment and 20 patients after CM treatment. Immunohistochemical tests and semi-quantitative imaging with NIH ImageJ 1.42 software were used to analyze the changes in protein expression of β-catenin, c-myc, and K6.

RESULTSFifty-three patients completed the trial; four patients in the CM treatment group and five patients in the WM group dropped out. Among them, four were dissatisfied with the treatment process, two could not continue because of their jobs, two failed to complete the course of follow-up appointments, and one was diagnosed with squamous cell carcinoma during treatment. The comparison of ulcer healing rates between the two groups showed insignificant differences (P=0.77). The ulcer healing rates were 33.33% (9/27) in the CM group and 26.92% (7/26) in the WM group. However, the effective rate was significantly higher in the CM group (81.48%, 22/27) than in the WM group (57.69%, 15/26, P=0.04). The mean wound healing time was shorter in the CM group (22.71 ±5.46 days) than in the WM group (26.56 ±7.56 days, P=0.04). CM treatment was well tolerated, and there was no withdrawal due to adverse reactions. Immunohistochemical analysis in the refractory wound indicated higher expressions of β-catenin, c-myc and K6 compared with the normal skin. β-catenin was abnormally expressed in the nuclei of the keratinocytes and fibroblasts at the wound margins, and the expressions of c-myc and K6 were highly expressed in the full hyperplastic epidermis, especially in the granular layer (P<0.05). The expressions of these proteins decreased after CM treatment. The expression levels of β-catenin, c-myc, and K6 proteins before and after the treatment were 101.88 ± 10.76 vs. 140.42 ±8.45; 113.27 ± 16.75 vs. 153.79 ±8.32; 90.39 ±11.07 vs. 151.29 ±7.39, respectively.

CONCLUSIONSCM treatment using Hongyou Ointment and Shengji Powder was efficient in the management of diabetic skin ulcers. The mechanism of action might be related to the inhibition of the Wnt signaling pathway.

Adult ; Aged ; Diabetes Complications ; metabolism ; therapy ; Female ; Humans ; Immunohistochemistry ; Male ; Medicine, Chinese Traditional ; Middle Aged ; Polysaccharides, Bacterial ; metabolism ; Prospective Studies ; Proto-Oncogene Proteins c-myc ; metabolism ; Single-Blind Method ; Skin Ulcer ; metabolism ; therapy ; beta Catenin ; metabolism

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Acupuncture for treating attention deficit hyperactivity disorder: a systematic review and meta-analysis.

Myeong Soo LEE ; Tae-Young CHOI ; Jong-In KIM ; Lakhyung KIM ; Edzard ERNST

Chinese journal of integrative medicine.2011;17(4):257-260. doi:10.1007/s11655-011-0701-7

OBJECTIVETo assess the effectiveness of acupuncture as a treatment option for attention deficit hyperactivity disorder (ADHD).

METHODSThe literatures were searched using 15 databases, including MEDLINE, AMED, CINAHL, EMBASE, PsycInfo, the Cochrane Central Register of Controlled Trials, the Cochrane Database of Systematic Reviews, six Korean medical databases and two Chinese databases without language restritions. Prospective controlled clinical studies of any type of acupuncture therapy for ADHD autistic patients were included. Trials in which acupuncture was part of a complex intervention were also included. All articles were read by two independent reviewers, who extracted data from the articles according to predefined criteria. Risk of bias was assessed using the Cochrane risk of bias tool.

RESULTSOf 114 articles, only three randomized clinical trials (RCTs) met our inclusion criteria. One RCT found that electroacupuncture (EA) plus behavioural treatment was superior to sham EA plus behavioural treatment. Two RCTs reported a significant benefit of acupuncture or auricular acupuncture over conventional drug therapies.

CONCLUSIONSLimited evidence exists for the effectiveness of acupuncture as a symptomatic treatment of ADHD. Given that the risk of bias of the included studies was high, firm conclusions cannot be drawn.

Acupuncture ; Attention Deficit Disorder with Hyperactivity ; therapy ; Humans ; Information Storage and Retrieval ; Treatment Outcome

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An overview of current oriental medicine herbal cancer research in Korea.

Jeungwon YOON ; Hwa-Seung YOO ; Yeon-Weol LEE ; Chong-Kwan CHO

Chinese journal of integrative medicine.2011;17(4):251-256. doi:10.1007/s11655-011-0710-6

Cancer is the number one cause of death in Korea with annual mortalities of 69 780. Research suggests one in every four Koreans will end up getting cancer at some point in their life time. With these persistent threats, strive for cancer cure is continued. Ten years of Korea's oriental medicine herbal research on cancer have been reviewed. Researches between the years of 2000 and 2010 are analyzed in terms of their published year, study types, tested subjects, testing measures, cancer types, and institutions. In the past ten years, cancer researches have blossomed from null to full in Korean peninsula, and further development is much anticipated in the next ten years to come.
Academies and Institutes ; Biomedical Research ; Herbal Medicine ; Humans ; Neoplasms ; therapy ; Republic of Korea

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Integrative oncology in Australia.

Daniel WEBER ; Janelle M WHEAT ; Geoffrey M CURRIE

Chinese journal of integrative medicine.2011;17(4):246-250. doi:10.1007/s11655-011-0711-5

The use of alternative medicine (AM) in Australia dates back to its earliest times, with the indigenous medicine of the aboriginal peoples and the folk medicine of the early English settlers. AM has until recently existed quite separately from Western biomedicine (WB) and there has been little integration of the two systems. Now, referred to as complementary medicine (CM), there has been a movement over the last 20 years to include CM in WB mainstream practices. Varying degrees of success have been reported but for the discipline of oncology. Medical oncology (MO) in Australia is demanding CM provide high levels of evidence for any inclusion in cancer protocols. There are just now the beginnings of this integration, particularly as CM is now being taught in the public university system to a PhD level as well as the public demand for their medical doctors to communicate with their CM practitioners. MO specialists are now open to a dialogue with their CM counterparts.
Australia ; Humans ; Integrative Medicine ; Medical Oncology ; Neoplasms ; therapy

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Integrative medicine: a characteristic China model for cancer treatment.

Jie LI ; Hong-Sheng LIN

Chinese journal of integrative medicine.2011;17(4):243-245. doi:10.1007/s11655-011-0712-4

Integrative medicine (IM) has attracted increasing attention of the experts and patients around the world. Chinese medicine (CM), as the important part of IM, has played an important role in the treatment of cancer. CM is practiced side by side with Western medicine in many of China's hospitals and clinics. On the basis of the review of the clinical practices and basic researches these years, we introduce the current situation and progress in integrative oncology in China, and show the main feature of CM approach in the cancer treatment. Furthermore, we also discuss the main problems limiting the progress of CM, and point out international collaboration will provide new opportunity to promote the development of IM in China.
China ; Humans ; Integrative Medicine ; Neoplasms ; therapy

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Protective effect of Renshen Yangrong Decoction (人参养荣汤) on bone marrow against radiation injury in mouse.

Yan-zhi CHEN ; Fei LIN ; Gui-bao ZHUANG ; Yan REN ; Ping-ping LI

Chinese journal of integrative medicine.2011;17(6):453-458. doi:10.1007/s11655-011-0634-1

OBJECTIVETo explore the effect of Renshen Yangrong Decoction (人参养荣汤, RYD) in protecting bone marrow from radiation injury.

METHODSOne hundred and eighty Kuming mice were subjected to the three tests for anti-radiation injury effect evaluation, i.e. the test of peripheral white blood cell (WBC) count, the test of bone marrow nucleated cell count, and the bone marrow micronucleus test, using 60 mice for each test. The mice in each test were divided into 6 groups: the blank control group, the model control group, the positive control group treated by Shiyiwei Shenqi Tablet (十一味参芪片, 1.0 g/kg), and three RYD groups treated with high (42.0 g/kg), moderate (21.0 g/kg), and low (10.5 g/kg) doses of crude drugs of RYD, with 10 mice in each group. The treatment was given by gastrogavage perfusion continuously for 7-14 days before mice received (60)Co-γ ray radiation and continued until the end of the experiment. The body weights of the mice were monitored, the changes in peripheral WBC and bone marrow nucleated cells were counted, and the variation in bone marrow micronucleated cells was observed on the respective appointed days.

RESULTSA significant decrease in body weight, peripheral WBC count, and bone marrow nucleated cell count, as well as marked changes in bone marrow micronucleated cells were observed in the mice after radiation, indicating that the radiation injury model was successfully established. As compared with the model control group, the decrease in body weight, peripheral WBC count, and bone marrow nucleated cell count, as well as the increase in bone marrow micronucleus cell count in the high dosage RYD treated group were obviously inhibited or lessened (P<0.05 or P<0.01).

CONCLUSIONRYD showed obvious protective effect in mice with bone marrow injury induced by radiation.

Animals ; Body Weight ; drug effects ; radiation effects ; Bone Marrow ; drug effects ; pathology ; radiation effects ; Bone Marrow Cells ; drug effects ; pathology ; radiation effects ; Drugs, Chinese Herbal ; pharmacology ; Leukocyte Count ; Mice ; Radiation Injuries ; blood ; pathology ; prevention & control ; Radiation-Protective Agents ; pharmacology

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Effects of Herba epimedii and Fructus ligustri lucidi on the transcription factors in hypothalamus of aged rats.

Jing CAI ; Teng ZHENG ; Lei ZHANG ; Yun TIAN ; Min-he YANG ; Jian DU

Chinese journal of integrative medicine.2011;17(10):758-763. doi:10.1007/s11655-011-0636-z

OBJECTIVETo comparatively analyze the difference in the expression of 54 transcription factors in the hypothalamus using protein chips following the medication of Chinese drugs for Shen-tonification, Herba Epimedii, and Fructus Ligustri lucidi (FL) to aged rats.

METHODSWistar rats, aged 15 months of SPF grade, were randomized into three groups, three males and three females in each group. They were medicated with Herba Epimedii decoction (HED, 0.14 g/kg), Fructus Ligustri lucidi decoction (FLD, 0.12 g/kg), and distilled water, respectively, twice a day for 15 days. The rats were sacrificed at the morning of the 16th day 1 h after medication, and their hypothalamus was taken and made into homogenate under an ice-bath for detecting the expression of transcription factors with chip technique.

RESULTSThe expressions of signal transduction and transcription activation factor-6 (Stat-6) and androgen receptor (AR) were up-regulated, and those of pre-B transcription factor1 (Pbx-1), stat-1 and AP-2 were down-regulated in both HED and FLD treated groups, but these changes occurred mainly in female rats in the former while mainly in males in the latter.

CONCLUSIONSChinese drugs for Shen-tonification could impact the expression of transcription factors in the hypothalamus of aged rats, dominantly on the neuro-endocrine factors responsible for the growth and development. The effects of drugs for tonifying Shen-yang and for tonifying Shen-yin are different, which is probably one of the pharmacological mechanisms of the Shen-tonifying drugs.

Aging ; drug effects ; metabolism ; Animals ; Down-Regulation ; drug effects ; Drugs, Chinese Herbal ; pharmacology ; Female ; Hypothalamus ; drug effects ; metabolism ; Male ; Protein Array Analysis ; Rats ; Rats, Wistar ; Transcription Factors ; metabolism ; Up-Regulation ; drug effects

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Incorporation of massage into psychotherapy: an integrative and conjoint approach.

Paul POSADZKI ; Sheetal PAREKH-BHURKE

Chinese journal of integrative medicine.2011;17(2):154-158. doi:10.1007/s11655-011-0633-2

This article presents the potential integration of psychotherapy and massage when considering the essence of their beneficial effects. The essence of this model of practice is multifaceted, combining principles from anatomy, physiology and neuroscience with psychotherapy to benefit patient care. It has been advocated that possessing multidisciplinary knowledge from these areas of science enhances psychotherapists' holistic care of their depressive patients. A narrative review of the literatures and a qualitative, conceptual synthesis has been performed to create a new theoretical-pragmatic construct. This article introduces the concept of massage practice as a part of psychotherapy practice and presents the potential integration of psychotherapeutic knowledge with clinical decision-making and the management of depressive symptoms. The authors emphasize the usefulness of multi- and interdisciplinary knowledge in the psychotherapeutic process and explain how this knowledge might be extrapolated and incorporated into theoretical and practical settings to benefit depressive patients. The justification for this concept is also presented. The principles set out in this article may be a useful source of information for psychotherapists concerned about their patients' holistic well-being in addition to the psychopathology for which they have sought treatment. Researchers and psychotherapists can obtain valuable and additional knowledge through cross-fertilization of ideas across the arguments presented here.
Combined Modality Therapy ; methods ; Depression ; therapy ; Humans ; Integrative Medicine ; methods ; Massage ; methods ; utilization ; Mental Disorders ; therapy ; Psychotherapy ; methods ; Treatment Outcome

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Literature research of Chinese medicine recipes for the treatment of psoriasis vulgaris with blood-heat syndrome type.

Ya-Qi TAN ; Jiu-Li LIU ; Yan-Ping BAI ; Li-Xin ZHANG

Chinese journal of integrative medicine.2011;17(2):150-153. doi:10.1007/s11655-011-0645-y

OBJECTIVETo analyze and investigate the rules for drug utilization of Chinese medicine for the treatment of psoriasis vulgaris with blood-heat syndrome.

METHODSThe literatures that met the following inclusion criteria were screened out from China National Knowledge Infrastructure (CNKI) from January 1998 to December 2008, including the compositions and dosages of the recipes reported completely and accurately, the sample size being [Symbol: see text] 30 cases and the total effective rate being [Symbol: see text] 70%.

RESULTSIn total, 289 papers meeting the inclusion criteria were retrieved, involving 301 recipes; in which 111 recipes consisting of 145 individual drugs were the function for clearing the heat, accounting for 52.84%. The three drugs with the highest utilized frequency were Radix Rehmanniae, Radix Arnebiae seu Lithospermi and Cortex Moutan. Meridian adscription of the drugs was mainly the Gan-meridian.

CONCLUSIONThere were rules for the treatment of psoriasis vulgaris of blood-heat syndrome with Chinese medicine prescriptions.

Chemistry, Pharmaceutical ; Drugs, Chinese Herbal ; therapeutic use ; Hematologic Diseases ; drug therapy ; etiology ; Hot Temperature ; Humans ; Medicine, Chinese Traditional ; methods ; Psoriasis ; complications ; drug therapy ; Review Literature as Topic ; Syndrome

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