Acute Exacerbation of Interstitial Lung Disease in Newly Diagnosed Probable Dermatomyositis.
Korean Journal of Clinical Neurophysiology.2013;15(2):77-79. doi:10.14253/kjcn.2013.15.2.77
Korean Journal of Clinical Neurophysiology
1999 to Present ISSN: 1229-6414
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Spinal MRI Abnormality in Zoster Sine Herpete.
Korean Journal of Clinical Neurophysiology.2013;15(2):74-76. doi:10.14253/kjcn.2013.15.2.74
No abstract available.
Herpes Zoster* ; Herpesvirus 3, Human ; Magnetic Resonance Imaging* ; Zoster Sine Herpete*
Herpes Zoster* ; Herpesvirus 3, Human ; Magnetic Resonance Imaging* ; Zoster Sine Herpete*
A Case of Ramsay Hunt Syndrome with Multicranial Nerve Palsy.
Korean Journal of Clinical Neurophysiology.2013;15(2):71-73. doi:10.14253/kjcn.2013.15.2.71
Recurrent Atopic Myelitis Presenting as an Isolated Lhermitte's Sign.
Korean Journal of Clinical Neurophysiology.2013;15(2):68-70. doi:10.14253/kjcn.2013.15.2.68
Atopic myelitis (AM) is a relatively mild form of myelitis associated with allergic diathesis, and present with predominant sensory manifestations. Lhermitte's sign has been considered as a relatively non-specific clinical sign suggesting demyelinating lesion in cervical cord. Here we report a patient with recurrent AM who presented with isolated Lhermitte's sign, both in first and second attacks. This report suggests that either the diagnosis or recurrence of AM can be frequently underdiagnosed because of its predominant sensory manifestations.
Diagnosis ; Disease Susceptibility ; Humans ; Myelitis* ; Recurrence
Diagnosis ; Disease Susceptibility ; Humans ; Myelitis* ; Recurrence
Korean Journal of Clinical Neurophysiology.2013;15(2):63-67. doi:10.14253/kjcn.2013.15.2.63
Multiple cranial and peripheral neuropathies as a delayed sequellae of ethylene glycol poisoning is a less well known clinical entity and its information about long-term electrophysiological and clinical outcomes is limited. We report a 45-year-old male who presented with acute renal failure and subsequently developed multiple cranial neuropathy, respiratory failure, and flaccid tetraparesis. Through sequential electrophysiological studies, we would like suggest that the main pathophysiology of ethylene glycol-related neuropathy is a demyelinating polyradiculoneuropathy with secondary axonal degeneration.
Acute Kidney Injury ; Axons ; Cranial Nerve Diseases* ; Ethylene Glycol* ; Humans ; Male ; Middle Aged ; Peripheral Nervous System Diseases ; Poisoning ; Polyneuropathies ; Polyradiculoneuropathy* ; Respiratory Insufficiency
Acute Kidney Injury ; Axons ; Cranial Nerve Diseases* ; Ethylene Glycol* ; Humans ; Male ; Middle Aged ; Peripheral Nervous System Diseases ; Poisoning ; Polyneuropathies ; Polyradiculoneuropathy* ; Respiratory Insufficiency
A Case of Man-in-the-Barrel Syndrome Induced by Cervical Spinal Cord Ischemia.
Korean Journal of Clinical Neurophysiology.2013;15(2):59-62. doi:10.14253/kjcn.2013.15.2.59
Man-in-the-barrel syndrome (MIBS) is a clinical syndrome of bilateral upper limb weakness with normal lower extremity function. It can be caused by various neurological conditions such as bilateral cerebral hypoperfusion, syringomyelia, motor neuron disease, or cervical myelopathies. We report a patient with MIBS after cervical spinal cord ischemia. It is postulated to be caused by ischemic insults of anterior spinal artery from repeated and prolonged neck extension.
Arteries ; Humans ; Lower Extremity ; Motor Neuron Disease ; Neck ; Spinal Cord Diseases ; Spinal Cord Ischemia* ; Spinal Cord* ; Syringomyelia ; Upper Extremity
Arteries ; Humans ; Lower Extremity ; Motor Neuron Disease ; Neck ; Spinal Cord Diseases ; Spinal Cord Ischemia* ; Spinal Cord* ; Syringomyelia ; Upper Extremity
Korean Journal of Clinical Neurophysiology.2013;15(2):53-58. doi:10.14253/kjcn.2013.15.2.53
BACKGROUND: The autophagy is the major route for lysosomal degradation of misfolded protein aggregates and oxidative cell components. We hypothesized that rapamycin (autophagy enhancer) would prolong the survival of motor neuron and suppress the disease progression in amyotrophic lateral sclerosis (ALS). METHODS: A total of 24 transgenic mice harboring the human G93A mutated SOD1 gene were used. The clinical status involving rotarod test and survival, and biochemical study of ALS mice model were evaluated. RESULTS: The onset of symptoms was significantly delayed in the rapamycin administration group compared with the control group. However, after the clinical symptom developed, the rapamycin exacerbated the disease progression and shortened the survival of ALS mice model, and apoptosis signals were up-regulated compared with control group. CONCLUSIONS: Even though further detailed studies on the relevancy between autophagy and ALS will be needed, our results revealed that the rapamycin administration was not effective for being novel promising therapeutic strategy in ALS transgenic mice and exacerbated the apoptosis.
Amyotrophic Lateral Sclerosis* ; Animals ; Apoptosis ; Autophagy ; Cellular Structures ; Disease Progression ; Humans ; Mice* ; Mice, Transgenic ; Motor Neurons ; Neuroprotective Agents* ; Rotarod Performance Test ; Sirolimus*
Amyotrophic Lateral Sclerosis* ; Animals ; Apoptosis ; Autophagy ; Cellular Structures ; Disease Progression ; Humans ; Mice* ; Mice, Transgenic ; Motor Neurons ; Neuroprotective Agents* ; Rotarod Performance Test ; Sirolimus*
Clinical and Electrophysiological Characteristics of Meralgia Paresthetica.
Korean Journal of Clinical Neurophysiology.2013;15(2):48-52. doi:10.14253/kjcn.2013.15.2.48
BACKGROUND: Meralgia paresthetica (MP) is a mononeuropathy affecting the lateral femoral cutaneous nerve. The disease is often diagnosed clinically, but electrophysiological tests play an important role. The aim of this study is to clarify clinical characteristics of MP as well as the role of sensory nerve conduction study (NCS) in the diagnosis of MP. METHODS: Sixty-five consecutive patients with clinical diagnosis of MP between March 2001 and June 2012 were retrospectively reviewed at a single tertiary center. General demographics, clinical characteristics and sensory NCS findings were investigated. Measurements of sensory NCS included the baseline-to-peak amplitude, side-to-side amplitude ratio and the conduction velocity. To compare between the normal and abnormal NCS groups, independent t-tests and chi-square test were performed. RESULTS: Sixty-five patients had male predominance (56.9%) with mean age of 48.4+/-13.4 years (range: 16-75). Seven patients (13.5%) had undergone operation or procedure before the symptom onset. The sensory nerve action potentials were obtainable in 52 (80%) of 65 clinically diagnosed MP patients. Sensory NCS revealed abnormalities in 38 patients (73.1%), and others (n=14, 26.9%) showed normal findings. Between the normal and abnormal NCS groups, there is no statistically significant difference on demographics or clinical features. CONCLUSIONS: We clarify the clinical features and sensory NCS findings of MP patients. Due to several limitations of sensory NCS, the diagnosis of MP could be accomplished both clinically and electrophysiologically.
Action Potentials ; Chi-Square Distribution ; Demography ; Diagnosis ; Humans ; Male ; Mononeuropathies ; Neural Conduction ; Retrospective Studies
Action Potentials ; Chi-Square Distribution ; Demography ; Diagnosis ; Humans ; Male ; Mononeuropathies ; Neural Conduction ; Retrospective Studies
Role of Diffusion-Weighted Imaging as a Prognostic Indicator in Acute Hypoxic Encephalopathy.
Korean Journal of Clinical Neurophysiology.2013;15(2):42-47. doi:10.14253/kjcn.2013.15.2.42
BACKGROUND: Diffusion-weighted image (DWI) might be useful to predict the prognosis of acute hypoxic encephalopathy. The aim of our study was to test whether the early change and extent of DWI abnormalities can be an indicator of the clinical outcome of hypoxic encephalopathy. METHODS: Forty-four patients who were diagnosed as hypoxic encephalopathy due to the cardiorespiratory arrest were retrospectively identified. Clinical variables were determined, and the DWI abnormalities were counted by four areas: cortex, subcortical white matter, cerebellum and deep grey matter, and were divided into three groups by the extent of lesions. Prognosis was classified as 'poor' (Glasgow coma scale (GSC) at 30 days after arrest <9 or death) and 'good' (GSC at 30 days after arrest > or =9). RESULTS: GCS at day 3 (p<0.001), presence of seizure (p=0.01), and presence of lesion (p<0.001) were significantly different in prognosis, but statistically there is no association with the extent of lesions and prognosis (p=0.26). CONCLUSIONS: Presence of early DWI changes could predict the clinical outcome of hypoxic encephalopathy after cardiorespiratory arrest.
Cerebellum ; Coma ; Humans ; Hypoxia, Brain* ; Prognosis ; Retrospective Studies ; Seizures
Cerebellum ; Coma ; Humans ; Hypoxia, Brain* ; Prognosis ; Retrospective Studies ; Seizures
Cerebellar Control of Saccades.
Korean Journal of Clinical Neurophysiology.2013;15(2):37-41. doi:10.14253/kjcn.2013.15.2.37
Saccades are rapid eye movements that shift the line of sight between successive points of fixation. The cerebellum calibrates saccadic amplitude (dorsal vermis and fastigial nucleus) and the saccadic pulse-step match (flocculus) for optimal visuo-ocular motor behavior. Based on electrophysiology and the pharmacological inactivation studies, early activity in one fastigial nucleus could be important for accelerating the eyes at the beginning of a saccade, and the later activity in the other fastigial nucleus could be critical for stopping the eye on target, which is controlled by inhibitory projection from the dorsal vermis. The cerebellum could monitor a corollary discharge of the saccadic command and terminate the eye movement when it is calculated to be on target. The fastigial nucleus and dorsal vermis also participate in the adaptive control of saccadic accuracy.
Cerebellum ; Electrophysiology ; Eye Movements ; Saccades* ; Sleep, REM
Cerebellum ; Electrophysiology ; Eye Movements ; Saccades* ; Sleep, REM
Country
Republic of Korea
Publisher
Korean Society of Clinical Neurophysiology
ElectronicLinks
http://synapse.koreamed.org/LinkX.php?code=1208KJCNEditor-in-chief
Jong-Seok Bae
Abbreviation
Korean Journal of Clinical Neurophysiology
Vernacular Journal Title
대한임상신경생리학회지
ISSN
1229-6414
EISSN
2288-1026
Year Approved
2013
Current Indexing Status
Currently Indexed
Start Year
1999
Description
Korean Journal of Clinical Neurophysiology (Korean J Clin Neurophysiol) is the official Journal of The Korean Society of Clinical Neurophysiology, published twice a year in Korean or English. The journal publishes full-length original paper, case report, invited reviews, controversies in clinical neurophysiology, images in clinical neurophysiology, and other articles requested by editorial board. The journal aims to publish evidence-based, scientific and creative research materials in the field of clinical neurophysiology, clinical neurology, and neuroscience. All submitted manuscripts should be original and should not be considered by other scientific journals for publication at the same time.
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