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A Rare Case of Tumor-to-Tumor Metastasis of Thyroid Papillary Carcinoma within a Pulmonary Adenocarcinoma.

Taebum LEE ; Yoon Jin CHA ; Sangjeong AHN ; Joungho HAN ; Young Mog SHIM

Journal of Pathology and Translational Medicine.2015;49(1):78-80. doi:10.4132/jptm.2014.12.15

No abstract available.
Adenocarcinoma* ; Carcinoma, Papillary* ; Neoplasm Metastasis* ; Thyroid Gland*

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A Rare Case of Mixed Type A Thymoma and Micronodular Thymoma with Lymphoid Stroma.

Yoon Jin CHA ; Joungho HAN ; Jimin KIM ; Kyung Soo LEE ; Young Mog SHIM

Journal of Pathology and Translational Medicine.2015;49(1):75-77. doi:10.4132/jptm.2014.10.27

No abstract available.
Thymoma*

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Placental Mesenchymal Dysplasia with Fetal Gastroschisis.

Binnari KIM ; Jiyeon HYEON ; Minju LEE ; Hyewon HWANG ; Yooju SHIN ; Suk Joo CHOI ; Jung Sun KIM

Journal of Pathology and Translational Medicine.2015;49(1):71-74. doi:10.4132/jptm.2014.12.14

No abstract available.
Gastroschisis*

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Ewing's Sarcoma/Primitive Neuroectodermal Tumor of the Uterine Corpus.

Eung Seok LEE ; Won HWANGBO ; Insun KIM

Journal of Pathology and Translational Medicine.2015;49(1):66-70. doi:10.4132/jptm.2014.10.14

No abstract available.
Neuroectodermal Tumors*

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Mixed Carcinoid-Mucinous Adenocarcinoma Arising in Mature Teratoma of Mesentery.

Su Jin SHIN ; Eun Mi SON ; Chang Ohk SUNG ; Kyu Rae KIM

Journal of Pathology and Translational Medicine.2015;49(1):61-65. doi:10.4132/jptm.2014.09.17

No abstract available.
Adenocarcinoma* ; Mesentery* ; Teratoma*

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Diagnostic Accuracy of Endoscopic Ultrasound-Guided Fine Needle Aspiration Cytology of Pancreatic Lesions.

Hae Woon BAEK ; Min Jee PARK ; Ye Young RHEE ; Kyoung Bun LEE ; Min A KIM ; In Ae PARK

Journal of Pathology and Translational Medicine.2015;49(1):52-60. doi:10.4132/jptm.2014.10.26

BACKGROUND: Endoscopic ultrasound-guided fine needle aspiration cytology (EUS-FNAC) is currently the most commonly used procedure for obtaining cytologic specimens of the pancreas. It is accurate, minimally invasive, safe and cost-effective. However, there is discrepancy between cytological and surgical diagnoses. This study was aimed at evaluating the diagnostic accuracy of EUS-FNAC of the pancreas. METHODS: We performed a retrospective review of 191 cases of pancreatic lesions initially diagnosed by EUS-FNAC with subsequent histological diagnosis between 2010 and 2012 in the Department of Pathology, Seoul National University Hospital. Cytologic and surgical diagnoses were categorized into five groups: negative, benign, atypical, malignant, and insufficient for diagnosis. Subsequently, 167 cases with satisfactory yield in both surgical and cytology specimens were statistically analyzed to determine correlations with diagnosis. RESULTS: In comparison to surgical diagnoses, cytologic diagnoses were true-positive in 103 cases (61.7%), true-negative in 28 cases (16.8%), false-positive in 9 cases (5.4%), and false-negative in 27 cases (16.1%). The diagnostic accuracy was 78.4%, sensitivity was 79.2%, and specificity was 75.7%. The positive predictive value was 92.0%, and negative predictive value was 50.9%. CONCLUSIONS: EUS-FNAC has high accuracy, sensitivity, specificity and positive predictive value. Overcoming the limitations of EUS-FNAC will make it a useful and reliable diagnostic tool for accurate evaluation of pancreatic lesions.
Diagnosis ; Endoscopic Ultrasound-Guided Fine Needle Aspiration* ; Pancreas ; Pathology ; Retrospective Studies ; Sensitivity and Specificity ; Seoul

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Expression of c-MET in Invasive Meningioma.

Sumi YUN ; Jae Moon KOH ; Kyu Sang LEE ; An Na SEO ; Kyung Han NAM ; Gheeyoung CHOE

Journal of Pathology and Translational Medicine.2015;49(1):44-51. doi:10.4132/jptm.2014.10.13

BACKGROUND: Meningiomas show high recurrence rates even after curative tumor removal. The invasiveness of meningiomas may contribute to their high recurrence rates. Recently, c-MET and hepatocyte growth factor (HGF) have been reported to be involved in cancer invasion. METHODS: We examined the immunohistochemical expression of c-MET and HGF in 100 cases of patients with meningiomas who have undergone complete tumor removal. RESULTS: c-MET(-High) and HGF(-High) were found in 17% and 13% of meningiomas, respectively. Brain invasion was observed in 17.6% of c-MET(-High) meningiomas, but in only 2.4% of c-MET(-Low) meningiomas (p=.033). Bone/soft tissue invasion was observed in 23.5% of c-MET(-High) meningiomas and in 9.6% of c-MET(-Low) meningiomas (p=.119). HGF(-High) did not show statistical association with brain invasion or bone/soft tissue invasion. c-MET(-High) demonstrated shorter recurrence-free survival (RFS, 93.5+/-8.2 months vs 96.1+/-1.9 months); however, this difference was not statistically significant (p=.139). There was no association of HGF(-High) with RFS. CONCLUSIONS: This study demonstrates that c-MET(-High) is associated with brain invasion of meningiomas, and that c-MET expression may be a useful predictive marker for meningioma recurrence. Patients with invasive meningiomas with high expressions of c-MET may be good candidates for targeted therapy using c-MET inhibitors.
Brain ; Hepatocyte Growth Factor ; Humans ; Immunohistochemistry ; Meningioma* ; Neoplasm Invasiveness ; Proto-Oncogene Proteins c-met ; Recurrence

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Transglutaminase 2 Expression and Its Prognostic Significance in Clear Cell Renal Cell Carcinoma.

Min Jee PARK ; Hae Woon BAEK ; Ye Young RHEE ; Cheol LEE ; Jeong Whan PARK ; Hwal Woong KIM ; Kyung Chul MOON

Journal of Pathology and Translational Medicine.2015;49(1):37-43. doi:10.4132/jptm.2014.10.25

BACKGROUND: A few recent studies have demonstrated a possible role of transglutaminase 2 (TG2) in tumorigenesis or progression of renal cell carcinoma (RCC). The aim of this study was to examine TG2 expression and its clinicopathologic significance in a large number of human clear cell RCCs (CCRCCs). METHODS: We analyzed 638 CCRCC patients who underwent partial or radical nephrectomy between 1995 and 2005. The expression of TG2 was determined by immunohistochemistry and categorized into four groups, according to staining intensity: negative (0), mild (1+), moderate (2+), and strong (3+). RESULTS: TG2 staining intensity was negative in 8.5% of CCRCC (n=54), 1+ in 32.6% (n=208), 2+ in 50.5% (n=322), and 3+ in 8.5% (n=54). Strong TG2 expression was correlated with high Fuhrman nuclear grade (p=.011), high T category (p=.049), metastasis (p=.043) and male sex (p<.001) but not with N category.The survival analysis showed a significant association between strong TG2 expression and worse overall and cancer-specific survival (p=.027 and p=.010, respectively). On multivariate analysis, strong TG2 expression was a marginally significant prognostic indicator for Fuhrman nuclear grade and TNM staging (p=.054). CONCLUSIONS: Our study is the first to demonstrate the clinicopathologic significance of TG2 expression in a large number of human CCRCC samples. Strong TG2 expression was associated with high nuclear grade and poor prognosis.
Carcinogenesis ; Carcinoma, Renal Cell* ; Humans ; Immunohistochemistry ; Male ; Multivariate Analysis ; Neoplasm Metastasis ; Neoplasm Staging ; Nephrectomy ; Prognosis ; Transglutaminases

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Clinical and Prognostic Significances of Cytokeratin 19 and KIT Expression in Surgically Resectable Pancreatic Neuroendocrine Tumors.

Eun Mi SON ; Joo Young KIM ; Soyeon AN ; Ki Byung SONG ; Song Cheol KIM ; Eunsil YU ; Seung Mo HONG

Journal of Pathology and Translational Medicine.2015;49(1):30-36. doi:10.4132/jptm.2014.10.23

BACKGROUND: Pancreatic neuroendocrine tumors (PanNETs) are malignant endocrine neoplasms that present diverse clinical behaviors. Therefore, identification of biomarkers of PanNETs is important for stratification of the prognosis of PanNET patients. Recently, cytokeratin 19 (CK19) and KIT expression were reported to have prognostic significance in PanNET patients. METHODS: To identify their prognostic significance, CK19 and KIT protein expression were assessed in 182 surgically resected PanNETs and compared with clinicopathologic factors. RESULTS: Of 182 PanNETs cases, CK19 and KIT expression was noted in 97 (53.3%) and 16 (8.8%) cases, respectively. PanNET patients with CK19 expression had larger tumors (p=.006), higher World Health Organization (WHO) grade (p=.002) and pT classification (p<.001), increased distant metastasis (p=.004), and lymphovascular (p=.012) and perineural (p=.019) invasion. Similarly, those with KIT expression had larger tumors (p=.030), higher WHO grade (p=.001), advanced pT classification (p<.001), distant metastasis (p=.001), and lymphovascular invasion (p=.014). The 5-year survival rate for PanNET patients with KIT expression was significantly lower (62%) than that of patients without KIT expression (77%, p=.011), as determined by univariate but not by multivariate analyses. CONCLUSIONS: CK19 and KIT expression correlate with higher metastatic potential and advanced disease stage, and KIT expression is associated with worse survival in PanNET patients.
Biomarkers ; Classification ; Humans ; Immunohistochemistry ; Keratin-19* ; Multivariate Analysis ; Neoplasm Metastasis ; Neuroendocrine Tumors* ; Pancreas ; Prognosis ; Survival Rate ; World Health Organization

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PHH3 as an Ancillary Mitotic Marker in Gastrointestinal Stromal Tumors.

Yooju SHIN ; Jiyeon HYEON ; Boram LEE ; Sang Yun HA ; Min Eui HONG ; In Gu DO ; Kyoung Mee KIM

Journal of Pathology and Translational Medicine.2015;49(1):23-29. doi:10.4132/jptm.2014.10.08

BACKGROUND: Counting mitoses is subjective and time-consuming. The adjunctive diagnostic utility of a recently reported mitotic marker, phosphohistone H3 (PHH3), was investigated in gastrointestinal stromal tumors (GISTs). METHODS: We reviewed 77 GISTs for several proliferative indices. These included the mitotic count per 50 high power fields (HPFs), the immunohistochemical Ki-67 labeling index and the immunohistochemical PHH3 mitotic index (MI). For comparison, Spearman's rank correlation and interclass correlation coefficient were used. RESULTS: Mitotic counts ranged from 0-138 (mean, 7.57+/-2.34) and the PHH3 MI ranged from 0-126 per 50 HPFs (mean, 9.61+/-2.27). We found a positive correlation between mitotic counts and PHH3 MI (r=0.810, p<.001). The inter-observer correlation coefficient for three participants was 0.975 for mitotic counts and 0.940 for the PHH3 MI. When using the PHH3 MI instead of mitotic counts in the Armed Forces Institute of Pathology (AFIP) stratification criteria, 10 cases were reclassified. In one patient with a mitotic count of 2 and a PHH3 MI of 6 per 50 HPFs, distant metastasis occurred. CONCLUSIONS: In GISTs, the PHH3 MI correlated adequately with mitotic counts and can be used as a useful adjunctive to count mitotic figures efficiently.
Arm ; Biomarkers ; Gastrointestinal Stromal Tumors* ; Humans ; Mitosis ; Mitotic Index ; Neoplasm Metastasis ; Pathology

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