Iatrogenic Gastric Pseudolipomatosis during Endoscopic Submucosal Dissection.
Journal of Pathology and Translational Medicine.2017;51(5):513-515. doi:10.4132/jptm.2017.04.25
Journal of Pathology and Translational Medicine
2002 (v1, n1) to Present ISSN: 1671-8925
Year of publication
Sort by
DISPLAY OPTIONS
Format:
Per page:
Journal of Pathology and Translational Medicine.2017;51(5):509-512. doi:10.4132/jptm.2017.03.22
Thymic adenocarcinoma is extremely rare. Although its histologic features have been occasionally reported, a lack of description of the cytologic features has hampered the prompt and accurate diagnosis of this condition. Herein, we describe the cytologic findings and histology of four aspiration cytology specimens of thymic adenocarcinoma. The specimens were obtained from primary tumors, metastatic lymph nodes, and pericardial effusions. All four specimens showed three-dimensional glandular clusters with a loss of polarity and nuclear overlapping. One specimen had extensive extracellular mucinous material. Three specimens contained tumor cells with intracytoplasmic vacuoles. While the specimen with extracellular mucin showed relatively mild cytologic atypia, other specimens exhibited more atypical cytologic changes: irregular nuclear membranes, a coarse chromatin pattern, and prominent nucleoli. The cytologic features were correlated with the histologic features in each case of enteric type thymic adenocarcinoma. The differential diagnosis included other thymic carcinomas, yolk sac tumors, and metastatic adenocarcinoma from the lung or colorectum.
Adenocarcinoma* ; Biopsy, Fine-Needle* ; Chromatin ; Diagnosis ; Diagnosis, Differential ; Endodermal Sinus Tumor ; Lung ; Lymph Nodes ; Mediastinum ; Mucins ; Nuclear Envelope ; Pericardial Effusion ; Thymoma ; Thymus Gland ; Vacuoles
Adenocarcinoma* ; Biopsy, Fine-Needle* ; Chromatin ; Diagnosis ; Diagnosis, Differential ; Endodermal Sinus Tumor ; Lung ; Lymph Nodes ; Mediastinum ; Mucins ; Nuclear Envelope ; Pericardial Effusion ; Thymoma ; Thymus Gland ; Vacuoles
A Rare Case of Aggressive Melanotic Schwannoma Occurred in Spinal Nerve of a 59-Year-Old Male.
Journal of Pathology and Translational Medicine.2017;51(5):505-508. doi:10.4132/jptm.2017.01.04
Melanotic schwannoma (MS) is a rare variant of nerve sheath neoplasm that shows ultrastructural and immunophenotypical features of Schwann cells but also has cytoplasmic melanosomes and is reactive for melanocytic markers as well. Unlike conventional schwannoma, which is totally benign, MS has an unpredictable prognosis and is thought to have low-malignant potential. Herein, we present a rare case of recurrent MS in lumbar spine of a 59-year-old male.
Cytoplasm ; Humans ; Male* ; Melanosomes ; Middle Aged* ; Neoplasm Metastasis ; Nerve Sheath Neoplasms ; Neurilemmoma* ; Prognosis ; Recurrence ; Schwann Cells ; Spinal Nerves* ; Spine
Cytoplasm ; Humans ; Male* ; Melanosomes ; Middle Aged* ; Neoplasm Metastasis ; Nerve Sheath Neoplasms ; Neurilemmoma* ; Prognosis ; Recurrence ; Schwann Cells ; Spinal Nerves* ; Spine
Intraosseous Hibernoma: A Rare and Unique Intraosseous Lesion.
Journal of Pathology and Translational Medicine.2017;51(5):499-504. doi:10.4132/jptm.2017.07.28
BACKGROUND: Hibernoma is a rare benign tumor of adults that is composed of multivacuolated adipocytes resembling brown fat cells. Hibernoma typically occurs in soft tissue, and intraosseous examples are very rare. Intraosseous hibernomas can radiologically mimic metastatic carcinoma and other tumorous conditions. METHODS: To collect the intraosseous hibernomas, we searched the pathologic database and reviewed the hematoxylin and eosin (H&E)–stained slides of bone biopsy samples performed to differentiate radiologically abnormal bone lesions from 2006 to 2016. A total of six intraosseous hibernoma cases were collected, and clinical and radiological information was verified from electronic medical records. H&E slide review and immunohistochemical staining for CD68, pan-cytokeratin, and S-100 protein were performed. RESULTS: Magnetic resonance imaging of intraosseous hibernomas showed low signal intensity with slightly hyperintense foci on T1 and intermediate to high signal intensity on T2 weighted images. Intraosseous hibernomas appeared as heterogeneous sclerotic lesions with trabecular thickening on computed tomography scans and revealed mild hypermetabolism on positron emission tomography scans. Histopathologically, the bone marrow space was replaced by sheets of multivacuolated, foamy adipocytes resembling brown fat cells, without destruction of bone trabeculae. In immunohistochemical analysis, the tumor cells were negative for CD68 and pan-cytokeratin and positive for S-100 protein. CONCLUSIONS: Intraosseous hibernoma is very rare. This tumor can be overlooked due to its rarity and resemblance to bone marrow fat. Pathologists need to be aware of this entity to avoid misdiagnosis of this rare lesion.
Adipocytes ; Adipocytes, Brown ; Adult ; Biopsy ; Bone Marrow ; Bone Neoplasms ; Diagnostic Errors ; Electronic Health Records ; Eosine Yellowish-(YS) ; Hematoxylin ; Humans ; Immunohistochemistry ; Lipoma* ; Magnetic Resonance Imaging ; Pathology ; Positron-Emission Tomography ; S100 Proteins
Adipocytes ; Adipocytes, Brown ; Adult ; Biopsy ; Bone Marrow ; Bone Neoplasms ; Diagnostic Errors ; Electronic Health Records ; Eosine Yellowish-(YS) ; Hematoxylin ; Humans ; Immunohistochemistry ; Lipoma* ; Magnetic Resonance Imaging ; Pathology ; Positron-Emission Tomography ; S100 Proteins
Placental Lesions in Meconium Aspiration Syndrome.
Journal of Pathology and Translational Medicine.2017;51(5):488-498. doi:10.4132/jptm.2017.07.20
BACKGROUND: Meconium aspiration syndrome (MAS) is defined by respiratory distress requiring supplemental oxygen in a meconium-stained neonate. MAS is clinically subclassified as mild, moderate, and severe according to the oxygen requirement. The aims of this study were to compare the histological findings in the placentas of MAS neonates with those of meconium-stained but non-MAS neonates and to analyze the correlation between the severity of MAS and the grade of its histological parameters. METHODS: We collected 160 singleton term placentas from neonates with meconium staining at birth from a tertiary medical center, Seoul, Republic of Korea. We reviewed hematoxylin and eosin sections of tissue samples (full-thickness placental disc, chorioamniotic membranes, and umbilical cord). RESULTS: Funisitis was present more frequently in MAS than in non-MAS (p < .01), of which the stage was correlated with the severity of MAS (p < .001). The histological findings consistent with maternal underperfusion and chronic deciduitis were more frequent in MAS than in non-MAS (p < .05). There was a correlation between the degree of chorionic vascular muscle necrosis and the severity of MAS (p < .05). CONCLUSIONS: Our results suggest that fetal inflammatory response evidenced by funisitis occurs prenatally in MAS and that the stage of funisitis and of chorionic vascular muscle necrosis may be a predictive marker of the severity of MAS.
Chorioamnionitis ; Chorion ; Eosine Yellowish-(YS) ; Female ; Hematoxylin ; Humans ; Infant, Newborn ; Meconium Aspiration Syndrome* ; Meconium* ; Membranes ; Necrosis ; Oxygen ; Parturition ; Placenta ; Pregnancy ; Republic of Korea ; Seoul
Chorioamnionitis ; Chorion ; Eosine Yellowish-(YS) ; Female ; Hematoxylin ; Humans ; Infant, Newborn ; Meconium Aspiration Syndrome* ; Meconium* ; Membranes ; Necrosis ; Oxygen ; Parturition ; Placenta ; Pregnancy ; Republic of Korea ; Seoul
Acid-Fastness of Histoplasma in Surgical Pathology Practice.
Journal of Pathology and Translational Medicine.2017;51(5):482-487. doi:10.4132/jptm.2017.07.11
BACKGROUND: Histoplasmosis (HP) is diagnosed by visualizing intracellular microorganisms in biopsy and/or culture. Periodic-acid Schiff (PAS) and Gomori methenamine silver (GMS) staining methods are routinely used for identification. The acid-fast property of Histoplasma was identified decades ago, but acid-fast staining has not been practiced in current surgical pathology. Awareness of the acid-fast property of Histoplasma, which is due to mycolic acid in the cell wall, is important in distinguishing Histoplasma from other infective microorganisms. Here, we examined acid-fastness in previously diagnosed cases of Histoplasma using the Ziehl-Neelsen (ZN) stain and correlated those findings with other known fungal stains. METHODS: All cases diagnosed as HP were retrieved and reviewed along with ZN staining and other fungal stains. We also stained cases diagnosed with Cryptococcus and Leishmania as controls for comparison. RESULTS: A total of 54 patients ranging in age from 11 to 69 years were examined. The most common sites of infection were the skin, adrenal tissue, and respiratory tract. Of the total 43 tissue samples, 20 (46.5%) stained positive with the ZN stain. In viable cases, a significant proportion of microorganisms were positive while necrotic cases showed only rare ZN-positive yeasts. In comparison to PAS and GMS stains, there was a low burden of ZN-positive yeasts. Cryptococcus showed characteristic ZN staining and all cases of Leishmania were negative. CONCLUSIONS: Although the morphology of fungal organisms is the foundation of identification, surgical pathologists should be aware of the acid-fast property of fungi, particularly when there is the potential for confusion with other infective organisms.
Biopsy ; Cell Wall ; Coloring Agents ; Cryptococcus ; Fungi ; Histoplasma* ; Histoplasmosis ; Humans ; Leishmania ; Methenamine ; Mycolic Acids ; Pathology, Surgical* ; Respiratory System ; Skin ; Yeasts
Biopsy ; Cell Wall ; Coloring Agents ; Cryptococcus ; Fungi ; Histoplasma* ; Histoplasmosis ; Humans ; Leishmania ; Methenamine ; Mycolic Acids ; Pathology, Surgical* ; Respiratory System ; Skin ; Yeasts
Journal of Pathology and Translational Medicine.2017;51(5):471-481. doi:10.4132/jptm.2017.06.02
BACKGROUND: Ductal adenocarcinoma (DAC) of the prostate is an uncommon histologic subtype whose prognostic factors and immunoprofile have not been fully defined. METHODS: To define its prognostic factors and immunoprofile, the clinicopathological features, including biochemical recurrence (BCR), of 61 cases of DAC were analyzed. Immunohistochemistry was performed on tissue microarray constructs to assess the expression of prostate cancer-related and mammalian target of rapamycin (mTOR) signaling-related proteins. RESULTS: During the median follow-up period of 19.3 months, BCR occurred in 26 cases (42.6%). DAC demonstrated a wide expression range of prostate cancer-related proteins, including nine cases (14.8%) that were totally negative for pan-cytokeratin (PanCK) immunostaining. The mTOR signaling-related proteins also showed diverse expression. On univariate analysis, BCR was associated with high preoperative serum levels of prostate-specific antigen (PSA), large tumor volume, predominant ductal component, high Gleason score (GS), comedo-necrosis, high tumor stage (pT), lymphovascular invasion, and positive surgical margin. High expressions of phospho-mTOR (p-mTOR) as well as low expressions of PSA, phospho-S6 ribosomal protein (pS6) and PanCK were associated with BCR. On multivariable analysis, GS, pT, and immunohistochemical expressions of PanCK and p-mTOR remained independent prognostic factors for BCR. CONCLUSIONS: These results suggest GS, pT, and immunohistochemical expressions of PanCK and p-mTOR as independent prognostic factors for BCR in DAC. Since DAC showed diverse expression of prostate cancer–related proteins, this should be recognized in interpreting the immunoprofile of DAC. The diverse expression of mTOR-related proteins implicates their potential utility as predictive markers for mTOR targeted therapy.
Adenocarcinoma* ; Carcinoma, Ductal ; Follow-Up Studies ; Immunohistochemistry ; Neoplasm Grading ; Prognosis ; Prostate* ; Prostate-Specific Antigen ; Prostatic Neoplasms ; Recurrence ; Ribosomal Proteins ; Sirolimus ; Tumor Burden
Adenocarcinoma* ; Carcinoma, Ductal ; Follow-Up Studies ; Immunohistochemistry ; Neoplasm Grading ; Prognosis ; Prostate* ; Prostate-Specific Antigen ; Prostatic Neoplasms ; Recurrence ; Ribosomal Proteins ; Sirolimus ; Tumor Burden
Journal of Pathology and Translational Medicine.2017;51(5):463-470. doi:10.4132/jptm.2017.05.25
BACKGROUND: When differential diagnosis is difficult in thyroid follicular lesions with overlapping histological features, the immunohistochemical staining can help confirm the diagnosis. We aimed to evaluate the effectiveness of rapid immunohistochemical stains of CD56 and cytokeratin 19 on frozen sections of thyroid follicular lesion and explore the possible gains and limitations of the practice. METHODS: Eighty-six nodules of 79 patients whose intraoperative frozen sections were selected as the control group, and 53 nodules of 48 patients whose intraoperative frozen sections were subject to rapid immunohistochemistry were selected as the study group. RESULTS: Five nodules (6%) in the control group were diagnosed as follicular neoplasm and six nodules (7%) were deferred. In the study group, six nodules (11%) were follicular neoplasm and none were deferred. Three nodules (4%) in the control group showed diagnostic discrepancy between the frozen and permanent diagnoses, but none in the study group. The average turnaround time for the frozen diagnosis of the control group was 24 minutes, whereas it was 54 minutes for the study group. CONCLUSIONS: Intraoperative rapid immunohistochemical stains significantly decreased the diagnostic discrepancy in this study. Considering the adverse effects of indefinite frozen diagnosis or discrepancy with permanent diagnoses, the intraoperative rapid immunohistochemical stain can help to accurately diagnose and hence provide guidance to surgical treatment.
Coloring Agents ; Diagnosis ; Diagnosis, Differential ; Frozen Sections ; Humans ; Immunohistochemistry ; Keratin-19 ; Thyroid Gland*
Coloring Agents ; Diagnosis ; Diagnosis, Differential ; Frozen Sections ; Humans ; Immunohistochemistry ; Keratin-19 ; Thyroid Gland*
Journal of Pathology and Translational Medicine.2017;51(5):456-462. doi:10.4132/jptm.2017.07.19
BACKGROUND: In this study, we hypothesized that microcystic, elongated, fragmented (MELF)-pattern, vascular endothelial growth factor (VEGF) expression by cancer cells and microvessel density of cancer stroma may be associated with progression of endometrioid adenocarcinoma. METHODS: The study used data from the Belarus Cancer Registry and archival histological material of 100 patients with retrospectively known good (survival) and poor (disease progression and death) outcomes. All cases were immunohistochemically stained for CD34 and VEGF. Two independent samples were compared for the characteristics of signs, and obtained results were analyzed by receiver operating characteristic analysis, Mann-Whitney U test, χ² test (Yates correction), and Mantel-Cox test. Multivariate Cox hazard analysis and Spearman correlation test were used. A p-value of less than .05 was considered statistically significant. RESULTS: The observed survival rate of patients with endometrioid adenocarcinoma was significantly lower (p = .002) in MELF-pattern positive patients when compared with MELF-pattern negative patients. The overall survival rate of patients whose tumors had more than 114 vessels/mm² of tissue was significantly low (p < .001). Interestingly, a similar observation was found in patients with increased vessel area, evidenced by VEGF expression in the glandular tumor component. CONCLUSIONS: Our study suggests, for the first time, that these criteria may be used as risk factors of endometrioid adenocarcinoma progression during 5 years after radical surgical treatment. However, a large independent cohort of samples should be considered in the future to validate our findings.
Carcinoma, Endometrioid ; Cohort Studies ; Endometrial Neoplasms* ; Female ; Humans ; Microvessels* ; Prognosis ; Republic of Belarus ; Retrospective Studies ; Risk Factors ; ROC Curve ; Survival Rate ; Vascular Endothelial Growth Factor A*
Carcinoma, Endometrioid ; Cohort Studies ; Endometrial Neoplasms* ; Female ; Humans ; Microvessels* ; Prognosis ; Republic of Belarus ; Retrospective Studies ; Risk Factors ; ROC Curve ; Survival Rate ; Vascular Endothelial Growth Factor A*
White Matter Injury of Prematurity: Its Mechanisms and Clinical Features.
Journal of Pathology and Translational Medicine.2017;51(5):449-455. doi:10.4132/jptm.2017.07.25
A developing central nervous system is vulnerable to various insults such as infection and ischemia. While increased understanding of the dynamic nature of brain development allows a deeper insight into the pathophysiology of perinatal brain injury, the precise nature of specific fetal and neonatal brain injuries and their short- and long-term clinical consequences need special attention and further elucidation. The current review will describe the pathophysiological aspects and clinical significance of white matter injury of prematurity, a main form of perinatal brain injury in premature newborns, with a particular emphasis on its potential antenatal components.
Brain ; Brain Injuries ; Central Nervous System ; Humans ; Infant, Newborn ; Ischemia ; Leukomalacia, Periventricular ; White Matter*
Brain ; Brain Injuries ; Central Nervous System ; Humans ; Infant, Newborn ; Ischemia ; Leukomalacia, Periventricular ; White Matter*
Country
Republic of Korea
Publisher
ElectronicLinks
Editor-in-chief
Abbreviation
Journal of Pathology and Translational Medicine
Vernacular Journal Title
ISSN
2383-7837
EISSN
Year Approved
2007
Current Indexing Status
Currently Indexed
Start Year
Description
Previous Title
Powered by IMICAMS(
备案号: 11010502037788, 京ICP备10218182号-8)