Journal of Pathology and Translational Medicine.2015;49(3):274-278. doi:10.4132/jptm.2015.03.12
Journal of Pathology and Translational Medicine
to Present ISSN: 2383-7837
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Cytomegalovirus-Associated Intussusception with Florid Vascular Proliferation in an Infant.
Journal of Pathology and Translational Medicine.2015;49(3):270-273. doi:10.4132/jptm.2015.04.01
Traumatic Bowel Perforation and Inguinal Hernia Masking a Mesenteric Calcifying Fibrous Tumor.
Journal of Pathology and Translational Medicine.2015;49(3):267-269. doi:10.4132/jptm.2015.03.20
Follicular Proliferative Lesion Arising in Struma Ovarii.
Journal of Pathology and Translational Medicine.2015;49(3):262-266. doi:10.4132/jptm.2015.03.26
Malignant struma ovarii is extremely rare and difficult to diagnose histologically, particularly in cases of follicular carcinoma. This case study is intended to describe three cases of follicular proliferative lesion arising in struma ovarii that we experienced. The first case was clearly malignant given the clinical picture of multiple recurrences, but there was little histological evidence of malignancy. Our second case featured architectural and cellular atypia and necrosis and was diagnosed as malignant despite the absence of vascular and stromal invasion. Our third case exhibited solid microfollicular proliferation without any definite evidence of malignancy (even the molecular data was negative); however, we could not completely exclude malignant potential after conducting a literature review. In cases such as our third case, it has been previously suggested that a diagnostic term recognizing the low-grade malignant potential, such as "proliferative stromal ovarii" or "follicular proliferative lesion arising in the stromal ovarii" would be appropriate.
Adenocarcinoma, Follicular ; Necrosis ; Recurrence ; Struma Ovarii*
Adenocarcinoma, Follicular ; Necrosis ; Recurrence ; Struma Ovarii*
Clear Cell Papulosis: A Case Report.
Journal of Pathology and Translational Medicine.2016;50(5):401-403. doi:10.4132/jptm.2016.02.16
No abstract available.
Journal of Pathology and Translational Medicine.2016;50(5):397-400. doi:10.4132/jptm.2016.01.11
Nodular Fasciitis of External Auditory Canal.
Journal of Pathology and Translational Medicine.2016;50(5):394-396. doi:10.4132/jptm.2016.03.11
Nodular fasciitis is a pseudosarcomatous reactive process composed of fibroblasts and myofibroblasts, and it is most common in the upper extremities. Nodular fasciitis of the external auditory canal is rare. To the best of our knowledge, less than 20 cases have been reported to date. We present a case of nodular fasciitis arising in the cartilaginous part of the external auditory canal. A 19-year-old man complained of an auricular mass with pruritus. Computed tomography showed a 1.7 cm sized soft tissue mass in the right external auditory canal, and total excision was performed. Histologic examination revealed spindle or stellate cells proliferation in a fascicular and storiform pattern. Lymphoid cells and erythrocytes were intermixed with tumor cells. The stroma was myxoid to hyalinized with a few microcysts. The tumor cells were immunoreactive for smooth muscle actin, but not for desmin, caldesmon, CD34, S-100, anaplastic lymphoma kinase, and cytokeratin. The patient has been doing well during the 1 year follow-up period.
Actins ; Calmodulin-Binding Proteins ; Desmin ; Ear ; Ear Canal* ; Erythrocytes ; Fasciitis* ; Fibroblasts ; Follow-Up Studies ; Humans ; Hyalin ; Keratins ; Lymphocytes ; Lymphoma ; Muscle, Smooth ; Myofibroblasts ; Phosphotransferases ; Pruritus ; Upper Extremity ; Young Adult
Actins ; Calmodulin-Binding Proteins ; Desmin ; Ear ; Ear Canal* ; Erythrocytes ; Fasciitis* ; Fibroblasts ; Follow-Up Studies ; Humans ; Hyalin ; Keratins ; Lymphocytes ; Lymphoma ; Muscle, Smooth ; Myofibroblasts ; Phosphotransferases ; Pruritus ; Upper Extremity ; Young Adult
Pulmonary Arteriovenous Fistula: Clinical and Histologic Spectrum of Four Cases.
Journal of Pathology and Translational Medicine.2016;50(5):390-393. doi:10.4132/jptm.2016.04.18
Pulmonary arteriovenous fistula (PAVF) is abnormally dilated vessels that provide a right-to-left shunt between pulmonary artery and pulmonary vein and is clinically divided into simple and complex type. Here, we report four cases of surgically resected sporadic PAVFs presenting various clinical and histologic spectrums. Cases 1 (a 57-old-female) and 2 (a 54-old-female) presented as incidentally identified single aneurysmal fistulas and the lesions were surgically removed without complication. On the other hand, case 3 (an 11-old-male) showed diffuse dilated vascular sacs involving both lungs and caused severe hemodynamic and pulmonary dysfunction. Embolization and surgical resection of the main lesion failed to relieve the symptoms. Case 4 (a 36-old-male) had a localized multiloculated cyst clinically mimicking congenital cystic adenomatoid malformation. Microscopically, the lesion consisted of dilated thick vessels, consistent with the diagnosis of fistulous arteriovenous malformation/hemangioma.
Aneurysm ; Arteriovenous Fistula* ; Arteriovenous Malformations ; Cystic Adenomatoid Malformation of Lung, Congenital ; Diagnosis ; Fistula ; Hand ; Hemodynamics ; Lung ; Pulmonary Artery ; Pulmonary Veins
Aneurysm ; Arteriovenous Fistula* ; Arteriovenous Malformations ; Cystic Adenomatoid Malformation of Lung, Congenital ; Diagnosis ; Fistula ; Hand ; Hemodynamics ; Lung ; Pulmonary Artery ; Pulmonary Veins
Mammary-Type Myofibroblastoma: A Report of Two Cases.
Journal of Pathology and Translational Medicine.2016;50(5):385-389. doi:10.4132/jptm.2016.03.26
Mammary-type myofibroblastoma (MFB) is a rare, benign spindle cell neoplasm occurring along the milkline, with extension from the mid-axilla to the medial groin. It is histologically and immunohistochemically identical to MFB of the breast and is part of a spectrum of lesions that includes spindle cell lipoma and cellular angiofibroma. Recently, we experienced two cases of mammary-type MFB involving male patients aged 30 and 58 years, respectively. The tumors were located in the right scrotal sac and in the right axilla. Wide excisions were performed. Microscopically, the masses were composed of haphazardly arranged, variably sized fascicles of bland spindle cells and were admixed with mature fat tissue. The spindle cells in both cases showed immunopositivity for desmin and CD34 and negativity for smooth muscle actin. Loss of retinoblastoma (RB)/13q14 loci is a characteristic genetic alteration of mammary-type MFB, and we identified loss of RB protein expression by immunohistochemical staining. We emphasize the importance of awareness of this rare neoplasm when a spindle cell neoplasm is accompanied by desmin immunopositivity. The second patient was alive without recurrence for 20 months, and the first patient had not been followed.
Actins ; Angiofibroma ; Axilla ; Breast ; Desmin ; Groin ; Humans ; Lipoma ; Male ; Muscle, Smooth ; Neoplasms, Muscle Tissue* ; Recurrence ; Retinoblastoma ; Retinoblastoma Protein
Actins ; Angiofibroma ; Axilla ; Breast ; Desmin ; Groin ; Humans ; Lipoma ; Male ; Muscle, Smooth ; Neoplasms, Muscle Tissue* ; Recurrence ; Retinoblastoma ; Retinoblastoma Protein
Do Helper T Cell Subtypes in Lymphocytic Thyroiditis Play a Role in the Antitumor Effect?.
Journal of Pathology and Translational Medicine.2016;50(5):377-384. doi:10.4132/jptm.2016.07.25
BACKGROUND: Papillary thyroid carcinoma (PTC) is frequently accompanied by lymphocytic thyroiditis (LT). Some reports claim that Hashimoto's thyroiditis (the clinical form of LT) enhances the likelihood of PTC; however, others suggest that LT has antitumor activity. This study was aimed to find out the relationship between the patterns of helper T cell (Th) cytokines in thyroid tissue of PTC with or without LT and the clinicopathological manifestation of PTC. METHODS: Fresh surgical samples of PTC with (13 cases) or without (10 cases) LT were used. The prognostic parameters (tumor size, extra-thyroidal extension of PTC, and lymph node metastasis) were analyzed. The mRNA levels of two subtypes of Th cytokines, Th1 (tumor necrosis factor α [TNF-α], interferon γ [IFN-γ ], and interleukin [IL] 2) and Th2 (IL-4 and IL-10), were analyzed. Because most PTC cases were microcarcinomas and recent cases without clinical follow-up, negative or faint p27 immunoreactivity was used as a surrogate marker for lymph node metastasis. RESULTS: PTC with LT cases showed significantly higher expression of TNF-α (p = .043), IFN-γ (p < .010), IL-4 (p = .015) than those without LT cases. Although the data were not statistically significant, all analyzed cytokines (except for IL-4) were highly expressed in the cases with higher expression of p27 surrogate marker. CONCLUSIONS: These results indicate that mixed Th1 (TNF-α, IFN-γ , and IL-2) and Th2 (IL-10) immunity might play a role in the antitumor effect in terms of lymph node metastasis.
Biomarkers ; Cyclin-Dependent Kinase Inhibitor p27 ; Cytokines ; Follow-Up Studies ; Interferons ; Interleukin-4 ; Interleukins ; Lymph Nodes ; Necrosis ; Neoplasm Metastasis ; RNA, Messenger ; T-Lymphocytes, Helper-Inducer ; Thyroid Gland ; Thyroid Neoplasms ; Thyroiditis ; Thyroiditis, Autoimmune*
Biomarkers ; Cyclin-Dependent Kinase Inhibitor p27 ; Cytokines ; Follow-Up Studies ; Interferons ; Interleukin-4 ; Interleukins ; Lymph Nodes ; Necrosis ; Neoplasm Metastasis ; RNA, Messenger ; T-Lymphocytes, Helper-Inducer ; Thyroid Gland ; Thyroid Neoplasms ; Thyroiditis ; Thyroiditis, Autoimmune*
Country
Republic of Korea
Publisher
ElectronicLinks
Editor-in-chief
Abbreviation
Journal of Pathology and Translational Medicine
Vernacular Journal Title
ISSN
2383-7837
EISSN
Year Approved
2007
Current Indexing Status
Currently Indexed
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