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Research progress on the mechanism of C-reactive protein mediated periodontitis and systemic diseases

Journal of Prevention and Treatment for Stomatological Diseases.2020;28(3):184-188. doi:10.12016/j.issn.2096-1456.2020.03.009

A large number of studies have confirmed that periodontitis is closely related to systemic multisystem diseases. Local inflammation of periodontal tissue may cause systemic inflammation. As an inflammatory factor, C-reactive protein (CRP) is widely used to monitor various inflammatory states. CRP is not only highly related to periodontitis but also closely related to systemic diseases. This article reviews the relationship between periodontitis and systemic disease epidemiology as well as the mechanism of CRP in the relationship between them. The literature review shows that periodontitis is closely related to cardiovascular diseases, diabetes, premature and low-birth-weight infants, chronic kidney disease, rheumatoid arthritis and other systemic diseases. Periodontitis, as a chronic inflammatory disease, can increase the level of serum CRP, thus increasing the risk of cardiovascular disease and affecting blood glucose control in diabetic patients, which may be related to the increased risk of premature delivery and low-birth-weight infants, may affect the development of chronic kidney disease, and may be used as one of the sensitive indicators of rheumatoid arthritis in the active stage. Through periodontal treatment, serum CRP levels can be reduced, which is helpful for the treatment of systemic diseases. CRP levels can be used as indicator for prevention, diagnosis and treatment of periodontitis and systemic diseases.

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Research progress on the effect of pH-sensitive drug delivery systems on oral microorganisms

PENG Xinyu ; PENG Xian ; CHENG Lei

Journal of Prevention and Treatment for Stomatological Diseases.2020;28(3):189-194. doi:10.12016/j.issn.2096-1456.2020.03.010

Microorganisms are closely related to the occurrence and development of common oral diseases. Due to the unique physiological and anatomical characteristics of the oral cavity, locally introduced antibacterial drugs cannot be maintained in the effective concentration range under the effect of saliva erosion. Therefore, to enhance the retention and bioavailability of antibacterial drugs in biofilms, some scholars designed pH sensitive drug delivery systems with the fact that the pH value of oral biofilm is lower than the physiological pH value. This article reviews the research reports of a pH-sensitive drug delivery system in the oral cavity and elaborates its application in oral diseases such as dental caries, endodontic disease, periapical disease, peri-implant diseases, and oral candidiasis. Literature review Results show that the pH-sensitive drug delivery system loaded with antibacterial drugs could be used for the control of oral microorganisms with excellent pH sensitivity and antibacterial properties, especially in the application of acid-producing bacteria such as Streptococcus mutans for the prevention and treatment of dental caries. However, the research of pH-sensitive drug delivery systems in the oral cavity is still limited to basic research,and in clinical applications, it still faces many challenges, such as a complex design and synthesis, difficulties with lasting effects and eliminating drug-resistance and persistent bacteria. Further optimization of pH sensitive systems, as well as animal experiments and in vivo studies will be the focus of future research.

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jptsd123

WANG Chunmeng ; HONG Lihua ; WANG Yu ; ZHANG Zhimin

Journal of Prevention and Treatment for Stomatological Diseases.2020;28(3):195-199. doi:10.12016/j.issn.2096-1456.2020.03.011

Esophageal cancer is one of the most lethal digestive system cancers, and its pathogenic factors have always been the focus of research. Recently, it has been found that microorganisms and their metabolites in the esophagus may also represent one of the pathogenic factors. Because of their continuity in anatomical structure, the oral cavity and esophagus have a certain correlation in terms of the composition of flora. In recent years, many scholars have studied the relationship between oral microorganisms and esophageal cancer to monitor changes in oral microorganisms as well as to diagnose and treat esophageal cancer more effectively. In this paper, the research status of oral microorganisms and esophageal cancer was reviewed. The Results of the literature review show that the diversity of bacteria in the esophagus is affected by oral flora in terms of the occurrence and development of esophageal cancer. Among these bacteria, the periodontal red complex, which includes Porphyromonas gingivalis, forsythia and Treponema dentata, as well as common oral microorganisms, such as Streptococcus viridis and Fusobacterium nucleatum, are all related to the occurrence and development of esophageal cancer to a certain extent. At present, there are few studies on the mechanism of microorganisms and esophageal cancer, but scholars have found that lipopolysaccharides and endotoxins, the products of Gram-negative bacteria in the esophagus, may participate in the innate immune response of the host, and the relevant mechanism of action needs further study in order to find new targets for monitoring and treatment.

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Research progress of scaffolds for promoting the vascularization of regenerated dental pulp

LIU Huimin ; LI Xiangwei

Journal of Prevention and Treatment for Stomatological Diseases.2020;28(3):200-204. doi:10.12016/j.issn.2096-1456.2020.03.012

Endothelial regeneration is a research hotspot in the field of dental pulp. The regeneration of endodontic blood flow is the bottleneck of dental pulp regeneration, and the applied scaffold material is the key to revascularization. Stent materials were reviewed. The literature review Results show that, depending on the source of the stent material used for endodontic revascularization, there are mainly natural, synthetic and composite materials. The natural scaffold materials used for vascular regeneration include chitosan, hyaluronic acid, bacterial cellulose, and proanthocyanidin; artificial scaffold materials include hydrogel, cryogel, and electrospinning. The bionic composite scaffold system with a double-layer tubular structure is low immunogenicity and good biocompatibility. Studies on the scaffold materials of bionic extracellular matrix, such as injectable hydrogels/microspheres, have promoted the development of dental pulp regeneration, that is, uniformly distributed scaffold materials in the root canal promote the generation of pulp-like tissue; Whether dental pulp tissue can establish effective blood circulation through the apical foramen remains a great challenge.

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The role of B cell osteoimmunity in periodontitis

LIN Xiaoping ; HAN Yakun

Journal of Prevention and Treatment for Stomatological Diseases.2020;28(4):205-213. doi:10.12016/j.issn.2096-1456.2020.04.001

As the most important pathological feature of periodontitis, alveolar bone resorption also results in tooth loss and oral dysfunction. According to recent research, the host immune response is the major factor leading to alveolar bone resorption. Antibodies, immune cells and inflammatory cytokines involved in this procedure cause an imbalance of bone formation and destruction, which is called osteoimmunity. Given the importance of adaptive humoral immunity during periodontitis, B cells are considered crucial in the development of periodontitis. Therefore, establishing B cell osteoimmunity is an effective way for us to deeply assess the start, development and prognosis of periodontitis. It has been proven that the development process of B cells is accompanied by changes in bone density or morphology. We have reviewed previous literature to understand the role of B cell bone immunity in the pathological process of periodontitis, and the results showed that B cells regulate the development of bone cell lines through transcription factors (such as RANKL, PU.1, E2A, etc.). In addition, various cytokines expressed by B cells (such as IFN-γ, IL-17, IL-10, TGF-β, etc.) can participate in the regulation of bone cells.

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Study on lncRNA ADAMTS9-AS2 promoting invasion and metastasis of salivary adenoid cystic carcinoma

WU Donghui ; ZHU Yunying ; LIANG Jianqiang ; LIN Zhaoyu ; LI Jinsong

Journal of Prevention and Treatment for Stomatological Diseases.2020;28(4):214-218. doi:10.12016/j.issn.2096-1456.2020.04.002

Objective: To investigate the role of lncRNAs in the invasion and metastasis of salivary adenoid cystic carcinoma (SACC) cells. Methods: With SACC-LM as the experimental group and SACC83 as the control group, lncRNA chips were used to screen the differentially expressed lncRNAs. The differentially expressed lncRNAs were further verified by real-time quantitative RT-PCR (qRT-PCR). The invasion and migration abilities of the adenoid cystic carcinoma cell lines before and after transfection with lncRNA siRNAs were detected by invasion and migration experiments. The clinicopathological features and prognosis of patients with different expression of lncRNAs and SACC were analyzed. Results: The microarray showed that ADAMTS9-AS2 was highly expressed in the SACC-LM cells. Real-time quantitative RT-PCR further confirmed that ADAMTS9-AS2 was significantly upregulated in the SACC-LM cells. Invasion and migration experiments showed that the invasion and migration were significantly reduced after the expression level of ADAMTS9-AS2 was downregulated (P ＜ 0.001). Analysis of the clinicopathological data showed that ADAMTS9-AS2 was highly expressed in SACC. High expression of ADAMTS9-AS2 was associated with poor prognosis and a high tumor metastasis rate in SACC patients. Conclusion High expression of ADAMTS9-AS2 promotes the migration and invasion of SACC cells. ADAMTS9-AS2 is upregulated in the SACC tissues and is related to a high metastasis rate and poor prognosis.

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The role of the mTORC1 signaling pathway during osteogenic differentiation of mouse bone marrow mesenchymal cells under tension stress

PENG Haiyan ; JIANG Xiaowen ; HUANG Huaqing ; CHEN Jinyong

Journal of Prevention and Treatment for Stomatological Diseases.2020;28(4):219-223. doi:10.12016/j.issn.2096-1456.2020.04.003

Objective: To investigate the expression of the mTORC1 signaling pathway during the osteogenic differentiation of mouse bone marrow mesenchymal cells (BMMSCs) under cyclic uniaxial tension and explore its possible role. Methods : The BMMSCs of mice were affected by uniaxial dynamic tensile force. Western blot was used to detect the expression changes of major molecules (mTOR, Raptor, S6K) in the endogenous mTORC1 signaling pathway at 0, 1, 2, 4, and 8 hours after stretching. Chemical colorimetry, ELISA and PCR were used to detect alkaline phosphatase (ALP), osteocalcin (OCN) and Runx2 mRNA, respectively. Then, inhibition, activation and control groups were established by administration of the drugs PP242, MHY1485 and PBS, respectively. Two hours after the stress, the expression of S6K was detected by western blot, and the expression of the osteogenic signal was continuously detected by the above methods. Results : Western blot analysis showed that the main molecules of the mTORC1 signaling pathway were all expressed within 8 hours after traction, and the highest expression was 2 hours after the stress. Compared with those in the control group, the ALP activity and OCN expression decreased and the Runx2 mRNA levels increased after the mTORC1 signal pathway was inhibited (P ＜ 0.001); ALP activity and OCN expression increased after the mTORC1 signal pathway was activated, while the Runx2 mRNA levels decreased (P ＜ 0.001). Conclusion The mTORC1 signaling pathway participates in the osteogenic differentiation of mouse BMMSCs under tension. The osteogenesis of BMMSCs under cyclic uniaxial tension would be enhanced if the mTORC1 signaling pathway was activated.

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The effect of the RW-splint on the position and occlusal relationship of class Ⅱ malocclusion patients with temporomandibular disorder

LIU Junfeng ; LIU Conghua ; ZHANG Wenzhong ; XIAO Hui ; Li Shaobing

Journal of Prevention and Treatment for Stomatological Diseases.2020;28(4):224-230. doi:10.12016/j.issn.2096-1456.2020.04.004

Objective: To explore the effect of RW splints on the position and occlusal relationship of classⅡ malocclusion patients with temporomandibular disorder (TMD) to provide a basis for the diagnosis and design of this kind of patient. Methods : Fifteen patients with class Ⅱ malocclusions with TMD were enrolled in this study. After 8 months of RW-splint treatment, the changes in jaw position (∠ANB, SN-MP, ∠S-G0/N-Me) and occlusal relationship (molar, cuspid teeth displacement and anterior overbite/overjet value) were recorded by a condylar displacement measuring instrument at the CR position and CO position. Results: After RW-splint treatment, the mean values of ∠ANB (t=4.971, P=0.001) and ∠SN-MP (t=9.895, P ＜ 0.01) were increased in all 15 patients, and the mean value of S-G0/N-Me (t=5.342, P=0.005) was decreased. The mean values of the distal movement of the first molars on the left and right sides of the mandible were (1.57 ± 0.79) mm and (1.69 ± 1.29) mm, respectively; the mean values of the distal movement of the canines on the left and right sides of the mandible were (1.54 ± 0.50) mm and (1.51 ± 1.08) mm, respectively; and the mean values of the overbite were (1.16 ± 0.60) mm and (1.99 ± 0.85) mm, respectively. Conclusion After RW-splint treatment, the jaw rotates clockwise, and the relationship between the molars and canines changes obviously in class Ⅱ patients with TMD, which provides a reference for the diagnosis and treatment plan of this kind of patient.

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Clinical application of laser selective melting titanium alloy for removable partial denture frameworks

ZHANG Wen ; XIE Wenqiang ; ZHENG Meihua ; KONG Xiangbo

Journal of Prevention and Treatment for Stomatological Diseases.2020;28(4):231-235. doi: 10.12016/j.issn.2096-1456.2020.04.005

Objective: To investigate the effect of denture stomatitis of selective laser melting (SLM) titanium alloy for removable partial denture frameworks. Methods : Twenty patients with dentition defects in our hospital were divided into two groups according to the different methods of creating a removable partial denture framework: the SLM group and casting group. The success rate, placement rate, masticatory efficiency and incidence of denture stomatitis were compared. Experimental data were analyzed with SPSS20.0. Results : The success rate of the SLM framework group was 100.00%, which was higher than that of the casting group (90.00%) (P ＜ 0.01). The rate of framework placement in the SLM group was slightly lower than that in the casting group (P ＜ 0.05). The masticatory efficiency of the SLM group was higher than that of the casting group (0.783 ± 0.030 vs. 0.699 ± 0.037, P ＜ 0.001). The incidence of denture stomatitis (10.00%) in the SLM group was significantly lower than that in the casting group (30.00%) (P ＜ 0.001). Conclusion SLM is superior to the traditional casting method in mastication efficiency and reducing the incidence of denture stomatitis. This method can meet the clinical requirements, but the accuracy of the long-term stent needs to be improved.

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Evaluation of the effect of concentrated growth factor in guided bone regeneration in maxillary anterior tooth defects

WANG Yamin ; ZHOU Zhen ; DAO Junfeng ; CHEN Qiyue ; LIU Wenjing ; SONG Guangbao

Journal of Prevention and Treatment for Stomatological Diseases.2020;28(4):236-240. doi:10.12016/j.issn.2096-1456.2020.04.006

Objective: To investigate the clinical effect of concentrated growth factor (CGF) applied in guided bone regeneration (GBR) for severe bone deficiency in the anterior maxilla. Methods : Forty patients with bone defects in the anterior maxilla were chosen to be treated with GBR, 20 patients were treated with CGF applied in GBR as the observation group, and the other 20 patients were treated only with GBR as the control group. The evaluation of wound healing was performed after the operation, and bone augmentation was evaluated half a year after the operation. Results: The first-stage healing rate of soft tissue wounds in the observation group was 100% and 75% in the control group, and the primary healing rate in the observation group was better than that in the control group (P=0.017). The changes in bone width of the observation group were （3.70 ± 0.28） mm, and those of the control group were （2.96 ± 0.16） mm. The bone augmentation in the observation group was higher than that in the control group (P=0.000). Conclusion CGF applied in GBR has a good effect on bone augmentation for severe bone deficiency in the anterior maxilla.

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