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Postmenopausal Meigs' Syndrome in Elevated CA-125: A Case Report.

Journal of Menopausal Medicine.2015;21(1):56-59. doi:10.6118/jmm.2015.21.1.56

Meigs' syndrome is a benign ovarian tumor associated with ascites and pleural effusion. Elevated cancer antigen 125 (CA-125) in Meigs' syndrome is an unusual clinical condition reported in few cases. We report here on a 61-year-old woman who presented with dyspnea; in imaging assessment, a heterogeneous pelvic mass measuring 12 x 11 cm with ascitic fluid was reported. Pleural effusion was detected on Chest X-ray. Aspiration of pleural fluid showed no evidence of malignancy. CA-125 level was 347 IU/mL. The patient underwent laparotomy during which a mass measuring 12 x 11 cm was detected in her left adnexa. Histology showed ovarian thecoma. The mass was resected, and, after that, the symptoms disappeared and CA-125 level reached 19 IU/mL. The patient had experienced no problem after 12 months of follow up. Although postmenopausal women with ovarian tumor, ascites, pleural effusion, and elevation of CA-125 levels probably have malignant ovarian tumors, Meigs' syndrome must be considered in the differential diagnosis.
Ascites ; Ascitic Fluid ; Diagnosis, Differential ; Dyspnea ; Female ; Follow-Up Studies ; Humans ; Laparotomy ; Meigs Syndrome* ; Middle Aged ; Pleural Effusion ; Thecoma ; Thorax

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Comparison of Surgical Outcomes according to Suturing Methods in Single Port Access Laparoscopic Myomectomy.

Jae Heok JEONG ; Yu Ri KIM ; Eun Jeong KIM ; Soo Hyeon MOON ; Mi Hwa PARK ; Jeong Tae KIM ; Jeong Hye KIM ; Kyu Sup LEE

Journal of Menopausal Medicine.2015;21(1):47-55. doi:10.6118/jmm.2015.21.1.47

OBJECTIVES: This study was performed to consider the clinical experience of surgical outcome of single port access (SPA) laparoscopic myomectomy according to suturing methods. METHODS: The authors operated with 2 suturing method in SPA laparoscopic myomectomy for 246 patients and compared the surgical outcomes. RESULTS: The some significant difference of surgical outcome according to two suturing methods was demonstrated. Operating time was 100.50 minutes (+/- 42.09 minutes) in interrupted suture method group than 121.04 minutes (+/- 61.56 minutes) in continuous interlocking suture method group (P = 0.021). Estimated blood loss was less 222.59 mL (+/- 144.94 mL) in interrupted suture group than 340.11 mL (+/- 380.62 mL) in continuous interlocking suture method group (P = 0.042). CONCLUSION: This experience suggests that interrupted suture method was effective for operating time and estimated blood loss than continuous interlocking method in SPA laparoscopic myomectomy.
Humans ; Laparoscopy ; Leiomyoma ; Suture Techniques ; Sutures ; Treatment Outcome

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A Pilot Study of the Impacts of Menopause on the Anogenital Distance.

Daegeun LEE ; Tae Hee KIM ; Hae Hyeog LEE ; Jun Mo KIM ; Dong Su JEON ; Yeon Suk KIM

Journal of Menopausal Medicine.2015;21(1):41-46. doi:10.6118/jmm.2015.21.1.41

OBJECTIVES: It has been known that there is a difference in anogenital distance (AGD) in the animals and newborn depending on the exposure of androgenic hormones. The anatomical changes occur in the female genitalia in women after menopause. This was pilot study to find out whether the menopause affects AGD. METHODS: We evaluated a total of 50 women targeted for premenopausal and postmenopausal group in each 25 people. AGD was defined as a length between the posterior commissure of labia and anal center. AGD was measured in lithotomy position using sterile paper ruler. In order to control bias of the height and weight, which could influence the AGD, anogenital index (AGI) is defined as the weight divided by the AGD value. We used a Mann-Whitney U test to analyze the relationship between AGD and menopause for statistical analysis. RESULTS: AGD was significantly longer in premenopausal women compared to postmenopausal women (34.8 +/- 6.4 vs. 30.3 +/- 6.6, P = 0.019). AGI was significantly higher in premenopausal women than postmenopausal women (1.7 +/- 0.4 vs. 1.3 +/- 0.3, P < or = 0.000). CONCLUSION: The changes of AGD and AGI in postmenopausal women demonstrated to have potential to be used as on scale predicting the physical changes that may occur after menopause. This study could be used as the cornerstone of a large-scale studies in the future.
Animals ; Bias (Epidemiology) ; Female ; Genitalia, Female ; Humans ; Infant, Newborn ; Menopause* ; Perineum ; Pilot Projects*

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Evaluation of Bone Density Measurement in Type 2 Diabetic Postmenopausal Women with Hypertension and Hyperlipidemia.

Emel Kiyak CAGLAYAN ; Yaprak ENGIN-USTUN ; Nagihan SARI ; Seyhan KARACAVUS ; Levent SECKIN ; Mustafa KARA

Journal of Menopausal Medicine.2015;21(1):36-40. doi:10.6118/jmm.2015.21.1.36

OBJECTIVES: The aim of the study was to compare bone mineral density (BMD) in healthy postmenopausal women to BMD in type 2 diabetic hypertensive postmenopausal women with hyperlipidemia. METHODS: Fifty type 2 diabetic and hypertensive postmenopausal women with hyperlipidemia and 51 age and body mass index (BMI) matched healthy postmenopausal women were included. Lumbar spine and femoral neck BMD were noted in both groups. BMD was measured using dual energy X-ray absorptiometry (DXA). Serum alkaline phosphatase (ALP), calcium and phosphorous were also measured. Pearson correlation coefficients were used to establish the relationship between various clinical characteristics. RESULTS: There were no significant differences between two groups in respect to lumbar and vertebral BMD values, age, BMI, gravidity, parity. Serum cholesterol and fasting glucose levels were significantly different between each groups (P = 0.0001, P = 0.002). CONCLUSION: We found that, accompanying chronic diseases such as diabetes, hypertension and hyperlipidemia don't affect the BMD measurements at postmenopausal period. So these postmenopausal women don't have excess risk regarding osteoporosis.
Absorptiometry, Photon ; Alkaline Phosphatase ; Body Mass Index ; Bone Density* ; Calcium ; Cholesterol ; Chronic Disease ; Fasting ; Female ; Femur Neck ; Glucose ; Gravidity ; Humans ; Hyperlipidemias* ; Hypertension* ; Osteoporosis ; Parity ; Postmenopause ; Spine

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Is Complementary and Alternative Therapy Effective for Women in the Climacteric Period?.

Mi Young KIM ; Seung Do CHOI ; Aeli RYU

Journal of Menopausal Medicine.2015;21(1):28-35. doi:10.6118/jmm.2015.21.1.28

Vasomotor symptoms start about 2 years prior to menopause in women who are approaching menopause, and early menopause symptoms appear including emotional disturbance and anxiety, followed by physical changes such as vaginal dryness, urinary incontinence and skin wrinkles. As time progresses, osteoporosis, cardiovascular diseases, and dementia occur consecutively. Hormone therapy is primarily considered for the relief of menopause symptoms in postmenopausal women. However, as hormone replacement has emerged as a therapy that increases the potential risk of thrombosis, cerebral infarction and breast cancer, complementary and alternative medicine has drawn much attention. This study aimed to examine the types and effects of evidence-based complementary and alternative therapies that are currently used.
Affective Symptoms ; Anxiety ; Breast Neoplasms ; Cardiovascular Diseases ; Climacteric* ; Complementary Therapies ; Dementia ; Female ; Humans ; Infarction ; Intracranial Thrombosis ; Menopause ; Osteoporosis ; Postmenopause ; Skin ; Urinary Incontinence

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Neutral Sphingomyelinase and Breast Cancer Research.

Sun Yong HWANG ; Tae Hee KIM ; Hae Hyeog LEE

Journal of Menopausal Medicine.2015;21(1):24-27. doi:10.6118/jmm.2015.21.1.24

Our understanding of the functions of neutral sphingomyelinase (N-SMase) signaling has advanced over the past decade. In this review, we focus on the roles and regulation of N-SMase 1, N-SMase 2, N-SMase 3, an enzyme that generates the bioactive lipid ceramide through the hydrolysis of the membrane lipid sphingomyelin. A large body of work has now implicated N-SMase 2 in a diverse set of cellular functions, physiological processes, and disease pathologies. We focus on different aspects of this enzyme's regulation from transcriptional, post-translational, and biochemical. Furthermore, we expected N-SMase involvement in cellular processes including inflammatory signaling, cell growth, apoptosis, and tumor necrosis factor which in turn play important roles in pathologies such as cancer metastasis, variable disease, and other organ system disorders. Lastly, we examine avenues where targeted N-SMase inhibition may be clinically beneficial in disease scenarios.
Apoptosis ; Breast Neoplasms* ; Hydrolysis ; Membranes ; Neoplasm Metastasis ; Pathology ; Physiological Processes ; Sphingomyelin Phosphodiesterase* ; Tumor Necrosis Factor-alpha

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Prevention of Cognitive Impairment in the Midlife Women.

Soo Ah KIM ; Hyuk JUNG

Journal of Menopausal Medicine.2015;21(1):19-23. doi:10.6118/jmm.2015.21.1.19

Forgetfulness is common symptom with age. Especially for midlife women, hormonal cessation by menopausal change is one of the causes in cognitive disorders. And neuropathological changes in brain can lead to mild cognitive impairment (MCI) and eventually dementia. Prevention of MCI is important for decreasing progression to dementia. This article presents therapeutic approaches based on pathophysiologic changes in brain for preventing cognitive decline.
Brain ; Dementia ; Female ; Hormone Replacement Therapy ; Humans ; Mild Cognitive Impairment ; Postmenopause

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A Flood of Health Functional Foods: What Is to Be Recommended?.

Eun Sil LEE

Journal of Menopausal Medicine.2015;21(1):12-18. doi:10.6118/jmm.2015.21.1.12

Health functional food is referred to a food prepared or processed from specific components or ingredients for functionality beneficial to the body through extraction, concentration, purification, blending and other methods. The demand for health functional foods is steadily increasing, and red ginseng is the most demanded food among women in the 50s, followed by multivitamin, omega-3, glucosamine and aloe. To date, there is insufficient evidence on the effect of red ginseng on exercise capacity, somatic symptom and cognitive performance in healthy individuals. Moreover, evidence is insufficient that a nutritional dose of vitamin or mineral reduces the incidence of cardiovascular disease and cancer, or mortality rate. A steady intake of oily fish is recommended to prevent the incidence of cardiovascular disease for postmenopausal women. Consumption of omega-3 fatty acids is expected to prevent cardiovascular disease in postmenopausal women with almost no intake of oily fish and those not taking statins. It still remains controversial whether glucosamine is effective in the treatment of osteoarthritis. Hence, physicians should fully inform patients with all controversial information about the effectiveness of glucosamine when prescribing glucosamine for patients with osteoarthritis.
Aloe ; Cardiovascular Diseases ; Fatty Acids, Omega-3 ; Female ; Functional Food* ; Glucosamine ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Incidence ; Mortality ; Osteoarthritis ; Panax ; Vitamins

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New Antiresorptive Therapies for Postmenopausal Osteoporosis.

Hee Jeong CHOI

Journal of Menopausal Medicine.2015;21(1):1-11. doi:10.6118/jmm.2015.21.1.1

Osteoporosis is a systemic skeletal disease whose risk increases with age and it is common among postmenopausal women. Currently, almost all pharmacological agents for osteoporosis target the bone resorption component of bone remodeling activity. Current antiresorptive agents are effective, but the effectiveness of some agents is limited by real or perceived intolerance, longterm adverse events (AEs), coexisting comorbidities, and inadequate long-term adherence. New antiresorptive therapies that may expand options for the prevention and treatment of osteoporosis include denosumab, combination of conjugated estrogen/bazedoxifene and cathepsin K inhibitors. However, the long-term efficacy and AEs of these antiresorptive therapies need to be confirmed in studies with a longer follow-up period.
Bone Density Conservation Agents ; Bone Remodeling ; Bone Resorption ; Cathepsin K ; Comorbidity ; Female ; Humans ; Osteoporosis ; Osteoporosis, Postmenopausal* ; Postmenopause ; Denosumab

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Erratum to: Sclerosing Stromal Tumor of the Ovary in Postmenopausal Women: A Report of Two Cases.

Chae Min LEE ; Soyi LIM ; Hyun Yi CHO ; Ji Sung LEE ; Jin Woo SHIN

Journal of Menopausal Medicine.2015;21(3):175-175. doi:10.6118/jmm.2015.21.3.175

In this article, on page 115, the title has been spelled incorrectly in this article.

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