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Effects of Shehuang Paste on hemodynamics, endotoxin, nitric oxide and endothelin-1 in patients with refractory cirrhotic ascites.

Guang-dong TONG ; Da-qiao ZHOU ; Jin-song HE ; Song-lin LI ; Li-sheng PENG

Chinese journal of integrative medicine.2006;12(4):255-261.

OBJECTIVETo explore the influence of Shehuang Paste (SHP) to the hemodynamics, endotoxin, nitric oxide (NO), and endothelin-1 (ET-1) in patients with refractory cirrhotic ascites.

METHODSFifty-nine cases of refractory cirrhotic ascites were randomly assigned to two groups, 32 cases in the treatment group and 27 cases in the control group. The basic treatment was the same for both groups, including liver protecting medicines, diuretics and supportive drugs, but SHP navel sticking was applied for the treatment group additionally once a day. A course of one month of treatment was applied and the general efficacy on ascites was observed by the end of the therapeutic course. Before and after the treatment, examinations by limulus lysate chromogenic test was conducted to measure plasma endotoxin content; colorimetry to measure plasma content of NO indirectly, radioimmunoassay to measure plasma ET-1 content; and color Doppler ultrasonography to measure the blood flow of portal vein and splenic vein. The relationship between the blood flow of portal vein and splenic vein and endotoxin, NO and ET-1 in the treatment group was analyzed as well.

RESULTSThe total effective rate on ascites was 84.4% in the treatment group, and 48. 1% in the control group, with significant difference shown between them (P<0.01). In the treatment group the blood flow of portal vein and splenic vein, contents of endotoxin, NO and ET-1 all got significantly reduced after treatment ( P<0.05 or P<0.01); while these indexes in the control group were not significantly changed ( P 0.05). Moreover, it was found that in the treatment group, the blood flow of portal vein and splenic vein had a positive correlation to the levels of NO, ET-1, and endotoxin, either before or after treatment.

CONCLUSIONApplication of SHP navel sticking could clearly reduce the blood flow of portal vein and splenic vein, and lower the content of endotoxin, NO and ET-1. The blood flow of portal vein and splenic vein in the treatment group showed a positive correlation with the contents of endotoxin, NO and ET-1. liver cirrhosis, refractory ascites, vasoactive substance, hemodynamics

Adult ; Endothelin-1 ; blood ; Endotoxins ; blood ; Female ; Follow-Up Studies ; Humans ; Liver ; drug effects ; physiopathology ; Liver Cirrhosis ; blood ; drug therapy ; physiopathology ; Male ; Medicine, Chinese Traditional ; Middle Aged ; Nitric Oxide ; blood ; Portal Vein ; drug effects ; physiopathology ; Potassium ; metabolism ; Regional Blood Flow ; drug effects ; Sodium ; metabolism

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Effects of Jinye Baidu Granule on fetal growth and development with maternal active human cytomegalovirus infection.

Hong JIANG ; Su-hua CHEN ; Liang-zhen WEN

Chinese journal of integrative medicine.2006;12(4):250-254.

OBJECTIVETo evaluate the effects of Jinye Baidu Granule ( JYBDG), a traditional Chinese medicine compound prescription, on fetal growth and development with maternal active human cytomegalovirus infection.

METHODSA prospective, randomized and controlled trial was adopted during January 1996 to June 2002. From the pregnant women with an abnormal pregnant history, 240 cases were screened to be infected by human cytomegalovirus (HCMV) by enzyme-linked immunoabsorbent assay (ELISA) and reverse transcription polymerase chain reaction (RT-PCR). They were assigned according to the random number table to two groups. The 122 cases in the treatment group were administrated with JYBDG, one package each time, three times a day for two continuous weeks, while the other 118 in the control group did not receive any treatment. The negative conversion rate of both HCMV-IgM and HCMV late mRNA, the positive rate of HCMV-DNA in placenta and the intrauterine transmission rate between the two groups were compared, and fetal growth and development in partial fetuses were also observed.

RESULTSThe negative conversion rate of both HCMV-lgM and HCMV late mRNA, the positive rate of HCMV-DNA in placenta and the intrauterine transmission rate in the treatment group were 77. 05% (94/122), 48. 98% (48/98) and 21.74% (10/46) respectively, while those in the control group were 38. 14% (45/118), 67.50% (54/80) and 52.63% (20/38) respectively, all showing significant difference between the two groups (P<0. 01). Totally 35 normal infants and 11 abnormal infants were born in the treatment group, and the number in the control group was 20 and 18 respectively, and comparison between the two groups showed significant difference (P<0.01). Six months of child birth, the scores of both mental development index (MDI) and psychomotor development index (PDI) of infants were higher in the treatment group (20 cases) than those in the control group (20 cases), but there was no significant difference between the two groups (P>0.05).

CONCLUSIONJYBDG could decrease the intrauterine transmission of HCMV and is beneficial to fetal growth and development.

Adult ; Antibodies, Viral ; blood ; Cytomegalovirus Infections ; drug therapy ; DNA, Viral ; analysis ; Female ; Fetal Development ; drug effects ; Humans ; Immunoglobulin M ; blood ; Medicine, Chinese Traditional ; Placenta ; virology ; Pregnancy ; Pregnancy Complications, Infectious ; drug therapy ; Prospective Studies

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Effect of traditional Chinese herbs combined with low dose human menopausal gonadotropin applied in frozen-thawed embryo transfer.

Hui-qin ZHANG ; Bei YAN ; Hong-xin ZHAO ; Dun-yu GU ; Xiao-feng JIA ; Lin CAO ; Lei WANG ; Hui-juan SHI

Chinese journal of integrative medicine.2006;12(4):244-249.

OBJECTIVETo assess embryo implantation rate (IR) and pregnancy rate (PR) in women who received Bushen Wengong Decoction (BSWGD), a Chinese herbal formula, combined with low dose of human menopausal gonadotropin (hMG) prior to frozen-thawed embryo transfer (FET).

METHODSA total of 262 subjects (674 transferred embryos) who received FET were analyzed retrospectively. In them, 122 women were under 30 years old, 106 between 30 - 35 years and 32 over 35 years. The 85 subjects with normal ovulation were assigned to Group A, the natural menstruation cycling group, on whom no pre-transfer treatment was applied. The other 177 subjects with abnormal ovulation were assigned to Group B, and subdivided, according to the pre-transfer treatment they received, into three groups, Group B1 (50 cases) received BSWGD, Group B2 (58 cases) received hMG and Group B3 (69 cases) received both BSWGD and low dose hMG. The IR and PR of FET in the four groups were compared, and the effect of the embryo cryotime on PR of FET were compared also. Besides, the influencing factors to FET were analyzed.

RESULTSIR and PR were significantly higher in all age sects of Group B3 than those in Group A, showing significant difference (P< 0.05). IR and PR in subjects in age sects of <30 years and > 35 years in group B3 were significantly higher than those in Group B1 ( P<0.05), but no significant difference was shown in the two parameters between Group B 2 and Group B3 (P>0.05). PR in the subjects who received embryos with cryo-time of > 200 days was significantly lower than that in those with cryo-time of < 100 days ( P<0.05). Embryo cryo-time, endometrial thickness, use of BSWGD and use of hMG were of significance in FET ( P 0.05).

CONCLUSIONA programmed cycle of BSWGD combined with low dose of hMG could improve the embryo IR and PR of FET. Embryo cryo-time, endometrial thickness, and the use of BSWGD and hMG are of significance for FET.

Adult ; Cryopreservation ; Drug Therapy, Combination ; Drugs, Chinese Herbal ; administration & dosage ; Embryo Transfer ; Female ; Humans ; Menotropins ; administration & dosage ; Pregnancy ; Pregnancy Rate ; Retrospective Studies

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Current status and prospect of prevention and treatment of oral diseases by integrative medicine.

Zhi-hong XU

Chinese journal of integrative medicine.2006;12(4):241-243.

Drugs, Chinese Herbal ; Humans ; Lichen Planus ; drug therapy ; Medicine, Chinese Traditional ; Mouth Diseases ; drug therapy ; prevention & control ; Mouth Neoplasms ; drug therapy ; Orthodontics ; Periodontal Diseases ; drug therapy ; Stomatitis, Aphthous ; drug therapy

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Progress in researches on the pharmaceutical mechanism and clinical application of Ginkgo Biloba extract on various kinds of diseases.

Guo-xia WANG ; Fu-liang CAO ; Jun CHEN

Chinese journal of integrative medicine.2006;12(3):234-239.

Progress made over the pharmaceutical mechanism and clinical application of Ginkgo Biloba extract (GBE) on various kinds of diseases were reviewed in this paper. The effective elements contained in GBE are mainly kinds of Ginkgo flavonoid and Ginkgolide, which have marked protective effects on cardio-cerebral vascular and central nerve systems. In clinical practice, it is applied mostly in treatment of cardio-cerebral vascular diseases. Also it shows apparent effects in the treatment processes of some other diseases as an adjuvant, and therefore, has been gradually accepted by the medical circle in the world, proving to be a medicine of wide prospect in development and application.
Cardiovascular Diseases ; drug therapy ; Diabetes Mellitus ; drug therapy ; Ginkgo biloba ; Humans ; Nervous System Diseases ; drug therapy ; Plant Extracts ; therapeutic use

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Survey of current experimental studies of effects of traditional chinese medicine on peripheral nerve regeneration.

Qun-li WU ; Xiao-chun LIANG

Chinese journal of integrative medicine.2006;12(3):229-233.

The repairing and regeneration of peripheral nerves is a very complex biological and cytological process, its mechanism is unclear so far, and thus results in the lack of specific and effectual therapy and medicament. Chinese herbs and their effective components have their own inimitable predominance in promoting peripheral nerve regeneration, such as their multi-factorial, multi-target and multi-functional action, abundant source, inexpensive, etc. In this paper, the experimental studies reported in recent 5 years concerning the effects of Chinese herbs or their active components on peripheral nerve repairing and regeneration are reviewed in respects of the integral level, cellular level, molecular level and gene level.
Animals ; Drug Evaluation, Preclinical ; Drugs, Chinese Herbal ; pharmacology ; Nerve Regeneration ; drug effects ; Peripheral Nervous System Diseases ; drug therapy ; Spinal Cord Injuries ; drug therapy

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Concerning the use of Western medical terms to represent traditional Chinese medical concepts.

Nigel WISEMAN

Chinese journal of integrative medicine.2006;12(3):225-228.

This paper strongly rejects the notion that the use of biomedical terms to represent traditional Chinese medical concepts is helpful to the internationalization of Chinese medicine. It further argues that this practice destroys the integrity and independence of Chinese medical concepts. Taking the term fēng huo yan as an example, it shows that the biomedical term "acute conjunctivitis" often suggested as the translation for this term is unsatisfactory, because (1) the clinical reference is not identical, (2) it introduces the concepts of "conjunctiva" and "inflammation" , which are not Chinese medical concepts, and (3) destroys the Chinese medical concepts "wind" and "fire" expressed in the Chinese, which reflect the way the disease is traditionally diagnosed and treated. While for English readers not familiar with Chinese medicine, "acute conjunctivitis" may be immediately intelligible, for those seeking a deep understanding of the subject, the literal translation (loan translation) "wind-fire eye" is much more helpful. This paper supports these arguments with numerous other examples.
Humans ; Language ; Medicine, Chinese Traditional ; Terminology as Topic ; Translating ; Western World

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Effect of Simotang oral liquid on anal exhaust in patients after abdominal gynecological operation.

Sheng-ping CHEN ; Xiang-ping WANG

Chinese journal of integrative medicine.2006;12(3):221-223.

OBJECTIVETo study the effect of Simotang oral liquid and glycerin enema on the patients' bowel sound (BS) restoration and anal exhaust after abdominal gynecological operation.

METHODNinety patients with benign tumor who had undergone gynecological operation were randomly divided into the Simotang group, treated after operation with Simotang oral liquid; the enema group, treated with glycerin enema, and the control group, non-treated. The restoration time of BS and anal exhaust were observed.

RESULTSCompared with the control group, the restoration time of BS and anus exhaust were both significantly shorter in the Simotang group and the enema group, showing statistical significance (P < 0.05); but the difference between the two treated groups was insignificant (P > 0.05).

CONCLUSIONSimotang oral liquid and glycerine enema both could benefit the restoration of anal exhaust and BS after abdominal operation.

Abdomen ; Administration, Oral ; Adolescent ; Adult ; Aged ; Constipation ; drug therapy ; etiology ; Drugs, Chinese Herbal ; administration & dosage ; Enema ; Female ; Gastrointestinal Motility ; drug effects ; Glycerol ; administration & dosage ; Humans ; Middle Aged ; Myoma ; surgery ; Postoperative Complications ; drug therapy ; Pregnancy ; Pregnancy, Ectopic ; surgery ; Uterine Neoplasms ; surgery

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Comparative study on the efficacy of Yiweining and Gestrinone for post-operational treatment of stage III endometriosis.

Dong-xia YANG ; Wen-guang MA ; Fan QU ; Bao-zhang MA

Chinese journal of integrative medicine.2006;12(3):218-220.

OBJECTIVETo observe the clinical efficacy and safety of Yiweining (YWN) and gestrinone (GT) in treating post-operational patients of stage III endometriosis (EM-III).

METHODSFifty-two patients of EM-III after operation were randomly assigned into three groups, the YWN group (20 patients) was treated through oral intake of YWN 200 ml, twice a day; the GT group (19 patients) treated with gestrinone 2.5 mg, twice every week, with the medication starting from the 7th post-operational day and lasting for 6 months. The control group (13 patients) was untreated. Six months was one therapeutic course, and follow-up study was carried out in the 6 - 30 months after the end of the medication.

RESULTSThe recurrence rate in the YWN group and the GT group were 5.0% and 5.3% respectively, showing insignificant difference between the two groups, but they were lower than that in the control group (30.7%, P < 0.05). Besides, the adverse reaction rate in the YWN group was lower than that in the GT group (10.0% vs 31.6%, P < 0.05).

CONCLUSIONApplication of YWN to prevent the post-operational recurrence of endometriosis is effective and safe, and its efficacy is similar to that of GT.

Administration, Oral ; Adult ; Drugs, Chinese Herbal ; administration & dosage ; adverse effects ; Endometriosis ; drug therapy ; pathology ; surgery ; Female ; Follow-Up Studies ; Gestrinone ; administration & dosage ; adverse effects ; Humans ; Postoperative Complications ; drug therapy ; prevention & control ; Pregnancy ; Pregnancy Rate ; Progestins ; administration & dosage ; adverse effects ; Secondary Prevention ; Treatment Outcome

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Clinical observation on effect of Kaixin capsule in treating 40 patients with diabetic myocardial ischemia.

Jun XUE ; Mei LIU ; Jing-he CHEN

Chinese journal of integrative medicine.2006;12(3):215-217.

OBJECTIVETo observe the effect of Kaixin Capsule (KXC) on myocardial ischemia and plasma endothelin (ET) level in patients with diabetic heart disease (DHD).

METHODSThe 72 subjects for observation were randomly selected from inpatients whose diagnosis fit to the standard of DHD. The 32 patients allocated in the control group were treated with conventional Western medicine, and the 40 patients in the treated group were treated with conventional Western medicine in combination with KXC, with the therapeutic course for both groups as 60 days.

RESULTSOn ECG, the total effective rate and markedly effective rate in the treated group was 85.0% and 37.5% respectively, higher than those in the control group's 68.7% and 28.1% respectively, and showing significant difference between the two groups (P < 0.05). The level of ET in patients in both groups was significantly higher than normal range, after treatment, but reduced to different extent, and the comparison between them also showed that the difference was significant (P < 0.05).

CONCLUSIONKXC might, by way of inhibiting and blocking the release of ET, lower its level in plasma so as to improve the myocardial ischemic condition of patients with DHD.

Adult ; Blood Glucose ; Diabetes Complications ; blood ; drug therapy ; Diabetes Mellitus, Type 2 ; complications ; Drugs, Chinese Herbal ; administration & dosage ; Electrocardiography ; Endothelins ; blood ; Female ; Gliclazide ; administration & dosage ; Humans ; Hypoglycemic Agents ; administration & dosage ; Male ; Middle Aged ; Myocardial Ischemia ; blood ; drug therapy ; etiology

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