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Endometriosis Detected in Postmenopausal Women Not Receiving Menopausal Hormone Therapy: Two Case Reports.

Tae Hee KIM ; Hae Hyeog LEE ; Soo Ho CHUNG ; Jeong Ja KWAK ; Hwang Shin PARK

The Journal of Korean Society of Menopause.2010;16(3):176-180.

Endometriosis is an estrogen dependent disease in reproductive age. Endometriosis is a chronic inflammatory gynecologic disease. Problems associated with endometriosis include dysmenorrhea, dyspareunia, and infertility. Postmenopausal endometriosis is rare; however, postmenopausal endometriosis is infrequently associated with cancer, thus management is most important for gynecologists. We present two cases of endometriosis associated with postmenopausal women who were not receiving menopausal hormone therapy with a retrospective review of the medical records and a brief review of the literature.
Dysmenorrhea ; Dyspareunia ; Endometriosis ; Estrogens ; Female ; Genital Diseases, Female ; Humans ; Infertility ; Medical Records ; Postmenopause ; Retrospective Studies

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Non-vertebral Fractures due to Recurrent Falls after Premature Menopause.

Tae Hee KIM ; Hae Hyeog LEE ; Soo Ho CHUNG ; Yun Jung YANG

The Journal of Korean Society of Menopause.2010;16(1):52-54.

Premature menopause is due to ovarian dysfunction. Premature menopause is characterized by arrested folliculogenesis before 40 years of age. Premature menopause is associated with health problems. The impact of estrogen deficiency tends to be chronic problems rather than acute. We have managed a case of recurrent non-vertebral fractures due to falls after premature ovarian dysfunction. We present this case with a brief review of the literature.
Estrogens ; Female ; Menopause, Premature

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Clinical Applications of Hysteroscopic Surgery in Postmenopausal Women.

Kina UY ; Tae Hee KIM ; Hae Hyeog LEE ; Soo Ho CHUNG ; Byoung Ick LEE

The Journal of Korean Society of Menopause.2010;16(1):46-51.

OBJECTIVES: To evaluate the spectrum of hysteroscopic surgery to be extended. METHODS: Forty-three women who underwent hysteroscopic procedures with Urione(R) solution or normal saline as distension media between March 2001 and March 2009 were randomized. The clinical characteristics, laboratory data, and post-operative results were retrospectively analyzed. RESULTS: The following hysteroscopic procedures were performed: endometrial biopsy, 26; endometrial polypectomy, 8; myomectomy, 7; ablation for dysfunctional uterine bleeding and endometrial hyperplasia, 1; and excision of an endometrial mass, 1. The mean size of the myomas was 3.2 cm. The average duration of hospitalization was 2 days. The average change in hemoglobin was 1.1 g/dl. The mean operative time was 36 minutes. CONCLUSION: The indications for hysteroscopic procedures can be extended. Pure intramural myomas, submucosal myomas, endometrial polyps, adenomyosis, endometrial hyperplasia, hydrometra, and abnormal uterine bleeding can be treated via a hysteroscope. Intra-operative transabdominal ultrasonographic guidance can be helpful during hysteroscopic procedures, and reduces the complication and morbidity rates.
Adenomyosis ; Biopsy ; Endometrial Hyperplasia ; Female ; Hemoglobins ; Hospitalization ; Humans ; Hysteroscopes ; Hysteroscopy ; Menopause ; Metrorrhagia ; Myoma ; Operative Time ; Polyps ; Retrospective Studies ; Uterine Hemorrhage

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The Effect of Pomegranate on Depression, Anxiety, and Food Intake in Ovariectomized Rats.

Ki Hoon AHN ; Kyong Wook YI ; Hyun Tae PARK ; Jung Ho SHIN ; Jun Young HUR ; Young Tae KIM ; Sun Haeng KIM ; Kyu Wan LEE ; Seung Hee KIM ; Chun Sik BAE ; Tak KIM

The Journal of Korean Society of Menopause.2010;16(1):39-45.

OBJECTIVES: To determine whether or not pomegranate extract can affect depression, anxiety, and food intake in ovariectomized rats. METHODS: Seventy-nine female Sprague-Dawley rats were divided into six groups: A, no operation and no drug intake; B, sham operation and distilled water; C, ovariectomy and distilled water; D, ovariectomy and 10% dilute pomegranate extract; E, ovariectomy and 20% dilute pomegranate extract; and F, ovariectomy and 40% dilute pomegranate extract. Beginning 2 days after surgery, drugs were administrated for 4 weeks. After that, the rats were subjected to the elevated plus maze (EPM) test and forced swim test (FST). RESULTS: The 10% pomegranate extract had a lower % closed arm entry frequency in the EPM test. A pomegranate dose-dependent decrease in the duration of immobility duration in FST was shown. Pomegranate did not reverse ovariectomy-related hyperphagia and weight gain. CONCLUSION: Pomegranate extract improved depression and anxiety in a postmenopausal model with ovariectomized rats.
Animals ; Anxiety ; Arm ; Depression ; Eating ; Female ; Humans ; Hyperphagia ; Ovariectomy ; Punicaceae ; Rats ; Rats, Sprague-Dawley ; Salicylamides

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Relationship between Body Composition and Bone Mineral Density in Pre- and Post-menopausal Women.

Jae Eun CHUNG ; Sung Jin HWANG ; Min Jung KIM ; Jae Yen SONG ; Hyun Hee CHO ; Dong Jin KWON ; Young Oak LEW ; Young Taik LIM ; Eun Jung KIM ; Jang Heub KIM ; Jin Hong KIM ; Mee Ran KIM

The Journal of Korean Society of Menopause.2010;16(1):29-38.

OBJECTIVES: We analyzed the relationship between body composition, metabolic parameters, and lumbar and femur bone mineral density (BMD) in pre-and post-menopausal women. METHODS: Of 394 females who participated in a medical check-up program, anthropometric measurements and fasting glucose levels and lipid profiles were measured. Body composition analysis was performed using the bioimpedence method and the BMD of the lumbar spine, femur neck, trochanter, ward's triangle, and total were measured by dual energy X-ray absorptiometry. RESULTS: The mean age was 49.5 +/- 9.8 years, and among the subjects, 203 (51.5%) were pre-menopausal and 191 (48.5%) were post- menopausal women. Skeletal muscle mass, fat- free mass, lean body mass, and basal metabolic rate had a positive correlation with the lumbar and femur spine BMD, even after adjustment for age and weight in pre-menopausal women. The abdominal fat ratio, fat mass, waist circumference, percent fat, and total cholesterol had a negative correlation with the lumbar and femur spine BMD, even after adjustment for age and weight in pre-menopausal women. The lean body mass in the legs and trunk, skeletal muscle mass, and fat free mass had a positive correlation with the BMD of the lumbar spine and femur neck, unlike the lean body mass of the arms did not, after adjustment for age and weight in post-menopausal women. CONCLUSION: In pre- and post-menopausal Korean women, body composition, lean body mass, fat -free mass, and skeletal muscle mass were positive correlates, and fat mass and percent fat were negative correlates with the lumbar spine and femur BMD.
Abdominal Fat ; Arm ; Basal Metabolism ; Body Composition ; Bone Density ; Cholesterol ; Fasting ; Female ; Femur ; Femur Neck ; Glucose ; Humans ; Leg ; Muscle, Skeletal ; Spine ; Waist Circumference

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Association between the Total Homocysteine Concentration and the Bone Marrow Density and Bone Turnover Rate in Postmenopausal Women.

Bom Taeck KIM ; Byung Hoon AHN ; Kwang Min KIM ; Nam Seok JOO ; Chan Won KIM ; Do Seung KWON ; Duck Joo LEE

The Journal of Korean Society of Menopause.2010;16(1):23-28.

OBJECTIVES: Hyperhomocysteinemia is related to fractures in the elderlies. We assessed the relationship between serum homocysteine and bone mass, size, and bone turnover rate. METHODS: This study included 2,670 postmenopausal women who underwent periodic health examinations in Ajou University Health Promotion Center, between January 2002 and December 2003. Serum homocysteine, bone turnover markers and bone mineral density were measured RESULTS: Patient age, osteocalcin, 25-vit D, total lumbar BMD, total lumbar T-score, the lowest lumbar BMD, the lowest lumbar T-score, femur neck BMD, femur neck T-score, femur trochanteric BMD and femur trochanteric T-score showed a significant correlation with the serum total homocysteine. However, after adjusting for age, the only osteocalcin was significantly correlated with the serum total homocysteine, At the 3rd lumbar vertebra, the BMC, volumetric BMD and areal BMD had a significant correlation with the serum total homocysteine but the bony size and the volume were not significant. After adjusting for age, the 3rd lumbar BMD was significantly correlated with the serum total homocysteine. CONCLUSION: Serum homocysteine level is correlated significantly with bone turnover rate, less with bone mass but not with bone size.
Bone Density ; Bone Marrow ; Female ; Femur ; Femur Neck ; Health Promotion ; Homocysteine ; Humans ; Hyperhomocysteinemia ; Osteocalcin ; Spine

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The Association between Serum Estradiol Level and Coronary Artery Calcification in Postmenopausal Women: A Preliminary Report.

Gyun Ho JEON ; Sung Hoon KIM ; So Ra KIM ; Hee Dong CHAE ; Chung Hoon KIM ; Byung Moon KANG

The Journal of Korean Society of Menopause.2010;16(1):16-22.

OBJECTIVES: To estimate whether coronary artery calcification in postmenopausal women is associated with serum estradiol level. METHODS: The present study retrospectively examined the clinical records of 162 postmenopausal women who visited the Health Promotion Center for a routine checkup and underwent a multidetector CT scan of the heart. Serum estradiol level, coronary heart disease (CHD) risk factors, current hormone therapy status, and BMD of the lumbar vertebrae and femoral neck were analyzed in women with coronary artery calcium score (CACS) > or = 100 and < 100. RESULTS: Compared to women with higher CACS (> or = 100), women with lower CACS (< 100) had a significantly higher level of serum estradiol (27.34 +/- 2.96 vs. 13.31 +/- 1.10 pg/ml, P = 0.030) and lower mean age (57.63 +/- 0.44 vs. 61.88 +/- 1.90, P = 0.037). Women with CACS < 100 were significantly more likely to have a serum estradiol level greater than 20 pg/ml (42.25 vs. 0 %, P = 0.022) and lower prevalence of hypertension (28.17 vs. 62.50%, P = 0.053, borderline significant). However, multiple logistic regression analysis showed that any factors did not have a significant association with CACS except hypertension (OR 5.831 [95% CI 1.035 to 32.85], P = 0.046). CONCLUSION: Serum estradiol level might be associated with the degree of calcification of coronary artery in postmenopausal women.
Calcium ; Coronary Disease ; Coronary Vessels ; Estradiol ; Female ; Femur Neck ; Health Promotion ; Heart ; Humans ; Hypertension ; Logistic Models ; Lumbar Vertebrae ; Postmenopause ; Prevalence ; Retrospective Studies ; Risk Factors

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The National Use of Antiosteoporosis Medication in 2009.

Jae Hong SANG ; Hyoung Moo PARK

The Journal of Korean Society of Menopause.2010;16(3):170-175.

OBJECTIVES: Osteoporosis is the most common chronic skeletal disease in postmenopausal women. The total sales of anti-osteoporosis medications have rapidly increased in Korea in recent years because of the rapid aging of our society. This study was intended to evaluate the trend in the use of anti-osteoporosis medications in 2009. METHODS: Data from the International Marketing Service (IMS) were used to analyze the sales of medications for osteoporosis. The total sales of anti-osteoporosis medications were considered to correspond to the use of anti-osteoporosis medications. RESULTS: The total market of anti-osteoporosis medications including hormones and calcium was 213.9 billion Korea won (KRW). The proportion of anti-osteoporosis medications accounted for by hormones and calcium was 16% and 84%, respectively. The total consumption of calcium was 26.9 billion KRW and nearly all the sales were over-the-counter products. Total hormone consumption was 35.6 billion KRW, of which tibolone comprised 41%. Bisphosphonate consumption was 129.6 billion KRW; the proportion of bisphosphonates in non-hormonal medications was 85.6%, followed in order by vitamin D (6.9%), raloxifene (5.0%), and calcitonin (2.0%). CONCLUSION: The most commonly used anti-osteoporosis medications based on sales were bisphosphonates comprising 60.6% of the total sales, followed by hormones and vitamin D.
Aging ; Calcitonin ; Calcium ; Commerce ; Diphosphonates ; Female ; Humans ; Korea ; Marketing ; Norpregnenes ; Osteoporosis ; Raloxifene Hydrochloride ; Vitamin D

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Changes in Atrophic Symptoms, the Vaginal Maturation Index, and Vaginal pH in Postmenopausal Women Treated with Vaginal Estrogen Tablets.

Myounghwan KIM ; Hoon CHOI

The Journal of Korean Society of Menopause.2010;16(3):162-169.

OBJECTIVES: The aim of this study was to assess atrophic symptoms, the vaginal maturation index (VMI), and vaginal pH in postmenopausal women after use of estriol vaginal tablets for the treatment of vaginal atrophy. METHODS: In a randomized prospective study, 67 postmenopausal women were treated with 500microg estriol tablets 3 times a week for 1 week in the 1-week treatment group (n = 40) and for 2 weeks in the 2-week treatment group (n = 27). The primary endpoints were changes in the VMI, vaginal pH, and improvement in participant-reported most bothersome symptom (MBS; vaginal dryness, irritation/itching, or dyspareunia). We compared three endpoints before and after treatment in each group and between the two treatment groups. The correlation between the vaginal pH and maturation value (MV) was assessed. RESULTS: A statistically significant increase in the MV, decrease in pH, and improvement in the MBS occurred for women treated with estriol vaginal tablets in the 1- (P = 0.000, P = 0.002, and P = 0.000, respectively) and 2-week treatment groups (P = 0.000, P = 0.000, and P = 0.000, respectively). There were no significant differences between the 1- and 2-week treatment groups with respect to improvement in the VMI, vaginal pH, or MBS. The correlation between the vaginal pH and MV showed a negative linear correlation at 0, 1, and 2 weeks (P = 0.000, P = 0.000, and P = 0.011, respectively). CONCLUSION: Treatment with 500microg estriol vaginal tablets thrice-weekly for 1 week was effective in improving. It is thought that the three primary endpoints (VMI, vaginal pH, and MBS) improved at the same time during treatment.
Estriol ; Estrogens ; Female ; Humans ; Hydrogen-Ion Concentration ; Prospective Studies ; Tablets ; Vaginal Creams, Foams, and Jellies

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Differences in Dietary Intake and Life-style of Female College Students in Seoul with and without Premenstrual Syndrome.

Heesoon LIM ; Yongsoon PARK

The Journal of Korean Society of Menopause.2010;16(3):153-161.

OBJECTIVES: We examined the association between premenstrual syndrome (PMS) and dietary intake and lifestyle risk factors of 203 female college students in Seoul. METHODS: PMS was diagnosed using the Menstrual Distress Questionnaire (MDQ), and dietary intake was accessed by a food frequency questionnaire. RESULTS: Fifteen percent of students were diagnosed with PMS; there were no significant differences with respect to age, height, weight, and body mass index (BMI) of the students with and without PMS symptoms. Students with PMS recognized their PMS symptoms, experienced significantly more severe PMS symptoms, and received more treatment and had more stress compared with students without PMS. Interestingly, students with PMS had greater alcohol intake and consumed more animal calcium than students with PMS. However, the intake of other nutrients was not significantly different between students with and without PMS. CONCLUSION: Out data suggest that students with PMS should increase intake of animal calcium and find ways to reduce stress.
Animals ; Body Mass Index ; Calcium ; Female ; Humans ; Life Style ; Premenstrual Syndrome ; Risk Factors ; Surveys and Questionnaires

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