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A analysis on adverse reactions of hydroxychloroquine in ophthalmology

Chinese Journal of New Drugs and Clinical Remedies.2001;20(3):235-236.

AIM: To study the adverse reactions of hydroxychloroquine (HCQ) in ophthalmology. 　METHODS: Thirty-nine patients treated with HCQ for more than six months were performed ophthalmic examinations including some specifie retinal function tests. 　RESULTS: There were 3 patients (8%) who presented the visual fields was minified. The visual acuity of one patient was decreased. The cumulative doses of HCQ were more than 100 g in this three patients. 　CONCLUSION: The adverse reactions of HCQ in ophthalmology are related with the cumulative doses of HCQ. The expression is that the visual fields and visual acuity are decreased.

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Effects of spirulina in prevention of liver fibrosis in rats

Yanru LU ; Yanjun CHU

Chinese Journal of New Drugs and Clinical Remedies.2001;20(3):198-199.

AIM: To study the effects of spirulina (Spirin) in the prevention of liver fibrosis in rats.　METHODS: Wistar rats were divided into three groups: control group(n=8); CCl4 group(n=8), spirulina group(n=8). CCl4 group and spirulina group rats were induced by 40% CCl4 olive oil solution into models of liver fibrosis, meanwhile spirulina group was given the feed with spirulina powder for 12 wk. Liver histological changes, hydroxyproline(HYP) content in liver tissues, serum procollagen type Ⅲ(PC-Ⅲ) and hyaluronic acid(HA) levels were observed. 　RESULTS: The pathological studies showed that the liver fibrosis degree of spirulina group was obviously lighter than that of CCl4 group. Spirulina group had significantly lower levels of HYP(174 μg*g-1±37 μg*g-1), PC-Ⅲ(140 μg*L-1±37 μg*L-1) and HA(262 μg*L-1±92 μg*L-1) than those of CCl4 group (243 μg*g-1±49 μg*g-1, 274 μg*L-1±69 μg*L-1 and 484 μg*L-1±114 μg*L-1, respectively).　CONCLUSION: The experimental evidence suggests that spirulina can prevent the formation of liver fibrosis.

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Influence of benazepril to left ventricular diastolic dysfunction in patients with hypertension and coronary heart disease

Xiaorui CHEN ; Wanhua CUI

Chinese Journal of New Drugs and Clinical Remedies.2001;20(3):196-198.

AIM: To understand the effects of benazepril in treating the diastolic function of the left ventricular in patients with hypertention and coronary heart diseases(CHD).　METHODS: Forty-five hypertension patients with the left ventricular diastolic dysfunction(LVDD) received benazepril 10-20 mg, po,qd, for 5 mo. On the basis of receiving nitrates 36 CHD patients with LVDD added to receive benazepril 5 mg, po, qd, for 5 mo. Before and after the therapy, the utmost speed of the peak value at the left ventricular early diastole stage (E peak), the utmost speed of the peak value at the left ventricular late diastolic stage (A peak), the E/A ratio and peak filling rate (PFR) were determined by color Doppler echocardiography. 　RESULTS: After the therapy, the E peak, the E/A ratio and PFR were up higher than before the therapy, meanwhile the A peak dropped lower, there were significant difference respectively (P<0.01). 　CONCLUSION: The LVDD can be improved distinctly if the patients with hypertension and CHD take benazepril for 5 mo or so.

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Dual wavelength spectrophotometry and K-ratio spectrophotometry in determining compatible stability of cefepime with metronidazole

Yufen LUO ; Ping YE ; Shan ZHAO

Chinese Journal of New Drugs and Clinical Remedies.2001;20(3):194-195.

AIM: To study the compatible stability of cefepime with 0.5% metronidazole injection.　METHODS: Dual wavelength spectrophotometry and K-ratio spectrophotometry were described for the determination of cefepime with metronidazole injection during 6 h. 　RESULTS: There was no evident variation in content during 6 h at room temperature. The average recovery rates of cefepime and metronidazole were (100.9±0.4)% and (99.8±0.6)% (n=5).　CONCLUSION: The compatiblity of cefepime with metronidazole injection is stable. The method of using dual wavelength spectrophotometry and K-ratio spectrophotometry to determine the compatible stability of cefepime with metronidazole is simple, accurate and usable.

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Affect of ammonium glycyrrhizinate on extracellular matrix of chronic viral hepatitis

Xiaoou LI ; Jianchun GUO ; Ting LI

Chinese Journal of New Drugs and Clinical Remedies.2001;20(3):192-194.

AIM:To study the affect of two kind preparations of ammonium glycyrrhizinate on serum extracellular matrix level of chronic viral hepatitis.　METHODS: Seventy patients with chronic viral hepatitis were randomly divided into two groups. The first group of 41 patients (M36,F5;age 47a±s 13a) was treated with diammonium glycyrrhizinate 0.15 g, iv, gtt, qd×30 d. The second group of 29 patients (M23,F6; age 48a±12a) was treated with monoamonium glycyrrhizinate 0.2 g iv, gtt, qd×30 d. Serum ECM levels were assayed using RIA method.　RESULTS: After treatment the serum ECM levels of both groups reduced remarkably and there was no differance in the reduction of serum ECM levels of the two groups except LN (P<0.05, P<0.01).　CONCLUSION: Both preparations of glycyzzhizinate have the efficacy to reduce serum ECM level of chronic viral hepatitis patients and play some role in anti-hepatic fibrosis. Diammonium glycyrrhizinate is more potent than monoammonium glycyrrhizinate.

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Shenmai Zhusheye vs vitamine C injection in adjuvant treatment of dilated cardiomyopathy

Rongjiang ZHANG ; Limin AN ; Lianjuan ZHANG ; Li LIN ; Hongyuan XIA

Chinese Journal of New Drugs and Clinical Remedies.2001;20(3):190-192.

AIM: To observe the therupeatic effects of Shemai Zhusheye vs vitamine C injection in treating dilated cardiomyopathy (DCM).　METHODS: Fifty-two patients with DCM were divided into 2 groups, 32 patients in treatment group (M 20, F 12; age 46 a± s 13 a), 20 patients in control group (M 11, F 9; age 47 a±14 a). Besides the patients in two groups were treated with conventional therapy, the patients in treatment group were given Shenmai Zhusheye 30 mL and 5% glucose injection 100 mL, iv, gtt, qd for 2 wk. The patients in control group were given vitamine C 5.0 and 5% glucose injection 100 mL, iv, gtt, qd for 2 wk. 　RESULTS: Treatment group total effective rate was 84%. Control group total effective rate was 65% (P>0.05).　CONCLUSION: Shenmai zhusheye has better effect in treating DCM. Symptom improving rate of Shenmai Zhusheye has better than vitamin C.

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Quality control of Suxiao Xiaoyan Gao

Yumin GUAN ; Lihua CUI ; Lihua XU

Chinese Journal of New Drugs and Clinical Remedies.2001;20(3):187-189.

AIM: To probe the quanlity and control of Suxiao Xiaoyan Gao. METHODS: The microscopy and TLC were applied to identify Scutellaria baicalensis; Hibiscus mutabilis; Curcuma longa; Rheum palmatum; Phellodendron chinese and borneol. The HPLC on C18column was used to determine the content of baicalin in Suxiao Xiaoyan Gao. Mobile phase was methanol∶0.4% phosphoric acid solution(47∶53). Detection wavelength was 280 nm. RESULTS： The micro-character and thin-layer chromatography was clear with no disturbance of negative sample. The average recovery of baicalin was (99±3)%, RSD was 3.35%. CONCLUSION: The method is simple and feasible. Its repetition is well. It can be used as a quality control method of Suxiao Xiaoyan Gao.

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Citicoline in treating neuroleptic-induced extrapyramidal side effect

Hexiang LIU ; Ping CHENG ; Shixun HUANG ; Yiyun WANG

Chinese Journal of New Drugs and Clinical Remedies.2001;20(3):185-187.

AIM：To study the effects of citicoline in treating neuroleptic-induced extrapyramidal side effect (EPS)．　METHODS：Seventy-five patients were divided into two groups：citicoline group of 38 patients ( M25，F13；age 28 a±s 9 a) received citicoline injection 0.5 g.d-1，in 5 % glucose injection 500 mL，iv，drip，qd ，for 14 d and control group of 37 patients ( M23，F14；age 27 a±6 a) received 5 % glucose injection 500 mL，iv, drip, qd，for 14 d．　RESULTS: The total efficacy of citicoline or control group was 92 % and 11 % (P＜0.05 ), respectively．The tremour, muscular rigidity, gait and muscle dystonia were better in citicoline group than in control group. No side effects were found. 　CONCLUSION: Citicoline is effective for neuroleptic-induced EPS.

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Nicardipine vs labetalol in treating acute and severe hypertension

Jian MENG ; Hualing LIU

Chinese Journal of New Drugs and Clinical Remedies.2001;20(3):182-184.

AIM: To compare the therapeutic effects and adverse reactions of nicardipine and labetalol injection in treating acute and severe hypertensions. 　METHODS: Sixty-seven patients in nicardipine group (M 46, F 21; age 52 a± s 11 a) were given nicardipine 2 mg in 0.9 % sodium chloride or 5 % glucose injection 10 mL within 2 min iv, first, and then given 30 mg nicardipine in 0.9 % sodium chlocide or 5 % glucose injection 250 mL by continual intravenous infusion for 6 h. Sixty-one patients in labetalol group (M 41, F 20; age 53 a±9 a) received 50 mg labetalol in 5 % glucose injection 20 mL by intravenous once. The treatment could be repeated every 15 min, in case it was less effective, but the total dose should be no more than 200 mg.　RESULTS: The treatment for the nicardipine group and the labetalol group, reached the marked effect within 5 min. The total marked effective rate was all 100 % (P>0.05). Severe adverse reactions occured in the two patients (one occured significantly lowering of blood pressure, and the other aggravated asthma) in the labetalol group. 　CONCLUSION: Intravenous nicardipine and labetalol are fast and smooth in reducing the blood pressure of the patients with acute and severe hypertension, but the safety of nicardipine is superior to that of labetalol

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Affect of living quality from indapamide vs nifedipine in treating mild to moderate hypertension

Luyi ZHANG ; Weimin PAN ; Zuxuan CHEN ; Yasha CHEN

Chinese Journal of New Drugs and Clinical Remedies.2001;20(3):179-181.

AIM: To study the effects of indapamide and nifedipine in treating the patients with mild to moderate hypertension and the affect to the living quality.　METHODS: One hundred and twenty seven patients with mild to moderate hypertension were divided into two groups, indapamide group 67 patients (M 30, F 37; age 63 a± s 12 a) received indapamide 2.5 mg, po, tid ×2 mo; nifedipine group 60 patients (M 30, F 30; age 61 a±12 a) received nifedipine 10 mg, po, tid× 2 mo.　RESULTS: Both above medicines could reduce blood pressure effectively (P>0.01), and there was no obvious affect to the lipid, renal function, uric acid, electrolyte. Indapamide group had the results of getting living quality improved; while nifedipine group had that of increasing some self testing sonse symptoms and ling quality reduced.　CONCLUSION: Both indapamide and nifedipine have definite effects in treating hypertension, while no obvious bad affect on blood lipid, renal function, et al. But the indapamide is less adverse reaction, and superior to nifedipine on the aspect of improving living quality.

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