Misdiagnosis analysis of childhood ovary disease in 10 cases.
Chinese Journal of Contemporary Pediatrics.2012;14(2):150-151.
Adolescent ; Child ; Diagnostic Errors ; Female ; Humans ; Ovarian Diseases ; diagnosis ; pathology ; surgery
Chinese Journal of Contemporary Pediatrics
1999 to Present ISSN: 1008-8830
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Adolescent ; Child ; Diagnostic Errors ; Female ; Humans ; Ovarian Diseases ; diagnosis ; pathology ; surgery
Application of continuous blood purification in critically ill children.
Chinese Journal of Contemporary Pediatrics.2012;14(2):147-149.
Adolescent ; Anticoagulants ; therapeutic use ; Body Temperature ; Child ; Child, Preschool ; Critical Illness ; therapy ; Female ; Hemodynamics ; Hemofiltration ; Humans ; Infant ; Male
Clinical analysis of permanent neonatal diabetes mellitus in 10 cases.
Chinese Journal of Contemporary Pediatrics.2012;14(2):144-146.
Diabetes Mellitus ; drug therapy ; genetics ; Female ; Follow-Up Studies ; Humans ; Infant, Newborn ; Insulin ; therapeutic use ; Male
Chinese Journal of Contemporary Pediatrics.2012;14(2):139-143.
OBJECTIVETo study the effects of environmental enrichment on neuron proliferation, learning and memory ability and motor ability in neonatal rats with hypoxic-ischemic brain damage (HIBD).
METHODSOne hundred and eight 7-day-old Sprague-Dawley rats were randomly divided into three groups: sham operation (CON group), HIBD and intervention group. HIBD model was prepared according to the classic Rice-Vannucci method. Environmental enrichment was administered for the rats in the intervention group after HIBD inducement. Behavioral tests (Water maze test, Suspension test and Slope test) were performed and the number of neural cells in the left hippocampus was examined 7, 14 and 28 days after intervention.
RESULTSThe pyramid cells in the hippocampus CA1 area in the HIBD group were significantly less than in the CON group at 7, 14 and 28 days (P<0.05). The number of pyramid cells in the hippocampus CA1 area in the intervention group was significantly higher than in the HIBD group (P<0.01) at 7, 14 and 28 days. The hidden platform escape latency period (EL) in the Water maze test was significantly more prolonged and the cross-platform number within 2 minutes was significantly less in the HIBD and the intervention groups than in the CON group at all observed time points (P<0.01). The EL was significantly shorter and the cross-platform number within 2 minutes was significantly higher in the intervention group than in the HIBD group at all observed time points (P<0.01). The maintain time and score in the Suspension test were significantly lower and the time in the Slope test was significantly more prolonged in the HIBD and intervention groups than in the CON group at 7, 14 and 28 days (P<0.01). An increased maintain time and score and a decreased time in the Slope test were found in the intervention group compared with the HIBD group at 14 and 28 days (P<0.01).
CONCLUSIONSEnvironmental enrichment can improve motor function, learning and memory ability, and promote the repair and proliferation of neurons in neonatal rats with HIBD.
Animals ; Animals, Newborn ; Cell Proliferation ; Environment ; Female ; Hippocampus ; pathology ; Hypoxia-Ischemia, Brain ; physiopathology ; Male ; Maze Learning ; Motor Activity ; Neurons ; physiology ; Rats ; Rats, Sprague-Dawley
Recruitment maneuver in the treatment of young piglets with acute lung injury.
Chinese Journal of Contemporary Pediatrics.2012;14(2):134-138.
OBJECTIVETo study the feasibility, efficiency and any benefits of recruitment maneuver (RM) in the facilitation of lung repair during recovery from ALI in acute lung injury (ALI) model of young piglets.
METHODSThe piglet model of ALI was established by an intravenous injection of lipopolysaccharide (LPS). Twelve ALI piglets were randomly divided into two groups: conventional ventilation (CON) and RM with low tidal volume. Arterial blood gas, dynamic lung compliance (Cdyn) and systematic hemodynamics were monitored during the treatment. TGF-β1 levels in bronchoalveolar lavage fluid (BALF) and plasma were measured. The mRNA expression of TGF-β1 in the lungs was assessed by real time PCR. Lung tissue was examined for morphological changes.
RESULTSNo significant difference was observed in cardiac output and peripheral vascular resistance (PVR) between the two groups. The extravascular lung water index (ELWI) from 6 hrs after ALI inducement and the pulmonary vascular permeability index (PVPI) 8 hrs after ALI inducement in the RM group decreased significantly compared with the CON group. Cdyn in the RM group increased quickly 1 hr after ALI inducement, and there was a significant difference between the two groups (P<0.05). P/F (ratio of PaO2 to FiO2) in the RM group was significantly higher than in the CON group from 2 hrs after ALI inducement (P<0.05). Alveolar-to-arterial oxygen difference in the RM group was obviously lower compared with the CON group from 2 hrs after ALI inducement (P<0.05). The levels of TGF-β1 in plasma and BALF and the mRNA expression of TGF-β1 in the lung tissue were lower than in the CON group. Volume density of alveolar aeration in the RM group was significantly higher than in the CON group, and the injury score in the RM group was lower (P<0.05).
CONCLUSIONSRM can improve gas exchange and Cdyn in the treatment of piglets with ALI. RM is a safe and effective approach to alveolar recruitment and can alleviate ventilation induced lung injury.
Acute Lung Injury ; pathology ; physiopathology ; therapy ; Aging ; Animals ; Disease Models, Animal ; Hemodynamics ; Lung ; pathology ; Male ; RNA, Messenger ; analysis ; Swine ; Transforming Growth Factor beta1 ; analysis ; genetics
Clinical features of drug-induced liver injury in children.
Chinese Journal of Contemporary Pediatrics.2012;14(2):131-133.
OBJECTIVETo study the clinical features of drug-induced liver injury in children.
METHODSThe clinical data of the hospitalized children with drug-induced liver injury over 5 years were retrospectively reviewed.
RESULTSOf 641 cases of hospitalized children with liver injury, there were 64 cases (10%) of drug induced liver injury. Hepatocellular injury was the most common type of drug-induced liver injury (81%). The major drugs causing drug-induced liver injury included chemotherapy drugs, antibiotics and anti-tuberculosis drugs. Rash (16%), gastrointestinal reaction (15%), fever (14%) and liver intumescence (12%) were common clinical symptoms. A part of patients with drug-induced liver injury (11%) had no symptoms and signs.
CONCLUSIONSDrug-induced liver injury is one of the common causes of liver damage in hospitalized children. Some children with drug-induced liver injury have no symptoms and signs. Hepatocellular injury is a major type of drug-induced liver injury in children, resulting less severe liver damage.
Adolescent ; Chemical and Drug Induced Liver Injury ; diagnosis ; epidemiology ; Child ; Child, Preschool ; Female ; Humans ; Infant ; Male ; Retrospective Studies
An epidemiological survey of febrile convulsions among pupils in the Wenzhou region.
Chinese Journal of Contemporary Pediatrics.2012;14(2):128-130.
OBJECTIVETo study the prevalence and clinical features of febrile convulsion (FC) among pupils in the Wenzhou region, Zhejiang Province, China.
METHODSUsing a random stratified cluster sampling method, 6406 children under 12 years from two primary schools of urban areas and two primary schools of rural areas were surveyed.
RESULTSThe prevalence of FC was 3.67% (235/6406). Most children (75.7%) experienced their first onset of FC at 6 months to 3 years of age (median: 16 months). The seizures were generalized (95.3%, 224/235), with a duration of less than 10 minutes (86.4%, 203/235). FC was developed into epilepsy in 13 children (5.5%) who all suffered from complex FC. Relapses were noted in 88 cases (37.4%), among whom 38 patients had only 1 recurrence and 50 patients had 2 or more relapses. EEG was performed in 200 cases, among whom 12(6.0%) showed abnormalities.
CONCLUSIONSThe prevalence of FC is 3.67% among pupils in the Wenzhou region. The seizures are generalized, with a short duration. A part of complex FC can be developed into subsequent epilepsy.
Child ; Child, Preschool ; China ; epidemiology ; Female ; Humans ; Male ; Prevalence ; Recurrence ; Risk Factors ; Seizures, Febrile ; epidemiology
Epileptiform discharges and sleep structure in children with nocturnal epilepsy.
Chinese Journal of Contemporary Pediatrics.2012;14(2):124-127.
OBJECTIVETo study the epileptiform discharges and sleep structure in children with nocturnal epilepsy.
METHODSA total of 54 children with nocturnal epilepsy (NE group) between December 2009 and June 2011 were enrolled in this study using a cluster sampling method. Their epileptiform discharges and sleep structure were monitored using nocturnal 12 h-video-echoencephalography (EEG) and polysomnography. Meanwhile, 40 age- and gender-matched normal children were enrolled as the control group.
RESULTSAll the 54 children in the NE group suffered from epileptiform discharges and a varied number of clinical seizures, especially at S1 and S2 states. Compared with the control group, S1 and S2 states had significantly higher proportions in the NE group, and S3 and S4 states and REM state had significantly lower proportions (P<0.01).
CONCLUSIONSEpileptiform discharges and clinical seizures are more common in children with nocturnal epilepsy, especially during the non-rapid eye movement sleep. Meanwhile, remarkably disordered sleep structure also exists.
Child ; Child, Preschool ; Electroencephalography ; Epilepsy ; physiopathology ; Female ; Humans ; Male ; Polysomnography ; Sleep ; physiology
Relationship between TIM-4 polymorphism and childhood asthma.
Chinese Journal of Contemporary Pediatrics.2012;14(2):120-123.
OBJECTIVETo elucidate whether the polymorphism of asthma immune regulator gene TIM-4 is associated with the risk of childhood allergic asthma in the southwest region of China.
METHODSTIM-4 gene promoter region RS6882076 and intron RS4704727 were studied. PCR-RFLP was used to test the genotypes of two polymorphism loci among 579 cases (average 7.2 years old) of asthma and 524 controls (average 7.6 years old) in a case-control study.
RESULTSThere were significant differences in the frequency of gene types at RS4704727 site between the asthma and the control groups (P<0.01). The results of PCR-RFLP showed that the polyporphisms of RS6882076 and RS4704727 in TIM-4 gene were present in this study population. The frequency of T allele at the RS4704727 site in the asthma group was significantly lower than that in the control group (OR=1.603; 95%CI 1.304-1.971; P<0.01). There were no significant differences in the frequencies of gene types and allele at RS6882076 site between the two groups (P>0.05).
CONCLUSIONSRS4704727 polymorphism of TIM-4 gene may be associated with childhood asthma, providing a better understanding of the pathogenesis of childhood asthma in the Southwest region of China.
Asthma ; etiology ; genetics ; Child ; Female ; Humans ; Male ; Membrane Proteins ; genetics ; Polymorphism, Single Nucleotide ; Promoter Regions, Genetic
Correlation between insulin resistance and myocardial injury in critically ill children.
Chinese Journal of Contemporary Pediatrics.2012;14(2):117-119.
OBJECTIVETo study the relationship between insulin resistance and myocardial injury in children with critical diseases in light of the fact that such children usually suffer from noticeable insulin resistance and myocardial injury.
METHODSSixty-three children with critical diseases who were admitted between March 2010 and June 2011 were enrolled to comprise a case group. Fasting blood glucose, serum insulin, myocardial enzyme, and troponin I (CTnI) levels were measured. The insulin resistance index (HOMA-IR) was calculated. The children were classified into two groups: insulin resistance (HOMA-IR>1.0; n=30) and non-insulin resistance (HOMA-IR≤1.0; n=33). Thirty healthy children served as the control group.
RESULTSHOMA-IR, lactate dehydrogenase (LDH), aspartate aminotransferaseaspartate transaminase (AST), creatine kinase (CK), isoenzymes of creating kinase (CK-MB), α-hydroxybuty rate dehydrogenase (α-HBDH) and CTnI in the insulin resistance group were higher than those in the non-insulin resistance and the control groups (all P<0.05). The non-insulin resistance group also showed obviously higher levels in terms of LDH, AST, CK, CK-MB, α-HBDH, and CTnI than the control group (P<0.05). In the insulin resistance group, there exists a positive correlation between HOMA-IR and such indicators as LDH, CK, CK-MB, AST, α-HBDH and CTnI (r=0.697, 0.739, 0.781, 0.642, 0.381, 0.792 respectively; all P<0.05).
CONCLUSIONSInsulin resistance makes myocardial injury more serious; HOMA-IR can serve as a forecast indicator for the degree of myocardial injury.
Aspartate Aminotransferases ; blood ; Cardiomyopathies ; etiology ; Child ; Child, Preschool ; Creatine Kinase, MB Form ; blood ; Critical Illness ; Female ; Humans ; Insulin Resistance ; L-Lactate Dehydrogenase ; blood ; Male ; Troponin I ; blood
Country
China
Publisher
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Abbreviation
Chinese Journal of Contemporary Pediatrics
Vernacular Journal Title
中国当代儿科杂志
ISSN
1008-8830
EISSN
Year Approved
2013
Current Indexing Status
Currently Indexed
Start Year
1999
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