Allergy, Asthma & Respiratory Disease.2016;4(6):463-463. doi:10.4168/aard.2016.4.6.463
In this paper, acknowledgments section for grant support was omitted unintentionally.
Allergy, Asthma & Respiratory Disease
2013 to Present ISSN: 2288-0402
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Allergy, Asthma & Respiratory Disease.2016;4(6):462-462. doi:10.4168/aard.2016.4.6.462
Acknowledgments section for grant support was misprinted unintentionally.
Oral allergy syndrome associated with weed pollinosis.
Allergy, Asthma & Respiratory Disease.2016;4(6):458-461. doi:10.4168/aard.2016.4.6.458
Oral allergy syndrome (OAS) is caused by cross-reactivity between certain pollens and plant foods, including vegetables, nuts, or fruits. Here, we experienced 2 cases of OAS patients associated with mugwort pollinosis without sensitization to Fagales. A 54-year-old female repeatedly experienced skin rashes, perioral edema, nasal obstruction after eating fresh vegetables (celery, lettuce, chicory, radish sprouts, ginseng, etc.). She had suffered from allergic rhinitis worsening in autumn for 5 years. Specific IgE (sIgE) titers to ragweed and mugwort were elevated to 54.1 and 24.9 kU/L, respectively. With regard to the allergen component of pollens, sIgE to Art v 1 (mugwort) and Amb a 1 (ragweed) were elevated to 21.9 and 36.1 kU/L, respectively. Birch sIgE (including Bet v 1 and Bet v 2) was not detected. A 35-year-old male suffered from abdominal pain, skin rashes after eating mango and kiwi. In addition, systemic allergic reaction developed after consumption of tomato and ginseng. He had chronic rhinitis. The sIgE levels to ragweed, mugwort, and tomato were elevated to 0.55, 6.39, and 0.78 kU/L, respectively. The sIgE test results were all negative for Amb a 1, Bet v 1, and Bet v 2 sIgE. Specific IgE levels to Art v 1, Art v 2 sIgE were 3.51 and 4.46 kU/L, respectively. Based on the history and sIgE test results, 2 cases OAS were related to mugwort. We experienced 2 cases of weed pollinosis related to OAS. Culprit foods of OAS can vary depending on their cuisine cultures.
Abdominal Pain ; Adult ; Ambrosia ; Apium graveolens ; Artemisia ; Betula ; Chicory ; Eating ; Edema ; Exanthema ; Female ; Food Hypersensitivity ; Fruit ; Humans ; Hypersensitivity* ; Immunoglobulin E ; Lettuce ; Lycopersicon esculentum ; Male ; Mangifera ; Middle Aged ; Nasal Obstruction ; Nuts ; Panax ; Plants ; Pollen ; Raphanus ; Rhinitis ; Rhinitis, Allergic ; Rhinitis, Allergic, Seasonal* ; Vegetables
Abdominal Pain ; Adult ; Ambrosia ; Apium graveolens ; Artemisia ; Betula ; Chicory ; Eating ; Edema ; Exanthema ; Female ; Food Hypersensitivity ; Fruit ; Humans ; Hypersensitivity* ; Immunoglobulin E ; Lettuce ; Lycopersicon esculentum ; Male ; Mangifera ; Middle Aged ; Nasal Obstruction ; Nuts ; Panax ; Plants ; Pollen ; Raphanus ; Rhinitis ; Rhinitis, Allergic ; Rhinitis, Allergic, Seasonal* ; Vegetables
Allergy, Asthma & Respiratory Disease.2016;4(6):453-457. doi:10.4168/aard.2016.4.6.453
A variety of diseases are associated with the development of unilateral pleural effusion. Although unilateral pleural effusion is common, refractory unilateral pleural effusion is rare. It is important to make an accurate diagnosis using proper diagnostic tools. Thrombocytopenia is one of the rare conditions occurring from various diseases such as severe infection or autoimmune diseases. It can be life-threatening if accurate diagnosis and treatment are delayed and be a clue to accurate diagnosis in differential diagnosis from refractory pleural effusion. Kasabach-Merrit syndrome (KMS) is often accompanied by extensive vascular tumors and characterized by consumptive coagulopathy with profound thrombocytopenia. It is also important to have a high index of suspicion for the diagnosis. We report a case of KMS in a 2-month-old female infant with a vascular tumor on her left intrathoracic cage, who had presented refractory unilateral pleural effusion and thrombocytopenia. Initially, the patient was diagnosed as having complications of severe infection, and a chest tube was inserted for aggressive treatment. However, her unilateral pleural effusion persisted, and thrombocytopenia and hypofibrinogenemia were refractory. Chest imaging revealed an infiltrating large vascular tumor involving the cardiac border, diaphragm, and chest wall. The patient’s unilateral pleural effusion was misidentified as an infectious condition at the initial stage. As a result of the ultrasonography-guided biopsy, it was revealed to be Kaposiform hemangioendothelioma. The patient was cured after treatment for KMS.
Autoimmune Diseases ; Biopsy ; Chest Tubes ; Diagnosis ; Diagnosis, Differential ; Diaphragm ; Female ; Hemangioendothelioma* ; Humans ; Infant ; Pleural Effusion* ; Thoracic Wall ; Thorax ; Thrombocytopenia* ; Vascular Neoplasms
Autoimmune Diseases ; Biopsy ; Chest Tubes ; Diagnosis ; Diagnosis, Differential ; Diaphragm ; Female ; Hemangioendothelioma* ; Humans ; Infant ; Pleural Effusion* ; Thoracic Wall ; Thorax ; Thrombocytopenia* ; Vascular Neoplasms
Anaphylaxis after consumption of abalone.
Allergy, Asthma & Respiratory Disease.2016;4(6):449-452. doi:10.4168/aard.2016.4.6.449
Abalone is popular seafood in Asia; however, allergy to abalone was rarely reported. We report a case of anaphylaxis after consumption of abalone. A 24-year-old female visited an Emergency Department, complaining of cough, dyspnea, rhinorrhea, generalized urticaria, facial edema, and wheezing that had developed 1 hour after consumption of abalone. She was discharged when her symptoms subsided after antihistamine and dexamethasone were given. One month later, she was referred to our outpatient clinic. We performed skin prick tests, measurement of serum specific IgE antibody level, and sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) with IgE immunoblotting. Both skin prick and specific IgE antibody tests were positive for abalone crude extract. In SDS-PAGE with IgE immunoblotting, we identified possible antigens sized 55, 100, and 25 kDa, respectively. This is the first case of abalone-induced anaphylaxis in Korea.
Ambulatory Care Facilities ; Anaphylaxis* ; Asia ; Cough ; Dexamethasone ; Dyspnea ; Edema ; Electrophoresis ; Electrophoresis, Polyacrylamide Gel ; Emergency Service, Hospital ; Female ; Food Hypersensitivity ; Humans ; Hypersensitivity ; Immunoblotting ; Immunoglobulin E ; Korea ; Respiratory Sounds ; Seafood ; Shellfish ; Skin ; Sodium ; Urticaria ; Young Adult
Ambulatory Care Facilities ; Anaphylaxis* ; Asia ; Cough ; Dexamethasone ; Dyspnea ; Edema ; Electrophoresis ; Electrophoresis, Polyacrylamide Gel ; Emergency Service, Hospital ; Female ; Food Hypersensitivity ; Humans ; Hypersensitivity ; Immunoblotting ; Immunoglobulin E ; Korea ; Respiratory Sounds ; Seafood ; Shellfish ; Skin ; Sodium ; Urticaria ; Young Adult
Allergy, Asthma & Respiratory Disease.2016;4(6):442-448. doi:10.4168/aard.2016.4.6.442
PURPOSE: Hypersensitivity reactions to contrast media (CM) are one of the most common causes of drug adverse reactions. The overall prevalence of immediate hypersensitivity reaction (IHR) was 0.16%–7.7% to nonionic CM. Although IHR to CM has been traditionally considered nonallergic, there is growing evidence that the mechanism of IHR to CM is mediated by IgE. It can be severe, even fatal, and a legal problem. To reduce IHR, the prescreening skin test is on the rise. METHODS: We reviewed cases of IHR to CM during enhanced computed tomography (CT) from 2008 to 2015 at a secondary hospital in South Korea. Patients who underwent enhanced CT were performed the 2-step prescreening skin test before nonionic CM-enhanced CT. If patients had adverse reactions to CM, the reactions were reported. IHR to CM was defined as an immediate reaction within 1 hour after CM administration. The Ring and Messmer system was used to classify the severity of reactions by grades I to IV, and we defined grades III and IV as severe reactions. RESULTS: A total of 30,105 CM-enhanced CT cases were recruited from 2008 to 2015. A total 46 patients with CM adverse reactions were reported. The IHR were noted in 30 of the total patients (0.1%), of which 6 had severe reaction. CONCLUSION: The prevalences of IHR and severe IHR to CM were 0.1% and 0.02%, respectively. Further studies are needed to evaluate the usefulness of prescreening skin tests to prevent IHR to CM.
Contrast Media* ; Humans ; Hypersensitivity* ; Hypersensitivity, Immediate ; Immunoglobulin E ; Korea ; Prevalence* ; Skin Tests* ; Skin*
Contrast Media* ; Humans ; Hypersensitivity* ; Hypersensitivity, Immediate ; Immunoglobulin E ; Korea ; Prevalence* ; Skin Tests* ; Skin*
Allergy, Asthma & Respiratory Disease.2016;4(6):436-441. doi:10.4168/aard.2016.4.6.436
PURPOSE: Food-dependent exercise-induced anaphylaxis (FDEIA) is a rare subtype of food allergy in which both sensitization to food allergen and exercise as a trigger contribute to its development. However, its pathogenesis is still under investigation. This study compared clinical features, the causative foods, and the degree of sensitization to food between FDEIA and food anaphylaxis to characterize FDEIA more clearly. METHODS: We retrospectively reviewed the medical records of patients who were diagnosed with FDEIA (n=89) or food anaphylaxis (n=115) between 2003 and 2015 at Seoul National University Hospital. RESULTS: Subjects with FDEIA more frequently had urticaria than those with food anaphylaxis (88.8% vs. 76.5%, P=0.024). Whereas patients with FDEIA had less laryngeal edema than those with food anaphylaxis (12.4% vs. 30.4%, P=0.02). Wheat (67.4%) was the most common causative food allergen in FDEIA, whereas seafood (40.9%) was the most common culprit food allergen in food anaphylaxis. Also, subjects with FDEIA showed a lower atopic index score than those with food anaphylaxis (0.55±1.07 vs. 1.21±1.82, P=0.006). CONCLUSION: There were significant differences in clinical manifestation, causative food allergens and the degree of sensitization to food between FDEIA and food anaphylaxis.
Allergens ; Anaphylaxis* ; Food Hypersensitivity ; Humans ; Hypersensitivity ; Laryngeal Edema ; Medical Records ; Retrospective Studies ; Seafood ; Seoul ; Tertiary Care Centers* ; Triticum ; Urticaria
Allergens ; Anaphylaxis* ; Food Hypersensitivity ; Humans ; Hypersensitivity ; Laryngeal Edema ; Medical Records ; Retrospective Studies ; Seafood ; Seoul ; Tertiary Care Centers* ; Triticum ; Urticaria
Allergy, Asthma & Respiratory Disease.2016;4(6):429-435. doi:10.4168/aard.2016.4.6.429
PURPOSE: This study aimed to evaluate the clinical factors that could influence the length of hospital stay (LHS) of infants with acute bronchiolitis using the bronchiolitis severity score (BSS). METHODS: The medical records of 105 infants aged 0–12 months with acute bronchiolitis who were admitted to a tertiary hospital between December 2014 and May 2015 were reviewed. The BSS was composed 5 factors, namely general condition, wheezing, chest retraction, respiration rate, and peripheral oxygen saturation, which were evaluated at admission. In addition, the age of the infants, LHS, body weight, birth history, familial history, laboratory test result, chest X-ray, and treatment modalities were reviewed. Subjects were classified into 3 groups according to their BSS, and logistic regression analysis was used to identify the association of the BSS with longer LHS. RESULTS: Among subjects, 62 were studied. Their mean LHS and age were 5.5±2.0 days and 3.9±2.7 months, respectively. Twelve infants were classified as mild (20.3%), 43 as moderate (68.8%), and 7 as severe (10.9%). Venous blood gas pH value and white blood cell count were the best predictors of disease severity. The LHS was associated with the BSS, age, body weight and pCO2 by venous blood gas analysis (P<0.05). CONCLUSION: The LHS was associated with the BSS, age, body weight, and pCO₂ by venous blood gas analysis at admission. The BSS could be a useful tool to predict disease severity and decide treatment strategies for infants with acute bronchiolitis who have no known risk factors.
Blood Gas Analysis ; Body Weight ; Bronchiolitis* ; Hospitalization ; Humans ; Hydrogen-Ion Concentration ; Infant* ; Length of Stay* ; Leukocyte Count ; Logistic Models ; Medical Records ; Oxygen ; Reproductive History ; Respiratory Rate ; Respiratory Sounds ; Risk Factors ; Tertiary Care Centers ; Thorax
Blood Gas Analysis ; Body Weight ; Bronchiolitis* ; Hospitalization ; Humans ; Hydrogen-Ion Concentration ; Infant* ; Length of Stay* ; Leukocyte Count ; Logistic Models ; Medical Records ; Oxygen ; Reproductive History ; Respiratory Rate ; Respiratory Sounds ; Risk Factors ; Tertiary Care Centers ; Thorax
Association between the serum 25-hydroxyvitamin D level and allergic rhinitis in Korean children.
Allergy, Asthma & Respiratory Disease.2016;4(6):423-428. doi:10.4168/aard.2016.4.6.423
PURPOSE: Vitamin D is known to play an important role in the regulation of the immune system and in the prevention of allergic disease. Herein, we examined the association between vitamin D and allergic rhinitis (AR) in children. METHODS: A total of 72 aeroallergen-proven AR and 57 healthy control subjects who visited Severance Children's Hospital between 2012 and 2014 were evaluated. The mean serum 25-hydroxyvitamin D (25(OH)D) level was measured in all subjects to evaluate their vitamin D status. RESULTS: The mean serum 25(OH)D levels was significantly lower in patients with AR than in controls (19.5±6.4 ng/mL vs. 22.3±5.8 ng/mL, P=0.013). The incidence of AR is higher in the 25(OH)D-insufficient group (15–20 ng/mL) and in the 25(OH)D-deficient group (≤15 ng/mL) compared with the 25(OH)D-sufficient group (>20 ng/mL) (40.3% vs. 84.4% vs. 22.2%, P<0.001). There was no significant difference in the serum 25(OH)D level between subgroups with mild and moderate-to-severe AR symptoms (19.8±6.5 vs. 19.0±6.3, P=0.596). After adjusting for confounding factors, the lower serum vitamin D level groups had increased odds of AR compared with the 25(OH)D-sufficient group (odds ration [95% confidence interval]; 3.67 [1.29–10.38] in the 25(OH)D-insufficient group; P=0.014 and 6.04 [1.49–24.51] in the 25(OH)D-deficient group; P=0.012). CONCLUSION: The serum vitamin D levels were significantly lower in children with AR compared with healthy controls. Therefore, lower serum level of 25(OH)D may be associated with the development of AR.
Child* ; Humans ; Immune System ; Incidence ; Rhinitis, Allergic* ; Vitamin D
Child* ; Humans ; Immune System ; Incidence ; Rhinitis, Allergic* ; Vitamin D
Evaluation of the association between pollen count and the outbreak of allergic disease.
Allergy, Asthma & Respiratory Disease.2016;4(6):415-422. doi:10.4168/aard.2016.4.6.415
PURPOSE: This study focused on the evaluation of the relation between pollen concentration and the outbreak of allergic disease (symptom index), and this outcome would be necessary to upgrade risk grade for the pollen forecasting system. METHODS: Airborne particles carrying allergens, such as pollen, were collected daily at the Seoul and Guri area by using 7-day Burkard samplers for 6 years. A total of 596 Subjects were recruited from Hanyang University Seoul Hospital (n=144 for spring, n=139 for autumn), and Hanyang University Guri Hospital (n=157 for spring, n=156 for autumn). Symptom index was evaluated and recorded by phone calling to study subjects daily or asking questionnaire when they visit outpatient clinic every week. Statistical analysis of data was performed by using correlation coefficients and regression models with time series graph. RESULTS: Two peak seasons of pollen concentration were May and September in Korea. In skin prick tests, the sensitization rate to ragweed pollen was gradually increased in children. In the same period, sensitization rates to airborne pollen, especially oak, birch for spring, and Japanese hop for autumn were increased annually. There was a significantly relationship between symptom index of allergic patients and allergic pollen concentrations in this study. Especially symptom index was significantly correlated to the concentration of oak pollen of day 1 in spring and to the concentration of Japanese hop pollen of day 0 in autumn. CONCLUSION: Sensitization rates to pollens increased annually. There is a significant relationship between allergy symptom index and pollen concentration. There remains to confirm the Korean own risk grade of pollen allergy.
Allergens ; Ambrosia ; Ambulatory Care Facilities ; Asian Continental Ancestry Group ; Betula ; Child ; Forecasting ; Humans ; Hypersensitivity ; Korea ; Pollen* ; Rhinitis, Allergic, Seasonal ; Seasons ; Seoul ; Skin
Allergens ; Ambrosia ; Ambulatory Care Facilities ; Asian Continental Ancestry Group ; Betula ; Child ; Forecasting ; Humans ; Hypersensitivity ; Korea ; Pollen* ; Rhinitis, Allergic, Seasonal ; Seasons ; Seoul ; Skin
Country
Republic of Korea
Publisher
Korean Academy of Pediatric Allergy and Respiratory Disease; Korean Academy of Asthma, Allergy and Clinical Immunology
ElectronicLinks
http://synapse.koreamed.org/LinkX.php?code=0206AARDEditor-in-chief
Kyu-Earn Kim
Abbreviation
Allergy Asthma Respir Dis
Vernacular Journal Title
ISSN
2288-0402
EISSN
2288-0410
Year Approved
2013
Current Indexing Status
Currently Indexed
Start Year
2013
Description
Aims and Scope Download PDF in Korean The Allergy Asthma & Respiratory Disease journal (Allergy Asthma Respir Dis, AARD) is a peer-reviewed and open-access journal. Published bimonthly (January, March, May, July, September, and November), the journal features cuttingedge original research, state-of-the-art reviews in the specialties of allergy, asthma, clinical immunology and pediatric respiratory disease, including clinical and experimental studies and instructive case reports. Editorials explore controversial issues and encourage discussion among physicians dealing with allergy, asthma, clinical immunology and pediatric respiratory disease and related medical fields.
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