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Sonication Induces Apoptosis in HL-60 Cells.

Moonyoung CHOI ; Incheol SEO ; Seong Il SUH ; Min Ho SUH ; Won Ki BAEK

Keimyung Medical Journal.2014;33(2):109-119.

To investigate a specific mechanism of apoptosis induced by sonication, we applied 20 kHz ultrasound to leukemia cell line HL-60 with different intensities (0-60 W/cm2) and time durations (0-100 sec). In accordance with previous reports, ultrasound treatment in HL-60 cells induced immediate cell death and delayed cell death which are associated with cell lysis and apoptosis, respectively. Delayed cell death of HL-60 was also detected 5 hours after sonication in our experiment. Detection of caspase activation by Western blot and sub-G1 accumulation by flow cytometry confirmed that apoptosis plays a role in delayed cell death induced by sonication in HL-60 cells. In addition, we found that decrease in lysosomes of HL-60 cells after sonication suggesting lysosomal rupture is involved in the mechanism of cell death induced by sonication.
Apoptosis* ; Blotting, Western ; Cell Death ; Cell Line ; Flow Cytometry ; HL-60 Cells* ; Humans ; Leukemia ; Lysosomes ; Rupture ; Sonication* ; Ultrasonic Therapy ; Ultrasonography

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Characteristics of Pubertal Development and Environment in Girsl with Precocious Puberty According to the Level of Peak LH.

Chul JIN ; Heung Sik KIM ; Ji Yoon KIM

Keimyung Medical Journal.2014;33(2):99-108.

There are some reports that high incidence of early onset of sexual development is related to improved nutrition, changes in living habits caused by social and economic developments, and especially to obesity. Our prospective study attempted to identify the features by investigating and analyzing the physical development status, results of specific hormone tests, living environment, and dietary habits of 60 girls who visited our university hospital with symptoms of early secondary sexual characteristics, and to explore the elements that could be helpful for future medical examinations and treatments. Patients were divided in two groups due to the result of gonadotropin-releasing hormone stimulation test. In Group 1, peak luteinizing hormone levels of > or = 5 mIU/mL and the rest of the patients were included in Group 2. In Group 1, there showed early onset of maternal menstruation (menarche), increased intake of chicken-based foods, increased insulin-like growth factor 1 and estradiol. These result showed that precocious puberty was related to genetic and environmental effects, especially diets such as chicken-based foods. Correcting living environments and diet habits will be helpful for prevention of precocious puberty in girls and future study will be needed.
Diet ; Estradiol ; Female ; Food Habits ; Gonadotropin-Releasing Hormone ; Humans ; Incidence ; Luteinizing Hormone ; Menstruation ; Obesity ; Prospective Studies ; Puberty, Precocious* ; Sexual Development

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Uremic Pericarditis Accompanying Cardiac Tamponade after Emergency Hemodialysis.

Ha Yeun PARK ; Seong Sik KANG ; Yae Rim KIM ; O Hyun KWON ; Kyu Bok JIN ; Seung Yeup HAN ; Sung Bae PARK ; Woo Yeong PARK

Keimyung Medical Journal.2016;35(1):25-29.

Although the incidence of uremic pericarditis was high in the past, it has decreased in recent decades with early and appropriate dialysis. However, cardiac tamponade caused by uremic pericarditis is still a life-threatening emergency and it requires urgent management. Herein we report a case of 38-year-old man with chronic renal disease who represented critical uremic pericarditis followed by cardiac tamponade despite of appropriate hemodialysis. Careful consideration of risk factors and aggressive treatment are very important for effective and safe treatment of uremic pericarditis and cardiac tamponade.
Adult ; Cardiac Tamponade* ; Dialysis ; Emergencies* ; Humans ; Incidence ; Pericardial Effusion ; Pericardiocentesis ; Pericarditis* ; Renal Dialysis* ; Renal Insufficiency, Chronic ; Renal Replacement Therapy ; Risk Factors

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An Intra-procedural Stent Thrombosis in a Prasugrel Resistant Patient Treated with Ticagrelor.

Jung Ho PARK ; Seung Ho HUR ; Yun Kyeong CHO ; Hyoung Seob PARK ; Hyuck Jun YOON ; Sang Hoon LEE ; Hyung Seop KIM ; Chang Wook NAM ; Seong Wook HAN

Keimyung Medical Journal.2016;35(1):18-24.

Stent thromboses due to multifactorial causes including hypercoagulable conditions and high on treatment platelet reactivity (HTPR), which means a low response to anti-platelet therapy, especially clopidogrel. Prasugrel is a third generation thienopyridine and inactive pro-drug requiring metabolic activation in vivo, which improves the rate of HTPR with clopidogrel. This drug is mostly effective, with a potent, fast, and consistent anti-platelet action, but rare cases of inadequate platelet inhibition with prasugrel have been reported. Here we describe the case of a 47-year-old man who presented with a recurrent acute myocardial infarction and ST during an intravascular ultrasound pullback and was resistant to prasugrel, was successfully treated with ticagrelor.
Activation, Metabolic ; Blood Platelets ; Humans ; Middle Aged ; Myocardial Infarction ; Prasugrel Hydrochloride* ; Stents* ; Thrombosis* ; Ultrasonography

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Differences of Perceptual Importance for Graduate Outcomes among Faculties, Students and Parents in a Medical School.

Hye Jin PARK ; Won Kyun PARK ; Dong Hoon SHIN ; Jae Bum KIM ; Min Seo KIM

Keimyung Medical Journal.2016;35(1):8-17.

To find out the different cognition of the members of medical school about the importance of graduate outcomes such as 'clinical performance, communication, supporting patients, professionalism, problem solving and research, self-development', a survey applied with self-report method was conducted with 110 faculties, 132 students (71 premedical 2nd graders and 61 medical 2nd graders), and 30 parents about graduate outcomes and sub-outcome competences. Parents usually thought highly of the importance of graduate outcomes, while medical second graders comparatively regarded them as less important. Among graduate outcomes, 'clinical performance' was definitely considered the most important and was followed by 'communication'. As for 'self-development', parents and premedical 2nd graders regarded it as important, while faculty and medical 2nd graders had lower awareness about its importance. As to the suboutcome competences, faculty generally had lower awareness about their importance compared to students and parents.
Cognition ; Humans ; Methods ; Parents* ; Problem Solving ; Professionalism ; Schools, Medical*

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Guidelines for Improvement of Integrated Courses in a Medical School.

Hye Jin PARK ; Won Kyun PARK ; Dae Hyun KIM ; Jin Hee KIM ; Min Seo KIM

Keimyung Medical Journal.2016;35(1):1-7.

To systematically develop the courses or programs of medical education, guidelines were developed for the improvement of integrated courses, modifying the existing evaluation model of school curriculum to fit the curriculum of medical school. The guidelines were divided into three parts, prior-class, mid-class, and post-class, and 18 items were developed in the areas of situation analysis, developing process, goals, contents, organization, management, performance, and evaluation.
Curriculum ; Education, Medical ; Humans ; Schools, Medical*

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A Case of Apocrine Hidrocystoma on the Ankle.

Osung KWON ; Yong Woo CHOI ; Kyung Duck PARK ; Hyun CHUNG ; Joonsoo PARK

Keimyung Medical Journal.2017;36(1):65-68.

Apocrine hidrocystoma is a benign tumor arising from apocrine sweat gland. It presents as a solitary translucent nodule, usually on the face, head, and neck. However it is extremely rare for the apocrine hidrocystoma to arise on the extremities, and no case of apocrine hidrocystoma on lower extremity has been reported in Korean dermatologic literature. Herein, we report a case of 63-year-old male apocrine hidrocystoma that developed in ankle area with a review of the literature.
Ankle* ; Extremities ; Head ; Hidrocystoma* ; Humans ; Lower Extremity ; Male ; Middle Aged ; Neck ; Sweat Glands

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Two Cases of Severe Fever with Thrombocytopenia Syndrome Manifested with Hemophagocytic Lymphohistiocytosis Successfully Treated with Steroids.

Yoon Jung KIM ; So Hyun BAE ; Hye Jin JUNG ; Sang Ah LEE ; Min Jung KIM ; Hyun Ha CHANG ; Shin Woo KIM ; Su Jeong KIM ; Jong Myung LEE

Keimyung Medical Journal.2017;36(1):58-64.

Severe fever with thrombocytopenia syndrome (SFTS) is an emerging and potentially life-threatening tick-borne virus disease in Korea. It can be presented with hemophagocytic lymphohistiocytosis (HLH) as severe complicated cases. Here, we report two cases of SFTS associated HLH patients fully recovered with steroids and conservative treatment, even though they had high risk factors of poor prognosis.
Fever* ; Humans ; Korea ; Lymphohistiocytosis, Hemophagocytic* ; Prognosis ; Risk Factors ; Steroids* ; Thrombocytopenia* ; Virus Diseases

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Serous Retinal Detachment Following Laser Peripheral Iridotomy for the Angle Closure Secondary to Posterior Scleritis.

A Young CHOI ; Kwang Soo KIM ; Chong Eun LEE

Keimyung Medical Journal.2017;36(1):52-57.

This study was aimed to report a case of serous retinal detachment following laser peripheral iridotomy (LPI) for the treatment of angle closure secondary to posterior scleritis. A 55-year-old man with bilateral ocular pain, redness, and headache was referred to Keimyung University Dongsan Medical Center. At the initial examination, his visual acuity was 1.0 in the both eyes. The intraocular pressure (IOP) was 25 mmHg in the right eye and 28 mmHg in the left eye. Slit lamp examination showed a shallow anterior chamber, which was found to be Shaffer grade I by gonioscopy. There were no specific findings in the fundus, except a slightly edematous disc margin in both eyes. LPI was performed on both eyes. Fourth day after LPI, the patient complained of a central scotoma and visual disturbance of the left eye, in which the visual acuity had decreased to 0.06. The optical coherence tomography showed serous retinal detachment at the posterior pole. Fluorescein angiography revealed a focal leakage in the superotemporal area, as well as multiple hyperfluorescence lesions. Posterior scleritis of the left eye was diagnosed. Systemic steroid therapy was initiated and the area with the leakage was treated by focal laser photocoagulation. Two weeks later, the serous retinal detachment of the left eye resolved and visual acuity improved to 0.63. Laser peripheral iridotomy can exacerbate serous retinal detachment in patients with posterior scleritis that presented as acute angle closure.
Anterior Chamber ; Fluorescein Angiography ; Gonioscopy ; Headache ; Humans ; Intraocular Pressure ; Light Coagulation ; Middle Aged ; Retinal Detachment* ; Retinaldehyde* ; Scleritis* ; Scotoma ; Slit Lamp ; Tomography, Optical Coherence ; Visual Acuity

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Successful Tracheal Intubation Using Rigid Video-Stylet in a Ptiaent with Tracheobronchopathia Osteochondroplastica.

Eun Ah CHO ; Keulame SONG ; Tae Young LIM ; Kyoung Ho RYU ; Hyun Soo KIM

Keimyung Medical Journal.2017;36(1):46-51.

Tracheobronchopathia osteochondroplastica (TO) is a rare dysplastic disease of the trachea characterized by cartilaginous or bony nodules in the tracheobronchial lumen. Rigid video-stylet is an intubating device that provides favorable conditions even in the difficult cases. In this report, we describe a successful airway management using the rigid video-stylet in a 62-year-old man with unanticipated difficult intubation later diagnosed for TO. He was planned for elective percutaneous nephrolithotomy under general anesthesia. He was healthy without any airway symptoms. With the rigid video-stylet, we not only performed successful tracheal intubation but also examined endotracheal lumen simultaneously. Using the rigid video-stylet, we noticed multiple whitish projecting nodules in the trachea, which were the typical findings for TO.
Airway Management ; Anesthesia, General ; Humans ; Intubation* ; Middle Aged ; Nephrostomy, Percutaneous ; Trachea

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