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Bronchial Washing Cytology of Pulmonary Langerhans Cell Histiocytosis: A Case Report.

Taeyeong KIM ; Hyeong Ju KWON ; Minseob EOM ; Sang Wook KIM ; Min Hi SIN ; Soon Hee JUNG

Journal of Pathology and Translational Medicine.2017;51(4):444-447. doi:10.4132/jptm.2017.02.15

No abstract available.
Histiocytosis, Langerhans-Cell*

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Metastatic Squamous Cell Carcinoma from Lung Adenocarcinoma after Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Therapy.

Hyung Kyu PARK ; Youjeong SEO ; Yoon La CHOI ; Myung Ju AHN ; Joungho HAN

Journal of Pathology and Translational Medicine.2017;51(4):441-443. doi:10.4132/jptm.2016.10.18

No abstract available.
Adenocarcinoma* ; Carcinoma, Squamous Cell* ; Epidermal Growth Factor* ; Epithelial Cells* ; Lung* ; Receptor, Epidermal Growth Factor*

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A Rare Case of Intramural Müllerian Adenosarcoma Arising from Adenomyosis of the Uterus.

Sun Jae LEE ; Ji Y. PARK

Journal of Pathology and Translational Medicine.2017;51(4):433-440. doi:10.4132/jptm.2017.06.11

Müllerian adenosarcomas usually arise as polypoid masses in the endometrium of post-menopausal women. Occasionally, these tumors arise in the cervix, vagina, broad and round ligaments, ovaries and rarely in extragenital sites; these cases are generally associated with endometriosis. We experienced a rare case of extraendometrial, intramural adenosarcoma arising in a patient with adenomyosis. A 40-year-old woman presented with sudden-onset suprapubic pain. The imaging findings suggested leiomyoma with cystic degeneration in the uterine fundus. An ill-defined ovoid tumor with hemorrhagic degeneration, measuring 7.5 cm in diameter, was detected. The microscopic findings showed glandular cells without atypia and a sarcomatous component with pleomorphism and high mitotic rates. There was no evidence of endometrial origin. To recognize that adenosarcoma can, although rarely, arise from adenomyosis is important to avoid overstaging and inappropriate treatment.
Adenomyosis* ; Adenosarcoma* ; Adult ; Cervix Uteri ; Endometriosis ; Endometrium ; Female ; Humans ; Leiomyoma ; Ovary ; Round Ligaments ; Uterus* ; Vagina

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Perivascular Epithelioid Cell Tumor in the Stomach.

Sun Ah SHIN ; Jiwoon CHOI ; Kyung Chul MOON ; Woo Ho KIM

Journal of Pathology and Translational Medicine.2017;51(4):428-432. doi:10.4132/jptm.2016.09.16

Perivascular epithelioid cell tumors or PEComas can arise in any location in the body. However, a limited number of cases of gastric PEComa have been reported. We present two cases of gastric PEComas. The first case involved a 62-year-old woman who presented with a 4.2 cm gastric subepithelial mass in the prepyloric antrum, and the second case involved a 67-year-old man with a 5.0 cm mass slightly below the gastroesophageal junction. Microscopic examination revealed that both tumors were composed of perivascular epithelioid cells that were immunoreactive for melanocytic and smooth muscle markers. Prior to surgery, the clinical impression of both tumors was gastrointestinal stromal tumor (GIST), and the second case was erroneously diagnosed as GIST even after microscopic examination. Although gastric PEComa is a very rare neoplasm, it should be considered in the differential diagnosis of gastric submucosal lesions.
Aged ; Diagnosis, Differential ; Epithelioid Cells* ; Esophagogastric Junction ; Female ; Gastrointestinal Stromal Tumors ; Humans ; MART-1 Antigen ; Middle Aged ; Muscle, Smooth ; Perivascular Epithelioid Cell Neoplasms ; Stomach Neoplasms ; Stomach*

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Mammary Carcinoma Arising in Microglandular Adenosis: A Report of Five Cases.

Mimi KIM ; Milim KIM ; Yul Ri CHUNG ; So Yeon PARK

Journal of Pathology and Translational Medicine.2017;51(4):422-427. doi:10.4132/jptm.2016.11.11

Mammary carcinoma arising in microglandular adenosis (MGA) is extremely rare, and MGA is regarded as a non-obligate precursor of triple-negative breast cancer. We report five cases of carcinoma arising in MGA of the breast. All cases showed a spectrum of proliferative lesions ranging from MGA to atypical MGA, ductal carcinoma in situ or invasive carcinoma. Immunohistochemically, all cases were triple-negative and expression of S-100 protein gradually decreased as the lesions progressed from MGA to atypical MGA and carcinoma. Three cases showed acinic cell differentiation with reactivity to α1-antitrypsin, and one case was metaplastic carcinoma. During clinical follow-up, one patient developed local recurrence. Carcinoma arising in MGA is a rare but distinct subset of triple-negative breast cancer with characteristic histologic and immunohistochemical findings.
Acinar Cells ; Breast ; Carcinoma, Intraductal, Noninfiltrating ; Fibrocystic Breast Disease* ; Follow-Up Studies ; Humans ; Recurrence ; S100 Proteins ; Triple Negative Breast Neoplasms

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Metaplastic Carcinoma with Chondroid Differentiation Arising in Microglandular Adenosis.

Ga Eon KIM ; Nah Ihm KIM ; Ji Shin LEE ; Min Ho PARK

Journal of Pathology and Translational Medicine.2017;51(4):418-421. doi:10.4132/jptm.2016.10.06

Microglandular adenosis (MGA) of the breast is a rare, benign proliferative lesion but with a significant rate of associated carcinoma. Herein, we report an unusual case of metaplastic carcinoma with chondroid differentiation associated with typical MGA. Histologically, MGA showed a direct transition to metaplastic carcinoma without an intervening atypical MGA or ductal carcinoma in situ component. The immunohistochemical profile of the metaplastic carcinoma was mostly similar to that of MGA. In both areas, all the epithelial cells were positive for S-100 protein, but negative for estrogen receptor, progesterone receptor, HER2/neu, and epidermal growth factor receptor. An increase in the Ki-67 and p53 labelling index was observed from MGA to invasive carcinoma. To the best of our knowledge, this is the first case of metaplastic carcinoma with chondroid differentiation arising in MGA in Korea. This case supports the hypothesis that a subset of MGA may be a non-obligate morphologic precursor of breast carcinoma, especially the triple-negative subtype.
Breast ; Breast Neoplasms ; Carcinoma, Intraductal, Noninfiltrating ; Epithelial Cells ; Estrogens ; Fibrocystic Breast Disease* ; Korea ; Receptor, Epidermal Growth Factor ; Receptors, Progesterone ; S100 Proteins

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The Use of the Bethesda System for Reporting Thyroid Cytopathology in Korea: A Nationwide Multicenter Survey by the Korean Society of Endocrine Pathologists.

Mimi KIM ; Hyo Jin PARK ; Hye Sook MIN ; Hyeong Ju KWON ; Chan Kwon JUNG ; Seoung Wan CHAE ; Hyun Ju YOO ; Yoo Duk CHOI ; Mi Ja LEE ; Jeong Ja KWAK ; Dong Eun SONG ; Dong Hoon KIM ; Hye Kyung LEE ; Ji Yeon KIM ; Sook Hee HONG ; Jang Sihn SOHN ; Hyun Seung LEE ; So Yeon PARK ; Soon Won HONG ; Mi Kyung SHIN

Journal of Pathology and Translational Medicine.2017;51(4):410-417. doi:10.4132/jptm.2017.04.05

BACKGROUND: The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) has standardized the reporting of thyroid cytology specimens. The objective of the current study was to evaluate the nationwide usage of TBSRTC and assess the malignancy rates in each category of TBSRTC in Korea. METHODS: Questionnaire surveys were used for data collection on the fine needle aspiration (FNA) of thyroid nodules at 74 institutes in 2012. The incidences and follow-up malignancy rates of each category diagnosed from January to December, 2011, in each institute were also collected and analyzed. RESULTS: Sixty out of 74 institutes answering the surveys reported the results of thyroid FNA in accordance with TBSRTC. The average malignancy rates for resected cases in 15 institutes were as follows: nondiagnostic, 45.6%; benign, 16.5%; atypical of undetermined significance, 68.8%; suspicious for follicular neoplasm (SFN), 30.2%; suspicious for malignancy, 97.5%; malignancy, 99.7%. CONCLUSIONS: More than 80% of Korean institutes were using TBSRTC as of 2012. All malignancy rates other than the SFN and malignancy categories were higher than those reported by other countries. Therefore, the guidelines for treating patients with thyroid nodules in Korea should be revisited based on the malignancy rates reported in this study.
Academies and Institutes ; Biopsy, Fine-Needle ; Data Collection ; Follow-Up Studies ; Humans ; Incidence ; Korea* ; Thyroid Gland* ; Thyroid Nodule

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Clear Cell Papulosis: A Case Report.

So Woon KIM ; Jin ROH ; Chan Sik PARK

Journal of Pathology and Translational Medicine.2016;50(5):401-403. doi:10.4132/jptm.2016.02.16

No abstract available.

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Pelvic Nodular Histiocytic and Mesothelial Hyperplasia in a Patient with Endometriosis and Uterine Leiomyoma.

Yumin CHUNG ; Rehman ABDUL ; Se Min JANG ; Joong Sub CHOI ; Kiseok JANG

Journal of Pathology and Translational Medicine.2016;50(5):397-400. doi:10.4132/jptm.2016.01.11

No abstract available.
Endometriosis* ; Female ; Humans ; Hyperplasia* ; Leiomyoma*

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Nodular Fasciitis of External Auditory Canal.

Jihyun AHN ; Sunyoung KIM ; Youngsil PARK

Journal of Pathology and Translational Medicine.2016;50(5):394-396. doi:10.4132/jptm.2016.03.11

Nodular fasciitis is a pseudosarcomatous reactive process composed of fibroblasts and myofibroblasts, and it is most common in the upper extremities. Nodular fasciitis of the external auditory canal is rare. To the best of our knowledge, less than 20 cases have been reported to date. We present a case of nodular fasciitis arising in the cartilaginous part of the external auditory canal. A 19-year-old man complained of an auricular mass with pruritus. Computed tomography showed a 1.7 cm sized soft tissue mass in the right external auditory canal, and total excision was performed. Histologic examination revealed spindle or stellate cells proliferation in a fascicular and storiform pattern. Lymphoid cells and erythrocytes were intermixed with tumor cells. The stroma was myxoid to hyalinized with a few microcysts. The tumor cells were immunoreactive for smooth muscle actin, but not for desmin, caldesmon, CD34, S-100, anaplastic lymphoma kinase, and cytokeratin. The patient has been doing well during the 1 year follow-up period.
Actins ; Calmodulin-Binding Proteins ; Desmin ; Ear ; Ear Canal* ; Erythrocytes ; Fasciitis* ; Fibroblasts ; Follow-Up Studies ; Humans ; Hyalin ; Keratins ; Lymphocytes ; Lymphoma ; Muscle, Smooth ; Myofibroblasts ; Phosphotransferases ; Pruritus ; Upper Extremity ; Young Adult

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