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Focal Nodular Hyperplasia with Aberrant Lymphatics: A Case Report.

Kyu Yun JANG ; Woo Sung MOON ; Baik Hwan CHO ; Dae Ghon KIM

The Korean Journal of Hepatology.1998;4(3):278-282.

No abstract available.
Focal Nodular Hyperplasia*

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Survival and Prognostic Factors in Patients with Hepatocellular Carcinoma Who Showed Initial Good-Response to Transarterial Chemoembolization.

Kyong Han SHIN ; Hyo Suk LEE ; June Sung LEE ; Gwang Hoon WOO ; Dong Kyung CHANG ; Jin Uk JUNG ; Jae Hyung PARK ; Chung Yong KIM

The Korean Journal of Hepatology.1998;4(3):264-277.

Focal nodular hyperplasia (FNH) is a benig nepithelial tumor of the liver. The etiology of FNH is unknown, but recent evidence suggests that FNH may represent a localized, hyperplastic response to a pre-existing vascular malformat ion. There is a high probability of as sociat edlesions , most commonly hepatic hemangiomas, meningioma, as trocytoma, and arterial dysplasia in various organs . In the present report we describe a FNH with aberrant lymphatics in a 24-year-old woman. In operation field, lymphatics were located on the site of falciform ligament. Histologically, aberrant lymphatics were composed of well vas cularized complex lymphatic channels and the mass were typical FNH. In this case, the role of aberrant lymphatics in the development of FNH was unclear . But as the FNH frequently as sociated with ot her anomalies , we think the aberrant lymphatic as such anomaly that have not been reported.
Carcinoma, Hepatocellular* ; Female ; Focal Nodular Hyperplasia ; Hemangioma ; Humans ; Ligaments ; Liver ; Meningioma ; Young Adult

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Ito Cell Activity and Hepatocyte Proliferation Activity According to Collagen Content in Liver Cirrhosis.

Kee Taek JANG ; Young Mi JUNG ; In Kyoung LIM ; Yun Sil LEE ; Nan Kyung MYUNG ; Mi Ran KIM ; Min Jae LEE ; Ja June JANG

The Korean Journal of Hepatology.1998;4(3):254-263.

BACKGROUND/AIMS: Liver cirrhosis is an end-stage liver disease. Ito cell is known to have central role in fibrogenes is of liver cirrhosis. But collagen content and Ito cell activity in liver cirr hosis have received little attention. So Ito cell activity and hepatocyte proliferation activity according to collagen content was investigated. WAF-1 and c- met were studied to evaluate the effect of cell cycle. METHODS: We analyzed 56 cases of liver cirrhosis ( viral:41, biliary:11, alcoholic:2, Wilson' s disease:2). Collagen content was measured by spectrophot ometry. Ito cell activity and prolifer ation index was measured by-SMA and Ki- 67 immunohistochemistry. RESULTS: In viral cirrhosis, high collagen group showed increased Ito cell activity compared to low collagen group. There was no difference in hepatocyte prolifer ation activity bet ween high and low collagen group in viral cirrhosis. In biliary cirrhos is, high collagen group showed increased Ito cell activity in septal zones compared to low collagen group. WAF- 1and c- met were negative in most of cases. CONCLUSION: Collagen content of liver cirrhosis is closely related to increment of activated Ito cells . Ito cell activity was prominent in septal zones than in parenchymal areas of viral cirrhosis and that was only significant in septal zones of biliary cirrhosis. There is no correlation bet ween collagen content and hepatocyte proliferation activity.
Cell Cycle ; Collagen* ; Fibrosis ; Hepatic Stellate Cells ; Hepatocytes* ; Immunohistochemistry ; Liver Cirrhosis* ; Liver Cirrhosis, Biliary ; Liver Diseases ; Liver*

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Distribution of hepatitis C virus genotypes determined by line probe assay in Korean patients with chronic HCV infection.

Geun Chan LEE ; Hyung Gun KIM ; Neung Hwa PARK ; Seon Young WON ; Young Hwa CHUNG ; Yung Sang LEE ; Dong Jin SUH

The Korean Journal of Hepatology.1998;4(3):244-253.

BACKGROUND/AIMS: The hepat it is C virus (HCV) genotypes have been shown to be differently distributed among distinct geographic areas and as sociated with different clinical present at ions. The aut hors investigated the distribution of HCV genotypes in Korean patients with chronic HCV infection and the as sociation of HCV genotypes with age, sex, severity of the liver disease, and the possible mode of transmission. METHODS: The study population consisted of 143 patients with chronic HCV infect ion: 13 with normal ALT , 78 with chronic hepatitis , 35 with cirrhosis , 17 with hepat ocellular car cinoma (HCC). HCV genotypes were determined by line probe assay. RESULTS: The principal HCV genotype was 1b ( 56%) and followed by 2a/ c ( 32%), mixed (8%), 2b ( 3%), and 1a (1%). Patients infected with type 1b and 2a/ c were older than those with ot her genotypes (p< 0.05). Genotype 1b tended to be more prevalent among patients with HCC ( 76% compared with 53% for patients with other liver diseases ; p=0.07). There was no significant relations hip bet ween genotypes and sex or mode of transmission. CONCLUSION: The most common HCV genotype in Korea was type 1b and followed by 2a/ 2c. Although patients infected with type 1b and 2a/c were older than those with other genotypes, there was no correlation between genotypes and sex, severity of liver disease, or mode of transmission.
Fibrosis ; Genotype ; Hepacivirus* ; Hepatitis C* ; Hepatitis* ; Hepatitis, Chronic ; Hip ; Humans ; Ions ; Korea ; Liver Diseases

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Hepatitis C virus genotyping of 100 consecutive anti-HCV positive cases with PCR using type=specific primers.

Yung Sang LEE ; Young Hwa CHUNG ; Young Il MIN ; Dae Hyuk MOON ; Doe Sun NA ; Dong Jin SUH

The Korean Journal of Hepatology.1998;4(3):235-243.

BACKGROUND/AIMS: The distribut ion of HCV genotypes varies with geographical area, and genot ypes can affect t he nat ur al course of HCV infection, but adequate genot yping data were not accumulat ed in Korea. This study was des igned to det ermine the pattern of distribution of HCV genotypes in Korea and it's clinical implications. METHODS: 100 cons ecut ive anti- HCV( +), RT-PCR(+) cases were recruited. Genotype specific oligonucleotide primers were made according to the sequence variation of NS5 region of HCV genome. Heminested PCR with mixed primersets was per formed, and genotype specific PCR products of different size were verified. Sequencing of cloned PCR products was done in cases with representative genotypes. Clinical profiles of genotype 1b and 2a were compared. RESULTS: Genotyping was done in 78 among 100 cases. Genotype 1b (48/ 78, 57.7%) and 2a (25/ 78, 32.1%) were most prevalent , and 1a (1/ 78, 1.3%) and mixed form (7/ 78, 9.0%) were also found. Milder cases with persistent normal ALT levels were more frequently seen in genotype 2a ( 9/ 25, 36.0%) than in genot ype 1b (3/ 45, 6.7%) (p< 0.01). CONCLUSIONS: Genotype 1b and 2a were major ones in anti- HCV( +) Korean adults, and the tendency of milder clinical course of genotype 2a was suggested.
Adult ; Clone Cells ; DEET ; DNA Primers ; Genome ; Genotype ; Hepacivirus* ; Hepatitis C* ; Hepatitis* ; Humans ; Korea ; Polymerase Chain Reaction*

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Molecular Biological Advances in Human Copper Metabolism: Molecular Genetics in Wilson's Disease.

Si Houn HAHN

The Korean Journal of Hepatology.1998;4(3):223-234.

No abstract available.
Copper* ; Hepatolenticular Degeneration* ; Humans* ; Metabolism* ; Molecular Biology*

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Role of vitamin D in chronic hepatitis C.

Tae Yeob KIM

The Korean Journal of Hepatology.2011;17(2):170-172. doi:10.3350/kjhep.2011.17.2.170

No abstract available.

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Posttransplantation lymphoproliferative disorder involving liver after renal transplantation.

Yong Moon SHIN

The Korean Journal of Hepatology.2011;17(2):165-169. doi:10.3350/kjhep.2011.17.2.165

No abstract available.
Adolescent ; Biopsy, Fine-Needle ; Fluorodeoxyglucose F18/diagnostic use ; Glomerulosclerosis, Focal Segmental/therapy ; Graft Rejection/drug therapy ; Humans ; Immunosuppressive Agents/therapeutic use ; *Kidney Transplantation ; Liver/radiography/ultrasonography ; Lymphoproliferative Disorders/pathology/*radiography/radionuclide imaging ; Male ; Positron-Emission Tomography ; Tomography, X-Ray Computed

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Cholangiocarcinoma arising in von Meyenburg complexes.

Hee Kyung KIM ; So Young JIN

The Korean Journal of Hepatology.2011;17(2):161-164. doi:10.3350/kjhep.2011.17.2.161

No abstract available.
Aged ; Bile Duct Neoplasms/etiology/*pathology ; Bile Ducts, Intrahepatic ; Cholangiocarcinoma/etiology/*pathology ; Hamartoma/complications/pathology ; Humans ; Immunohistochemistry ; Liver/pathology/surgery ; Male ; Tomography, X-Ray Computed

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Metronidazole-induced encephalopathy in a patient with liver cirrhosis.

Hyeong Cheol CHEONG ; Taek Geun JEONG ; Young Bum CHO ; Bong Joon YANG ; Tae Hyeon KIM ; Haak Cheoul KIM ; Eun Young CHO

The Korean Journal of Hepatology.2011;17(2):157-160. doi:10.3350/kjhep.2011.17.2.157

Encephalopathy is a disorder characterized by altered brain function, which can be attributed to various causes. Encephalopathy associated with metronidazole administration occurs rarely and depends on the cumulative metronidazole dose, and most patients with this condition recover rapidly after discontinuation of therapy. Because metronidazole is metabolized in the liver and can be transported by the cerebrospinal fluid and cross the blood-brain barrier, it may induce encephalopathy even at a low cumulative dose in patients with hepatic dysfunction. We experienced a patient who showed ataxic gait and dysarthric speech after receiving metronidazole for the treatment of hepatic encephalopathy that was not controlled by the administration of lactulose. The patient was diagnosed as metronidazole-induced encephalopathy, and stopping drug administration resulted in a complete recovery from encephalopathy. This case shows that caution should be exercised when administering metronidazole because even a low dose can induce encephalopathy in patients with liver cirrhosis.
Anti-Infective Agents/*adverse effects/therapeutic use ; Brain Diseases/*chemically induced/diagnosis ; Hepatic Encephalopathy/*drug therapy/etiology ; Humans ; Liver Cirrhosis/*complications ; Magnetic Resonance Imaging ; Male ; Metronidazole/*adverse effects/therapeutic use ; Middle Aged ; Tomography, X-Ray Computed

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