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Korean Journal of Otolaryngology - Head and Neck Surgery

2002 (v1, n1) to Present ISSN: 1671-8925

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Biomechanical Characteristics of the Ossicular Prostheses Model Using the Finite Element Method.

Moon Suh PARK ; Yong Soo KIM

Korean Journal of Otolaryngology - Head and Neck Surgery.2003;46(8):641-648.

BACKGROUND AND OBJECTIVES: Extrusion of the ossicular prosthesis into the eardrum has been a persisting a problem accompanying ossiculoplasty. There are several factors concerning extrusion of the prosthesis, for instance, eardrum retraction, infection and the figure of the prosthesis, etc. Recently, many studies have been performed to evaluate the cause of extrusion; however, there have not been any attempts to analyze the extrusion cause from the viewpoint of biomechanics. The purpose of this study is to calculate the stress and strain of the eardrum and the prosthesis and to find the ideal model that prevents extrusion. MATERIALS AND METHOD: Three kinds of the imaginary total ossicular replacement prosthesis (TORP) were designed and biomechanically analyzed using the 3 dimensional finite element method. Equivalent stress and strains were measured and compared between the each group. The distribution of equivalent stress and strain on the eardrum and TORP were also observed. RESULTS: The concave disc shows the smallest in value of the maximum equivalent stress & the maximum equivalent strain. In all eardrums, the stress was concentrated along the contact area with the disc margin, especially toward the center of the eardrum. In all TORPs, the upper 1/4 of the shaft and margin of the disc toward center of the eardrum was the most stress-concentrated area. CONCLUSION: These results indicate that concave disc could be the most suitable for preventing extrusion.

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Auditory Steady State Evoked Responses (ASSR).

Sang Heun LEE

Korean Journal of Otolaryngology - Head and Neck Surgery.2003;46(8):621-626.

No abstract available.

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Prognostic Factors of Pediatric Endoscopic Sinus Surgery.

Hun Jong DHONG ; Young Jun CHUNG ; Byung Suk HA

Korean Journal of Otolaryngology - Head and Neck Surgery.2003;46(8):654-658.

BACKGROUND AND OBJECTIVES: Pediatric endoscopic sinus surgery (ESS) is performed for refractory cases of sinusitis that do not respond to medical management. However, studies evaluating the prognostic factors affecting outcomes of pediatric ESS have not been reported much. The aim of this study is to investigate the prognostic factors affecting the outcomes of pediatric ESS. MATERIALS AND METHOD: A retrospective review of medical records was carried out on 71 patients, 15 years or younger, who had undergone ESS from February, 1995 through January, 2002 at our institution. We classified them into two groups, one with good outcome, and the other with poor outcome, according to the postoperative endoscopic findings. We compared the following 8 parameters between the two groups: presence of allergy, bronchial asthma, adenotonsillar hypertrophy, previous sinus surgery, degree of polyposis, preoperative disease extent scored with OMC CT finding, blood eosinophil count, and eosinophil infiltration in nasal mucosa. RESULT: There were no statistical differences between the two groups on the presence of allergy, bronchial asthma, adenotonsillar hypertrophy, previous sinus surgery, degree of polyposis, preoperative disease extent scored with OMC CT finding, blood eosinophil count, and eosinophil infiltration in nasal mucosa. CONCLUSION: Prognostic factors affecting the outcome of pediatric ESS are not clear. We assume that postoperative care, including appropriate postoperative medication, debridement and irrigation, etc., is more important in pediatric ESS.

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Expression of 15-Lipoxygenase and Cyclooxygenase-2 in Human Nasal Mucosa and Cultured Human Nasal Epithelial Cells.

Kyung Su KIM ; Joo Heon YOON ; Chang Hoon KIM ; Sun Goo KIM ; Jung Hyun CHANG ; Ji Hoon KIM

Korean Journal of Otolaryngology - Head and Neck Surgery.2003;46(8):649-653.

BACKGROUND AND OBJECTIVES: The purpose of our study was to examine the expression of 15-lipoxygenase (15-LO) in human nasal mucosa and to investigate the change of expression of 15-LO and cyclooxygenase-2 (COX-2) as a function of mucociliary and squamous differentiation. MATERIALS AND METHOD: Human inferior turbinates were used and immunohistochemistry with 15-LO and COX-2 antibody was done. Passage-2 normal human nasal epithelial cell culture using air-liquid interface method was performed for 14 days and the cells were divided as retinoic acid (RA)-sufficient and RA-deficient group. Western blot analysis for 15-LO and COX-2 expression was performed on each group on 0, 7, and 14 days. RESULTS: 15-LO expression of mucociliated epithelium was noted in ciliated cells and basal cells, but was not found in goblet cells and secretory acini. In squamous epithelium, the expression of 15-LO was weaker than that in the mucociliated epithelium, but the expression of COX-2 showed no difference between them. In Western blot analysis, 15-LO expression was significantly higher in RA-sufficient culture than in RA-deficient culture and this expression was time-dependent. COX-2 expression was almost same level in RA-deficient culture, but its expression was significantly higher in RA-sufficient culture on 7 and 14 days than on zero day. CONCLUSION: 15-LO and COX-2 may be related to differentiation and development of nasal epithelial cells. However, it is unclear whether this relationship is direct or indirect effect of 15-LO and COX-2. This question remains to be solved.
Humans

Humans

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Real Time RT-PCR Quantification of Mucin Genes Expression in Human Mastoid Mucosa.

Hyung Wook CHANG ; Dong Won SHIN ; Seung Heon SHIN ; Soo Joon SOHN ; Chang Ho JEON ; Sang Heun LEE

Korean Journal of Otolaryngology - Head and Neck Surgery.2003;46(8):634-640.

BACKGROUND AND OBJECTIVES: Mucin is involved in the pathogenesis of otitis media, but little is known about its expression in the mastoid mucosa with chronic otitis media. The purpose of this study is to identify MUC1, 2, 4, 5AC, 5B, 8 gene expression in the mastoid mucosa with chronic otitis media, and to compare the results with normal mastoid mucosa. MATERIALS AND METHOD: Normal or inflamed mastoid mucosal specimen were taken at the time of surgery, who underwent cochlear implant surgery and middle ear surgery for chronic otitis media. The profiles of mucin gene expression were examined by Real time reverse transcription polymerase chain reaction. RESULTS: This study revealed that RT-PCR of cDNAs from mastoid mucosa specimen of chronic otitis media showed the expression of MUC1, MUC4, MUC5AC, MUC5B, and MUC8 but MUC2 was not detected while normal mastoid mucosa showed the same pattern of mucin gene expression. In mastoid mucosa with chronic otitis media, mucin mRNA expression was upregulated in MUC1 1.2+/-1.1, MUC4 3.2+/-2.5, MUC5AC 2.5+/-1.0, MUC5B 4.1+/-2.2, and MUC8 2.7+/-2.1 times compared with that of normal mucosa and MUC5B is statistically significant (p<0.05). The MUC1, 4, 5AC, 5B, 8 mRNA expressions were correlated to infiltration of inflammatory cells in the submucosa of mastoid mucosa with chronic otitis media. CONCLUSION: These results suggest that MUC1, MUC4, MUC5AC, MUC5B, and MUC8 are expressed in the normal and inflamed mastoid mucosa and up-regulated by chronic inflammation.
Humans

Humans

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Normal Distribution of Nitric Oxide Synthase(NOS) in the Inner Ear of Guinea Pig.

Won Ho CHUNG ; Sook Kyung PARK ; Do Yeon CHO ; Sung Hwa HONG

Korean Journal of Otolaryngology - Head and Neck Surgery.2003;46(8):627-633.

BACKGROUND AND OBJECTIVES: The purpose of this study is to find out the exact distribution of nitric oxide synthase (NOS) in the cochlea and vestibular organ of normal guinea pig. Nitric oxide (NO) is synthesized from L-arginine catalyzed by NOS and it activates the soluble guanyl cyclase that activates cyclic GMP from GTP. These NO/cGMP pathways are involved in the neurotransmission of the inner ear and the regulation of cochlear blood flow in physiological condition. In addition, excess NO is involved in cytotoxicity. MATERIALS AND METHOD: Five normal guinea pigs were used. Antibodies to three isoforms of NOS (nNOS, eNOS, iNOS) were utilized to stain the paraffin sections of cochlea and vestibular organ (crista and maculae utriculi). Staining patterns were compared to previous reports. RESULTS: Neuronal NOS (nNOS) was constitutively expressed in the lateral cochlear wall (stria vascularis, spiral ligament), spiral ganglion, hair cells and supporting cells in the cochlea. In the vestibular organs, hair cells were well expressed. Endothelial NOS (eNOS) was expressed in the vascular endothelium, cochlear lateral wall, basal parts of hair cells and spiral ganglion in the cochlea. Vascular endothelium and nerve fiber including nerve calyx were also prominently expressed. No inducible NOS (iNOS) was identified in any sections. CONCLUSION: Neuronal and endothelial NOS were constitutively expressed in the inner ear of normal guinea pig. This distribution can explain the role of NO in physiologic conditions, which can be used as basic data in studying the role of NO in pathologic inner ear conditions.

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A Case of Schwannoma Arising from the Sphenoid Sinus.

A Young CHOI ; Ji Sun KIM ; Sang Won YOON ; Young Ok HONG

Korean Journal of Otolaryngology - Head and Neck Surgery.2011;54(1):89-92. doi:10.3342/kjorl-hns.2011.54.1.89

Schwannomas are neurogenic tumors that arise from the Schwann cells of the nerve sheath. Although up to 45% of all schwannomas occur in the head and neck region, only 4% involve the nasal cavity and paranasal sinuses. A 56-year-old female presented with an incidentally discovered lesion in the left posterior ethmoid and sphenoid sinuses on the brain magnetic resonance imaging. Magnetic resonance imaging showed a well demarcated mass without bony destruction with isointensity in T1 and hyperintensity in T2 weighted scans. Eighteen months later, repeated computed tomography showed an enlargement of the mass with the erosion of the adjacent sinus wall and left vidian canal. She underwent an endoscopic mass removal, which revealed a pale yellowish, firm mass in the left posterior ethmoid and sphenoid sinuses. Final histopathology confirmed the diagnosis of a schwannoma. There has been no evidence of recurrence during the two-year follow-up.
Brain ; Female ; Follow-Up Studies ; Head ; Humans ; Magnetic Resonance Imaging ; Middle Aged ; Nasal Cavity ; Neck ; Neurilemmoma ; Paranasal Sinuses ; Recurrence ; Schwann Cells ; Sphenoid Sinus

Brain ; Female ; Follow-Up Studies ; Head ; Humans ; Magnetic Resonance Imaging ; Middle Aged ; Nasal Cavity ; Neck ; Neurilemmoma ; Paranasal Sinuses ; Recurrence ; Schwann Cells ; Sphenoid Sinus

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Retraction: Development of the Mucociliary System in the Murine Eustachian Tube and Middle Ears.

Keehyun PARK ; Ho Ki LEE ; Myung Hyun CHUNG ; Young Myoung KIM ; Jae Young KIM ; David LIM

Korean Journal of Otolaryngology - Head and Neck Surgery.2011;54(1):95-95. doi:10.3342/kjorl-hns.2011.54.1.95

No abstract available.

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Retraction: Development of the Secretory Elements in the Murine Middle Ear and Eustachian Tube.

Keehyun PARK ; Myung Hyun CHUNG ; Young Myoung KIM ; Sung Kyun MOON ; David LIM

Korean Journal of Otolaryngology - Head and Neck Surgery.2011;54(1):93-93. doi:10.3342/kjorl-hns.2011.54.1.93

No abstract available.

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A Case of Bilateral Carotid Body Tumor.

Moo Kyun PARK ; Seung Kuk BAEK ; Eun Jae JUNG ; Kwang Yoon JUNG

Korean Journal of Otolaryngology - Head and Neck Surgery.2006;49(10):1042-1045.

Carotid body tumor is a rare lesion of the neuroendocrine system. It typically presents as a slow growing, painless neck mass found along the anterior border of the sternocleidomastoid muscle. We present clinicoradiologic findings of a bilateral carotid body tumor from a 35-year-old woman with a review of literatures. Magnetic resonance imaging showed a vascular mass at the carotid bifurcation, displacing the external and internal carotid arteries. After embolization of feeding vessels using polyvinyl alcohol and gelfoam, we excised the mass without severe bleeding and neurologic symptoms.
Adult ; Angiography ; Carotid Artery, Internal ; Carotid Body Tumor* ; Carotid Body* ; Female ; Gelatin Sponge, Absorbable ; Hemorrhage ; Humans ; Magnetic Resonance Imaging ; Neck ; Neurologic Manifestations ; Neurosecretory Systems ; Polyvinyl Alcohol

Adult ; Angiography ; Carotid Artery, Internal ; Carotid Body Tumor* ; Carotid Body* ; Female ; Gelatin Sponge, Absorbable ; Hemorrhage ; Humans ; Magnetic Resonance Imaging ; Neck ; Neurologic Manifestations ; Neurosecretory Systems ; Polyvinyl Alcohol

Country

Republic of Korea

Publisher

Korean Society of Otolaryngology-Head and Neck Surgery

ElectronicLinks

http://www.jkorl.org/

Editor-in-chief

E-mail

Abbreviation

Korean J Otorhinolaryngol-Head Neck Surg

Vernacular Journal Title

대한이비인후과학회지

ISSN

2092-5859

EISSN

2092-6529

Year Approved

2007

Current Indexing Status

Currently Indexed

Start Year

Description

Previous Title

Korean Journal of Otolaryngology - Head and Neck Surgery

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