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A Case of Refractory Choriocarcinoma that Showed Complete Remission with Paclitaxel.

Yun Hyun CHO ; Mi Kyung KIM ; Sang In JUNG ; Jong Yun WHANG ; Ji Hyung CHO ; Young Tak KIM ; Joo Hyun NAM

Korean Journal of Obstetrics and Gynecology.2002;45(6):1097-1100.

High-risk gestational choriocarcinoma in patients who have failed primary chemotherapy is known to have a very poor prognosis. About 25% of high-risk metastatic choriocarcinoma become refractory to EMACO (etoposide, methotrexate, actinomycin D, cyclophosphamide and vincristine) and fail to achieve a complete remission. Currently, there is no standard salvage chemotherapeutic regimen for EMACO refractory choriocarcinoma. Paclitaxel, a taxane analog extracted from the bark of the western yew, has shown antitumor activity in a variety of cancers. However, there has been few case reports that described the effectiveness of paclitaxel to choriocarcinoma. We describe a 41-year old woman with refractory choriocarcinoma, who demonstrated dramatic response to paclitaxel treatment with a brief review of literature.
Adult ; Choriocarcinoma* ; Cyclophosphamide ; Dactinomycin ; Drug Therapy ; Female ; Humans ; Methotrexate ; Paclitaxel* ; Pregnancy ; Prognosis

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Hyperreactio luteinalis associated with a normal singleton pregnancy.

Kwang Beom LEE ; Gwang Jun KIM ; Byung Cheul HWANG ; Hyun Yee CHO

Korean Journal of Obstetrics and Gynecology.2002;45(6):1092-1096.

Hyperreactio luteinalis is a rare disease characterized by marked cystic enlargement of the ovary due to multiple benign theca lutein cyst. The cause of this disease is not well known but is believed to be induced by high serum levels of human chorionic gonadotropins (hCG). It occurs usually in gestational trophoblastic disease, multiple pregnancies, and rarely in normal pregnancy. In nature, hyperreactio luteinalis is a benign condition. Therefore, the appropriate management is conservative, but surgical intervention is definitely indicated to remove infarcted tissue, control hemorrhage, or decrease androgen production in virilized patients. Here we report a case of hyperreactio luteinalis which was diagnosed at 11 weeks gestation. Lower abdominal pain was developed and progressed. Emergent right wedge oophorectomy and left salpingoophorectomy was performed due to probable torsion of left ovarian cyst and the pregnancy maintained. Theca lutein cysts were confirmed on pathologic examination.
Abdominal Pain ; Chorionic Gonadotropin ; Female ; Gestational Trophoblastic Disease ; Hemorrhage ; Humans ; Lutein ; Ovarian Cysts ; Ovariectomy ; Ovary ; Pregnancy* ; Pregnancy, Multiple ; Rare Diseases

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A Case of Hemorrhagic Huge Bartholin Abscess.

Jong Ha HWANG ; Sung Hoon PARK ; Jin Woo SHIN ; Nak Woo LEE ; Tak KIM ; Hai Joong KIM ; Seong Jin CHO

Korean Journal of Obstetrics and Gynecology.2002;45(6):1086-1091.

A bartholin gland cysts and abscesses are common problems in women of reproductive age. Although the cysts are usually asymptomatic, they may become enlarged or infected and cause significant pain. Bartholin gland abscesses usually develop over two to four days and can become larger than 8 cm by literature but huge bartholin abscess is very rare. A number of vulvar and vaginal lesions can mimic bartholin gland cysts or abscesses and should be included in the differential diagnosis. So we report a case of hemorrhagic huge bartholin abscess with a brief review of the literatures.
Abscess* ; Diagnosis, Differential ; Female ; Humans

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Ultrasound Diagnosis of Bladder Exstrophy in the Second Trimester of Pregnancy: A Case Report.

Sung Woo CHO ; Eun Hye LEE ; Jeong Yun SHIM ; Sung Woon CHANG

Korean Journal of Obstetrics and Gynecology.2002;45(6):1082-1085.

Bladder exstrophy is a rare congenital malformation in which the anterior wall of the bladder is absent, and the posterior wall is exposed. Because of the poor prognosis, prenatal diagnosis is important. We present a case of bladder exstophy which was presented as a solid mass in the lower part of the fetal abdomen instead of fluid-filled urinary bladder, and confirmed at autopsy after termination of pregnancy. To the best of our knowledge, this is the first report of bladder exstrophy prenatally diagnosed in the Korean literature.
Abdomen ; Autopsy ; Bladder Exstrophy* ; Diagnosis* ; Female ; Fetus ; Humans ; Pregnancy ; Pregnancy Trimester, Second* ; Pregnancy* ; Prenatal Diagnosis ; Prognosis ; Ultrasonography* ; Urinary Bladder* ; Urogenital System

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A case of tuberculosis of the vagina.

Youn Seok CHOI ; Tea Sung LEE

Korean Journal of Obstetrics and Gynecology.2002;45(6):1078-1081.

Tuberculosis of the vagina is very rare disease reported to be involved in less than 1% of female genital tuberculosis. A 53-year-old woman presented with abnormal cervicographic finding at the private clinic. On vaginal physical examination, there were multiple elevated nodular lesion in the vagina and ectocervical area. There was no abnormal vessels or acetowhite epithelium on colposcopic examination. Direct biopsy for histologic examination revealed granulomatous lesion. We performed PCR of mycobacterial DNA and Ziehl-Neelsen staining for acid-fast bacilli (AFB). The Ziehl-Neelsen staining for AFB was negative, but mycobacterial DNA fragments were detected using the PCR method. Diagnosis was confirmed by the detection of acid-fast bacilli in histologic preparations. Anti-tuberculosis medication was effective for this patient.
Biopsy ; Diagnosis ; DNA ; Epithelium ; Female ; Humans ; Middle Aged ; Physical Examination ; Polymerase Chain Reaction ; Rare Diseases ; Tuberculosis* ; Tuberculosis, Female Genital ; Vagina*

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One Case of Primary Malignant Mixed M llerian tumor of the Pelvic Peritoneum.

Kwang Hyun KIM ; Chan LEE ; Sung Jo KIM ; Sun Young LEE ; Won Joong KIM ; Yong Hee LEE

Korean Journal of Obstetrics and Gynecology.2002;45(6):1074-1077.

Malignant mixed m llerian tumors (MMMTs) are highly aggressive biphasic neoplasm composed of carcinomatous and sarcomatous components. In the female genital tract, most cases arise from the endometrium, but cases also are encountered, although less frequently, in the ovaries, fallopian tubes, cervix, and vagina. Extragenital primary peritoneal MMMTs are rare and to our knowledge, 29 cases with primary peritoneal MMMTs have been reported in the literature. We experienced a case of extragenital primary peritoneal MMMT and report with a brief review of literature.
Cervix Uteri ; Endometrium ; Fallopian Tubes ; Female ; Humans ; Ovary ; Peritoneum* ; Vagina

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A Case of Mixed Germ Cell Tumor of Ovary: Complete Remission after Conservative Surgery and Bleomycin, Etoposide, Cisplatin (BEP) therapy.

Moon Ki KWON ; Poong Do HAM ; Min Jung KWON ; Mi Kyung JEE ; Wook Yull NA

Korean Journal of Obstetrics and Gynecology.2002;45(6):1069-1073.

Malignant germ cell tumor of ovary is very rare and one of the most malignant gynecologic neoplasms usually affecting younger women. we experienced a case of 19-year old female with mixed germ cell tumor of ovary which was composed of endodermal sinus tumor and dysgerminoma. we report this case with a brief review of the literature.
Bleomycin* ; Cisplatin* ; Dysgerminoma ; Endodermal Sinus Tumor ; Etoposide* ; Female ; Genital Neoplasms, Female ; Germ Cells* ; Humans ; Neoplasms, Germ Cell and Embryonal* ; Ovary* ; Young Adult

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A Case of Spontaneous Rupture of a Splenic Artery Aneurysm in the Third Trimester.

Hea Eun LEE ; Byoung Hun JOUNG ; Ju Young NO ; In Sook JOO ; Jae Sik SHIM ; Kyung Young SEO

Korean Journal of Obstetrics and Gynecology.2002;45(6):1064-1068.

The spontaneous rupture of splenic artery aneurysm during pregnancy is a rare but catastrophic event. Two thirds of all ruptures happen during the third trimester. Clinical presentation is often non-specific, with good hemodynamic compensation, followed by a rapid deterioration. Active management and operation are the most important procedures for diagnosis and therapy of the bleeding. Abdominal delivery will help to establish diagnosis and should be performed immediately. We report a case of a patient at 38 weeks of gestation suffering epigastric pain and fetal distress. At emergency cesarean delivery, an aneurysmal rupture of the splenic artery was found to be the reason for the hemoperitoneum. Spleen, aneurysm and the tail of the pancreas were removed. In spite of fatal hemorrhage, the patient survived but her fetus was dead. With a review of the literature on this topic, diagnostic aspects and treatment options are discussed.
Aneurysm* ; Cesarean Section ; Compensation and Redress ; Diagnosis ; Emergencies ; Female ; Fetal Distress ; Fetus ; Hemodynamics ; Hemoperitoneum ; Hemorrhage ; Humans ; Pancreas ; Pregnancy ; Pregnancy Trimester, Third* ; Rupture ; Rupture, Spontaneous* ; Spleen ; Splenic Artery*

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A Case of successful delivery after hysteroscopic removal of intrauterine device with missing tail during early pregnancy.

You Young BAE ; Ho Ryong KIM ; Hyoung Ho KIM ; Yong Pil KANG ; Jin Gyu SUN ; Kwang Soo KEE

Korean Journal of Obstetrics and Gynecology.2002;45(6):1060-1063.

In the case of pregnancy complicated by intrauterine device, complications such as ectopic pregnancy, septic abortion, preterm delivery are increased significantly. Especially in relation to intrauterine pregnancy, IUD should be removed to prevent complication. But when the tail is missed, therapeutic abortion has been done as an alternative method conventionally. Recently we experienced a case of hysteroscopic removal of IUD complicated by intrauterine pregnancy of 9th week without any harm to the G -sac or embryo. And she delivered healthy girl weighing 2950 gm. So we report this case with the review of articles related.
Abortion, Septic ; Abortion, Therapeutic ; Embryonic Structures ; Female ; Humans ; Intrauterine Devices* ; Pregnancy* ; Pregnancy, Ectopic

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A case of Sertoli-Leydig Cell Tumor.

In Sook KIM ; Jung Ho CHOI ; Sin Ho KIM ; Hyun Jin PARK ; Heung Gon KIM ; Hyung Bae MOON

Korean Journal of Obstetrics and Gynecology.2002;45(6):1056-1059.

The Sertoli-Leydig cell tumor is a gonadal tumor of sex-cord type, similar to that seen in the various phase of testicular development in the male. It is the most common type of all virilizing ovarian tumors and account for less than 0.5% of all ovarian tumors. This case has been presented of a 16 years old girl who had Sertoli-Leydig cell tumor of the right ovary. The clinical manifestation included deepening voice and hirsutism. The removal of the tumor, which proved to be a Sertoli-Leydig cell tumor, so we present it with a brief review of literature.
Adolescent ; Female ; Gonads ; Hirsutism ; Humans ; Male ; Ovary ; Sertoli-Leydig Cell Tumor* ; Voice

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