Journal Detail Information

1

Cite

Share

Reliability and Validity of Korean Bowel Disease Questionnaire for Functional Gastrointestinal Disorders.

The Ewha Medical Journal.2011;34(2):39-46. doi:10.12771/emj.2011.34.2.39

OBJECTIVES: The Korean version of Bowel disease questionnaire (BDQ-K) was developed to evaluate the symptom items required to meet the definition of functional gastrointestinal disorders (FGIDs). We evaluated the test-retest reliability and validity of the self-reported BDQ-K and prevalence of functional dyspepsia (FD) and irritable bowel syndrome (IBS) according to the Rome-III criteria. METHODS: Sixty-nine patients participated in the test-retest reliability study, with a two week interval, and another 74 patients were enrolled to assess the self-reported questionnaire versus a doctor's interview (concurrent validity). A total of 3,325 subjects (mean age, 44+/-9 yrs; 58.3% male) presenting for an upper endoscopy responded to the BDQ-K at a health promotion center, but 797 subjects with organic diseases were excluded. RESULTS: In the validity study of the BDQ-K, the median kappa value was 0.74 (0.36~1.0). The median kappa value for the test-retest was 0.56 (range 0.22~1.0), including abdominal pain (kappa=0.51, P<0.001), pain onset before 6 months (kappa=0.51, P<0.001), epigastric pain (kappa=0.69, P<0.001), early satiety (kappa=0.40, P<0.001), and postprandial fullness (kappa=0.34, P<0.001). The prevalence of FD was 8.3% (209/2,528); epigastric pain more than once a week 4.4%, early satiety 2.5%, and postprandial fullness 6.1%. FD was more prevalent in women (P=0.001). The prevalence of IBS was 6.1% and IBS also predominated in women (7.1% vs 5.1% in men, P=0.032). CONCLUSION: The BDQ-K is a reliable and valid instrument for identifying FGIDs. The prevalence of FD according to the Rome III criteria was 8.3% and that of IBS was 6.1%.
Abdominal Pain ; Dyspepsia ; Endoscopy ; Female ; Gastrointestinal Diseases ; Health Promotion ; Humans ; Irritable Bowel Syndrome ; Male ; Prevalence ; Reproducibility of Results ; Rome ; Surveys and Questionnaires

2

Cite

Share

The Clinical Effect of Androgen Replacement Therapy for Female Sexual Dysfunction.

Seong Ju LEE ; Woo Sik CHUNG ; Hana YOON

The Ewha Medical Journal.2011;34(2):33-38. doi:10.12771/emj.2011.34.2.33

OBJECTIVES: Androgen plays an important role in female sexual function, and its insufficiency causes a clinically significant sexual dysfunction. This study examines the association between sex hormones and the clinical effect of testosterone replacement therapy in female sexual dysfunction. METHODS: This study examined 75 female patients who visited our hospital from March 2002 to June 2008 to treat sexual dysfunction. For the rest of the patients, we performed primary treatment and physiotherapy in accordance with the main cause of their sexual dysfunction. We also performed combination treatment of androgen replacement therapy for the patients who did not make medical progress after two months of primary treatment and for the patients whose free testosterone level is in the bottom group out of three normal range groups. RESULTS: The mean age of target patients was 39.6+/-8.7 years (range, 35~66 years) old. 10 patients out of 75 patients were postmenopausal women, and estrogen replacement therapy had been performed without androgen replacement therapy. We performed a combination treatment of androgen replacement therapy for the patients with sexual desire disorder, and 60% of them answered that they had an increased sexual response after they were given combination treatment of androgen replacement therapy. CONCLUSION: The results support the concepts that sex hormones significantly affect sexual response in women with sexual dysfunction. Clinically, it is effective and safe to perform a combination treatment of androgen replacement therapy in treating sexual dysfunction if medication is administered properly and carefully.
Estrogen Replacement Therapy ; Female ; Gonadal Steroid Hormones ; Humans ; Reference Values ; Testosterone

3

Cite

Share

Usefulness of Oral Glucose Insulin Sensitivity Index in Women with Polycystic Ovary Syndrome.

Jee Young OH ; Hyejin LEE ; Yeon Ah SUNG

The Ewha Medical Journal.2011;34(2):27-32. doi:10.12771/emj.2011.34.2.27

OBJECTIVES: Insulin resistance is a major pathophysiology in polycystic ovary syndrome (PCOS), and assessment of insulin sensitivity is important. Various insulin sensitivity indices from fasting state or oral glucose tolerance test (OGTT) have been compared with euglycemic hyperinsulinemic clamp. We aimed to evaluate the usefulness of these indices in young Korean women with PCOS. METHODS: Euglycemic hyperinsulinemic clamp test and 75 g OGTT were performed in 290 women with PCOS. Insulin mediated glucose uptake (IMGU), the insulin sensitivity index from clamp, was compared with various insulin sensitivity indices such as composite insulin sensitivity index (ISIcomp), estimated metabolic clearance rate (MCRest) of glucose and estimated insulin sensitivity index (ISIest), area under the curve of glucose and insulin ratio (AUC-GIR), OGTT-derived Belfiore index, and oral glucose insulin sensitivity index (OGSI) by Kazama. Fasting state indices such as glucose insulin ratio (GIR), homeostasis model assessment for insulin resistance (HOMA-IR), fasting Belfiore index, and quantitative insulin sensitivity check index (QUICKI) were also compared with IMGU. RESULTS: The correlation coefficients of ISIcomp, MCRest, ISIest, AUC-GIR, OGTT-Belfiore index, and OGSI with IMGU were all about 0.5 (Ps'<0.001) in PCOS women as a whole. The MCRest and ISIest were significantly correlated with IMGU in both obese (r=0.58 and 0.58, P<0.0001) and non-obese subjects (r=0.33 and 0.32, P<0.001). Fasting glucose and insulin-derived indices showed worse correlation with IMGU than OGTT-derived ones. CONCLUSION: The MCRest and ISIest from OGTT might be the best replacement for the insulin sensitivity index from hyperinsulinemic euglycemic clamp independent of obesity.
Fasting ; Female ; Glucose ; Glucose Clamp Technique ; Glucose Tolerance Test ; Homeostasis ; Humans ; Insulin ; Insulin Resistance ; Metabolic Clearance Rate ; Obesity ; Polycystic Ovary Syndrome

4

Cite

Share

Comparison of Short-term Follow-up Results of Open, Laparoscopic and Hand-assisted Laparoscopic Colectomy in Colorectal Cancer.

Kyung Sook HONG ; Kyoung Tae NOH ; Boyoung OH ; Ryung Ah LEE ; Soon Sup CHUNG ; Kwang Ho KIM

The Ewha Medical Journal.2011;34(2):19-26. doi:10.12771/emj.2011.34.2.19

OBJECTIVES: Hand-assisted laparoscopic surgery had both technical advantages of open surgery and better postoperative short-term follow-up results of laparoscopic surgery. We compared open colectomy, laparoscopic colectomy and hand-assisted laparoscopic colectomy, and tried to find the most effective operative modality. METHODS: 90 patients, who were diagnosed with colorectal cancer and underwent colectomy in our institution, were categorized as 3 groups of open colectomy (OC) group, laparoscopic colectomy (LC) group and hand-assisted laparoscopic colectomy (HALC) group by the surgical modality. RESULTS: In this study, ratio of male and female was 57 : 37, and mean age was 64.1 years old. LC group and HALC group showed longer operation time, shorter hospital stay after operation, lesser pain and earlier removal of closed drainage catheter than OC group. Amount of bleeding during operation, frequency of transfusion and incidence of complication showed no significant difference. In permanent pathologic results, the number of harvested lymph nodes had significant difference between OC group and other groups (P=0.030), but it was probably caused by the bias of the different distribution of the stages in each group. Overall 14 of the cases resulted in complications while there was no mortality. CONCLUSION: Laparoscopic colectomy and hand-assisted laparoscopic colectomy showed better short-term follow-up results rather than open colectomy. And hand-assisted laparoscopic surgery could provide tactile sensation to operator, which lacked in laparoscopic surgery. Hand-assisted laparoscopic colectomy could be an alternative surgical option for colorectal cancer with these advantages.
Bias (Epidemiology) ; Catheters ; Colectomy ; Colorectal Neoplasms ; Drainage ; Female ; Follow-Up Studies ; Hand-Assisted Laparoscopy ; Hemorrhage ; Humans ; Incidence ; Laparoscopy ; Length of Stay ; Lymph Nodes ; Male ; Sensation

5

Cite

Share

Review of Injection Laryngoplasty as Treatment of Voice Disorders.

Sung Min CHUNG ; Han Su KIM ; Hae Sang PARK

The Ewha Medical Journal.2011;34(2):13-18. doi:10.12771/emj.2011.34.2.13

In the past decade, vocal fold injection (VFI) has re-emerged as a valuable treatment modality for a variety of laryngeal disorders. It offers many advantages for the treatment of glottal insufficiency. It can avoid surgical scar and is easily performed with local anesthesia. In this article, we describe the indication of injection laryngoplasty, variable injection materials and discuss about vocal fold injection approaches.
Anesthesia, Local ; Cicatrix ; Laryngoplasty ; Vocal Cords ; Voice ; Voice Disorders

6

Cite

Share

Clostridium difficile Infections in Children.

Joo Hyun GIL ; Jeong Wan SEO

The Ewha Medical Journal.2011;34(2):3-12. doi:10.12771/emj.2011.34.2.3

During the past decade, rates of Clostridium difficile infection (CDI) increased worldwide. Hypervirulent strains of C. difficile such as NAP1/BI/027 and PCR ribotype 078 have emerged that have changed the epidemiology of CDI. Especially, CDI rates also have increased in the community, in children previously thought to be at low risk. Recently, the use of gastric acid suppressant that facilitates intestinal transit of the bacteria and presence of inflammatory bowel disease has been reported as risk factors. Treatment for CDI usually relies on metronidazole or vancomycin, but recurrence rates remains high. New treatment options for multiple recurrence are challenging. In this article, we reviewed recent epidemiological changes, current knowledge of virulence factors, reasonable approach to the diagnosis, and optimal treatment of CDI. But, clinical guidelines for pediatric C. difficile disease have not been defined. It seems that the consensus and recommendations for managing pediatric CDI are urgently needed.
Bacteria ; Child ; Clostridium ; Clostridium difficile ; Consensus ; Gastric Acid ; Humans ; Inflammatory Bowel Diseases ; Metronidazole ; Polymerase Chain Reaction ; Recurrence ; Ribotyping ; Risk Factors ; Vancomycin ; Virulence Factors

7

Cite

Share

The Future of the Ewha Medical Journal.

Ryung Ah LEE ; Ki Sook HONG

The Ewha Medical Journal.2011;34(2):1-2. doi:10.12771/emj.2011.34.2.1

No abstract available.

8

Cite

Share

Avascular Necrosis of the Femoral Head in Patient Visiting for Abdominal Pain.

Jae Hyun JUNG ; Young Ho SEO ; Sung Jae CHOI

The Ewha Medical Journal.2015;38(3):144-145. doi:10.12771/emj.2015.38.3.144

No abstract available.
Abdominal Pain* ; Head* ; Humans ; Necrosis*

9

Cite

Share

Long-term Complete Response with Lapatinib Plus Capecitabine in a Patient with HER2-Positive Breast Cancer Metastasized to the Pancreas.

Kichul SHIN ; Jinsu KIM ; Seokyoung YOON ; Eung Ho CHO ; Changwon JUNG ; Hye Jin KANG

The Ewha Medical Journal.2015;38(3):138-143. doi:10.12771/emj.2015.38.3.138

A 37-year-old woman underwent a total mastectomy and adjuvant chemotherapy for HER2-positive breast cancer (pT1N0M), and then recurred in the right lung followed by the pancreas. Lung lobectomy and pylorus-preserving pancreaticoduodenectomy were performed, and systemic chemotherapies including trastuzumab were sequentially administered. However, metastasis to the pancreatic tail was detected. She underwent image-guided radiation therapy, but this was not effective. Lapatinib plus capecitabine combination was administered as forth-line treatment and the metastatic lesion was disappeared. She is continuing this regimen with a complete response for 48 months until now.
Adult ; Breast Neoplasms* ; Breast* ; Chemotherapy, Adjuvant ; Drug Therapy ; Female ; Humans ; Lung ; Mastectomy, Simple ; Neoplasm Metastasis ; Pancreas* ; Pancreaticoduodenectomy ; Radiotherapy, Image-Guided ; Tail ; Capecitabine ; Trastuzumab

10

Cite

Share

Acute Myocardial Infarction Occurred in Multivessel Disease Including Chronic Total Occlusion.

Jee Seon KIM ; Tae Hoon YIM ; Byung Chul KIM ; Hyun Sik JU ; Ja Joong GU ; Tae Jin KIM

The Ewha Medical Journal.2015;38(3):133-137. doi:10.12771/emj.2015.38.3.133

Simultaneous multi-vessel acute myocardial infarction is rare and has poor prognosis. We report a 70-year-old Korean man with an anteroseptal wall ST-elevation myocardial infarction presenting as ventricular tachycardia, sudden cardiac arrest and cardiogenic shock. After successful cardiopulmonary resuscitation, a coronary angiogram revealed three-vessel coronary disease; simultaneous total occlusions of the proximal left anterior descending artery (LAD) and the proximal left circumflex artery (LCX), and chronic total occlusion of the proximal right coronary artery. Primary percutaneous coronary intervention (PCI) of the LAD and LCX was successful and an intra-aortic balloon pump was inserted. Despite the timely and successful PCI result, he died on the 58th day in the hospital due to pneumonia with multiple organ failure.
Aged ; Arteries ; Cardiopulmonary Resuscitation ; Coronary Disease ; Coronary Occlusion ; Coronary Vessels ; Death, Sudden, Cardiac ; Humans ; Multiple Organ Failure ; Myocardial Infarction* ; Percutaneous Coronary Intervention ; Pneumonia ; Prognosis ; Shock, Cardiogenic ; Tachycardia, Ventricular

DISPLAY OPTIONS

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share