Obstructive pneumonitis of right lower lung field.
Tuberculosis and Respiratory Diseases.1992;39(4):366-369.
Tuberculosis and Respiratory Diseases
to Present ISSN: 1738-3536
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A case of mediastinal cystic lymphangioma.
Tuberculosis and Respiratory Diseases.1992;39(4):361-365.
Tuberculosis and Respiratory Diseases.2014;77(5):227-229. doi:10.4046/trd.2014.77.5.227
Segniliparus species is a novel genus that is reported to be the new emerging respiratory pathogens. Here, we report a very rare case of S. rugosus pulmonary infection in an immunocompetent patient with non-cystic fibrosis. The organism was identified by 16S rRNA gene sequencing. The patient was successfully treated with antibiotics.
Anti-Bacterial Agents ; Fibrosis* ; Genes, rRNA ; Humans ; Nontuberculous Mycobacteria ; Respiratory Tract Infections ; Sequence Analysis, RNA
Anti-Bacterial Agents ; Fibrosis* ; Genes, rRNA ; Humans ; Nontuberculous Mycobacteria ; Respiratory Tract Infections ; Sequence Analysis, RNA
Aspergillus Tracheobronchitis in a Mild Immunocompromised Host.
Tuberculosis and Respiratory Diseases.2014;77(5):223-226. doi:10.4046/trd.2014.77.5.223
Aspergillus tracheobronchitis is a form of invasive pulmonary aspergillosis in which the Aspergillus infection is limited predominantly to the tracheobronchial tree. It occurs primarily in severely immunocompromised patients such as lung transplant recipients. Here, we report a case of Aspergillus tracheobronchitis in a 42-year-old man with diabetes mellitus, who presented with intractable cough, lack of expectoration of sputum, and chest discomfort. The patient did not respond to conventional treatment with antibiotics and antitussive agents, and he underwent bronchoscopy that showed multiple, discrete, gelatinous whitish plaques mainly involving the trachea and the left bronchus. On the basis of the bronchoscopic and microbiologic findings, we made the diagnosis of Aspergillus tracheobronchitis and initiated antifungal therapy. He showed gradual improvement in his symptoms and continued taking oral itraconazole for 6 months. Physicians should consider Aspergillus tracheobronchitis as a probable diagnosis in immunocompromised patients presenting with atypical respiratory symptoms and should try to establish a prompt diagnosis.
Adult ; Anti-Bacterial Agents ; Antitussive Agents ; Aspergillosis, Allergic Bronchopulmonary ; Aspergillus* ; Bronchi ; Bronchoscopy ; Cough ; Diabetes Mellitus ; Diagnosis ; Gelatin ; Humans ; Immunocompromised Host* ; Invasive Pulmonary Aspergillosis ; Itraconazole ; Lung ; Sputum ; Thorax ; Trachea ; Transplantation
Adult ; Anti-Bacterial Agents ; Antitussive Agents ; Aspergillosis, Allergic Bronchopulmonary ; Aspergillus* ; Bronchi ; Bronchoscopy ; Cough ; Diabetes Mellitus ; Diagnosis ; Gelatin ; Humans ; Immunocompromised Host* ; Invasive Pulmonary Aspergillosis ; Itraconazole ; Lung ; Sputum ; Thorax ; Trachea ; Transplantation
Pneumatosis Intestinalis Complicated by Pneumoperitoneum in a Patient with Asthma.
Tuberculosis and Respiratory Diseases.2014;77(5):219-222. doi:10.4046/trd.2014.77.5.219
Pneumatosis intestinalis (PI) is a very rare condition that is defined as the presence of gas within the subserosal or submucosal layer of the bowel. PI has been described in association with a variety of conditions including gastrointestinal tract disorders, pulmonary diseases, connective tissue disorders, organ transplantation, leukemia, and various immunodeficiency states. We report a rare case of a 74-year-old woman who complained of dyspnea during the management of acute asthma exacerbation and developed PI; but, it improved without any treatment.
Adrenal Cortex Hormones ; Aged ; Asthma* ; Connective Tissue ; Dyspnea ; Female ; Gastrointestinal Tract ; Humans ; Leukemia ; Lung Diseases ; Organ Transplantation ; Pneumatosis Cystoides Intestinalis ; Pneumoperitoneum* ; Transplants
Adrenal Cortex Hormones ; Aged ; Asthma* ; Connective Tissue ; Dyspnea ; Female ; Gastrointestinal Tract ; Humans ; Leukemia ; Lung Diseases ; Organ Transplantation ; Pneumatosis Cystoides Intestinalis ; Pneumoperitoneum* ; Transplants
Tuberculosis and Respiratory Diseases.2014;77(5):215-218. doi:10.4046/trd.2014.77.5.215
Tracheal invasion is an uncommon complication of thyroid cancer, but it can cause respiratory failure. A rigid bronchoscope may be used to help relieve airway obstruction, but general anesthesia is usually required. Tracheal balloon dilatation and stent insertion can be performed without general anesthesia, but complete airway obstruction during balloon inflation may be dangerous in some patients. Additionally, placement of the stent adjacent to the vocal cords can be technically challenging. An 86-year-old female patient with tracheal invasion resulting from thyroid cancer was admitted to our hospital because of worsening dyspnea. Due to the patient's refusal of general anesthesia and the interventional radiologist's difficulty in completing endotracheal stenting, we performed endotracheal tube balloon dilatation and argon plasma coagulation. We have successfully treated tracheal obstruction in the patient with thyroid cancer by using endotracheal tube balloon inflation and a flexible bronchoscope without general anesthesia or airway obstruction during balloon inflation.
Aged, 80 and over ; Airway Obstruction ; Anesthesia, General ; Argon Plasma Coagulation ; Bronchoscopes ; Bronchoscopy ; Dilatation ; Disulfiram ; Dyspnea ; Female ; Humans ; Inflation, Economic* ; Intubation, Intratracheal ; Neoplasm Invasiveness ; Respiratory Insufficiency ; Stents ; Thyroid Neoplasms* ; Trachea ; Vocal Cords
Aged, 80 and over ; Airway Obstruction ; Anesthesia, General ; Argon Plasma Coagulation ; Bronchoscopes ; Bronchoscopy ; Dilatation ; Disulfiram ; Dyspnea ; Female ; Humans ; Inflation, Economic* ; Intubation, Intratracheal ; Neoplasm Invasiveness ; Respiratory Insufficiency ; Stents ; Thyroid Neoplasms* ; Trachea ; Vocal Cords
The Effects of Bronchiectasis on Asthma Exacerbation.
Tuberculosis and Respiratory Diseases.2014;77(5):209-214. doi:10.4046/trd.2014.77.5.209
BACKGROUND: Bronchiectasis and asthma are different in many respects, but some patients have both conditions. Studies assessing the effect of bronchiectasis on asthma exacerbation are rare. The aim of this study is to investigate the effect of bronchiectasis on asthma exacerbation. METHODS: We enrolled 2,270 asthma patients who were followed up in our hospital. Fifty patients had bronchiectasis and asthma. We selected fifty age- and sex-matched controls from the 2,220 asthma patients without bronchiectasis, and assessed asthma exacerbation and its severity based on the annual incidence of total asthma exacerbation, annual prevalence of steroid use, and frequency of emergency room visits and hospitalizations due to asthma exacerbation in each group. RESULTS: Fifty patients (2.2%) had bronchiectasis and asthma. The annual incidence of asthma exacerbation was higher in patients with asthma and bronchiectasis than in patients with asthma alone (1.08+/-1.68 vs. 0.35+/-0.42, p=0.004). The annual prevalence of steroid use (0.9+/-1.54 vs. 0.26+/-0.36, p=0.006) and the frequency of emergency room visits (0.46+/-0.84 vs. 0.02+/-0.13, p=0.001) due to asthma exacerbation were also higher in patients with asthma and bronchiectasis than in patients with asthma alone. CONCLUSION: Bronchiectasis is associated with difficult asthma control.
Asthma* ; Bronchiectasis* ; Disease Progression ; Emergency Service, Hospital ; Hospitalization ; Humans ; Incidence ; Prevalence
Asthma* ; Bronchiectasis* ; Disease Progression ; Emergency Service, Hospital ; Hospitalization ; Humans ; Incidence ; Prevalence
Tuberculosis and Respiratory Diseases.2014;77(5):203-208. doi:10.4046/trd.2014.77.5.203
BACKGROUND: In this study, we investigated whether lobetyolin, lobetyol, and methyl linoleate derived from Codonopsis pilosula affect MUC5AC mucin secretion, production, and gene expression from airway epithelial cells. METHODS: Confluent NCI-H292 cells were pretreated with lobetyolin, lobetyol, or methyl linoleate for 30 minutes and then stimulated with phorbol 12-myristate 13-acetate (PMA) for 24 hours. The MUC5AC mucin gene expression, and mucin protein production and secretion were measured by reverse transcription polymerase chain reaction and enzyme-linked immunosorbent assay, respectively. RESULTS: Lobetyolin, lobetyol, and methyl linoleate inhibited the gene expression of MUC5AC mucin induced by PMA; lobetyolin did not affect PMA-induced MUC5AC mucin production. However, lobetyol and methyl linoleate inhibited the production of MUC5AC mucin; lobetyolin and lobetyol did not significantly affect PMA-induced MUC5AC mucin secretion from NCI-H292 cells. However, methyl linoleate decreased the MUC5AC mucin secretion. CONCLUSION: These results suggest that among the three compounds, methyl linoleate can regulate gene expression, production, and secretion of MUC5AC mucin by directly acting on the airway epithelial cells.
Codonopsis ; Enzyme-Linked Immunosorbent Assay ; Epithelial Cells* ; Gene Expression* ; Linoleic Acid* ; Mucins* ; Polymerase Chain Reaction ; Reverse Transcription
Codonopsis ; Enzyme-Linked Immunosorbent Assay ; Epithelial Cells* ; Gene Expression* ; Linoleic Acid* ; Mucins* ; Polymerase Chain Reaction ; Reverse Transcription
A Case of Suspected Behcet's Desease Diagnosed by Manifestation of Pulmonary Artery Aneurysm.
Tuberculosis and Respiratory Diseases.2002;52(4):405-410. doi:10.4046/trd.2002.52.4.405
Behcet's disease is a chronic systemic inflammatory disorder with an unknown etiology. It affects many organs and is characterized by recurrent attacks. Pulmonary artery aneurysms occur more frequent in males, and it is o ne of the rare pulmonary complications of Behcet's disease. It has a poor and prognosis, and is also one of the leading causes of death from Behcet's disease. Here we report a case of suspected Behcet's disease diagnosed by a manifestation of a pulmonary artery aneurysm in a 37-year-old woman.
Adult ; Aneurysm* ; Cause of Death ; Female ; Humans ; Male ; Prognosis ; Pulmonary Artery*
Adult ; Aneurysm* ; Cause of Death ; Female ; Humans ; Male ; Prognosis ; Pulmonary Artery*
The Effect of Dexamethasone on Gene Expression and Total Amount of Surfactant Protein A.
Tuberculosis and Respiratory Diseases.2002;52(4):395-404. doi:10.4046/trd.2002.52.4.395
BACKGROUND: Surfactant protein A (SP-A) is importanpt for regulating surfactant secretion, synthesis and recycling. However, It's regulation in vivo is unclear. SP-A has important roles in regulating surfactant met abolism as well as determining its physical properties. Glucocorticoid accelerates the morphologic differentiation of epithelial cells into type II cells and increase the rate of phosphatidylcholine synthesis. METHODS: The authors investigated the effects of glucocorticoid on the accumulation of mRAN encoding SPA and SP-A protein content. A dult rats were given various doses of subcutaneous dexamethasone and sacrificed after 24 hours and one week. SP-A mRNA was measured using a filter hybridization method. The lung SP-A protein content was determined using a double sandwich ELISA assay with polyclonal antiserum raised in rabbits against purified rat SP-A. RESULTS: 1) The accumulation of SP-A mRNA in the dexamethasone treated group 24 hours after 0.2 mg/kg dexamethasone treatment was increased 38.8% compared to the control group. 2) The accumulation of SP-A mRNA in the dexamethasone treated group 1 week after 2 mg/kg dexamethasone treatment was 49.7% higher than the control group(P<0.01). 3)The total lung SP-A level was not altered after 24 hours by the 0.2 mg/kg treatment. The total lung SP-A content one week after 2 mg/kg dexamethasone administration was 373.7% higher than the control group(P<0.005). CONCLUSIONS: Dexamethasone treatment results in an increase in the SP-A mRNA and SP-A protein levels, suggesting that the pretranslational events in vivo may in part contribute to this process.
Animals ; Dexamethasone* ; Enzyme-Linked Immunosorbent Assay ; Epithelial Cells ; Gene Expression* ; Lung ; Phosphatidylcholines ; Pulmonary Surfactant-Associated Protein A* ; Rabbits ; Rats ; Recycling ; RNA, Messenger
Animals ; Dexamethasone* ; Enzyme-Linked Immunosorbent Assay ; Epithelial Cells ; Gene Expression* ; Lung ; Phosphatidylcholines ; Pulmonary Surfactant-Associated Protein A* ; Rabbits ; Rats ; Recycling ; RNA, Messenger
Country
Republic of Korea
Publisher
The Korean Academy of Tuberculosis and Respiratory Diseases
ElectronicLinks
http://www.e-trd.org/Editor-in-chief
Kisuck Jung
katrd@lungkorea.org / katrd@hanmail.net
Abbreviation
Tuberc Respir Dis
Vernacular Journal Title
결핵및호흡기질환
ISSN
1738-3536
EISSN
2005-6184
Year Approved
2007
Current Indexing Status
Currently Indexed
Start Year
Description
Tuberculosis and Respiratory Diseases (Tuberc Respir Dis) is the official journal of the Korean Academy of Tuberculosis and Respiratory Diseases. The journal publishes high-quality, peer-reviewed clinical or research articles that contribute to the understanding of the pathophysiology, diagnosis, and treatment of tuberculosis and other respiratory diseases. The aims of the journal are to publish important articles, encourage the exchange of information between members and related healthcare providers, and improve patient and public health.
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