Journal Detail Information

1

Cite

Share

Protective Effects of Inonotus Obliquus Polysaccharide on Liver Injury Induced by Anti-tuberculosis Drugs in Mice

Xiuhong ZHONG ; Shuyan YANG ; Liwei ZHAO ; Zhonghua ZHENG ; Yizhong ZHANG ; Shuang WANG ; Yue ZHONG ; Min GUO ; Ningjiang YANG

Herald of Medicine.2014;(5):558-561. doi:10.3870/yydb.2014.05.002

Objective To study the protective effect and mechanism of Inonotus obliquus polysaccharide on liver injury induced by isoniazid( INH) combined with rifampicin( RFP) in mice. Methods Forty-eight mice were randomly divided into six groups ( control, model, huganpian, Inonotus obliquus polysaccharide at low, middle, and high dose ) . The mice were administered orally with isoniazid and rifampicin simultaneously except the control. After 2 h,the control and model groups were administered with normal saline,and others were treated with huganpian and Inonotus obliquus polysaccharide,respectively,once a day for 2 weeks. The liver index and serum levels of ALT and AST,malondialdehyde(MDA),superoxide dismutase(SOD) and glutathione peroxidase( GPx) were measured. Pathology examination of liver tissue was performed. Results The activities of ALT and AST, liver index, content of MDA in liver homogenate of mice treated with Inonotus obliquus polysaccharide and huganpian decreased obviously, while the liver SOD activity increased. Histopathological exzamination showed that Inonotus obliquus polysaccharide alleviated the degeneration and necrosis of hepatic cells. Conclusion Inonotus obliquus polysaccharide shows protective effects on mice with hepatic toxic injury induced by isoniazid and rifampicin,which maybe due to its antioxidation effect.

2

Cite

Share

Comparative Studies of Anti-inflammation and Analgesic Effects between X. Sibiricum and X. Mongolicum

Xiaomei FU ; Yanchao SUN ; Jing LIU ; Zhigui WU ; Jianguo PEI ; Shuimei PENG ; Daopeng TAN

Herald of Medicine.2014;(5):555-557. doi:10.3870/yydb.2014.05.001

Objective To investigate the anti-inflammatory and analgesic activities of different extracts from X. mongolicum compared with that of X. sibiricum. Methods Seventy male Kunming mices were randomly divided into seven groups:control group,aspirin group,the ethanol extracts of X. sibiricum group and X. mongolicum group,the extracts from X. mongolicum with ether,ethyl acetate,and n-butyl alcohol group(n=10 each). The mice were administrated with 500 mg·kg-1 ( p. o. ) of different extracts. The hot-plate tests and the xylene-induced ear edema in mice were performed to observe the analgesic and anti-inflammatory activities,respectively. Results In the hot-plate tests,the pain threshold from the extracts of X. sibiricum and the different extracts from X. mongolicum at 60,120,180 min were prolonged,and there was no statistically significant differences(P>0. 05) between the ethanol extracts from X. sibiricum and X. mongolicum. The best analgesic activity was the ether and butyl alcohol extracts from X. mongolicum. Meanwile,the ear edema from the extracts of X. sibiricum and the different extracts of X. mongolicum were inhibited significantly(P<0. 05). There was also no significant differences between the ethanol extracts of X. sibiricum and X. mongolicum(P>0. 05). The ether and butyl alcohol extracts from of X. mongolicum showed the best anti-inflammatory effect. Conclusion X. mongolicum exhibites significant anti-inflammatory and analgesic activities comparable to that of X. sibiricum. The best anti-inflammation and analgesic activities were from ether and butyl alcohol extracts from X. mongolicum.

3

Cite

Share

Clinical Analysis of 94 Cases of Drug Eruption

Wu TING ; Xia QING

Herald of Medicine.2001;(3):197-198. doi:10.3870/j.issn.1004-0781.2001.03.048

Objective:To make clear which drugs can cause drug eruption.Methods:Clinical analysis was made based on the patients data regarding the types of the drup eruption and the severity of liver impairment.Results:There are four types of drugs which can cause drug eruption:antibiotics (55.3%),antipyretic analgesic(26.6%)，Chinese medicine (9.6%) and biological preparations (8.5%).The drug eruptions usually manifested as unticaria,measles-like eruption,multiform erythma and stable eruption.Conclusion:The main allergic drugs are antibiotics and antipyretic analgesic.However,attention should also be payed to the Chinese medicine and biological preparations.

4

Cite

Share

Analysis of Application of Antihypertensive Drugs in Wuhan Xiehe Hospital

Pu HUANG ; Dongsheng CHEN ; Jing LIU

Herald of Medicine.2001;(3):188-189. doi:10.3870/j.issn.1004-0781.2001.03.038

Objective:To review the application of antihypertensive drugs in Wuhan Xiehe Hospital in the period of 1996 to 1998.Methods:Statistically analyze the application of antihypertensive drugs during the period in terms of their types,sales income,DDDs*d-1 as well as the changes of daily expense on drugs.Results:During the period analyzed,the newly applied drugs are mainly ACEI drugs.The DDDs*d-1 of metoprotol,benazepril,nifedipine and nimodipine had been among the highest.The increase of DDDs*d-1 was rapid.The newly prescribed drugs were mainly oral and retard preparations.Conclusion:The Prescription of antihypertensive drugs in Wuhan Xiehe Hospital was rational and in accordance to the principles of convenience and cost-effectiveness.

5

Cite

Share

Treating Primary Hypertension with Felodipine—a report of 98 cases

Jiang WEN

Herald of Medicine.2001;(3):158-159. doi:10.3870/j.issn.1004-0781.2001.03.010

Objective:To observe the therapeutic effect of felodipine in treatment of primary hypertension.Methods:Among 98 patients with primary hypertension (60 male,38 female,aged 56±4 years) recruited in the outpatient department,81 were treated with oral intake of 5 mg of felodipine once a day for a total of 8 weeks; 17 with the same dose of felodipine plus captopril.Results:The total effective rate was 90.8%,with 49.0% of the patients showing a significant improvement.Conclusion:Felodipine is effective for the treatment of primary hypertension,it can decrease the SDP up to 3.9±0.4 kPa.Meanwhile,the side effect is mild.

6

Cite

Share

Therapeutic Effect of milrinone in Treatment of Refractory Heart Failure Patients

Wenxia ZONG ; Li LIN ; Chang LI

Herald of Medicine.2001;(3):156-157. doi:10.3870/j.issn.1004-0781.2001.03.008

Objective:To evaluate the effect of milrinone in treating refractory heart failure.Methods:5mg of milrinone in 250ml of 5% Glucose or 0.9% NaCl Solution were given daily by intravenous drip to 56 cases of refractory heart failure for a period of consecutive 7 days.The symptoms and signs were observed before and after the treatment,heart rate,blood pressure and heart function examined by Doppler echocardiography.Results:a.The total effective rate was 85.7%.b.The left ventricular ejection fraction (LVEF) and fraction shortening (FS) were increased significantly (P＜0.01) after treatment.The rate of filling velocity in early diastole (E) over that in late diastole (A) was increased significantly (P＜0.05).Conclusion:Milrinone has good effect for treating refractory heart failure.It improves not only the cardiac systolic function but also the diastolic function.

7

Cite

Share

The Effect of Fragmin in Treatment of Unstable Angina

Hongbin LU ; Jianhua LI ; Qingjun WU

Herald of Medicine.2001;(3):154-155. doi:10.3870/j.issn.1004-0781.2001.03.006

Objective:To study the effect of Fragmin in treatment of unstable angina (UA).Methods:100 patients with UA were randomized into treatment group and control group.In the control group,the subjects were given routine drugs such as sorbitrate,nifedipine and aspirin,while those in the treatment group given fragmine in addition to the routine drugs.Results:The response rates in the treatment and control groups were 82.1% and 54.5%,respectively (P＜0.01).The total effective rates in the treatment and control groups were 92.9% and 63.6%,respectively (P＜0.01).The total effective rate of EKG improvement in the treatment and control groups were 80.4% and 50.0%,respectively (P＜0.01).Conclusion:Fragmin is effective in the treatment of UA.

8

Cite

Share

Effect of Different Does of Simvastatin in Reducing Serum Lipid

Zhe QI ; Jilin CHEN ; Li FANG ; Julan XIANG ; Min WANG

Herald of Medicine.2001;(3):152-153. doi:10.3870/j.issn.1004-0781.2001.03.004

Objective:Comparing the effect of different doses of simvastatin in lowering the serum lipid.Methods:79 patients were randomized into group A and group B,and were given simvastatin 10 mg*d-1 (group A) and 20 mg*d-1 (group B),respectively for a total of 8 weeks.Results:Comparing with baseline,in group A,TC,TG,LDL-C were decreased by 23.4%,20.0% and 30.7%,respectively (P＜0.01); HDL-C was increased by 17.5%.The content of serum TC,TG and LDL-C was decreased to the normal range in 12.8%,28.2% and 15.4% of the patients in group A.For the group B,TC,TG,LDL-C were decreased by 32.7%,22.8% and 42.8%,respectively (P＜0.01); HDL-C was increased by 13.7%.The content of serum TC,TG and LDL-C was decreased to the normal range in 65.0%,57.5% and 65.0% of the group B patients.Conclusion:Oral intake of 20 mg of simvastatin once a day can effectively reduce the serum lipid.The patients can well tolerate and no obvious side effect was observed in our study.

9

Cite

Share

Treating acute myocardial infarct with recombinant tissue-type plasminogen activator

Zhongdu GAO ; Li LIU ; Heng JIANG ; Baohong LIU ; Benxiang CAI

Herald of Medicine.2001;(3):150-151. doi:10.3870/j.issn.1004-0781.2001.03.003

Objective:To Observe the effect of recombinant tissue-type plasminogen activator (rt-PA) in treatment of acute myocardial infarct.Methods:Two groups of patients were observed.The subjects in the control group (35 patients) were treated with routine intervention,while those in thrombolysis group (15 patients) were treated with rt-PA in addition to the routine intervention.Results:There is a better outcome in the thrombolysis group as compared with that in the control group,in terms of length of angina relief,degree and length of EKG changes as well as the time for serum enzyme changes.The mortality rate in the thrombolysis group was significantly lower than that in the control group (P＜0.01).Conclusion:The rt-PA for thrombolysis in acute myocardial infarct patients can reduce the infarct size and improve the cardiac function rapidly as well as increase the survival rate.

10

Cite

Share

Thrombolysis for Treating Acute Deep Vein Thrombosis in the Lower Limbs

Zhongchao WANG ; Haijun DU ; Guoxi WEI

Herald of Medicine.2001;(3):182-183. doi:10.3870/j.issn.1004-0781.2001.03.029

Objective:To observe the effect of thrombolysis in treating acute deep vein thrombosis (DVT) in the lower limbs.Methods:For the 14 patients diagnosed by colour Doppler ultrasonographic examination,intravenous drip of urokinase,dextran and mailuoning was ministered alternatively through the superficial venosus dorsalis pedis in the involved side.Meanwhile,oral intake of aspirin and dipyridamole was also prescribed.Results:Ten patients healed and four significantly improved.Conclusion:The efficacy of thrombolysis for treatment of DVT in the lower limbs is valid.This intervention is especially suitable for those patients who missed the optimum time window of operation.

DISPLAY OPTIONS

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share