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Correlation of zearalenone pollution with precocious puberty girls

Wei GU ; Weixing SHEN ; Xing SHI ; Qiaoli ZHOU

Chinese Journal of Applied Clinical Pediatrics.2014;29(12):923-926. doi:10.3760/cma.j.issn.2095-428X.2014.12.012

Objective To explore the relationship of zearalenone (ZEA) and precocious puberty in girls.Methods The peripheral serums from 71 cases of precocious puberty girls and 50 cases of healthy girls were collected respectively and concentrations of ZEA were detected by high performance liquid chromatography.Bone age,body mass index (BMI),volume of uterus and ovaries,concentrations of estradiol (E2),luteinizing hormone (LH) and folliclestimulating hormone (FSH) were detected,and the residence of each subject was recorded as well.Results (1) In 71 patients,52 patients were diagnosed as idiopathic central precocious puberty,others were diagnosed as premature thelarche.(2) In 71 patients,serum ZEA was detected from 51 patients,and undetected in 20 patients.(3)Concentration of ZEA in precocious puberty girls [(318 ±34) ng/L]was significantly increased than that in healthy girls [(143 ± 35) ng/L,P =0.002],but no distinct difference existed between ICPP group and PT group(P =0.326).(4)Compared with uterus volume of ZEA in the undetected patients (1.975 ±0.150) cm3,the uterus volume of ZEA detected patients (2.972 ±0.180) cm3,which was significantly enlarged,there was significant difference (P =0.01) ; Percentage of overweight girls in ZEA detected patients (31.4％,16/51 cases) was lower than which in ZEA undetected patients (65.0％,13/20 cases,P =0.01) ; Although there was no statistical differences in the breast diameter,bone age,value of E2,LH and FSH between ZEA detected patients and undetected patients (all P ＞ 0.05),but the increased tendency in ZEA detected patients existed.(5) ZEA in serum was detected in 53.3％ (16/30 cases) patients living in the cities,and the rate was obviously lower than 82.9％ of the patients (34/41 cases) living in the countryside,there was significant difference (P =0.007).Conclusions ZEA is correlated with precocious puberty in girls.ZEA pollution might be one of reasons for precocious puberty occurrence.

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Speed up the development of pediatric immunology discipline quickly in China

Huasong ZENG

Chinese Journal of Applied Clinical Pediatrics.2014;29(9):641-644. doi:10.3760/cma.j.issn.2095-428X.2014.09.001

Pediatric allergy,immunology and rheumatology (PAIR) discipline is one of the important branch of pediatrics in China.It covers the pediatric allergic diseases,immunodeficiency diseases,rheumatic diseases and the clinical and research aspect which is associated with infection and immunity including inflammation,and inflammatory diseases,et al.Though it is an interdisciplinary discipline which has a long history and being paid great attention and construction rapidly in early a decade,but it is still in the early stages of development in China.How to promote its reasonable,scientific,and further development quickly to adapt to the high-speed social medical service growth of demand in this field is an important task which we have to face to.This article reviews the discipline development history,present situation and futue trend.

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Weight evaluation of long-term prognosis: criterion of the treatment on childhood-onset systemic lupus erythematosus

Jian HU

Chinese Journal of Applied Clinical Pediatrics.2014;29(9):645-647. doi:10.3760/cma.j.issn.2095-428X.2014.09.002

This article mainly discusses the relationship between the active treatment concept of the systemic lupus erythematosus (SLE) and its positive outcome in long-term prognosis,which is the overall prognosis of SLE benefits from the improvement on the liying conditions of patients with lupus nephritis (LN).Although more argumentations are still required in regards to whether to use the different general conclusions of the meta analysis between the childhood-onset SLE (cSLE) and the early adulthood-onset SLE patients at the same age as more proactive induction therapy in early phase,yet the time point for early therapy before clinical symptoms appearing can be determined and thereby positive anticipation can be achieved through keeping the difference between the long-term prognosis of the cSLE and the adult-onset patients as evidences,and making in-depth study on the innate laws of the heterogeneity of cSLE,meanwhile giving biological markers more application which can be highly reliable in reflecting the morbid status,supported by the study outcomes of pharmacogenetics/pharmacogenomics and further optimization of current immunoregulation/immune inhibitors approaches (as evidences required by long-term effects).

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Sequential treatment of juvenile idiopathic arthritis

Ping ZENG ; Huasong ZENG

Chinese Journal of Applied Clinical Pediatrics.2014;29(9):648-652. doi:10.3760/cma.j.issn.2095-428X.2014.09.003

With the improvement of the therapy and the drugs we known more results in a therapeutic ambitious goals of juvenile idiopathic arthritis.Selection of individualized sequential therapy is beneficial to the recovery of the disease.

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Do immunoglobulin A vasculitis and immunoglobulin A nephropathy belong to one desease

Xiaochuan WU ; Juan LIAO

Chinese Journal of Applied Clinical Pediatrics.2014;29(9):653-654. doi:10.3760/cma.j.issn.2095-428X.2014.09.004

The immunopathogenesis of IgA vasculitis and IgA nephropathy both demonstrate IgA deposition,and abnormal glycosylation of IgAl molecule is their major pathogenesis.Therefore,it is clinically controversial that they are actually one disease.The present text will delineate their similarities and differences from aspects of epidemiology,clinic,pathology,mechanism and prognosis.

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Sleep frequent tongue bite

Lei GAO ; Liping ZOU ; Linyan HU ; Jun JU ; Yujie LIU ; Xiaoqiao CHEN ; Xiuyu SHI

Chinese Journal of Applied Clinical Pediatrics.2014;29(9):716-718. doi:10.3760/cma.j.issn.2095-428X.2014.09.020

The 10-month baby boy,with normal development,mainly due to sleep in frequent tongue bite nearly 4 months.Bitten his tongue after faring asleep,biting bleeding,bite pain awake.Many of his tongue ulcers,serious impact on children's lives,family companionship in suffering.History found in the supplementary week before the onset of the left frontal children hurt skin bruising.Electroencephalogram showed:Sleep of epileptiform discharges in the left frontal and central anterior temporal areas,but bite the tongue during sleep electroencephalogram synchronization no relevant abnormal discharge.The final diagnosis of traumatic epilepsy,frontal lobe epilepsy syndrome automatically lead to tongue bite tongue with traumatic ulcers.Oral Clonazepam 0.25 mg before sleep,the symptoms disappeared that night,nighttime sleep peacefully.His tongue ulceration has healed after a month.Readers are advised to take advantage of these key parts of the diagnostic process and diagnostic thinking or diagnostic procedures,combined with their own clinical practice,serious thinking,learning,summarized,and benefit from it.

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New problem and progress of transient tachypnea of the newborn

Hongjin YU ; Chao CHEN

Chinese Journal of Applied Clinical Pediatrics.2014;29(9):713-715. doi:10.3760/cma.j.issn.2095-428X.2014.09.019

Transient tachypnea of the newborn (TTN) is the most common cause of respiratory distress.TTN is a self-limiting disease which has a good prognosis but sometimes severe cases may cause pulmonary edema,respiratory distress,pulmonary air leak or persistent pulmonary hypertension.Researchers have many studies about pathogenesis,clinical features,treatment of TTN at home and abroad,and they have new progress.This article will summarize recent research progress on TTN.

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Progress of interventional therapy of congenital valvular aortic stenosis

Lijun FU ; Fen LI

Chinese Journal of Applied Clinical Pediatrics.2014;29(10):721-724. doi:10.3760/cma.j.issn.2095-428X.2014.10.001

Congenital vahular aortic stenosis (AS),which refers to a congenital malformation of the aortic valve,is the most common causes of left ventricular outflow tract obstruction in chiidren.In 1983,percutaneous balloon aortic valvuloplasty (PBAV) was firstly described as the treatment for congenital AS in children.Over the past 30 years advancement in technique and equipment had radically improved the safety and outcome of balloon valvuloplasty of aortic valve.Nowadays the technique is widely regarded as the therapy of first choice for children with congenital AS.However,it is essential to make decisions about treatment and define which approach has the best chance of success for any given patient before the initial intervention,especially for the neonate with critical AS.PBAV is usually effective for acutely relieving left ventricular outflow obstruction and has excellent short term results in most childen with congenital AS.The mid-and long-trem outcome after a successful balloon dilation of congenital AS in childhood is also good,but late restenosis and valve regurgitation eventually necessitate reintervention in the majority of children,which included aortic valve replacement.PBAV was found to have a high incidence of complications and remains one of the most challenging procedures in the inttcventional therapy of congenital heart disease.Operators should not only acquire the necessary manual skills,but also have the ability to make sound clinical judgment and deal with critical events.Owing to its palliative nature of balloon dilation for congenital AS,the follow-up care of patients after procedure is quite important.

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Transcatheter treatment of postoperative pulmonary stenosis:current status and future perspectives

Tingliang LIU ; Wei GAO

Chinese Journal of Applied Clinical Pediatrics.2014;29(10):725-727. doi:10.3760/cma.j.issn.2095-428X.2014.10.002

Postoperative pulmonary artery stenosis is one of the popular complications.The disappointing results of surgical treatment for such lesions led to the introduction of interventional procedures (balloon angioplasty and stent implantation).Balloon angioplasty is applicable for branch pulmonary artery stenosis,however,balloon dilation alone rarely been effective in the long-term for these lesions.Since pulrmonary artery stenting was introduced in 1991,indications and use of stents for dealing with pulmonary artery stenosis have played a leading role in recent times.Intravascular stents are effective for stenotic artery dilation,can reduce right ventricle pressure and improve heart function.Excellent mid-and long-term results after stenting of postoperative pulmonary artery stenosis are demonstrated by numerous researches,with the new developments in stent design,indications for pulmonary artery stent implantation are likely to widen in the future.

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Criteria evolution of autism spectrum disorders and the significance of the criteria in Diagnostic and Statistical Manual of Mental Disorders 5th ed

Yanni CHEN

Chinese Journal of Applied Clinical Pediatrics.2014;29(12):881-883. doi:10.3760/cma.j.issn.2095-428X.2014.12.001

Autism spectrum disorders have gradually been known and its concept is also changing.It is important that comprehend the changing timely for clinical work.This paper is mainly about the formation and evolution for the term,as well as the change in Diagnostic and Statistical Manual of Mental Disorders 5th ed and the significance.

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