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Erratum to: Raloxifene Administration in Women Treated with Long Term Gonadotropin-releasing Hormone Agonist for Severe Endometriosis: Effects on Bone Mineral Density.

Young Hwa CHO ; Mi Jung UM ; Suk Jin KIM ; Soo Ah KIM ; Hyuk JUNG

Journal of Menopausal Medicine.2017;23(1):77-77. doi:10.6118/jmm.2017.23.1.77

The author and author's affiliation should be corrected.
Bone Density* ; Endometriosis* ; Female ; Gonadotropin-Releasing Hormone* ; Humans ; Raloxifene Hydrochloride*

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A Rare Case of an Autoamputated Ovary with Mature Cystic Teratoma.

Hwi Gon KIM ; Yong Jung SONG ; Yong Jin NA ; Juseok YANG ; Ook Hwan CHOI

Journal of Menopausal Medicine.2017;23(1):74-76. doi:10.6118/jmm.2017.23.1.74

Autoamputated ovary with mature cystic teratoma (MCT) is a rarely reported gynecologic entity with an unknown prevalence. A 34-year-old woman referred to our clinic for presumed left ovarian tumor. Pelvic examination, ultrasonography and computed tomography scan revealed a 5-cm, cystic ovarian mass with calcification and fat component, and tumor markers were as follows, cancer antigen (CA) 125; 10.4 U/mL, CA19-9; 2 U/mL. Laparoscopy was performed. The mass was identified in the left adnexal region without any ligamentous or direct connection with the pelvic organs. The right ovary was normal. However, the left ovary and the tube could not be identified in its proper anatomical location. The mass was successfully removed with sharp and blunt dissection. A review of histopathologic study revealed a MCT. The patient became pregnant within seven months and gave birth to a healthy baby by cesarean section. We present a rare case of an autoamputated ovary with MCT.
Adult ; Amputation ; Biomarkers, Tumor ; Cesarean Section ; Dermoid Cyst ; Female ; Gynecological Examination ; Humans ; Laparoscopy ; Ligaments ; Ovarian Neoplasms ; Ovary* ; Parturition ; Pregnancy ; Prevalence ; Teratoma* ; Ultrasonography

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Case Report of Menopausal Woman Diagnosed with Endometrial Cancer after Colon Cancer with Germline Mutation in MSH6 in Korea.

Hyun Jung LEE ; Min Hee LEE ; Min Chul CHOI ; Sang Geun JUNG ; Won Duk JOO ; Tae Hoen KIM ; Chan LEE ; Ja Hyun JANG

Journal of Menopausal Medicine.2017;23(1):69-73. doi:10.6118/jmm.2017.23.1.69

We present a case of an endometrial cancer patient with germline mutation in MutS homolog 6 (MSH6), associated with Lynch syndrome. A 60-year-old Korean woman had a personal history of colon cancer 23 years ago. She also had a family history of endometrial cancer and colon cancer of her sisters and brothers. Immunohistochemistry was negative for MutL homolog 1 (MLH1) and positive for MutS homolog 2 (MSH2). Based on these findings, she underwent genetic counseling and testing that revealed a frameshift germline mutation at MSH6 (c. 3261dupC).
Colon* ; Colonic Neoplasms* ; Colorectal Neoplasms, Hereditary Nonpolyposis ; Endometrial Neoplasms* ; Female ; Genetic Counseling ; Germ-Line Mutation* ; Humans ; Immunohistochemistry ; Korea* ; Middle Aged ; Siblings

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Rejuvenation Using Platelet-rich Plasma and Lipofilling for Vaginal Atrophy and Lichen Sclerosus.

Seok Hwan KIM ; Eun Soo PARK ; Tae Hee KIM

Journal of Menopausal Medicine.2017;23(1):63-68. doi:10.6118/jmm.2017.23.1.63

Vaginal atrophy is a common condition among peri- and post-menopausal women. Symptoms of vaginal dryness, pruritus, irritation, loss of subcutaneous fat, sparse pubic hair and dyspareunia occur due to decreased estrogen level. Estrogen-based treatments are effective. But many patients are reluctant to be treated due to health concerns. As alternatives, we explored the efficacy of platelet-rich plasma (PRP) and lipofilling. A 67-year-old female patient with vaginal atrophy was referred to our department. Treatment using estrogen cream had failed to improve patient's symptoms. Diminished volume and aged look of genitalia were also major concerns. We treated her using lipofilling mixed with PRP. A total of 40 cc of autologous fat mixed with PRP was transferred to labia majora. Lipofilling with PRP relieved the clinical symptoms. Missing fullness and tone was corrected and the augmented volume was well maintained. White patchy lesions of lichen sclerosus on labia minora also improved. Lipofilling with PRP relieved symptoms, restored contour of the labia majora and achieved remission of lichen sclerosus on labia minora. As vulvar lesions were repaired and the aged appearance of genitalia was rejuvenated, both functional and cosmetic outcomes were satisfactory. Lipofilling with PRP can be effective for vaginal atrophy and lichen sclerosus.
Aged ; Atrophy* ; Dyspareunia ; Estrogens ; Female ; Genitalia ; Hair ; Humans ; Lichen Sclerosus et Atrophicus* ; Lichens* ; Platelet-Rich Plasma* ; Pruritus ; Rejuvenation* ; Subcutaneous Fat ; Vaginal Diseases ; Vulvar Lichen Sclerosus

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Combination Therapy of Raloxifene and Alendronate for Treatment of Osteoporosis in Elderly Women.

Mi Jung UM ; Eun A CHO ; Hyuk JUNG

Journal of Menopausal Medicine.2017;23(1):56-62. doi:10.6118/jmm.2017.23.1.56

OBJECTIVES: To evaluate and compare the efficacy and safety of the combination of raloxifene and alendronate with those of monotherapies in elderly women with osteoporosis. METHODS: Sixty-two postmenopausal women (mean age 63.5 ± 0.5 years) attending gynecologic osteoporosis clinics with established osteoporosis were randomly allocated to one of four treatment groups and monitored for 3 years. All patients enrolled in this study, including those in the control group (n = 14), received 1.0 g elemental calcium and 400 units of vitamin D per day. The raloxifene group (n = 16) received raloxifene 60 mg (Evista®) per day; alendronate group (n = 17) received low-dose (5 mg) alendronate with calcitriol 0.5 µg (Maxmarvil®) per day; and the combination therapy group (n = 15) received both raloxifene 60 mg and low-dose (5 mg) alendronate with calcitriol 0.5 µg. Bone mineral density (BMD) was measured in the lumbar spine and hip before and after 3 years of treatment. RESULTS: In patients who received the combined therapy, BMD increased in the lumbar spine and the hip by 7.2% (P<0.001) and 4.8% (P<0.001) at 3 years. For patients in the alendronate group, the increases were 6.7% (P<0.001) and 3.1% (P<0.01) respectively, for the raloxifene group, the increases were 4.36% (P<0.001) and 1.9% (P<0.05) in the vertebrae and femora, respectively; however, the BMD of patients in the control group decreased by 1.81% (P<0.05) and 1.6% (P<0.05), respectively, after 3 years. Patients who received the combination therapy had significantly higher BMD in both the vertebrae femora (P<0.01) in comparison to that in those treated with raloxifene or alendronate individually. CONCLUSIONS: This 3-year randomized study showed the improved effects of alendronate and raloxifene combination on spine and hip BMD in elderly postmenopausal women with established osteoporosis.
Aged* ; Alendronate* ; Bone Density ; Calcitriol ; Calcium ; Female ; Hip ; Humans ; Osteoporosis* ; Raloxifene Hydrochloride* ; Spine ; Vitamin D

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Effect of Group Counseling on Quality of Life among Postmenopausal Women in Hamadan, Iran.

Parisa PARSA ; Roya Ahmainia TABESH ; Farzaneh SOLTANI ; Manoochehr KARAMI

Journal of Menopausal Medicine.2017;23(1):49-55. doi:10.6118/jmm.2017.23.1.49

OBJECTIVES: This study aimed to investigate the effect of counseling on quality of life (QOL) in postmenopausal women conducted in Hamadan, Iran in 2015. METHODS: In this quasi-experimental study, 80 postmenopausal women were randomly selected and allocated to case and control groups (40 per group). Data collection tool included questionnaires of demographic information and QOL during menopause, which were completed by the samples before the intervention. In the case group, training program was run during four sessions in the form of weekly consulting sessions for 45 to 60 minutes. Training program included familiarity with menopause symptoms, confrontation and self-care during this period. The control group, only received routine cares. Three months after intervention, information were collected in both groups. Data were analyzed using SPSS for Windows. RESULTS: Before the intervention, mean ± standard deviation for QOL in case group was 101.2 ± 31.4 and it was significantly decreased to 96.9 ± 27.0 after intervention (P < 0.05). While no significant change was observed in the control group (from 98.9 ± 35.5 to 102.3 ± 35.0, P = 0.443). Symptoms of physical (P = 0.033) and sexual (P < 0.001) dimensions significantly decreased in the case group. While significant increase was observed in terms of psychosocial (P = 0.049) and sexual symptoms in control group. CONCLUSIONS: Findings suggested impact of consulting on improvement of QOL during menopause. Supportive consulting can be a suitable approach for improving women's health, reducing problems and enhancing QOL in menopause period.
Counseling* ; Data Collection ; Education ; Female ; Humans ; Iran* ; Menopause ; Non-Randomized Controlled Trials as Topic ; Quality of Life* ; Recognition (Psychology) ; Referral and Consultation ; Self Care ; Women's Health

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Sexual Self-concept and Its Relationship to Depression, Stress and Anxiety in Postmenopausal Women.

Mohammad HEIDARI ; Mansureh GHODUSI ; Hossein RAFIEI

Journal of Menopausal Medicine.2017;23(1):42-48. doi:10.6118/jmm.2017.23.1.42

OBJECTIVES: Women in menopause have the more mood swings than before menopause. At the same time seem to sexual self-concept and sexual aspects of self-knowledge has a great impact on their mental health. This study aimed to investigate the sexual self-concept and its relationship to depression, stress and anxiety in postmenopausal women's. METHODS: In this descriptive correlation research, 300 of postmenopausal women referred to healthcare and medical treatment centers in Abadeh city were selected by convenience sampling method. The information in this study was collected by using questionnaires of multidimensional sexual self-concept and depression anxiety stress scale 21 (DASS-21). For data analysis, SPSS/17 software was used. RESULTS: The results showed the mean score positive sexual self-concept was 41.03 ± 8.66 and the average score of negative sexual self in women's was 110.32 ± 43.05. As well as scores of depression, stress, and anxiety, 35.67%, 32.33% and 37.67% respectively were in severe level. Positive and negative sexual self-concept scores with scores of stress, anxiety, and depression, of post-menopausal women in the confidence of 0.01, is significantly correlated (P < 0.05). CONCLUSIONS: Being stress, anxiety, and depression in severe level and also a significant correlation between increased stress, anxiety and depression with negative and weak self-concept of women's, it is necessary to devote more careful attention to mental health issues of women's and have appropriate interventions.
Anxiety* ; Delivery of Health Care ; Depression* ; Female ; Humans ; Menopause ; Mental Health ; Methods ; Statistics as Topic ; Stress, Psychological

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Comparative Evaluation of Salivary Neopterin Levels and Its Effects to Periodontal Therapy in Pre- and Post-Menopausal Women.

Jammula Surya PRASANNA ; Chinta SUMADHURA ; Parupalli KARUNAKAR ; Naineni ROHINI

Journal of Menopausal Medicine.2017;23(1):32-41. doi:10.6118/jmm.2017.23.1.32

OBJECTIVES: Neopterin is a valuable diagnostic biomarker, which is elevated in inflammatory conditions like periodontitis, that is characterized by destruction of the supporting structures of the teeth. Among the biomarkers, neopterin occurs in body fluids, and acts as a diagnostic marker for present and future disease activity. METHODS: Thirty female subjects with chronic periodontitis, mean age 50 years (40-60 years) were included in this study. Depending upon their menstrual history, subjects were categorized into two groups of fifteen each. Group I 15 pre-menopausal women, and Group II 15 post-menopausal women. Saliva was collected, and neopterin levels were assessed by enzyme-linked immunosorbent assay in both the groups, at base line and after three months of nonsurgical periodontal therapy (NSPT). Periodontal parameters like pocket probing depth (PD) and Russell's periodontal disease index (PDI) were assessed before treatment as well as after three months of scaling and root planning. RESULTS: Intra group analysis showed significant markdown in the mean values of all the parameters from baseline to three months (P < 0.001), for all patients. The intergroup comparison, from baseline to 3 months also showed no significant change in PD and PDI values, but there was a statistically significant difference in the salivary neopterin levels (P = 0.04). CONCLUSIONS: Neopterin levels were found to be reduced in three months after NSPT in both the groups, suggesting that the NSPT is the gold standard therapy, and also that neopterin levels in saliva can be used as an indicator to identify periodontal inflammation and destruction.
Biomarkers ; Body Fluids ; Chronic Periodontitis ; Enzyme-Linked Immunosorbent Assay ; Female ; Humans ; Inflammation ; Neopterin* ; Periodontal Diseases ; Periodontitis ; Reactive Oxygen Species ; Root Planing ; Saliva ; Tooth ; Women's Health

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Ovarian Volume in Korean Women with Polycystic Ovary Syndrome and Its Related Factors.

Young Shin HAN ; Ah Rha LEE ; Hee Kyoung SONG ; Jeong In CHOI ; Jang Heub KIM ; Mee Ran KIM ; Min Jeong KIM

Journal of Menopausal Medicine.2017;23(1):25-31. doi:10.6118/jmm.2017.23.1.25

OBJECTIVES: The aim of this study was to determine the relationship of ovarian volume (OV) to age, height, and weight in Korean young women with the polycystic ovary syndrome (PCOS) undergoing ultrasonography (US) and to investigate the relationship between ovarian follicle count and volume on US and serum hormone levels including the levels of the anti-Müllerian hormone (AMH) and gonadotropin. METHODS: A total of 272 Korean nulliparous women aged 15 to 39 years who were newly diagnosed with PCOS at a university hospital were included in this study. Evaluation of the ovaries and measurement of OVs in all cases were randomly performed by ultrasound. The OV and follicle number (FN) were obtained in all cases. RESULTS: In Korean women with PCOS, mean OV was 7.9 ± 3.6 cm3 (right) and 6.7 ± 3.1 cm3 (left). Mean FN in the PCOS group was 14.2 ± 4.6 (right) and 13.8 ± 4.3 (left). OV and ovarian FN were unrelated to patient weight, height and body mass index. The left ovarian FN was related to patient age. AMH levels ranged from 5.31 to 43.1 ng/mL and the mean level was 13.9 ± 7.2 ng/mL. Serum AMH was related to OV and FN, and serum total testosterone was related to FN in Korean women with PCOS. CONCLUSIONS: In Korean nulliparous women with PCOS, OV was smaller than that in other ethnic groups and the right OV was larger than the left OV. Ovarian FN, AMH, testosterone are good markers for the diagnosis of PCOS in Korean women.
Anti-Mullerian Hormone ; Body Mass Index ; Diagnosis ; Ethnic Groups ; Female ; Gonadotropins ; Humans ; Ovarian Follicle ; Ovary ; Polycystic Ovary Syndrome* ; Testosterone ; Ultrasonography

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The Effect of Husbands' Education Regarding Menopausal Health on Marital Satisfaction of Their Wives.

Nooshin YOSHANY ; Mohammad Ali MOROWATISHARIFABAD ; Hamideh MIHANPOUR ; Narjes BAHRI ; Khair Mohammad JADGAL

Journal of Menopausal Medicine.2017;23(1):15-24. doi:10.6118/jmm.2017.23.1.15

OBJECTIVES: Marital satisfaction has an important effect on people's mental health. Due to the increasing average age and life expectancy of Iranian women, obtaining knowledge about sexual aspects of post-menopause women for partners can improve their health and quality of life. This study aimed to determine the effect of education for the husbands regarding menopause on marital satisfaction of their wives. METHODS: This randomized controlled trial was conducted on 100 women aged 45 to 55 years old and their husbands in Yazd in 2014. Subjects were randomly assigned to intervention group (50 couples) and control group (50 couples). The data gathering tools included two questionnaires, the first one contained questions about demographic information of women and men, and the other one was used to assess knowledge and practice in men about menopause and Enrich marital satisfaction. The second questionnaire was applied twice; before intervention and two months after that. In the intervention group an educational program in the form of three 60-minute sessions were conducted using speech, but the control group received no training. Analysis was performed through the statistical SPSS software, paired t-test, t-test and chi-square. RESULTS: In the intervention group, two months after the educational program the knowledge of menopausal health and women's marital satisfaction scores increased significantly (P<0.001). But there was no significant difference in control group. CONCLUSIONS: Training menopausal health to husbands can increase women's marital satisfaction in the period of menopausal transition. Therefore, designing and implementing educational programs for husbands is recommended.
Education* ; Female ; Humans ; Life Expectancy ; Male ; Marriage ; Menopause ; Mental Health ; Personal Satisfaction ; Postmenopause ; Quality of Life ; Spouses*

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