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Retinal Detachment with Macular Hole Following Combined Photodynamic Therapy and Intravitreal Bevacizumab Injection.

Korean Journal of Ophthalmology.2007;21(3):185-187. doi:10.3341/kjo.2007.21.3.185

PURPOSE: To report a case of retinal detachment with a macular hole following photodynamic therapy (PDT) using verteporfin and intravtreal bevacizumab injection in the treatment of myopic choroidal neovasclarization (CNV). METHODS: A 58 -year-old woman was diagnosed with myopic CNV and treated with a combination of PDT with verteporfin and intravitreal bevacizumab injection that same day. She received the second injection of intravitreal bevacizumab four weeks after the initial treatment. RESULTS: The patient developed a sudden decline in vision one week after the second injection; and was subsequently diagnosed with retinal detachment associated with a macular hole. She underwent standard three-port pars plana vitrectomy with internal limiting membrane peeling, fluid-air exchange and silicone oil injection. The retina was still firmly attached at the patient's final follow-up visit. CONCLUSIONS: PDT and intravitreal bevacizumab injection used for the treatment of myopic CNV can be associated with retinal detachment with a macular hole. Patients need to be informed about this potential complication, and a higher index of suspicion may be warranted in patients who report sudden vision loss after the treatment.
Angiogenesis Inhibitors/administration & dosage/*adverse effects/therapeutic use ; Antibodies, Monoclonal/administration & dosage/*adverse effects/therapeutic use ; Choroidal Neovascularization/*drug therapy ; Female ; Humans ; Injections ; Middle Aged ; Photochemotherapy/*adverse effects ; Retinal Detachment/*etiology ; Retinal Perforations/*etiology ; Vitreous Body

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Retinal Capillary Hemangioma Treated with Verteporfin Photodynamic Therapy and Intravitreal Triamcinolone Acetonide.

Shin Cho SUH ; Sun Young JIN ; Seon Hee BAE ; Chul Gu KIM ; Jong Woo KIM

Korean Journal of Ophthalmology.2007;21(3):178-184. doi:10.3341/kjo.2007.21.3.178

PURPOSE: To report a case of retinal capillary hemangioma treated with verteporfin photodynamic therapy combined with intravitreal triamcinolone acetonide. METHODS: A 15-year-old female presented with metamorphopsia in the left eye for 7 days. Examination showed peripheral endophytic retinal capillary hemangioma, macular edema, and a best-corrected visual acuity of 20/50. The hemangioma and macular edema were treated with verteporfin photodynamic therapy and intravitreal triamcinolone acetonide. RESULTS: After 5 months of follow-up, involution of the hemangioma, reduction of macular edema, decrease of the feeder and draining vessel diameter, and improvement of best-corrected visual acuity to 20/25 was seen. CONCLUSIONS: This verteporfin photodynamic therapy combined with intravitreal triamcinolone acetonide appeared to cause involution of the hemangioma with reduction in macular edema and improvement in visual acuity.
Adolescent ; Female ; Fundus Oculi ; Glucocorticoids/*administration & dosage/therapeutic use ; Hemangioma, Capillary/diagnosis/*drug therapy ; Humans ; Injections ; *Photochemotherapy ; Photosensitizing Agents/*therapeutic use ; Porphyrins/*therapeutic use ; Retinal Neoplasms/diagnosis/*drug therapy ; Tomography, Optical Coherence ; Triamcinolone Acetonide/*administration & dosage/therapeutic use ; Ultrasonography ; Vitreous Body

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Optical Coherence Tomographic Finding in a Case of Macular Coloboma.

Joo Youn OH ; Young Suk YU ; Jeong Min HWANG ; Kyu Hyung PARK

Korean Journal of Ophthalmology.2007;21(3):175-177. doi:10.3341/kjo.2007.21.3.175

PURPOSE: To report the optical coherence tomography (OCT) findings in a patient with unilateral macular coloboma. METHODS: A 12-year-old male was presented with macular coloboma in the left eye. The optical coherence tomography was performed with fluorescein angiography (FA). RESULTS: The OCT revealed the crater-like depression in the macula, demonstrating atrophic neurosensory retina, and an absence of retinal pigment epithelium and choroid in the lesion. FA showed hypofluorescence corresponding to the size of the lesion in both early and late frames without leakage of dye at any stage. CONCLUSIONS: The OCT can be beneficial to confirm the diagnosis of macular coloboma.
Child ; Coloboma/*diagnosis ; Fluorescein Angiography ; Humans ; Macula Lutea/*abnormalities ; Male ; *Tomography, Optical Coherence/standards

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Bilateral Peripheral Infiltrative Keratitis After LASIK.

Sung Woon MOON ; Yong Hwan KIM ; Seung Chan LEE ; Mi Ae LEE ; Kyung Hyun JIN

Korean Journal of Ophthalmology.2007;21(3):172-174. doi:10.3341/kjo.2007.21.3.172

PURPOSE: To present a case of peripheral infiltrative keratitis mimicking infectious keratitis on the flap margin and limbus, which appeared on the first postoperative day after the laser in situ keratomileusis (LASIK). METHODS: A 36-year-old woman who underwent uneventful bilateral simultaneous LASIK developed multiple round infiltrate along the flap margin reaching to limbus from the 11 o'clock to 6 o'clock area in both eyes. RESULTS: The flap was lifted and irrigation was performed with antibiotics. but infiltration seemed to appear again. The infiltrate was more concentrated at the periphery and was extended to the limbus. Direct smear and culture for bacteria and fungus were negative. Topical prednisolone acetate 1% eye drops was added, infiltrative condition was resolved. CONCLUSIONS: LASIK induced peripheral infiltrative keratitis, in which infectious origin was ruled out, is reported.
Adult ; Anti-Inflammatory Agents/therapeutic use ; Bacterial Infections ; Diagnosis, Differential ; Female ; Humans ; Keratitis/diagnosis/drug therapy/*etiology/microbiology ; Keratomileusis, Laser In Situ/*adverse effects ; Mycoses ; Prednisolone/analogs & derivatives/therapeutic use ; Surgical Flaps/adverse effects

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A Solitary Fibrofolliculoma in the Eyelid.

June Kyu CHANG ; Dong Cho LEE ; Moo Hwan CHANG

Korean Journal of Ophthalmology.2007;21(3):169-171. doi:10.3341/kjo.2007.21.3.169

PURPOSE: To report the first case of a solitary eyelid fibrofolliculoma and to review the literature. METHODS: A 37-year-old female patient visited the outpatient department with a lesion in the right upper lid that had been growing steadily for a year. The patient had visited the local clinic, and under the diagnosis of chalazion had received incision and curettage twice, but the lesion had recurred. RESULTS: The 5 x 5 mm lesion was located near the upper lid margin. It was a red, hemispheric, smooth nodule, relatively solid to palpation and not painful. Excision and biopsy were performed, and through a histological exam, the diagnosis of fibrofolliculoma was later confirmed. CONCLUSIONS: Solitary fibrofolliculoma is rare, and to the authors' knowledge, a lesion arising in the eyelid has not yet been reported. Fibrofolliculoma should be included in the differential diagnosis when a localized mass lesion arising in the eyelid is encountered.
Adult ; Chalazion/*diagnosis ; Diagnosis, Differential ; Eyelid Neoplasms/*diagnosis/pathology/surgery ; Female ; Fibroma/*diagnosis/pathology/surgery ; Humans ; Ophthalmologic Surgical Procedures

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Relations between Age, Weight, Refractive Error and Eye Shape by Computerized Tomography in Children.

Ha Tae SONG ; Young Jun KIM ; Soo Jung LEE ; Yeon Sung MOON

Korean Journal of Ophthalmology.2007;21(3):163-168. doi:10.3341/kjo.2007.21.3.163

PURPOSE: To investigate relationships between age, weight, refractive error, and morphologic changes in children's eyes by computerized tomography (CT). METHODS: Of the 772 eyes of 386 patients under the age of 20 years, who visited our Department of Ophthalmology between January 2005 to August 2006 and underwent CT of the orbit, 406 eyes of 354 patients with clear CT images and normal eyeball contour were enrolled in the present retrospective study. The axial lengths, widths, horizontal and vertical lengths, refractive errors, and body weight of eyes were measured, and relationship between these parameters were investigated. RESULTS: Axial length was found to correlate significantly with eye width (r=0.914), and in emmetropic eyes and myopic eyes, axial lengths and widths were found to increase as age and body weight increased. Axial lengths increased rapidly until age 10, and then increased slowly. In emmetropic eyes, widths / axial lengths increased with age, but in myopic eyes these decreased as age or severity of myopia increased. Moreover, as age increased, the myopic population and severity also increased. CONCLUSIONS: The axial length was longer in case of myopia compared to emmetropia in all age groups and there was almost no difference in the increase rate of axial length by the age of myopia and emmetropia. However, the width was wider in case of myopia compared to emmetropia in all age groups and the increase rate of width in myopia by age was smaller than that of emmetropia. Myopia showed decreasing rate of width/axial length with increase of age, from 1.004 in 5 years to 0.971 in 20 years. However, emmetropia showed increasing rate of width/axial length with increase of age, from 0.990 in 5 years to 1.006 in 20 years.
Adolescent ; *Aging ; *Body Weight ; Child ; Child, Preschool ; Eye/*radiography ; Female ; Humans ; Male ; Myopia/*radiography ; Orbit/radiography ; Retrospective Studies ; *Tomography, X-Ray Computed

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Reduction of Deviation Angle During Occlusion Therapy: In Partially Accommodative Esotropia with Moderate Amblyopia.

Bo Young CHUN ; Soon Jae KWON ; Sun Hwa CHAE ; Jung Yoon KWON

Korean Journal of Ophthalmology.2007;21(3):159-162. doi:10.3341/kjo.2007.21.3.159

PURPOSE: To evaluate changes in ocular alignment in partially accommodative esotropic children age ranged from 3 to 8 years during occlusion therapy for amblyopia. METHODS: Angle measurements of twenty-two partially accommodative esotropic patients with moderate amblyopia were evaluated before and at 2 years after occlusion therapy. RESULTS: Mean deviation angle with glasses at the start of occlusion treatment was 19.45+/-5.97 PD and decreased to 12.14+/-12.96 PD at 2 years after occlusion therapy (p<0.01). After occlusion therapy, 9 (41%) cases were indications of surgery for residual deviation but if we had planned surgery before occlusion treatment, 18 (82%) of patients would have had surgery. There was a statistical relationship between increase of visual acuity ratio and decrease of deviation angle (r=-0.479, p=0.024). CONCLUSIONS: There was a significant reduction of deviation angle of partially accommodative esotropic patients at 2 years after occlusion therapy. Our results suggest that occlusion therapy has an influence on ocular alignment in partially accommodative esotropic patients with amblyopia.
*Accommodation, Ocular ; Adult ; Aged ; Amblyopia/*etiology/*physiopathology ; Esotropia/*physiopathology/*therapy ; Female ; Humans ; Male ; Middle Aged ; Occlusive Dressings/adverse effects ; Retrospective Studies ; *Sensory Deprivation ; Treatment Outcome

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Consecutive Esotropia in Intermittent Exotropia Patients with Immediate Postoperative Overcorrection More Than 17 Prism Diopters.

Hyoung Seok KIM ; Young Woo SUH ; Seung Hyun KIM ; Yoonae A CHO

Korean Journal of Ophthalmology.2007;21(3):155-158. doi:10.3341/kjo.2007.21.3.155

PURPOSE: To report the incidence and the factors of consecutive esotropia (ET) in patients with immediate postoperative overcorrection of at least 17 prism diopters (PD) after surgery for intermittent exotropia (X(T)). METHODS: Four-hundred-five patients under the age of 18 were included in this study. They underwent bilateral lateral rectus recession (LROU-rec) or unilateral recession-resection (R&R) for X(T). On postoperative day one, the patients with at least 17 PD overcorrection were classified as group 1 and those with less than 17 PD as group 2. Age, refractive error, type of surgery, lateral incomitancy, and the incidence of consecutive ET were analyzed for each group. RESULTS: Group 1 consisted of 116 patients (28.6%) and group 2 consisted of 289 (71.4%). At the six-month follow-up visit, consecutive ET had developed in 16 patients (13.8%) in group 1, and in five patients (1.7%) in group 2 (p<0.001). The occurrence of consecutive ET was not related to age at the time of surgery (p=0.46 in group 1 ; p=0.54 in group 2), refractive error (p=0.18 in group 1 ; p=0.08 in group 2), or the type of surgery (p=0.69 in group 1 ; p=1.00 in group 2). The incidence in group 1 was 23.8% in patients with lateral incomitancy and 8.1% in patients without lateral incomitancy (p<0.05). In group 2, the incidence was 4.4% in patients with lateral incomitancy and 0.5% in patients without lateral incomitancy (p=0.04). CONCLUSIONS: Consecutive ET developed in 13.8% of patients with immediate overcorrection of at least 17 PD. Lateral incomitancy was the most important risk factor.
Adolescent ; Child ; Child, Preschool ; Esotropia/*epidemiology/etiology/*physiopathology ; Exotropia/physiopathology/*surgery ; Female ; Follow-Up Studies ; Humans ; Incidence ; Male ; Oculomotor Muscles/surgery ; Ophthalmologic Surgical Procedures/*adverse effects ; Severity of Illness Index

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Dark-room Prone-position Test for Intermittent Angle Closure.

Tae Woo KIM ; Ki Ho PARK ; Chul HONG

Korean Journal of Ophthalmology.2007;21(3):151-154. doi:10.3341/kjo.2007.21.3.151

PURPOSE: To determine the efficacy and safety of the dark-room prone-position test (DRPT) for intermittent angle closure (IAC) and to investigate the correlation between A-scan ultrasound biometric measurements and the results of DRPT. METHODS: Medical records were reviewed of 37 eyes in 24 patients who were diagnosed with IAC and received DRPT. The increase of intraocular pressure (IOP) induced by DRPT and the results from A-scan ultrasound biometric measurements were obtained. An increase in IOP of at least 8 mmHg from baseline was considered a positive result for DRPT. Associations between the increase of IOP induced by DRPT and the parameters of A-scan biometry were tested by linear regression analysis. RESULTS: The DRPT results were positive in 28 eyes of 19 patients. After DRPT, the IOP returned to near-baseline levels within 2 hours in all patients; some patients were treated with anti-glaucoma eye drops. Lens thickness was significantly correlated with the amount of IOP elevation induced by DRPT (r=0.338, p=0.041). CONCLUSIONS: DRPT is a safe and effective test in patients with IAC. DRPT can be used effectively to make a concrete diagnosis of IAC. Lens thickness appears to be associated with a positive response to DRPT.
Adult ; Aged ; *Darkness ; *Diagnostic Techniques, Ophthalmological/standards ; Female ; Glaucoma, Angle-Closure/*diagnosis ; Humans ; Male ; Middle Aged ; *Prone Position ; Ultrasonography

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Evaluation of the Efficacy of Vitrectomy for Persistent Diabetic Macular Edema and Associated Factors Predicting Outcome.

Su Jeong SONG ; Joon Hong SOHN ; Kyu Hyung PARK

Korean Journal of Ophthalmology.2007;21(3):146-150. doi:10.3341/kjo.2007.21.3.146

PURPOSE: To evaluate the efficacy of vitrectomy for persistent diabetic macular edema after laser photocoagulation or intravitreal triamcinolone injections and to determine the demographic and ocular factors that influence functional and anatomical outcomes. METHODS: We retrospectively evaluated 55 eyes (51 patients) that had persistent diffuse macular edema after laser photocoagulation or intravitreal triamcinolone injections. We compared preoperative and postoperative best corrected visual acuity and macular thickness by Optical Coherence Tomography and investigated factors including patient's age, presence of vitreomacular traction, grade of diabetic retinopathy, and intraoperative internal limiting membrane removal that may influence the surgical results. RESULTS: The mean preoperative BCVA (log MAR) was 0.91+/-0.40 (0.8-1.2). The BCVA improved to 0.72+/-0.39 (0.3-1.2). The mean preoperative macular thickness was 440+/-130 (202-805) micrometer and the mean macular thickness decreased to 306+/-97 (136-580) micrometer postoperatively. The eyes showed statistically significant improvement in BCVA and central macular thickness (p<0.001). Preoperative better BCVA was associated with an improved postoperative visual acuity. (p=0.04). No other covariates were found to be statistically significant factors for prognosis of postoperative BCVA. CONCLUSIONS: In eyes with persistent diabetic macular edema after laser or IVTA injections, vitrectomy was effective for decreasing macular thickness and improvement of vision. The visual improvement after vitrectomy was associated with the preoperative better BCVA.
Adult ; Aged ; Diabetic Retinopathy/*surgery/therapy ; Female ; Humans ; Injections ; Laser Coagulation ; Macular Edema/*surgery/therapy ; Male ; Middle Aged ; Retreatment ; Retrospective Studies ; Treatment Outcome ; Triamcinolone/administration & dosage/therapeutic use ; *Vitrectomy ; Vitreous Body

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