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Result of DSA for 56 cases large liver cancer that there is bloody supply from arteria musculophrenica right and the value of selective interventional embolization therapy

Xiaoping LUO ; Mingxian YU

Chongqing Medicine.2001;(3):215-216,268. doi:10.3969/j.issn.1671-8348.2001.03.010

Objective To study the result of DSA for 56 cases with large liver cancer that there is bloody supply from arteria musculophrenica right and the clinical value of super selective interventional embolization,so that to improve the clinical curative effects of interventional therapy. Methods Employ 4F, 3F catheter super selectively into arteria musculophrenica that supply blood to cancer. Result 56 cases(21.7% )were discoverod that there was bloody supply from arteria musculphrenica right to cancer in 258 cases with large liver cancer, liver neoplastic size of all cases wasin 5～15cm,22 cases(8.6% ) were discovered in the first interventional operation,34 cases ( 13.3% )were discovered in the second or the third interventional operation. Obvious tumor shrinking in all cases: the 6month survival as 56 cases(100 % ), the 1-year survival as 45 cases (80.4%), the 2-year survival as 21 cases(37.5%). Conchssion Arteria musculophrenica right supply blood to cancer is common in large liver cancer eases, super selectively embolized the supply blood from the arteria musculophrenica right is very important for acquiring success by interventional operation.

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The early effect of the percutaneous kyphoplasty (PKP) in the treatment of age-related osteoporotic vertebral compression fractures

Lianghua TANG ; Zhigang CHENG ; Kai ZHONG ; Hongcheng YI ; Yi XIONG ; Ying LV ; Changying PENG

Chongqing Medicine.2013;(24):2837-2838,2841. doi:10.3969/j.issn.1671-8348.2013.24.006

Objective To investigate the early clinical effects of percutaneous kyphoplasty in the treatment of age-related osteo-porotic vertebral compression fractures .Methods Retrospected 54 cases with osteoporotic verebral compression fractures were treated with PKP ,summarized early clinical effects and complications .analysis of preoperative and postoperative wound vertebral height average recovery rate ,Cobb Angle ,VAS scores and ADL scores .Results Operations in all the 54 cases were completed smoothly ,47 cases for 6 to 24 months follow-up(mean 13 .5 months) .postoperative pain in 31patients obtained remission immedi-ately ,1 week after operation ,12 cases with lower back pain and need the non-steroidal anti-inflammatory medications ,the symptoms remissed significantly or disappeared after 8 weeks postoperatively .At the last follow-up ,4 patients still had low back pain and need oral analgesics .Preoperative and postoperative wound vertebral height average recovery rate ,Cobb Angle ,VAS scores and ADL scores was statistically significant .Conclusion PKP is a minimally invasive ,effective and safe procedure that provides pain relief and stabilization of spinal stability and activities under the bed early ,and improves quality of life at the same time .Grasping the indi-cations Strictly and holding the surgical skills can be obtained clinical results efficiently and safely .

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Analysis on safety of joint arthroplasty during perioperative period in 56 aged cases of femoral neck fracture

Xuquan WANG ; Ping HUANG ; Hao CHEN ; Zheng WANG

Chongqing Medicine.2013;(26):3115-3116,3119. doi:10.3969/j.issn.1671-8348.2013.26.014

Objective To investigate the safety of hip arthroplasty during the perioperative period in aged patients with femoral neck fracture .Methods The clinical data in 56 elderly cases of femoral neck fracture treated by hip arthroplasty ,aged more than 65 years old ,were performed the retrospective analysis .Results Among 56 cases ,54 cases hospitalized for 21d[(18-31)d] and suc-cessfully were discharged ,the Harris scores were increased from preoperative 30 (0 -38) to postoperative 83 (72 -91) ,the func-tion of hip joint was obviously improved ;2 cases with the preoperative poor tolerance score died during perioperative period ,there were 3 cases(5 .4% ) of postoperative hip hematoma ,1 cases(1 .79% ) of postoperative hematoma developed secondary bacterial in-fection after puncture and 3 cases (5 .4% ) of postoperative posterior dislocation in the early stage and no case of deep venous thrombosis (DVT) accompanying clinical symptoms .Conclusion Hip arthroplasty is a effective measure for treating aged patients with femoral neck fracture .But those patients with poor operative tolerance should select this operation cautiously

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Association study of cirrhosis and IL-12B gene polymorphism*

Weifeng ZHAO ; Gaoling GU ; Jingpei DU ; Changan LI ; Qian DOU ; Changyu SUN

Chongqing Medicine.2013;(24):2825-2826,2831. doi:10.3969/j.issn.1671-8348.2013.24.001

Objective To detect the genetic association between cirrhosis and polymorphism of IL-12B gene .Methods Observed in a sample of 173 parent/offspring trios where the proband net for cirrhosis using correlation analysis and haplotype relative risk a-nalysis .The polymorphism of rs15677380 ,rs14050311 of IL-12B gene was detected with PCR methods and SNP typing in all nucle-us families .Results The rs15677380 allele was connected with cirrhosis(P=0 .009) .Allele G was protect factor(Z= -2 .36) and allele A was the hazard factor(Z=2 .36) .The rs14050311 allele was connected with cirrhosis(P=0 .013) .Allele T was protect fac-tor(Z= -2 .24) and allele C was the hazard factor (Z=2 .24) .The haplotypes of G/T and A/C in the rs15677380 ,rs14050311 were associated with cirrhosis (P=0 .021 ,0 .015 ,Z= -1 .85、2 .16) .Conclusion It shows an association between cirrhosis and the poly-morphism of IL-12B gene in Chinese .

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Study on interventional preventive service in venereal clinic *

Shanchuan LEI ; Yin WU ; Qianqiu WANG ; Suping WANG ; Mao XUE ; Guohui WU

Chongqing Medicine.2013;(27):3264-3265,3268. doi:10.3969/j.issn.1671-8348.2013.27.023

Objective To study and evaluate the effect of developing the preventive service in venereal clinic .Methods The questionnaire survey on the selected outpatients was performed by the trained medical personnel in the venereal disease clinic of 5 medical institutions in Chongqing .The intervention services were carried out by providing healthy advices and tailor-made preven-tive packs .The healthy knowledge publicity were posted in the waiting area of the venereal clinic .The questionnaire investigation in the re-visiting patients was performed again to understand the awareness of prevention venereal disease knowledge and the condom use .Results 96 .4% of outpatients in this study accepted the AIDS-related knowledge at the first visit .84 .1% of them acquired the knowledge by consulting their doctor ,60 .9% of the patients insisted on using condom in sexual activity after accepting the interven-tion knowledge ,which was much higher than 17 .4% before intervention .Conclusion The STD clinic attenders satisfy the interven-tional preventive service in the venereal clinic ,the improvement of the venereal disease related knowledge and the adverse behaviors is obvious .

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Analysis of risk factors to acute lung injury based on multiple trauma *

Yaqin YANG ; Yonghua XIA ; Bing SUN ; Jinhe SHI ; Dongliang LIANG

Chongqing Medicine.2013;(27):3255-3256,3259. doi:10.3969/j.issn.1671-8348.2013.27.019

Objective To investigate the risk factors to acute lung injury based on multiple trauma to provide a theoretical basis for early intervention .Methods The emergency surgical patients with multiple trauma in our hospital from March 2006 to March 2011 were selected .The patients meeting the diagnostic criteria for acute lung injury were taken as the study group and the others as the control group .All patients were enrolled for evaluating the injury severity score (ISS) ,acute physiology and chronic health Ⅱ(APACHE Ⅱ) score and recording smoking ,alcohol abuse ,diabetes mellitus ,number of organ damage ,gastrointestinal bleeding , pulmonary contusion ,diffuse intravascular coagulation (DIC ) ,vomiting ,traumatic shock ,time to correct shock ,blood transfusion . The polymorphism of rs3788853 ,rs13306087 ,rs12709426 of angiotensin-converting enzyme(ACE) gene were analyzed .Results In the study group and the control group ,there were statistical differences in 6 influencing factors of the ISS ,APACHE Ⅱ score ,blood transfusion ,DIC ,traumatic shock ,time to correct shock>6 h(P<0 .05);the gene and genotype frequencies of ACE between the two groups had no statistical difference (P>0 .05);the 6 kinds of influencing factors were risk to acute lung injury based on multi-ple trauma by Logistic regression analysis .Conclusion The ISS ,APACHE Ⅱ score ,blood transfusion ,DIC ,traumatic shock ,long time to correct shock are the risk factors to acute lung injury based on multiple trauma .

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Efficacy and immune of gamma globulin in treatment of dilated cardiomyopathy complicating heart failure *

Xinling MO ; Fusheng XIE ; Guangdao HOU

Chongqing Medicine.2013;(27):3249-3250,3254. doi:10.3969/j.issn.1671-8348.2013.27.017

Objective To observe the anti-cardiac myosin heavy chain IgG changes and efficacy of the antibody titration during the treatment of dilated cardiomyopathy (DCM ) complicating heart failure by a large number of gamma globulin .Methods 28 inpa-tients with dilated cardiomyopathy complicating heart failure were taken as the experimental group ,28 cases of healthy examination as the control group .The anti-cardiac myosin heavy chain IgG antibodies were detected by ELISA ;moreover ,among the patients with heart failure treated by the conventional therapy ,14 cases were selected and added large dose of gamma globulin for observing the curative effect .The remaining 14 cases were taken as the standard control group of this experiment .The anti-cardiac myosin heavy chain IgG antibodies were detected by ELISA .Results The anti-cardiac myosin heavy chain IgG antibodies before gamma globulin therapy in the DCM complicating heart failure group had statistical difference compared with the healthy examination goup (P<0 .05);in the 14 cases of heart failure treated by large dose of gamma globulin ,11 cases (78 .57% ) in the treatment group were improved ,while 5 cases(35 .71% ) in the standard control group were improved ,the anti-cardiac myosin heavy chain IgG antibody had no significant differences between the gamma globulin treatment group and the healthy examination group .The left ventricular ejection fraction(LVEF) in the gamma globulin treatment group was increased from (36 .12 ± 9 .98)% to (46 .15 ± 12 .18)% ,the left ventricular end-diastolic diameter was decreased from (59 .68 ± 9 .60) mm to (50 .05 ± 10 .20) mm ,the effects after gamma glob-ulin treatment were more significant than the conventional traditional control group .Conclusion Large dose of gamma globulin for treating dilated cardiomyopathy complicating heart failure has more significant effect than the traditional method ,reduces the titra-tion of in vivo anti-cardiac myosin heavy chain IgG antibody and contributes to explain the drug action mechanism from immune mechanism .

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Clinical analysis of 35 cases of upper gastrointestinal heterotopic pancreas

Jie SHEN ; Zhi LI ; Yuliang XIAO ; Yu ZOU ; Han CHEN ; Xikun HE

Chongqing Medicine.2013;(27):3244-3245,3248. doi:10.3969/j.issn.1671-8348.2013.27.015

Objective To explore the cinical ,endoscopic and endoscopic ultrasonography (EUS) manifestations of upper gastro-intestinal heterotopic pancreas(HP) and the treatment value .Methods The clinical data in 35 cases of upper gastrointestinal HP confirmed by pathology in our hospital were retrospectively analyzed for summarizing its clinical symptoms ,endoscopic and EUS manifestations and the treatment effect under endoscopy .Results Among all the 35 cases ,the cinlincal symptoms were in 30 cases , upper abdominal pain in 18 cases ,abdominal distension in 5 cases ,belching in 4 cases ,melena in 3 cases ,the lesion was located in gastric antrum in 23 cases ,in gastric body in 3 cases ,in gastric fundus in 3 cases ,in gastric angle in 2 cases ,in the junction of gastric antrum and corpus ventriculi in 2 cases ,in durodenal bulb in 2 cases ,most HP were represented by protuberant lesions under endos-copy ,the diameter of the lesions ranged 0 .5-2 .0 cm .20 cases were centrally umbilicated hollow with ducts opening on the top of the protuberant lesion .Under EUS ,the lesions involved submucosa in 28 cases ,mucosa in 2 cases ,muscularis mucosae in 4 cases , and muscularis propria in 1 case .4 cases appeared as the midium echo ,24 cases as hypoecho and 7 cases as mixed echo ,among them ,the tubular structure echo within the lesions were found in 10 cases .20 cases were treated by endoscopic mucosal resection (EMR) ,15 cases were performed the ligation combined with the high frequency electroresection .Intraoperative bleeding occurred in 3 cases and no other complicntions such as perforation occurred .Conclusion The clinical manifestations of upper gastrointestinal HP have no specificity .Gastroendoscopy combimed with EUS has the important value in the diagnosis and endoscopis therapy .En-doscopic EMR and ligation combined with the high frequency electroresection are the safe and effective means for treating upper gastrointestinal HP .

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Treatment regimen selection for newly diagnosed type 2 diabetes after short-term intensive insulin therapy with insulin pump *

Hao YANG ; Juan XIANG ; Xi YUE

Chongqing Medicine.2013;(27):3214-3216,3218. doi:10.3969/j.issn.1671-8348.2013.27.003

Objective To investigate the effects of short-term continuous subcutaneous insulin infusion (CSII) in newly diag-nosed type 2 diabetes mellitus(T2DM ) and to evaluate the treatment regimen conversion after CSII therapy .Methods 72 patients with newly diagnosed T2DM were treated with CSII for 2 weeks .Then they were randomly divided into two groups :the basal insu-lin group(glargine) and the oral anti-diabetic drug(OAD) group .Both groups were followed up for 2 years .Blood glucose ,insulin and HbA1c were measured before and after CSII and during the 2-year follow-up .Results CSII significantly controlled the glucose levels ,reduced the TG ,TC ,LDL levels and the homeostasis model assessment of insulin resistance ( HOMA-IR) and increased the homeostasis model assessment of insulin secretion (HOMA-IS)(all P< 0 .05) .During 1-year follow-up ,HbA1c in the glargine group and the OAD group was (6 .13 ± 0 .47)% and(6 .21 ± 0 .38)% respectively .During 2-year follow-up ,the HbA1c values in the two groups were (6 .91 ± 0 .57)% and(6 .43 ± 0 .62)% respectively .T HOMA-IR and HOAM-IS obtained the long tern improve-ment without significant body weight increase .Conclusion Short-term intensive insulin therapy can effectively control the blood glucose ,improve the sensitivity of insulin and the β-cell function ;after CSII ,adopting basic insulin and oral antidiabetic drugs can a-chieve the ideal glycemic control .

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Effect of alcohol consumption on bone mineral density in males *

Weibo XIE ; Li XU ; Qinghua ZHAO ; Mingjun ZHANG ; Yonghong WANG ; Yu WANG

Chongqing Medicine.2013;(21):2519-2520,2542. doi:10.3969/j.issn.1671-8348.2013.21.029

Objective To evaluate the effect of alcohol consumption on bone mineral density in males .Methods Association be-tween bone mineral density ,alkaline phosphatase and alcohol history ,daily alcohol consumption were analysed retrospectively in 563 men undergone physical examination .Results Of all the participates ,31 .6% has history of alcohol consumption for more than one year .The rate of osteopenia and osteoporosis was 31 .4% and 5 .9% ,respectively .The reduction of bone mineral density was posi-tively correlated with age ,length of alcohol consumption history ,daily alcohol consumption volume and the serum alkaline phospha-tase levels(P<0 .01) .The rate of osteopenia and osteoporosis were increased significantly in the males who had alcohol consump-tion history(P<0 .01) ,and paralleled with the increase of daily alcohol consumption (P<0 .01) .The alkaline phosphatase level of males with a history of alcohol consumption more than 20 years were higher than the ones without history of alcohol intake .While alkaline phosphatase level of the ones taking daily alcohol more than 50 g was higher than less than 50g or no consumption signifi-cantly(P<0 .05) .Conclusion Alcohol consumption is an important risk factor of male osteoporosis .

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