Journal Detail Information

1

Cite

Share

Sun Hee CHOI ; Dae Jin SONG ; Hye Yung YUM ; Yong Mean PARK ; Yeong Ho RHA

Allergy, Asthma & Respiratory Disease.2016;4(4):235-247. doi:10.4168/aard.2016.4.4.235

Cough is one of the common symptoms, which is usually related to respiratory infections for children. This symptom is not considered crucial. Published data reported that the community prevalence of chronic cough in primary school children is 5%-10%, while the prevalence is likely to be higher in younger children. The cause of persistent cough should be investigated. There were significant differences in the causes and management for cough according to age. Chronic cough is defined as duration of 4 weeks or longer. Common culprits for chronic cough in children are different from those in adults. The authors reviewed articles about chronic cough of children to help improve the understanding and management for pediatric chronic cough.
Adult ; Child* ; Cough* ; Diagnosis ; Humans ; Prevalence ; Respiratory Tract Infections

2

Cite

Share

Defining acute respiratory distress syndrome in children.

Joongbum CHO

Allergy, Asthma & Respiratory Disease.2016;4(4):233-234. doi:10.4168/aard.2016.4.4.233

No abstract available.
Child* ; Humans ; Respiratory Distress Syndrome, Adult*

3

Cite

Share

ERRATUM: Affiliation Correction. Evaluation of the association of vegetation of allergenic plants and pollinosis with meteorological changes.

Joo Hwa KIM ; Jae Won OH ; Ha Baik LEE ; Seong Won KIM ; Hai Lee CHUNG ; Myung Hee KOOK ; Kang Seo PARK ; Bong Seong KIM ; Ja Kyung KIM ; Dong Jin LEE ; Won Ki PAIK ; Kyu Rang KIM ; Hey Lim LEE ; Young Jin CHOI ; Seung Do YU ; Jeong Hwa KIM ; Yong Seong CHO

Allergy, Asthma & Respiratory Disease.2015;3(3):236-236. doi:10.4168/aard.2015.3.3.236

According to the author's request, in this paper, the eighth author's (Bong-Seong Kim) affiliation should be corrected.

4

Cite

Share

Birt-Hogg-Dube syndrome incidentally diagnosed during asthma management.

Jun Ho KIM ; Kyung Hee PARK ; Dong Hyun KIM ; Young Joo KIM ; Jung Won PARK ; Hye Jung PARK ; Jin Sung LEE ; Jong Rak CHOI ; Jae Hyun LEE

Allergy, Asthma & Respiratory Disease.2015;3(3):232-235. doi:10.4168/aard.2015.3.3.232

Birt-Hogg-Dube (BHD) syndrome is an autosomal dominant hereditary disorder characterized by 3 clinical manifestations, including skin fibrofolliculomas, multiple pulmonary cysts with or without spontaneous pneumothorax, and spontaneous renal tumor. A 60-year-old Korean male who had suffered from bronchial asthma incidentally diagnosed with multiple pulmonary cysts by computed tomography during a regular follow-up. Genetic studies revealed folliculin gene mutation that was a confirmative finding of BHD syndrome. Although this case showed no cutaneous manifestations or renal abnormality, genetic studies of his family and regular follow-up are recommended.
Asthma* ; Birt-Hogg-Dube Syndrome* ; Estrone ; Follow-Up Studies ; Humans ; Kidney Neoplasms ; Male ; Middle Aged ; Pneumothorax ; Skin

5

Cite

Share

Eosinophilic gastroenteritis which leads to mal-absorption and anemia associated with food allergies.

Young Geon KIM ; Eun Soo LIM ; Hyoung Joo KIM ; Won Sun CHOI ; Ga Na HONG ; Yoo Seob SHIN

Allergy, Asthma & Respiratory Disease.2015;3(3):228-231. doi:10.4168/aard.2015.3.3.228

Eosinophilic gastroenteritis (EG) is a rare disease characterized by massive eosinophilic infiltration of gastrointestinal tissue, peripheral eosinophilia, and nonspecific gastrointestinal symptoms. The mucosal type of EG commonly presented with malabsorption and anemia. However, the role of food allergy as a stimulus to EG has not yet been clearly defined. A 27-year-old man was referred to the Emergency Department with dyspepsia and leg swelling. The initial laboratory test should as follows: hemoglobin level, 6.4 g/dL; white blood cell count, 7,400/microL with 24.4% of eosinophil fraction; serum total protein, 3.9 g/dL; albumin level, 2.8 g/dL. Gastric endoscopy ruled out gastrointestinal bleeding showed multiple nodular raised lesions on the gastric antrum, which revealed increased eosinophilic infiltration (above 100/high power field). He had experienced nausea whenever eating beef, porks or fish. High serum specific IgE levels to offending foods (beef, 0.82 kU/L; pork, 0.83 kU/L; egg white, 0.40 kU/L; egg yolk, 0.54 kU/L; milk, 0.81 kU/L) were noted. He was instructed strictly to avoid food allergens with oral prednisolone therapy. Approximately 6 months after offending food restriction, the eosinophil count fell down to 400/microL, the hemoglobin level was returned to 11.5 g/dL and the serum albumin level was increased to 4.1 g/dL. We report a case of EG caused by multiple food allergy which leads to malabsorption and iron-deficiency anemia.
Adult ; Allergens ; Anemia* ; Anemia, Iron-Deficiency ; Dyspepsia ; Eating ; Egg White ; Egg Yolk ; Emergency Service, Hospital ; Endoscopy ; Eosinophilia ; Eosinophils* ; Food Hypersensitivity* ; Gastroenteritis* ; Hemorrhage ; Humans ; Immunoglobulin E ; Leg ; Leukocyte Count ; Malabsorption Syndromes ; Milk ; Nausea ; Prednisolone ; Pyloric Antrum ; Rare Diseases ; Serum Albumin

6

Cite

Share

Apple-dependent exercise-induced anaphylaxis.

Dong Hyun KIM ; Kyung Hee PARK ; Young Joo KIM ; Jun Ho KIM ; Hee Jae HAN ; Hye Jung PARK ; Jung Won PARK ; Jae Hyun LEE

Allergy, Asthma & Respiratory Disease.2015;3(3):224-227. doi:10.4168/aard.2015.3.3.224

Food-dependent exercise-induced anaphylaxis (FDEIA) is a specific variant of anaphylaxis that requires both vigorous physical activity and the ingestion of specific causative foods. In particular, occurrence for FDEIA is rarely associated with apples. A 17-year-old male experienced generalized urticaria, dyspnea, headache, vomiting, and presyncope after ingestion of an apple and then 2 hours of exercise. The skin prick test showed a strong positive reaction to apple crude allergen extract, whereas the results of an open food challenge and exercise provocation tests were negative. However, the exercise test after apple consumption provoked a positive reaction with generalized urticaria, dyspnea, and presyncope. We detected 17 kD IgE-reactive protein band in immunoblotting assay with apple crude extract and patient's serum.
Adolescent ; Anaphylaxis* ; Dyspnea ; Eating ; Exercise Test ; Food Hypersensitivity ; Headache ; Humans ; Immunoblotting ; Male ; Malus ; Motor Activity ; Skin ; Syncope ; Urticaria ; Vomiting

7

Cite

Share

Mixed plant extract-dependent exercise-induced anaphylaxis.

Jin Wha CHOI ; Jeong Ok LEE ; Jaehee CHOI ; Youngshin HAN ; Jihyun KIM ; Kangmo AHN

Allergy, Asthma & Respiratory Disease.2015;3(3):219-223. doi:10.4168/aard.2015.3.3.219

Food-dependent exercise-induced anaphylaxis (FDEIA) is a potentially life-threatening clinical reaction in which anaphylaxis develops when physical activity occurs within a few hours after ingesting a specific food. An 18-year-old girl experienced generalized urticaria, periorbital swelling, and dyspnea repeatedly by exercise after intake of a red ginseng health supplement. A confirmed diagnosis was established in this case by using an exercise challenge test after ingesting mixed-plant extract containing red ginseng health supplement. To the best of our knowledge, this is the first case of FDEIA caused by components in a red ginseng health supplement.
Adolescent ; Anaphylaxis* ; Diagnosis ; Dyspnea ; Female ; Humans ; Motor Activity ; Panax ; Plants* ; Urticaria

8

Cite

Share

Correlation between serum 25-hydroxyvitamin D3 and the severity of atopic dermatitis in children with allergic or nonallergenic sensitization.

Yong Jin HWANG ; Jin Wook CHOI ; Sung Woon KIM ; Kwang Hae CHOI ; Myong Soon SUNG

Allergy, Asthma & Respiratory Disease.2015;3(3):213-218. doi:10.4168/aard.2015.3.3.213

PURPOSE: The aim of this study was to assess the relationship between serum 25-hydroxyvitamin D3 levels and the severity of atopic dermatitis (AD), markers of atopy (total IgE, total eosinophil count, and eosinophil cationic protein) in AD children according to allergen sensitization. METHODS: This cross-sectional study was carried out on 160 AD patients aged 1 to 18 years between March 2012 and August 2014. The AD patients (AD group) were subdivided into 2 categories according to the results of the allergic skin prick and Unicap tests: the allergic and nonallergic AD groups. We compared 25-hydroxyvitamin D3 levels between the AD and control groups. We also investigated relationships between serum 25-hydroxyvitamin D3 levels, the severity of AD, and markers of AD (total IgE, total eosinophil count, and eosinophil cationic protein) in the allergic and nonallergic AD groups. RESULTS: The average 25-hydroxyvitamin D3 levels were 30.6+/-11.7 and 23.7+/-10.0 ng/mL, respectively, in the control and AD groups (P<0.001). The average 25-hydroxyvitamin D3 levels were 19.7+/-8.6 and 27.5+/-9.8 ng/mL, respectively, in the allergic and nonallergic AD groups, with clinical implications (P<0.001). The 25-hydroxyvitamin D3 levels were not significantly associated with SCORing Atopic Dermatitis index in the allergic (P=0.004, r=-0.092) or nonallergic (P=0.610, r=-0.58) AD groups. The 25-hydroxyvitamin D3 levels were not significantly associated with the aforementioned markers of atopy in the AD group. CONCLUSION: These results suggest that 25-hydroxyvitamin D3 may play a role in the pathogenesis of AD.
Allergens ; Calcifediol* ; Child* ; Cross-Sectional Studies ; Dermatitis, Atopic* ; Eosinophils ; Humans ; Immunoglobulin E ; Skin

9

Cite

Share

Indoor air pollutants and atopic dermatitis in socioeconomically disadvantaged children.

Sung Chul SEO ; In Soon KANG ; Soo Gil LIM ; Ji Tae CHOUNG ; Young YOO

Allergy, Asthma & Respiratory Disease.2015;3(3):206-212. doi:10.4168/aard.2015.3.3.206

PURPOSE: The aims of this study were to examine indoor concentrations of air pollutants in socioeconomically disadvantaged houses and to investigate relationships between indoor air pollutant levels and the severity of atopic dermatitis (AD). METHODS: A total of 54 children who had a past history or current symptoms of AD were enrolled in the study. To evaluate the levels of indoor air pollutants, we measured concentrations of CO2, total volatile organic compounds (TVOC), formaldehyde, particulate matter with diameter less than 10 microm (PM10), airborne mold and numbers of house dust mite (HDM) in dust of the children's houses. All studied subjects completed physical examination for the severity of AD and blood tests. RESULTS: Although the mean (+/-standard deviation [SD]) concentration of indoor CO2 (600.6+/-179.4 ppm) was lower than the standard recommended levels of multiplex buildings in Korea, there was a significant correlation between CO2 concentrations and the severity of AD (r=0.302, P=0.030). The geometric means (range of 1 SD) of TVOC (42.5 microg/m3 [22.2-81.5]), formaldehyde (24.3 microg/m3 [15.0-39.9]), PM10 (26.6 microg/m3 [14.6-48.4]), and airborne mold (49.9 CFU [colony forming unit]/m3 [26.3-94.6]) were not significantly higher than the standard recommended levels of multiplex buildings. Two-thirds of the subjects were sensitized to at least 1 of the common allergens. CONCLUSION: Generally, indoor air pollution was not serious in socioeconomically disadvantaged households. However, indoor CO2 concentrations are closely related to the severity of AD in children living in socioeconomically disadvantaged houses. Environmental amelioration targeting vulnerable population may improve the quality of life and decrease the prevalence of environmental allergic diseases.
Air Pollutants* ; Air Pollution, Indoor ; Allergens ; Child* ; Dermatitis, Atopic* ; Dust ; Family Characteristics ; Formaldehyde ; Fungi ; Hematologic Tests ; Humans ; Korea ; Particulate Matter ; Physical Examination ; Prevalence ; Pyroglyphidae ; Quality of Life ; Volatile Organic Compounds ; Vulnerable Populations*

10

Cite

Share

Component-resolved diagnosis using microarray for diagnosing hypersensitivity to raw fruits in birch pollen sensitized children.

Won Bok CHOI ; Jueng Sup YOU ; Yoon Young YI ; Soo In JEONG ; Joon Sup SONG ; Seong YANG ; Il Tae HWANG ; Ha Baik LEE ; Hey Sung BAEK

Allergy, Asthma & Respiratory Disease.2015;3(3):200-205. doi:10.4168/aard.2015.3.3.200

PURPOSE: Recently, component-resolved diagnosis (CRD) using microarray technology has been introduced to the field of clinical allergy. This study was aimed to investigate the clinical usefulness of microarray-based IgE detection for diagnosing clinical raw fruit allergy in birch pollen-sensitized children. METHODS: Thirty-one children with allergic disease who had been sensitized to pollen were studied. A pollen-sensitized patient was defined as having an allergen-specific history with concomitant positive skin-prick tests (SPTs) to natural allergen extracts or positive allergen-specific IgE. All subjects underwent SPTs for pollen and fruit. In all subjects, specific IgE to pollen and fruit were measured by ImmunoCAP. Specific IgE antibodies to allergen components were determined by a customized allergen microarray (ISAC). RESULTS: Thirteen of the 31 patients (41.9%) had a history of fruit hypersensitivity with positive SPTs. Measuring IgE to allergen components by ISAC, all the 13 patients with fruit hypersensitivity were positive to at least one of Mal d 1, Pru p 1, Pru p 3, Act d 8, and Act d 2 compared to 12 of the 13 patients (92.3%) who had at least 1 positive IgE to fruits (apple, peach, and kiwi) using ImmunoCAP. The sensitivity of ISAC microarray was 100.0% for the diagnosis of fruit hypersensitivity, but its specificity was 27.7% (5/18). The sensitivity of ImmunoCAP was 92.3%, and its specificity was 83.3%. CONCLUSION: The sensitivity of allergen components tested using microarray for the diagnosis of clinical fruit hypersensitivity in children with pollen allergy was high; however, its specificity was low.
Antibodies ; Betula* ; Child* ; Diagnosis* ; Fruit* ; Humans ; Hypersensitivity* ; Immunoglobulin E ; Pollen* ; Prunus persica ; Rhinitis, Allergic, Seasonal

DISPLAY OPTIONS

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share