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Laparoscopic management of a parasitic mature cystic teratoma

John Paul Y. Reyes ; Chiaoling S. Sua-Lao

Philippine Journal of Reproductive Endocrinology and Infertility.2025;22(1):3-6.

Parasitic dermoid cysts may form from autoamputation of the ovarian mass secondary to torsion or rupture. It may then reimplant in surrounding structures and undergo subsequent neovascularization and further growth. The true incidence of these cases is unknown, however, a study reported a 0.04% incidence among 1,007 cases of dermoid cysts. This report describes the case of a 30-year-old multigravida who presented with an ultrasound finding of an ovarian dermoid cyst, which, upon laparoscopic surgery, turned out to be a parasitic dermoid cyst adherent to the bladder, with grossly normal bilateral ovaries. Theories on the development of parasitic dermoid cyst are also presented.
Human ; Female ; Adult: 25-44 yrs old ; dermoid cyst ; laparoscopy

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Chronic pelvic pain secondary to adenomyosis in Mayer-Rokitansky-Kuster-Hauser syndrome

Philip Judson M. de la Vega ; Madonna Victoria S. Calderon-Domingo

Philippine Journal of Reproductive Endocrinology and Infertility.2025;22(1):7-15.

In Mayer-Rokitansky-K0ster-Hauser (MRKH) syndrome, the development of the uterus and some parts of the vagina is either completely absent or reduced. It is a rare congenital anomaly, and affects one in 4,000-5,000 female births and commonly presents as primary amenorrhea. Approximately 6% - 10% of these patients with MRKH syndrome report persistent pelvic pain, which may be attributed to the presence of myomas, endometriosis, adenomyosis or hematometra caused by a functioning endometrial tissue in a uterine remnant. This paper presents the case of a 37 year old nulligravid who experienced severe cyclic hypogastric pain, and was subsequently diagnosed with MRKH syndrome with adenomyosis. Clinical evaluation and definitive management of the index case are discussed.
Human ; Female ; Adult: 25-44 yrs old ; mullerian failure ; mullerian aplasia ; adenomyosis ; pelvin pain

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A second successful pregnancy in a hybrid uterus - coexistence of bicornuate and septate uterus: A case report

Jane Mierial A. Pesigan ; Crisostomo Santos O. Ordoñ ; o Jr. ; Ina S. Irabon

Philippine Journal of Reproductive Endocrinology and Infertility.2025;22(1):16-22.

Congenital malformations of the uterus are rare. Pregnancies in these uterine abnormalities are usually associated with poor reproductive outcomes such as recurrent pregnancy losses, preterm birth and intrauterine growth restriction. Presented here is the case of a 21-year old G2P1(1001), who was diagnosed intraoperatively with a septate bicornuate uterus during her second Cesarean delivery. She had to undergo abdominal delivery for both her pregnancies due to malpresentation, and delivered live healthy babies with no gross structural defects. Pathophysiology and classification of congenital uterine malformations are discussed in the case, as well as the diagnostics and management for such conditions.
Human ; Female ; Young Adult: 19-24 yrs old ; Bicornuate uterus ; Septate Uterus ; Uterine anomalies

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A tribute to Dr Delfin A. Tan (1939-2024)

Maria Isidora Yap-Garcia

Philippine Journal of Reproductive Endocrinology and Infertility.2025;22(1):1-2.

Human:Endocrinology ; Gynecologic surgical procedures ; Education, medical

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Clinical practice guideline for the diagnosis of endometriosis in the Philippines (Protocol)

Philippine Journal of Reproductive Endocrinology and Infertility.2025;22(1):23-33.

practice guideline ; literature ; diagnosis ; endometriosis

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Mosaic Turner syndrome presenting with ambiguous genitalia and mixed ovarian germ cell tumor in a Filipino adult

Khristine Rosemarie Bunda-Sabido ; Marie Janice Alcantara-Boquiren

Philippine Journal of Reproductive Endocrinology and Infertility.2025;22(2):68-72.

This report details the case of a 24-year-old Filipino individual born with ambiguous genitalia, assigned female at birth, and raised as such. Around the age of 13, the patient began to develop secondary male characteristics. Medical assessment was postponed until the onset of abdominal pain led the patient to seek consultation. Cytogenetic testing revealed a sex chromosome disorder of sexual development with a mosaic karyotype of 45,X/45,X,del(X)(q13). Imaging, surgical exploration, and histopathologic evaluation confirmed that a pelvoabdominal mass originated from the left ovary and was a mixed germ cell tumor containing yolk sac tumor and mature teratoma components. At presentation, the patient also reported symptoms consistent with gender dysphoria. This case highlights the wide phenotypic variability of mosaic Turner syndrome and reinforces the importance of accurate neonatal sex assignment in individuals with DSD. It further emphasizes the need for healthcare providers to remain vigilant for such presentations to enable prompt, tailored, and comprehensive management.

Human ; Female ; Young Adult: 19-24 Yrs Old ; Disorders Of Sex Development ; Ambiguous Genitalia

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Cervicovaginal agenesis with caudal regression syndrome: A multidisciplinary approach

Mary Ann C. Bernardo ; Marie Janice A. Boquiren ; Jeanmarie C. Salvador ; Irene L. Uy

Philippine Journal of Reproductive Endocrinology and Infertility.2025;22(2):73-81.

This paper describes a multidisciplinary management approach on a case of a 20 year old nulligravid who was diagnosed with both cervicovaginal agenesis and causal regression syndrome (CRS). The index patient mainly presented with complaints of failed vaginal penetration, amenorrhea and cyclic monthly pelvic pain. The coexistence of cervicovaginal agenesis and CRS is extremely rare, and the pathogenesis regarding the association of both conditions is not yet fully understood. This combination poses significant diagnostic and management challenges, requiring a multidisciplinary approach that includes reproductive medicine, radiology, neurosurgery, orthopedics, and psychological support. Surgical reconstruction remains highly complex and individualized due to anatomical and functional constraints.

Human ; Female ; Young Adult: 19-24 Yrs Old ; Amenorrhea

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Female genital schistosomiasis (fallopian tube)

Jannah A. Tapodoc ; Marie Janice Alcantara-Boquiren

Philippine Journal of Reproductive Endocrinology and Infertility.2025;22(2):82-88.

Female genital schistosomiasis (FGS) is a chronic form of urogenital schistosomiasis, associated with Schistosoma haematobium infection. It is linked to contaminated water exposure and poverty that increases the risk of poor sexual and reproductive health in women, including infertility, and a heightened susceptibility to sexually transmitted infections. The diagnosis of FGS begins with a high index of suspicion in female patients living in Schistosoma-endemic areas who present with vaginal or pelvic symptoms with or without hematuria. This paper presents the case of a 37 year old G1P1 (0100) who presented with chronic pelvic pain due to Pelvic Inflammatory Disease with bilateral hydrosalpinges. Schistosomiasis was detected on histopathology after surgical resection of the diseased fallopian tubes. This case highlights the importance of a high index of suspicion for prompt and accurate diagnosis of FGS.

Human ; Female ; Adult: 25-44 Yrs Old ; Infertility ; Schistosomiasis

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Clinical profiles and reproductive outcomes of Filipino women of advanced age who underwent autologous in vitro fertilization: A single center study

Marella A. Bugarin ; Virgilio M. Novero, Jr.

Philippine Journal of Reproductive Endocrinology and Infertility.2025;22(2):35-46.

BACKGROUND

Advanced maternal age is associated with diminished IVF outcomes, including reduced live birthrates and increased miscarriage risk.

OBJECTIVE

To determine clinical profiles and reproductive outcomes of Filipino women of advanced age who underwent autologous IVF at the Center for Advanced Reproductive Medicine and Infertility at St. Luke’s Medical Center Global City from January 1 , 2018 to December 31, 2024.

METHODS

This retrospective cohort study analyzed 667 Filipino women aged 38 years and above who underwent autologous IVF/ICSI-ET from 2018 to 2024. Clinical profiles and reproductive outcomes were compared across age groups and embryo transfer types.

RESULTS

Results showed significant age-related decline identified in reproductive outcomes such as clinical pregnancy and live birth rates, coupled with elevated miscarriage rates in older women. Frozen embryo transfers demonstrated superior outcomes versus fresh transfers. While PGT-A improved embryo selection, it did not fully mitigate age-related declines.

CONCLUSION

These findings underscore the persistent negative impact of advanced maternal age on IVF success, highlighting the importance of early fertility intervention, individualized treatment strategies, and context-specific research in resource-constrained settings.

Human ; Fertilization In Vitro ; Advanced Maternal Age ; Embryo Transfer

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The use of specialized pro-resolving mediators as anti-inflammatory agents in the treatment of chronic pelvic pain among patients with endometriosis: A systematic review

Ivannah Joelle C. Tobias ; Maricris Corduwa-Pacoli ; Leedah Rañ ; ola-Nisperos

Philippine Journal of Reproductive Endocrinology and Infertility.2025;22(2):47-53.

BACKGROUND

Endometriosis is an inflammation-dependent condition characterized by the uncontrolled development of lesions resembling the endometrium. For the host tissue to maintain homeostasis throughout the active process of inflammation resolution, endogenous factors must be activated.

OBJECTIVE

To determine if using specialized pro-resolving mediators (SPM) to treat endometriosis patients’ persistent pelvic pain is safe and effective.

METHODS

A systematic review was performed to determine studies that determined the effect of Specialized Pro-resolving Mediators (SPM) on endometriosis control. A descriptive narrative approach was applied to synthesize the findings of this systematic review.

RESULTS

Three prospective case-control studies and three in vitro studies were included. All studies involved Lipoxin A4 as the specialized pro-resolving mediator assessed for benefit on endometriosis control. All studies consistently reported that SPM can be potentially effective in treating endometriosis. The search terms used were: “Specialized Pro-resolving Mediators,” “SPM,” “Chronic inflammatory agent,” pelvic pain, and endometriosis.

CONCLUSION

Despite the lack of trials on the use of Specialized Pro-resolving Mediators to manage chronic pelvic pain, case-control and in vitro studies are consistent in detailing the potential benefits of SPM for endometriosis control. Given the concrete pathophysiologic basis for the mechanism of action for SPM, it is highly recommended that future trials be made to determine its efficacy and safety.

Human ; Endometriosis ; Inflammation ; Specialized Pro-resolving Mediators

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