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Response: Impact of HbA1c Criterion on the Detection of Subjects with Increased Risk for Diabetes among Health Check-Up Recipients in Korea (Diabetes Metab J 2012;36:151-6).

Hong Kyu KIM ; Sung Jin BAE ; Jaewon CHOE

Diabetes & Metabolism Journal.2012;36(3):253-253. doi:10.4093/dmj.2012.36.3.253

No abstract available.
Korea

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Efficacy of the Smartphone-Based Glucose Management Application Stratified by User Satisfaction.

Hun Sung KIM ; Wona CHOI ; Eun Kyoung BAEK ; Yun A KIM ; So Jung YANG ; In Young CHOI ; Kun Ho YOON ; Jae Hyoung CHO

Diabetes & Metabolism Journal.2014;38(3):204-210. doi:10.4093/dmj.2014.38.3.204

BACKGROUND: We aimed to assess the efficacy of the smartphone-based health application for glucose control and patient satisfaction with the mobile network system used for glucose self-monitoring. METHODS: Thirty-five patients were provided with a smartphone device, and self-measured blood glucose data were automatically transferred to the medical staff through the smartphone application over the course of 12 weeks. The smartphone user group was divided into two subgroups (more satisfied group vs. less satisfied group) based on the results of questionnaire surveys regarding satisfaction, comfort, convenience, and functionality, as well as their willingness to use the smartphone application in the future. The control group was set up via a review of electronic medical records by group matching in terms of age, sex, doctor in charge, and glycated hemoglobin (HbA1c). RESULTS: Both the smartphone group and the control group showed a tendency towards a decrease in the HbA1c level after 3 months (7.7%+/-0.7% to 7.5%+/-0.7%, P=0.077). In the more satisfied group (n=27), the HbA1c level decreased from 7.7%+/-0.8% to 7.3%+/-0.6% (P=0.001), whereas in the less satisfied group (n=8), the HbA1c result increased from 7.7%+/-0.4% to 8.1%+/-0.5% (P=0.062), showing values much worse than that of the no-smartphone control group (from 7.7%+/-0.5% to 7.7%+/-0.7%, P=0.093). CONCLUSION: In addition to medical feedback, device and network-related patient satisfaction play a crucial role in blood glucose management. Therefore, for the smartphone app-based blood glucose monitoring to be effective, it is essential to provide the patient with a well-functioning high quality tool capable of increasing patient satisfaction and willingness to use.
Blood Glucose ; Delivery of Health Care ; Diabetes Mellitus ; Electronic Health Records ; Glucose* ; Hemoglobin A, Glycosylated ; Humans ; Medical Staff ; Patient Satisfaction ; Smartphone ; Surveys and Questionnaires

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Current Status of Glycemic Control of Patients with Diabetes in Korea: The Fifth Korea National Health and Nutrition Examination Survey.

Ja Young JEON ; Dae Jung KIM ; Seung Hyun KO ; Hyuk Sang KWON ; Soo LIM ; Sung Hee CHOI ; Chul Sik KIM ; Jee Hyun AN ; Nan Hee KIM ; Jong Chul WON ; Jae Hyeon KIM ; Bong Yun CHA ; Kee Ho SONG

Diabetes & Metabolism Journal.2014;38(3):197-203. doi:10.4093/dmj.2014.38.3.197

BACKGROUND: The Korea National Health and Nutrition Examination Survey (KNHANES) III (2005) reported that 22.9% of individuals with diabetes have a glycated hemoglobin (HbA1c) <6.5% and that 43.5% have an HbA1c <7%. We investigated the levels of glycemic control and the factors associated with glycemic control using data from the KNHANES V (2010 to 2012). METHODS: Subjects with diabetes diagnosed by a physician or those taking antidiabetic medications were classified as individuals with known diabetes. Of 1,498 subjects aged > or =30 years with diabetes, we excluded 157 individuals who were missing HbA1c data. A total of 1,341 subjects were included in the final analysis. RESULTS: The prevalence of known diabetes was 7.7% (n=1,498, estimated to be 2.32 million people). The proportions of well-controlled diabetes meeting a HbA1c goal of <6.5% and <7% were 27% and 45.6%, respectively. HbA1c increased as the duration of diabetes increased. HbA1c in subjects with a duration of diabetes < or =5 years was lower than in subjects with a duration >5 years. HbA1c in the group taking only oral hypoglycemic agents (OHAs) was significantly lower than that in the group administered only insulin or OHA and insulin in combination. In logistic regression analysis, a longer duration of diabetes, insulin use and the absence of chronic renal failure were associated with HbA1c levels >6.5%. CONCLUSION: The level of adequate glycemic control was similar to but slightly improved compared with previous levels. The glycemic control of long-standing diabetes patients is more difficult even though they receive insulin treatment.
Diabetes Mellitus ; Hemoglobin A, Glycosylated ; Humans ; Hypoglycemic Agents ; Insulin ; Kidney Failure, Chronic ; Korea ; Logistic Models ; Nutrition Surveys* ; Prevalence

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It's Still Not Too Late to Make a Change: Current Status of Glycemic Control in Korea.

Sang Yong KIM

Diabetes & Metabolism Journal.2014;38(3):194-196. doi:10.4093/dmj.2014.38.3.194

No abstract available.
Korea

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Journal Metrics-Based Position of Diabetes & Metabolism Journal after the Change of Its Text Language to English.

Sun HUH

Diabetes & Metabolism Journal.2014;38(3):187-193. doi:10.4093/dmj.2014.38.3.187

After changing its language from Korean or English to English only in 2010, the journal metrics of Diabetes & Metabolism Journal (DMJ) were analyzed to assess whether this change in the journal policy was successful. The journal metric items that were analyzed were the following: impact factor; total citations; countries of authors; proportion of the articles funded out of the total number of original articles; and Hirsch-index (H-index). A retrospective, descriptive analysis was carried out using various databases, such as KoreaMed, Korean Medical Citation Index (KoMCI), KoreaMed Synapse, Web of Science, and Journal Citation Ranking. The journal's impact factor was 2.054, which corresponds to 83/122 (68.0%) out of the 2012 JCR endocrinology and metabolism category. The number of the journal's total citations was 330 in 2013. In addition to Korean authors, authors from 13 other countries published papers in the journal from 2010 to 2013. The number of funded papers from 2010 to 2013 was 65 out of 148 original articles (43.9%). The journal's H-index from KoreaMed Synapse was 7, and that from Web of Science was 9. It can be concluded that changing the journal's language to English was successful based on journal metrics. DMJ is currently positioned as an international journal based on the international diversity of authors and editors, its sufficiently high proportion of funded articles, its relatively high impact factor, and the number of total citations.
Bibliometrics ; Databases, Bibliographic ; Endocrinology ; Financial Management ; Journal Impact Factor ; Korea ; Metabolism* ; Retrospective Studies ; Synapses

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The Role of Pyruvate Dehydrogenase Kinase in Diabetes and Obesity.

In Kyu LEE

Diabetes & Metabolism Journal.2014;38(3):181-186. doi:10.4093/dmj.2014.38.3.181

The pyruvate dehydrogenase complex (PDC) is an emerging target for the treatment of metabolic syndrome. To maintain a steady-state concentration of adenosine triphosphate during the feed-fast cycle, cells require efficient utilization of fatty acid and glucose, which is controlled by the PDC. The PDC converts pyruvate, coenzyme A (CoA), and oxidized nicotinamide adenine dinucleotide (NAD+) into acetyl-CoA, reduced form of nicotinamide adenine dinucleotide (NADH), and carbon dioxide. The activity of the PDC is up- and down-regulated by pyruvate dehydrogenase kinase and pyruvate dehydrogenase phosphatase, respectively. In addition, pyruvate is a key intermediate of glucose oxidation and an important precursor for the synthesis of glucose, glycerol, fatty acids, and nonessential amino acids.
Acetyl Coenzyme A ; Adenosine Triphosphate ; Amino Acids ; Carbon Dioxide ; Coenzyme A ; Diabetes Mellitus ; Fatty Acids ; Glucose ; Glycerol ; NAD ; Obesity* ; Oxidoreductases* ; Phosphotransferases* ; Pyruvate Dehydrogenase (Lipoamide)-Phosphatase ; Pyruvate Dehydrogenase Complex ; Pyruvic Acid*

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Ubiquitin Ligases in Cholesterol Metabolism.

Wei JIANG ; Bao Liang SONG

Diabetes & Metabolism Journal.2014;38(3):171-180. doi:10.4093/dmj.2014.38.3.171

To maintain cholesterol homeostasis, the processes of cholesterol metabolism are regulated at multiple levels including transcription, translation, and enzymatic activity. Recently, the regulation of protein stability of some key players in cholesterol metabolism has been characterized. More and more ubiquitin ligases have been identified including gp78, Hrd1, TRC8, TEB4, Fbw7, and inducible degrader of low density lipoprotein receptor. Their working mechanisms and physiological functions are becoming revealed. Here, we summarize the structure, substrates and function of these ubiquitin ligases. Their potential application in drug discovery is also discussed.
Cholesterol* ; Drug Discovery ; Homeostasis ; Ligases* ; Metabolism* ; Protein Stability ; Receptors, LDL ; Ubiquitin*

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Interrelationships between the Retinal Neuroglia and Vasculature in Diabetes.

Timothy S KERN

Diabetes & Metabolism Journal.2014;38(3):163-170. doi:10.4093/dmj.2014.38.3.163

For years, diabetic retinopathy has been defined based on vascular lesions, and neural abnormalities were not regarded as important. This review summarizes evidence that the neural retina has important effects on the retinal vasculature under normal conditions, and the interaction between the retinal neuroglial cells and vascular function is altered in diabetes. Importantly, new evidence raises a possibility that abnormalities within retinal neuroglial cells (notably photoreceptors) might actually be causing or initiating the vascular disease in diabetic retinopathy.
Diabetes Mellitus ; Diabetic Retinopathy ; Neuroglia* ; Retina ; Retinaldehyde* ; Vascular Diseases

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Response: The Effect of an Angiotensin Receptor Blocker on Arterial Stiffness in Type 2 Diabetes Mellitus Patients with Hypertension (Diabetes Metab J 2011;35:236-42).

Ji Hyun KIM ; Su Jin OH ; Jung Min LEE ; Eun Gyoung HONG ; Jae Myung YU ; Kyung Ah HAN ; Kyung Wan MIN ; Hyun Shik SON ; Sang Ah CHANG

Diabetes & Metabolism Journal.2011;35(4):429-430. doi:10.4093/dmj.2011.35.4.429

No abstract available.
Angiotensins ; Diabetes Mellitus, Type 2 ; Humans ; Hypertension ; Vascular Stiffness

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Letter: The Effect of an Angiotensin Receptor Blocker on Arterial Stiffness in Type 2 Diabetes Mellitus Patients with Hypertension (Diabetes Metab J 2011;35:236-42).

Chul Hee KIM

Diabetes & Metabolism Journal.2011;35(4):427-428. doi:10.4093/dmj.2011.35.4.427

No abstract available.
Angiotensins ; Diabetes Mellitus, Type 2 ; Humans ; Hypertension ; Vascular Stiffness

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