Osteoporosis and Sarcopenia.2016;2(4):257-258. doi:10.1016/j.afos.2016.10.003
No abstract available.
Osteoporosis and Sarcopenia
2002 (v1, n1) to Present ISSN: 1671-8925
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Osteoporosis and Sarcopenia.2016;2(4):250-255. doi:10.1016/j.afos.2016.10.001
Mandibular cortical erosion detected on dental panoramic radiographs is associated with increased risk of osteoporosis in older adults. Additionally, many reports have demonstrated an association between decreased number of teeth present and osteoporosis. However, whether mandibular cortical erosion is associated with a decreased number of teeth remains unclear. The purpose of this study, therefore, was to clarify the association between mandibular cortical erosion and number of teeth present in Japanese men and women aged 40 years and older. Among patients who visited our university hospital and underwent dental panoramic radiography for the diagnosis of dental diseases, 839 patients (293 men and 546 women) aged 40–89 years (mean [SD], 63.7 [10.6] years) participated in this study. Multiple regression analysis revealed that mildly to moderately eroded cortex (p = 0.007) and severe eroded cortex (p < 0.001) were significantly associated with a decreased number of teeth present. Analysis of covariance adjusted for covariates revealed a significant association between mandibular cortical erosion category and number of teeth present (p < 0.001). Subjects with a severely eroded cortex had significantly fewer teeth present than those with a normal cortex (mean [SE], 20.7 [0.5] vs. 23.4 [0.3], p < 0.001) or mildly to moderately eroded cortex (22.2 [0.4], p = 0.04). Subjects with a mildly to moderately eroded cortex had significantly fewer teeth present than those with a normal cortex (p = 0.033). Our results suggest the significant association between mandibular cortical erosion and number of teeth present in Japanese men and women aged 40 years and older.
Adult ; Asian Continental Ancestry Group* ; Cross-Sectional Studies* ; Cytochrome P-450 CYP1A1 ; Diagnosis ; Female ; Humans ; Male ; Mandible ; Osteoporosis ; Radiography, Panoramic ; Stomatognathic Diseases ; Tooth*
Adult ; Asian Continental Ancestry Group* ; Cross-Sectional Studies* ; Cytochrome P-450 CYP1A1 ; Diagnosis ; Female ; Humans ; Male ; Mandible ; Osteoporosis ; Radiography, Panoramic ; Stomatognathic Diseases ; Tooth*
Clinical features of atypical femur fracture.
Osteoporosis and Sarcopenia.2016;2(4):244-249. doi:10.1016/j.afos.2016.08.001
OBJECTIVES: We aim to elucidate the clinical outcomes of bisphosphonate-associated atypical femoral fracture and the clinical results depending on the bisphosphonate therapy period. METHODS: Twenty cases involving 15 patients who had been diagnosed with atypical femoral facture between 2004 and 2014 and who had been followed up for at least 12 months were retrospectively analyzed. The control group was composed of 15 typical femoral facture patients. We used plain radiography and physical examinations to determine the period of time required for fracture healing as well as complication occurrence. We investigated the bisphosphonate administration status and duration and the names of its components, bilateral fracture occurrence status, the period of time required for bone union, and reoperation or bone graft status due to nonunion. RESULTS: Revision surgery involving a bone graft was performed due to nonunion in 1 out of 15 cases. Except in one revision case, the duration of the union was 11.9 months on average in 14 cases of atypical fracture patients, and 4.3 months on average in the control group. This difference was statistically significant (p < 0.05). The bisphosphonate administration duration was positively correlated with the union period (p < 0.05). In contrast, there was no statistically significant correlation between the bisphosphonate administration duration and the incidence of bilateral atypical fractures (p > 0.05). CONCLUSIONS: Atypical femoral fractures required more time for bone union than typical ones and prolonged bisphosphonate administration led to a longer period of time required for bone union.
Femoral Fractures ; Femur* ; Fracture Healing ; Humans ; Incidence ; Physical Examination ; Radiography ; Reoperation ; Retrospective Studies ; Transplants
Femoral Fractures ; Femur* ; Fracture Healing ; Humans ; Incidence ; Physical Examination ; Radiography ; Reoperation ; Retrospective Studies ; Transplants
Osteoporosis and Sarcopenia.2016;2(4):238-243. doi:10.1016/j.afos.2016.09.002
OBJECTIVES: The purpose of the study was to assess the effectiveness of the Fracture Liaison service (FLS) in preventing secondary fracture and decreasing 1-year mortality rate after osteoporotic hip fracture, in patients at Police General Hospital, Bangkok, Thailand. METHODS: A prospective cohort study was conducted. We studied male and female patients, 50 years of age and older, who presented with a fragility fracture around the hip due to low energy trauma and were admitted to Police General Hospital, participating in PGH's Liaison service from April 1, 2014—March 30, 2015. The sample size was 75 patients, with a follow up time of 1 year. The data from this study was compared with that of a previous study done by Tanawat A. et al. [9] prior to commencement of the FLS project. RESULTS: After a follow up period of 1 year, the mortality rate was measured to be 10.7% and there was no evidence of secondary fragility fracture. Post-injury bone mineral density follow up and osteoporotic medication treatment rates were 48% and 80%, respectively. Patients who participated in the project were found to have a decreasing rate of secondary fracture from 30% to 0% (P < 0.0001), an increasing post-injury BMD follow up rate from 28.3% to 48% (P = 0.0053), and an increase in post-injury osteoporotic medication administration rate from 40.8% to 80% (P = 0.0148), all with statistical significance. However, the 1-year mortality rate was not significant (P = 0.731) when compared to the previous study. CONCLUSIONS: Patients with recent hip fractures participating in the Fracture Liaison service had a significantly higher post-injury BMD follow up and osteoporotic medication administration rates. This resulted in a lower risk of secondary fracture than those who did not participate in the Fracture Liaison service at a follow up time of one year.
Bone Density ; Cohort Studies ; Female ; Follow-Up Studies ; Hip ; Hip Fractures ; Hospitals, General ; Humans ; Male ; Mortality ; Osteoporosis ; Police* ; Prospective Studies ; Sample Size ; Thailand*
Bone Density ; Cohort Studies ; Female ; Follow-Up Studies ; Hip ; Hip Fractures ; Hospitals, General ; Humans ; Male ; Mortality ; Osteoporosis ; Police* ; Prospective Studies ; Sample Size ; Thailand*
Osteoporosis and Sarcopenia.2016;2(4):228-237. doi:10.1016/j.afos.2016.09.004
OBJECTIVE: There has been no prospective study that examined intramuscular injection of high-dose vitamin D in Korean adults. The aim of this study was to assess the efficacy and safety of high-dose vitamin D3 after intramuscular injection in Korean adults with vitamin D deficiency. METHODS: This study was a 24-week, prospective, multicenter, randomized, double-blind, placebo-controlled trial. A total of 84 subjects ≥19 and <65 years of age were randomly allocated to either the vitamin D3 or placebo group in a 2:1 ratio. After randomization, a single injection of plain vitamin D3 200,000 IU or placebo was intramuscularly administered. If serum 25-hydroxyvitamin D (25[OH]D) concentrations were <30 ng/mL on week 12 or thereafter, a repeat injection was administered. RESULTS: After a single intramuscular injection of vitamin D3 to adults with vitamin D deficiency, the proportion of subjects with serum 25(OH)D concentrations ≥30 ng/mL within 12 weeks was 46.4% in the vitamin D3 group and 3.6% in the placebo group (p < 0.0001). The proportion of subjects with serum 25(OH)D concentrations ≥30 ng/mL within 24 weeks was 73.2% in the vitamin D3 group and 3.6% in the placebo group (p < 0.0001). Mean change in serum 25(OH)D concentrations at weeks 12 and 24 after vitamin D3 injection was 12.8 ± 8.1 and 21.5 ± 8.1 ng/mL, respectively, in the vitamin D3 group, with no significant changes in the placebo group. Serum parathyroid hormone concentrations showed a significant decrease in the vitamin D3 group but no change in the placebo group. CONCLUSION: Intramuscular injection of vitamin D3 200,000 IU was superior to placebo in terms of its impact on serum 25(OH)D concentrations, and is considered to be safe and effective in Korean adults with vitamin D deficiency.
Adult* ; Asian Continental Ancestry Group ; Cholecalciferol* ; Humans ; Injections, Intramuscular* ; Parathyroid Hormone ; Prospective Studies ; Random Allocation ; Vitamin D Deficiency* ; Vitamin D* ; Vitamins*
Adult* ; Asian Continental Ancestry Group ; Cholecalciferol* ; Humans ; Injections, Intramuscular* ; Parathyroid Hormone ; Prospective Studies ; Random Allocation ; Vitamin D Deficiency* ; Vitamin D* ; Vitamins*
Osteoporosis and Sarcopenia.2017;3(3):160-160. doi:10.1016/j.afos.2017.07.004
No abstract available.
Humans
Humans
Osteoporosis and Sarcopenia.2017;3(3):159-159. doi:10.1016/j.afos.2017.07.004
Osteoporosis and Sarcopenia.2017;3(3):155-158. doi:10.1016/j.afos.2017.08.100
OBJECTIVES: Vitamin D deficiency has been shown to influence the development of some cardiovascular disease. In this study, the association between the existence of coronary artery plaque and vitamin D was examined among participants who were not previously diagnosed with coronary artery disease. METHODS: A total of 339 participants (246 men and 93 women) who visited a health examination center for check-up including blood test for serum vitamin D level and coronary computed tomography angiography (CCTA) were selected for this study. RESULTS: Among the total 339 participants, 106 displayed coronary artery plaques. The serum 25-hydroxy vitamin D (25(OH)D) level of the group with plaque was lower than that of the group without (17.7 ± 7.72 ng/mL vs. 19.6 ± 7.12 ng/mL, P = 0.0316). The group with plaque had higher incidence rates of diabetes mellitus, hypertension, and dyslipidemia than that without (P = 0.0078, P = 0.0065, and P = 0.0174, respectively). The former displayed higher serum glucose and glycated hemoglobin levels than the latter (P = 0.0055 and P = 0.0137, respectively). The group with plaque showed higher systolic and diastolic blood pressure than that without (P < 0.0001 and P = 0.0012, respectively). Stepwise multivariate logistic regression analysis revealed that 25(OH)D (coefficient, −0.06; odd ratio, 0.9433; 95% confidence interval, 0.8967–0.9924), age, and sex were independently related with presence of coronary artery plaque. CONCLUSIONS: Relatively low vitamin D level was observed among participants with plaque, which was determined through CCTA during a health examination. Plaque formation and serum 25(OH)D level showed inverse relationship.
Angiography* ; Blood Glucose ; Blood Pressure ; Cardiovascular Diseases ; Coronary Artery Disease* ; Coronary Vessels ; Diabetes Mellitus ; Dyslipidemias ; Hematologic Tests ; Hemoglobin A, Glycosylated ; Humans ; Hypertension ; Incidence ; Logistic Models ; Male ; Vitamin D Deficiency ; Vitamin D* ; Vitamins*
Angiography* ; Blood Glucose ; Blood Pressure ; Cardiovascular Diseases ; Coronary Artery Disease* ; Coronary Vessels ; Diabetes Mellitus ; Dyslipidemias ; Hematologic Tests ; Hemoglobin A, Glycosylated ; Humans ; Hypertension ; Incidence ; Logistic Models ; Male ; Vitamin D Deficiency ; Vitamin D* ; Vitamins*
Osteoporosis and Sarcopenia.2017;3(3):149-154. doi:10.1016/j.afos.2017.08.099
OBJECTIVES: The purpose of this study was to evaluate the effects of hyperthyroidism and their etiology on bone mineral density (BMD), on body soft tissue composition, on the prevalence of vertebral fractures detected by vertebral fracture assessment (VFA) and on the trabecular bone score (TBS). METHODS: From an initial population of 119 Portuguese men (78 with hyperthyroidism [HT]+ 41 controls [CTs]) admitted to the Endocrinology Department we selected 41 men aged over 50 with clinical hyperthyroidism to participate; each one was matched by age and height with a control person. BMD (g/cm²) at the lumbar spine, hip, radius 33% and whole body and the total body masses (kg) were studied by dual-energy X-ray absorptiometry (DXA). VFA with Genant semiquantitative method was used to detect fractures. The TBS was obtained from lumbar spine DXA images. No patient had been treated previously for hyperthyroidism or osteoporosis. Adequate statistical tests were used. RESULTS: In the hyperthyroidism group, total lean mass (CT 58.16 ± 7.7 vs. HT 52.3 ± 5.7, P = 0.03) and distal radius BMD (CT 0.769 ± 0.05 vs. HT 0.722 ± 0.08, P = 0.005) were lower; there was a significantly higher prevalence of osteoporosis (CT 9.7% vs. HT 29.3%, P = 0.015) and vertebral fractures (CT 2.4% vs. HT 24.4%, P = 0.007). TBS was similar in both groups (CT 1.328 ± 0.11 vs. HT 1.356 ± 0.11, P = not significant). Comparing patients with Graves' disease with patients with toxic goiter, there were no differences regarding BMD, BMD qualification, prevalence of fractures and TBS and just total lean mass was significantly lower in patients with Graves' disease. CONCLUSIONS: These results suggest that in a group of hyperthyroid men aged over 50 there are significant decreases in cortical bone BMD and lean mass and a higher prevalence of osteoporosis and silent vertebral fractures, but the etiology of the hyperthyroidism does not seem to influence it. Besides the antithyroid drugs, some patients may benefit from bone-directed treatments.
Absorptiometry, Photon ; Antithyroid Agents ; Bone Density ; Endocrinology ; Goiter ; Graves Disease ; Hip ; Humans ; Hyperthyroidism* ; Male ; Methods ; Osteoporosis* ; Prevalence* ; Radius ; Spine
Absorptiometry, Photon ; Antithyroid Agents ; Bone Density ; Endocrinology ; Goiter ; Graves Disease ; Hip ; Humans ; Hyperthyroidism* ; Male ; Methods ; Osteoporosis* ; Prevalence* ; Radius ; Spine
Osteoporosis and Sarcopenia.2017;3(3):138-148. doi:10.1016/j.afos.2017.08.097
OBJECTIVES: This analytic retrospective case-control study was designed to analyze risk factors and the epidemiological profile of hip fractures among the Indian population with special importance to the mechanism of injuries. METHODS: Patients of hip fractures (n = 41) and age- and sex-matched healthy volunteers (n = 41) were interviewed by a questionnaire regarding the occurrence of the fracture, past history of diseases and long-term medication usage, past and physical activity, supplements, smoking, and alcohol intake. The data were tabulated using descriptive statistics and logistic regression was used to determine significant risk factors. RESULTS: Age group 60–69 was found to be most affected by hip fractures, though an early onset of fractures was noted in males. Falls due to slipping indoors from standing position was found very commonly. However, an increasing trend of falls was noted from lying down position in the older age groups which was more common during the morning and night hours. Logistic regression analysis for the detection of risk factors was applied to the various variables in the questionnaire. Active status in the past was inversely related (odds ratio [OR], 0.33; P < 0.05) to fracture risk while alternative medication usage in the past 1 year (OR, 4.086; P < 0.05) and significant alcohol consumption were directly associated with fracture risk (OR, 5.484; P < 0.05). A potential inverse relation of use of calcium supplements in the past 3 months and fracture risk (OR, 0.872) was seen, although this was not significant. A potential positive relation of smoking with hip fractures was also seen, but not found significant (OR, 2.204). CONCLUSIONS: Hip fractures in the elderly population are on a rising trend especially in the Indian subcontinent due to a number of factors both hereditary and acquired. Simple measures like routine usage of bedside railing, wall-side railings at an appropriate height, high friction tiles inside rooms and washrooms, and adequate lighting indoors can play a significant role in reducing falls and hip fractures among the elderly.
Accidental Falls ; Aged ; Alcohol Drinking ; Calcium ; Case-Control Studies* ; Deception ; Friction ; Healthy Volunteers ; Hip Fractures* ; Hip* ; Humans ; Logistic Models ; Male ; Motor Activity ; Osteoporosis ; Posture ; Retrospective Studies ; Risk Factors* ; Smoke ; Smoking
Accidental Falls ; Aged ; Alcohol Drinking ; Calcium ; Case-Control Studies* ; Deception ; Friction ; Healthy Volunteers ; Hip Fractures* ; Hip* ; Humans ; Logistic Models ; Male ; Motor Activity ; Osteoporosis ; Posture ; Retrospective Studies ; Risk Factors* ; Smoke ; Smoking
Country
Republic of Korea
Publisher
ElectronicLinks
Editor-in-chief
Abbreviation
Osteoporosis and Sarcopenia
Vernacular Journal Title
ISSN
2405-5255
EISSN
Year Approved
2016
Current Indexing Status
Currently Indexed
Start Year
Description
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