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A case of HTLV-I associated myelopathy(HAM) in Korea.

Jae Hyeon PARK ; Byun In LEE ; Sae Il LEE ; Mitsuhiro OSAME

Yonsei Medical Journal.1991;32(2):190-194. doi:10.3349/ymj.1991.32.2.190

We report the first Korean case of HTLV-I associated myelopathy (HAM), which was confirmed by Western blot assay of serum and cerebrospinal fluid. Interestingly, the proband's wife was a Japanese Korean who had lived in the endemic area of HAM, Kyushu. Japan, Investigations revealed significantly elevated anti HTLV-I antibody titers in the serum, but not in the CSF, suggesting that she was a carrier of HTLV-I. Considering that the patient had not had a previous blood transfusion, the most common route of HTLV-I, it is likely that the patient was infected by his wife through sexual intercourse. Although previous reports suggest that the transmission of HTLV-I is essentially from man to man or man to woman, our case suggests that woman to man transmission also occurs.
Adult ; Blotting, Western ; HTLV-I Antibodies/analysis ; Human ; Korea/epidemiology ; Male ; Paraparesis, Tropical Spastic/*epidemiology/immunology

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Two cases of mitochondrial myopathy with predominant respiratory dysfunction.

Gyung Whan KIM ; Seung Min KIM ; Il Nam SUNWOO ; Je G CHI

Yonsei Medical Journal.1991;32(2):184-189. doi:10.3349/ymj.1991.32.2.184

Although it is well known that the respiratory failure is a major cause of death in most patients with chronic neuromuscular disease, predominant respiratory dysfunction without severe involvement of limb muscles is an unusual complication of mitochondrial myopathy in adult age. We experienced two cases of mitochondrial myopathy with severe involvement of respiratory function and only mild involvement of limb muscles. One is a 16 year old female and another is a 22 year old male. The diagnosis is based on morphologic characteristics of "ragged red fibers" under the light microscope and abnormal mitochondrias on the electron microscope in the muscle biopsy.
Adolescent ; Adult ; Electromyography ; Female ; Human ; *Mitochondria, Muscle/ultrastructure ; Muscular Diseases/*complications ; Respiration, Artificial ; Respiratory Insufficiency/*etiology/therapy

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Albright's syndrome with hypophosphatemic rickets and hyperthyroidism: a case report.

Soo Bong HAHN ; Seok Beom LEE ; Duk Hi KIM

Yonsei Medical Journal.1991;32(2):179-183. doi:10.3349/ymj.1991.32.2.179

In this abstract we report a case of Albright's syndrome associated with hypophosphatemic rickets and hyperthyroidism in a six-year-old girl. She had suffered from repeated fractures of her long bones owing to multiple locations of radiolucent areas and generalized skeletal demineralization. The biopsy in the lucent area revealed histologic appearance of fibrous dysplasia.
Child ; Female ; Femoral Fractures/etiology ; Fibrous Dysplasia, Polyostotic/*complications ; Human ; Hyperthyroidism/*complications ; Phosphates/*blood ; Rickets/*complications

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RETT's syndrome in Korea: report of two cases.

Young Chul CHOI ; Byung In LEE ; Kyoon HUH ; Gyung Whan KIM

Yonsei Medical Journal.1991;32(2):172-178. doi:10.3349/ymj.1991.32.2.172

Rett's syndrome(RS) is a progressive neurodegenerative disorder characterized by exclusive occurrence in females, autistic behavior, dementia, gait ataxia, loss of purposeful use of the hands with stereotypic hand movement, and seizures. Initially RS was considered to be very rare; however, recent reports suggest that the prevalence is considerably higher and occurrence is world-wide. Because the pathophysiological process remains unknown, the diagnosis of RS is based mainly on its characteristic clinical features and course. We experienced two cases of RS which, to our knowledge, are the first reported in Korea. It is quite possible that many patients with RS not yet being diagnosed in Korea.
Child ; Child Development/physiology ; Female ; Haloperidol/therapeutic use ; Human ; Korea/epidemiology ; Rett Syndrome/drug therapy/*epidemiology/physiopathology ; Sex Factors

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Osteoclastoma of occipital bone.

Vivek SHARMA ; Goodwin NEWTON

Yonsei Medical Journal.1991;32(2):169-171. doi:10.3349/ymj.1991.32.2.169

Osteoclastoma of the calvarial bone of membranous origin is a rare entity. This paper presents a case of osteoclastoma of the occipital bone and a brief review of literature.
Child ; Giant Cell Tumors/*diagnosis/surgery ; Human ; Male ; *Occipital Bone ; Skull Neoplasms/*diagnosis/surgery

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Association of Helicobacter pylori with gastritis and peptic ulcer diseases.

Jin Kyung KANG ; Eung KIM ; Kyung Hee KIM ; Seung Heon OH

Yonsei Medical Journal.1991;32(2):157-168. doi:10.3349/ymj.1991.32.2.157

The occurrence of Helicobacter pylori(H.pylori) and its relationship with gastric mucosa were studied by light and electron microscopy and culture of biopsy specimens from gastric mucosa of 160 patients with upper gastrointestinal symptoms. H. pylori were present in 96.6% of patients with active chronic gastritis, 100% of patients with duodenal ulcer and 76.9% of patients with gastric ulcer, while present in only 6.3% of individuals with histologically normal gastric mucosa. The bacteria colonized the antral mucosa more frequently than the body or than the duodenal cap mucosa. The bacteria were rarely seen in the intestinalized epithelium per se, but there was no significant difference in prevalence of H. pylori between gastritis with intestinal metaplasia and gastritis without intestinal metaplasia. H. pylori could be seen in close association with the surface of gastric epithelial cells below the mucus layer without evidence of intracellular parasitism, All of the strains tested were susceptible to penicillin, erythromycin, and most of them susceptible to tinidazole and bismuth salts. It is concluded that H. pylori are highly associated with gastritis and peptic ulcer diseases and its prevalence rates in patients with those diseases is higher than in developed countries. This strong association of H. pylori infection with gastritis and peptic ulcer diseases suggest a possible etiologic role for the bacterium in those diseases.
Adolescent ; Adult ; Aged ; Chronic Disease ; Duodenal Ulcer/*microbiology/pathology ; Female ; Gastric Mucosa/microbiology/pathology/ultrastructure ; Gastritis/*microbiology/pathology ; *Helicobacter Infections ; Helicobacter pylori/*isolation & purification ; Human ; Male ; Middle Aged ; Prospective Studies ; Stomach Ulcer/*microbiology/pathology ; Support, Non-U.S. Gov't

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Histological studies of surgically resected hepatocellular carcinoma following combined radiotherapy and hyperthermia.

Jin Sil SEONG ; Eun Kyung HAN ; Kwang Hyub HAN ; Sung Hoon NOH ; Chan Il PARK ; John J K LOH ; Heung Jai CHOI

Yonsei Medical Journal.1991;32(2):147-156. doi:10.3349/ymj.1991.32.2.147

Four cases of hepatocellular carcinoma (HCC) were surgically resected following combined radiotherapy (RT) and hyperthermia (HT). Complete necrosis of the tumor without viable tumor cell was found in one case and extensive tumor necrosis was observed in the other three cases; the percentage of necrosis in the specimens were 40%, 70%, and 80%, respectively. Histologic assessment showed mainly coagulative necrosis in the tumor with focal liquefactive necrosis. Cystic dilatation of sinusoids was observed in both tumor and nontumorous normal liver tissue. Other changes in normal liver tissue were unremarkable except for infiltration of inflammatory cells, fatty change, and proliferation of the bile ducts which can usually be seen beyond the area where any space occupying lesions are present. It is concluded that combined radiotherapy and hyperthermia can significantly induce coagulative necrosis of hepatocellular carcinoma with nonsignificant minimal histologic changes in adjacent nontumorous liver tissue.
Carcinoma, Hepatocellular/*pathology/radiotherapy/surgery/*therapy ; Combined Modality Therapy ; Female ; Human ; *Hyperthermia, Induced ; *Liver Neoplasms/*pathology/radiotherapy/surgery/*therapy ; Male ; Middle Aged ; Necrosis

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Effect of sodium hyaluronate on prevention of osteoarthritis.

Nam Hyun KIM ; Chang Dong HAN ; Hwan Mo LEE ; Ick Hwan YANG

Yonsei Medical Journal.1991;32(2):139-146. doi:10.3349/ymj.1991.32.2.139

The changes in the surface of articular cartilage of femoral condyle from rabbits were evaluated after degenerative changes were made by the technique advocated by Hulth. The medial collateral and both cruciate ligaments were excised, and a medial menisectomy was done. Then the right knee joint was injected with 1 ml of Na-hyaluronate gel every two weeks. The animals were sacrificed at two, four, six, eight, or sixteen weeks postoperatively. After sacrifice, the medial femoral condyle was excised and prepared for the light microscopic and scanning electron microscopic study. At eight to sixteen weeks, there were chondrocyte clones with clefts to the radial zone and increased loss of the height of articular cartilage on the control side; but, on theexperimental side there was a significant delay and lessening of the arthriticresponse. The biocompatibility and the protective effect of joint degeneration of this device make this material a valuable adjuvant in the treatment ofosteoarthritis and the traumatized joints.
Animals ; Cartilage, Articular/drug effects/ultrastructure ; Disease Models, Animal ; Gels ; Hyaluronic Acid/*therapeutic use ; Knee Joint/drug effects/ultrastructure ; Microscopy, Electron, Scanning ; Osteoarthritis/*prevention & control ; Rabbits ; Support, Non-U.S. Gov't

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A randomized controlled trial to motivate worksite fecal occult blood testing. Lee CY.

Chung Yul LEE

Yonsei Medical Journal.1991;32(2):131-138. doi:10.3349/ymj.1991.32.2.131

Colorectal cancer is second only to lung cancer as a cause of cancer death in the United States. Studies have shown that fecal occult blood (FOB) tests are effective in detecting colorectal cancer in its early stages. To increase the participation in the FOB test among the working population, a randomized controlled trial was conducted. A total 278 federal employees 40 years or older in Washington State were randomly divided into a intervention group which received a Colorectal Cancer Risk Appraisal and a control group which received a simple information letter. After three months a follow-up questionnaire was sent to all participants to measure the effectiveness of the intervention. As a result of the study, the intervention group had a 4.3% higher compliance rate with the FOB test during the three month follow-up period (p = .10). The largest effect of the intervention was on the employees' intention to get a FOB test within the next year (62.6% in the intervention group vs. 36.2% in the control group, OR = 3.18, p less than .001).
Adult ; Colorectal Neoplasms/*diagnosis/etiology ; Female ; Follow-Up Studies ; Human ; Male ; Middle Aged ; *Occult Blood ; Occupational Health ; Patient Compliance ; Risk Factors ; Support, U.S. Gov't, P.H.S. ; United States ; Washington

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Expression of prognostic factors (EGFR, ER) by immunohistochemical staining method in male breast cancer.

Hyun Cheol CHUNG ; Dong Lip KIM ; Eun Hee KOH ; Joo Hang KIM ; Jae Kyung ROH ; Jin Sik MIN ; Kyung Sik LEE ; Woo Ick YANG ; Byung Soo KIM ; Kyi Beom LEE

Yonsei Medical Journal.1991;32(2):126-130. doi:10.3349/ymj.1991.32.2.126

Twelve male patients with operable breast cancer were evaluated for the expression of prognostic factors by immunohistochemical staining assay. Seven patients were stage I and II, and five patients were stage III. Axillary lymph node positivity was 42%. Nine patients were nuclear grade I, three were nuclear grade II, and none were nuclear grade III. The expression rate of EGFR (epidermal growth factor receptor), ER (estrogen receptor) were 8.3%, 70.0% respectively. This limited data suggest better tumor behavior in male than in female breast cancer. Adjuvant treatment should be considered in male breast cancer just as in females, based on axillary lymph node and ER states.
Breast Neoplasms/*chemistry/pathology ; Carcinoma/*chemistry/pathology ; Human ; Immunohistochemistry ; Lymphatic Metastasis ; Male ; Neoplasm Staging ; Prognosis ; Receptor, Epidermal Growth Factor/*analysis ; Receptors, Estrogen/*analysis

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