Chinese Medical Journal
1966 to Present ISSN: 0366-6999
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Chinese Medical Journal.2016;129(20):2512-2513. doi:10.4103/0366-6999.191831
Henoch-Schönlein Purpura: A Rare Cause of Recurrent Acute Pancreatitis.
Chinese Medical Journal.2016;129(20):2510-2511. doi:10.4103/0366-6999.191830
Late-onset Juvenile Myoclonic Epilepsy or Frontal Lobe Epilepsy with Myoclonus.
Chinese Medical Journal.2016;129(20):2508-2509. doi:10.4103/0366-6999.191829
Chinese Medical Journal.2016;129(20):2506-2507. doi:10.4103/0366-6999.191827
Analysis of the Impact Factor of Emergency Medicine Journals in the Past 10 Years.
Chinese Medical Journal.2016;129(20):2504-2505. doi:10.4103/0366-6999.191826
Gaucher Disease with Mesenteric Lymphadenopathy: A Case with 13-year Follow-up.
Chinese Medical Journal.2016;129(20):2502-2503. doi:10.4103/0366-6999.191825
Role of Ring Finger Protein 213 in Moyamoya Disease.
Chinese Medical Journal.2016;129(20):2497-2501. doi:10.4103/0366-6999.191824
OBJECTIVEThe aim of this study was to help people comprehensively understand the research advances related to ring finger protein 213 (RNF213) in moyamoya disease (MMD) and to understand the disease at the molecular level to provide a new perspective of the diagnosis of the disease.
DATA SOURCESThis review was based on data in articles published between 2005 and 2015 that were retrieved from the PubMed database. The search terms included RNF213, MMD, intracranial major artery stenosis /occlusion (ICASO), genotype, phenotype, mutant and variants, and the combinations of these terms.
STUDY SELECTIONArticles related to MMD and RNF213 were selected for review, and we also reviewed publications related to ICASO.
RESULTSRNF213 is not only associated with MMD but also associated with intracranial major artery stenosis. In addition, RNF213 variants exhibit apparent ethnic diversity; specifically, the c.14576G>A variant is mainly detected in Korean, Chinese, and Japanese populations, particularly the latter population. The genotypes of RNF213 correlate with the phenotypes of MMD; for example, the homozygous c.14576G>A variant is associated with early-onset, severe symptoms, and an unfavorable prognosis. Furthermore, the RNF213 c.14576G>A variant should be considered during the diagnosis of MMD because no patients with quasi-MMD have been reported to carry the RNF213 c.14576G>A variant whereas 66 of 78 patients with definite MMD have been found to carry this variant.
CONCLUSIONSThe growing literature demonstrates that MMD is primarily caused by the synergy of genetic and environmental factors, and unknown genetic modifiers might play roles in the etiology of MMD. Further research should be conducted to clarify the pathogenic mechanism of MMD.
The Content of Statistical Requirements for Authors in Biomedical Research Journals.
Chinese Medical Journal.2016;129(20):2491-2496. doi:10.4103/0366-6999.191822
BACKGROUNDRobust statistical designing, sound statistical analysis, and standardized presentation are important to enhance the quality and transparency of biomedical research. This systematic review was conducted to summarize the statistical reporting requirements introduced by biomedical research journals with an impact factor of 10 or above so that researchers are able to give statistical issues' serious considerations not only at the stage of data analysis but also at the stage of methodological design.
METHODSDetailed statistical instructions for authors were downloaded from the homepage of each of the included journals or obtained from the editors directly via email. Then, we described the types and numbers of statistical guidelines introduced by different press groups. Items of statistical reporting guideline as well as particular requirements were summarized in frequency, which were grouped into design, method of analysis, and presentation, respectively. Finally, updated statistical guidelines and particular requirements for improvement were summed up.
RESULTSTotally, 21 of 23 press groups introduced at least one statistical guideline. More than half of press groups can update their statistical instruction for authors gradually relative to issues of new statistical reporting guidelines. In addition, 16 press groups, covering 44 journals, address particular statistical requirements. The most of the particular requirements focused on the performance of statistical analysis and transparency in statistical reporting, including "address issues relevant to research design, including participant flow diagram, eligibility criteria, and sample size estimation," and "statistical methods and the reasons."
CONCLUSIONSStatistical requirements for authors are becoming increasingly perfected. Statistical requirements for authors remind researchers that they should make sufficient consideration not only in regards to statistical methods during the research design, but also standardized statistical reporting, which would be beneficial in providing stronger evidence and making a greater critical appraisal of evidence more accessible.
Chinese Medical Journal.2016;129(20):2484-2490. doi:10.4103/0366-6999.191793
BACKGROUNDMelanoma is a type of cancer that develops from the pigment-containing cells. Until now, its pathological mechanisms remain largely unknown. The aim of this study was to identify metastasis-related microRNA (miRNAs) and gain an understanding of the biological functions in the metastasis of melanoma.
METHODSWe searched the PubMed and Gene Expression Omnibus database to collect miRNA expression profiling datasets about melanoma, with key words of "melanoma", "miRNA", "microarray", and "gene expression profiling". Only the original experimental works published before June 2016 for analyzing the metastasis of melanoma were retained, other nonhuman studies, reviews, and meta-analyses were removed. We performed a meta-analysis to explore the differentially expressed miRNA between metastatic and nonmetastatic samples. Moreover, we predicted target genes of the miRNAs to study their biological roles for these miRNAs.
RESULTSWe identified a total of 63 significantly differentially expressed miRNAs by meta-analysis of the melanoma expression profiling data. The regulatory network constructed by using these miRNAs and the predicted targets identified several key genes involved in the metastasis of melanoma. Functional annotation of these genes indicated that they are mainly enriched in some biological pathways such as mitogen-activated protein kinase signaling pathway, cell junction, and focal adhesion.
CONCLUSIONSBy collecting the miRNA expression datasets from different platforms, multiple biological markers were identified for the metastasis of melanoma. This study provided novel insights into the molecular mechanisms underlying this disease, thereby aiding the diagnosis and treatment of the disease.
Chinese Medical Journal.2016;129(20):2476-2483. doi:10.4103/0366-6999.191787
BACKGROUNDA single drilled tunnel from the lateral mastoid cortex to the cochlea via the facial recess is essential for minimally invasive cochlear implant surgery. This study aimed to explore the safety profile of this kind of new image-guided and bi-planar device-assisted surgery procedure in vitro.
METHODSImage-guided minimally invasive cochlear implantations were performed on eight cadaveric temporal bone specimens. The main procedures were: (1) temporal bone specimens were prepared for surgery and fiducial markers were registered. (2) computed tomography (CT) scans were performed for future reference. (3) CT scan images were processed and drill path was planned to minimize cochlear damage. (4) bi-planar device-assisted drilling was performed on the specimens using the registration. (5) surgical safety was evaluated by calculating the deviation between the drill and the planned paths, and by measuring the closest distance between the drilled path and critical anatomic structures.
RESULTSEight cases were operated successfully to the basal turn of the cochlear with intact facial nerves (FNs). The deviations from target points and entrance points were 0.86 mm (0.68-1.00 mm) and 0.44 mm (0.30-0.96 mm), respectively. The angular error between the planned and the drilled trajectory was 1.74° (1.26-2.41°). The mean distance from the edge of the drilled path to the FN and to the external canal was 0.60 mm (0.35-0.83 mm) and 1.60 mm (1.30-2.05 mm), respectively. In five specimens, the chorda tympani nerves were well preserved. In all cases, no injury happened to auditory ossicles.
CONCLUSIONSThis exploratory study demonstrated the safety of the newly developed image-guided minimally invasive cochlear implantation assisted by the bi-planar device and established the operational procedures. Further, more in vitro experiments are needed to improve the system operation and its safety.
Country
China
Publisher
中华医学会
ElectronicLinks
https://journals.lww.com/cmj/pages/default.aspxEditor-in-chief
cmjsubs@cmj.org
Abbreviation
Chinese Medical Journal
Vernacular Journal Title
中华医学杂志(英文版)
ISSN
0366-6999
EISSN
Year Approved
2007
Current Indexing Status
Currently Indexed
Start Year
1966
Description
历史沿革【现用刊名：Chinese Medical Journal;曾用刊名：中华医学杂志(英文版);创刊时间：1966】，该刊被以下数据库收录【CA 化学文摘(美)(2009);SCI 科学引文索引(美)(2009);CBST 科学技术文献速报(日)(2009);Pж(AJ) 文摘杂志(俄)(2009)】，期刊荣誉【中科双高期刊;第二届全国优秀科技期刊】。
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