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The Correlation Between The Histologic Activity and Fibrosis and The Distribution of Intrahepatic HBsAg and HBcAg in Patients With Chronic Hepatitis B.

Kwang Bum CHO ; Jung Ho SOHN ; Kyung Sik PARK ; Du Young KWON ; Jae Seok HWANG ; Jung Wook HUR ; Sung Hoon AHN ; Soong Kuk PARK ; Sang Pyo KIM

The Korean Journal of Hepatology.2001;7(4):401-412.

BACKGROUND/AIMS: The purpose of this study was to assess the correlation between histologic activity and fibrosis and the distribution of intrahepatic hepatitis B core antigen (HBcAg) and surface antigen (HBsAg) in patients with chronic hepatitis B. METHODS: 141 patients (M:F=141:27) with biopsy-proven chronic hepatitis B, abnormal liver function, and a positive HBV viral marker (serum HBeAg, serum HBV DNA) were enrolled. RESULTS: HBcAg was expressed in 96 of 141 patients (68.1%), nHBcAg in 23 (16.3%), cHBcAg in 58 (41.2%), and n-cHBcAg in 15 (10.6%). In the cases of HBsAg, 114 of 141 patients (80.9%) were expressed as cHBsAg, 2 (1.4%) as mHBsAg, and 16 (11.3%) as m-cHBsAg. The presence of intrahepatic HBcAg and HBsAg according to Gudat's classification was not correlated with activity and fibrosis. But the groups with nuclear expression of HBcAg revealed less inflammatory activity (grade, p=0.003), and less fibrotic stage (p = 0.002) than with cytoplasmic or no expression of HBcAg. HBsAg was not. CONCLUSIONS: These observations suggest that inflammatory activity and fibrosis of chronic hepatitis B are related to the presence of HBcAg in hepatocytes and the expression of HBcAg. This is a very important finding in hepatocytolysis.
Antigens, Surface ; Biomarkers ; Classification ; Cytoplasm ; Fibrosis* ; Hepatitis B Core Antigens* ; Hepatitis B e Antigens ; Hepatitis B Surface Antigens* ; Hepatitis B, Chronic* ; Hepatitis, Chronic* ; Hepatocytes ; Humans ; Immunohistochemistry ; Liver

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An Outbreak of Hepatitis A in South Korean Military Personnel: A Clinical and Epidemiologic Study.

Sung Hee HAN ; Soong Hwan LEE ; Byung Joo ROH ; Seong Chun SHIM ; Seung Chul CHO ; Joo Hyun SOHN ; Dong Hoo LEE ; Choon Suhk KEE

The Korean Journal of Hepatology.2001;7(4):392-400.

BACKGROUND/AIMS: Increasing the susceptibility of young populations to HAV infection could result in an outbreak in a high-risk group. The author investigated the characteristics of hepatitis A outbreaks among Korean military personnel to obtain the fundamental data for determining the necessity for selective HAV vaccination. METHODS: A case was defined as a person who had an onset of an illness compatible with acute viral hepatitis A between 4 February and 6 April 1998. RESULTS: A widespread outbreak of hepatitis A affected 102 military personnel. The epidemic curve indicated a common-source exposure in the initial stage. At the end of the first month of the initial onset, the occurrence was specific to the location of the military post. Investigation suggested that contamination most likely occurred prior to the local distribution of food. The mean age was 23 years. The overall attack rate was 91 cases per 10000 persons at risk. All cases were jaundiced. The most frequently reported symptoms included icteric sclerae, dark urine, anorexia, malaise and fatigue, nausea, fever, abdominal pain, headache, upper respiratory symptoms, vomiting, itching, diarrhea, light-colored stools, myalgia, arthralgia, and skin rash. The laboratory test showed the serum total bilirubin of 5.5 mg/dL, AST of 344 IU/L, and ALT of 868 IU/L (mean value). CONCLUSION: All patients were clinically apparently diseased with jaundice and were completely recovered. The outbreak was food borne common-source exposure. The changing epidemiology hepatitis A in Korea calls for the economic evaluation of costs and benefits for selective HAV vaccination in high risk adult groups including military personnel.
Abdominal Pain ; Adult ; Anorexia ; Arthralgia ; Bilirubin ; Cost-Benefit Analysis ; Diarrhea ; Disease Outbreaks ; Epidemiologic Studies* ; Epidemiology ; Exanthema ; Fatigue ; Fever ; Headache ; Hepatitis A* ; Hepatitis* ; Humans ; Jaundice ; Korea ; Military Personnel* ; Myalgia ; Nausea ; Pruritus ; Sclera ; Vaccination ; Vomiting

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The Hepatitis B Carrier Rate in Siblings of Patients with HBV-associated Chronic Liver Disease.

Hwi KONG ; Ji Hoon KIM ; Nam Young CHO ; Yoon Hong KIM ; Kil Man JUNG ; Jong Eun YEON ; Jae Seon KIM ; Young Tae BAK ; Kyung Hwan CHO ; Yong Kyu PARK ; Kwan Soo BYUN ; Chang Hong LEE

The Korean Journal of Hepatology.2001;7(4):387-391.

Backgrounds/Aims: This study aimed to estimate the seroepidemiology of hepatitis B virus (HBV) infection with emphasis on the transmission of HBV infection between mothers and their children. METHODS: For 452 patients with HBV associated chronic liver disease, and 1,098 of their offspring, who visited Korea University Kuro Hospital from February, 2000 to February, 2001, HBsAg was tested by radioimmunoassay. RESULTS: Among siblings whose mothers were HBsAg-positive, the overall prevalence rate of HBV infection was 44.9% (140/312) and decreased with decreasing age (54.7% in > or =20 years old age group, 33.3% in 10-19 years old age group, 7.6% in <10 years old age group). The estimated proportion of perinatal infection out of modes of HBV transmissions in the general population was 38% in <10 years and 63.4% in 10-19 years. CONCLUSION: The present hepatitis B vaccination strategies -especially against perinatal infection- of Korea have performed to their utmost. More effective methods for the prevention of HBV transmission are now needed.
Child ; Epidemiology ; Hepatitis B Surface Antigens ; Hepatitis B virus ; Hepatitis B* ; Hepatitis* ; Humans ; Korea ; Liver Diseases* ; Liver* ; Mothers ; Prevalence ; Radioimmunoassay ; Siblings* ; Vaccination

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Prevalence of HBV Genotypes in Korean Patients with Chronic Hepatitis B.

IL Hyun CHO ; Jung Youp SONG ; Deog Ki KIM ; Hong Seok LIM ; Seung Soo SHEEN ; Won Seok KIM ; Kee Myeong LEE ; Ki Baik HAHM ; Jin Hong KIM ; Sung Won CHO

The Korean Journal of Hepatology.2001;7(4):381-386.

BACKGROUND/AIMS: Hepatitis B virus (HBV) genotypes have distinct geographic distributions. The possibility of pathogenic differences among HBV genotypes has been suggested. We investigated the prevalence of HBV genotypes in Korea and the association between distinct genotypes and clinical outcomes. METHODS: Using a PCR-RFLP and sequencing, HBV genotypes were determined in 136 patients with chronic type B hepatitis. RESULTS: The genotype C was detected in 131 patients (96.3%), and other 5 patients (3.7%) had genotype B. There were no significant differences in sex, age, disease duration, ALT level, HBeAg/anti-HBe status, or HBeAg loss between genotype B and C patients. CONCLUSIONS: These results suggest that almost all patients with chronic hepatitis B are infected with genotype C. Genotypes do not influence the outcome of chronic hepatitis B patients in Korea.
Epidemiology ; Genotype* ; Hepatitis ; Hepatitis B e Antigens ; Hepatitis B virus ; Hepatitis B, Chronic* ; Hepatitis, Chronic* ; Humans ; Korea ; Prevalence*

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Distribution of HBV Genotypes in Patients With Chronic HBV Infection in Korea.

Soong Hwan LEE ; Sung Hee HAN ; Seung Chul CHO ; Byung Joo ROH ; Joo Hyun SOHN ; Duck An KIM ; Dong Hoo LEE ; Choon Suhk KEE

The Korean Journal of Hepatology.2001;7(4):373-380.

BACKGROUND/AIMS: Chronic HBV infection is associated with a wide spectrum of clinical manifestations, including asymptomatic carrier state, chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. Genotypically, HBV genomes have been classified into seven groups, designated A to G. Several studies have suggested recently that HBV genotypic differences influence the severity of liver disease and clinical outcomes. The distribution of HBV genotypes in Korea and its clinical relevance are poorly understood. We investigated the prevalence of HBV genotypes in Korea and the association between the distinct genotypes and the severity of liver disease. METHODS: A total of 214 HBV-DNA positive serum samples, were used for the genotyping. All patients were HBV-bDNA positive chronic HBsAg carriers. 199 patients were histologically verified with liver cirrhosis (6), chronic hepatitis (192) and fatty liver (1). The other patients were clinically diagnosed with liver cirrhosis (13) or hepatocellular carcinoma (2). HBV genotype was determined by PCR using type-specific primers. RESULTS: Genotyping was possible in all patients. Out of 214 patients, 213 (99.5%) were HBV genotype C. Only one (0.5%) was genotype A. The patient with genotype A had minimal hepatitis as diagnosed by liver biopsy. CONCLUSIONS: These results indicate that almost all chronic HBV infections are genotype C in Korea. HBV genotypic difference therefore does not influence the clinical outcome of HBV infection in Korea. Because genotype C may be associated with more severe liver disease, the predominance of genotype C in Korea may result in more severe outcomes than in other countries where other genotypes are predominant.
Biopsy ; Carcinoma, Hepatocellular ; Carrier State ; Epidemiology ; Fatty Liver ; Genome ; Genotype* ; Hepatitis A ; Hepatitis B Surface Antigens ; Hepatitis, Chronic ; Humans ; Korea* ; Liver ; Liver Cirrhosis ; Liver Diseases ; Polymerase Chain Reaction ; Prevalence

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Does Smoking Affect the Liver?.

Neung Hwa PARK

The Korean Journal of Hepatology.2007;13(2):248-250.

No abstract available.

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Intraductal Papillary Mucinous Cholangiocarcinoma.

Joon Koo HAN ; Se Hyung KIM ; Soo Jin KIM

The Korean Journal of Hepatology.2007;13(2):243-247.

No abstract available.
Adenocarcinoma, Mucinous/*diagnosis/pathology ; Bile Duct Neoplasms/*diagnosis/pathology ; *Bile Ducts, Intrahepatic ; Carcinoma, Papillary/*diagnosis/pathology ; Cholangiocarcinoma/*diagnosis/pathology ; Humans ; Male ; Middle Aged ; Tomography, X-Ray Computed

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Papillary Cholangiocarcinoma Arising from Biliary Papillomatosis.

Yoon Mi JEEN ; So Young JIN

The Korean Journal of Hepatology.2007;13(2):239-242.

No abstract available.
Aged ; Bile Duct Neoplasms/*diagnosis/pathology ; *Bile Ducts, Intrahepatic ; Carcinoma, Papillary/*diagnosis/pathology ; Cholangiocarcinoma/*diagnosis/pathology ; Female ; Humans

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A Case of Metastatic Cutaneous Nodules of Recurrent Hepatocellular Carcinoma.

Meyoung CHO ; Chang Soo CHOI ; Geom Seog SEO ; Tae Hyeon KIM ; Suck Chei CHOI ; Ki Jung YUN ; Haak Cheoul KIM

The Korean Journal of Hepatology.2007;13(2):234-238.

Common metastaic sites of hepatocellular carcinoma include lung, peritoneum, adrenal gland and bone, but rarely, skin can be metastatic sites. Although hepatocellular carcinoma is the third commonest malignancy in Korea, cutaneous metastasis from hepatocellular carcinoma was rarely reported. Cutaneous metastasis from malignant neoplasm of the internal organ occur at the variable stage and the growth pattern of cutaneous lesions is nonspecific and various, so the differential diagnosis of skin lesions must be considered to other malignant condition. We report a case of cutaneous metastasis from recurrent hepatocellular carcinoma that was confirmed by skin biopsy with immunohistochemical stain.
Carcinoma, Hepatocellular/*diagnosis/*secondary ; Humans ; Liver Neoplasms/*diagnosis/pathology ; Male ; Middle Aged ; Neoplasm Recurrence, Local/*diagnosis/pathology ; Skin Neoplasms/pathology/*secondary ; Tomography, X-Ray Computed

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A Case of Acute Hepatitis A Complicated by Guillain-Barre Syndrome.

Yun Jeong BAE ; Kang Mo KIM ; Kwang Kuk KIM ; Jae Hyung RHO ; Hyun Ki LEE ; Yung Sang LEE ; Dong Jin SUH

The Korean Journal of Hepatology.2007;13(2):228-233.

We report here a case of acute hepatitis A, which was complicated by Guillain-Barr? syndrome (GBS). A 32-year old male admitted to our hospital with the symptoms of acute hepatitis and was diagnosed to have acute hepatitis A with positive IgM anti hepatitis A virus antibody. On 9th day after the onset of jaundice, acute progressive, ascending, symmetric motor paralysis were developed and eventually respiratory failure ensued. Cerebrospinal fluid analysis showed albumino-cytologic dissociation and nerve conduction velocity test suggested a polyradiculopathy. He was diagnosed to have GBS and treated with intravenous immunoglobulin and required a ventilatory support. After 90 hospital days, he recovered in ambulatory condition with the aid of crutches. The clinical course, prognosis and the outcome of neuropathic symptoms of GBS following acute hepatitis A were relatively poor in our case.
Acute Disease ; Adult ; Guillain-Barre Syndrome/*diagnosis/etiology/therapy ; Hepatitis A/complications/*diagnosis ; Humans ; Immunoglobulins, Intravenous/therapeutic use ; Male

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