Application of antimalarial drugs in the control of malaria
Chinese Journal of Infection and Chemotherapy.2007;0(05):-.
Chinese Journal of Infection and Chemotherapy
2001 to Present ISSN: 1009-7708
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Place particular emphasis on accurate diagnosis and rational therapy of invasive fungal infections
Chinese Journal of Infection and Chemotherapy.2007;0(01):-.
One case of ceftazidime-induced muscular convulsion
Chinese Journal of Infection and Chemotherapy.2007;0(05):-.
Caseous pneumonia misdiagnosed as lobar pneumonia:one case report
Chinese Journal of Infection and Chemotherapy.2007;0(05):-.
Chinese Journal of Infection and Chemotherapy.2017;17(4):387-392. doi:10.16718/j.1009-7708.2017.04.008
Objective To investigate whether catestatin (bovine chromogranin A 344-364) can inhibit the biofilm formation of Candida albicans and examine its relationship with the expression of adhesion gene HWP1.Methods Clinical strains and standard strain ATCC 10231 of C.albicans were studied.XTT [2,3-bis-(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide] method was used to assess the ability of C.albicans biofilm formation.Antifungal activity against planktonic Candida ceils was evaluated in terms of minimum inhibitory concentrations (MICs) according to the description in CLSI-M27-A3.XTT assay and colony count were used to assess the effect of catestatin on inhibiting C.albicans biofilm formation.The lowest concentration showing 50 ％ inhibition on biofilm formation (BIC50) was decided by calculating the metabolic activity.The adhesion of C.albicans reduced by catestatin was visualized under an inverted microscope and quantified by colony count.The expression of HWP1 was analyzed by RT-PCR.One-way analysis of variance (ANOVA) and Dunnett's T3 test were used to compare the results.Results Clinical strains and standard strain ATCC 10231 of C.albicans showed strong ability in forming biofilm.Catestatin exhibited MICs ranging from 40 μmol/L to 80 μmol/L against planktonic C.albicans cells,and BIC50 of 80-160 μmol/L in inhibiting C.albicans biofilm formation.Catestatin reduced the adhesion of C.albicans.The colony forming unit (CFU) was 27 822.22-±-2 472.74 in blank control group,while the CFU was 5 355.55± 1 264.03,11 377.78±2 232.58,17 488.89±1 136.27,22 377.78±3 521.99,and 26 044.44±1 329.57 in the presence of 160,80,40,20,and 10 μmol/L catestatin,respectively (F=147.018,P=0.001).The difference between control group and 160,80,and 40 μmol/L catestatin was statistically significant (P＜0.05).RT-PCR found the expression of HWP1 in the presence of 160 μmol/L catestatin was about 12.24％ of that in blank control group.Conclusions Catestatin can effectively prevent C.albicans biofilm formation.This effect may be related to the down-regulated expression of adhesion gene HWP1 by catestatin,which results in reduced adhesion of C.albicans.Promising clinical prospect is expected for this finding.
Chinese Journal of Infection and Chemotherapy.2017;17(4):382-386. doi:10.16718/j.1009-7708.2017.04.007
Objective To understand the resistance mechanism and clinical feature of linezolid-resistant S.capitis isolated from blood samples.Methods Antimicrobial susceptibility testing was carried out to determine the susceptibility of clinical strains.PCR and sequencing analysis were used to analyze cfr gene and 23S rRNA mutation,which were associated with linezolid resistance.Patterns of pulsed-field gel electrophoresis (PFGE) were analyzed in combination with clinical data to understand the clinical feature of S.capitis strains.Results Five linezolid-resistant S.capitis strains were isolated from blood samples of 3 patients.These strains were resistant not only to linezolid,but also to most of the commonly used antimicrobial agents except glycopeptides,rifampin,and trimethoprim-sulfamethoxazole.Mutation was identified in 23S rRNA genes of all the five strains and cfr gene was found in four of the five strains.PFGE typing showed the same type,which supported the homology of the 5 strains.Three patients had deep vein indwelling catheter and two of them were treated with linezolid.Conclusions Linezolid-resistant S.capitis isolates showed the phenotype of resistance to multiple antimicrobial agents.Linezolid resistance may be mediated by cfr gene and 23S rRNA mutations in S.capitis.Long-term use of deep vein indwelling catheter and linezolid treatment may increase the risk of linezolid-resistant S.capitis infection.
Clinical implications of circulating mucosal associated invariant T (MALT) cells in septic patients
Chinese Journal of Infection and Chemotherapy.2017;17(4):376-381. doi:10.16718/j.1009-7708.2017.04.006
Objective To investigate the number and activation status of circulating mucosal associated invariant T (MAIT) cells in patients with sepsis.Methods Flow cytometric method was used to determine the number and percentage of MAIT cells and their expression of activation molecule CD69.Results The circulating MAIT cells dropped significantly at early stage of sepsis in septic patients.The MAIT cells in the sepsis group continued to express high levels of CD69 on day 1 and day 3 after admission to ICU.Conclusions Remarkable decrease of circulating MAIT cells may portend the possibility of sepsis in patients with severe infection.
Clinical analysis of 9 patients with Nocardia infection
Chinese Journal of Infection and Chemotherapy.2017;17(4):356-360. doi:10.16718/j.1009-7708.2017.04.002
Objective To review the clinical feature of Nocardia-positive patients and improve the awareness of Nocardia infection.Methods The clinical data were reviewed retrospectively for 11 patients from whom Nocardia was isolated during the period from May 2012 to December 2014 in the General Hospital of Ningxia Medical University.Results Contamination was suspected in 2 of the 11 cases.Nocardia infection was considered in the remaining 9 cases,including pulmonary infection in 6 cases,skin and soft tissue infection in 2 cases,peritoneal dialysis-related peritonitis in 1 case.Underlying diseases were documented in all the 9 patients,4 of which received corticosteroids or immunosuppressants for their underlying diseases.Conclusions Nocardia may cause infection in different body sites,especially lungs.The patients with underlying diseases,especially those receiving corticosteroids or immunosuppressants,are relatively more susceptible to Nocardia infections.
Chinese Journal of Infection and Chemotherapy.2017;17(4):353-355. doi:10.16718/j.1009-7708.2017.04.001
Objective To examine the effect of ultrasonic debridement combined with continuous skin stretching to repair refractory infective wound bed.Methods From January 2016 to July 2016,we treated 15 cases of chronic,refractory infective wound beds using ultrasonic debridement combined with skin stretching technique.Results All the 15 (100％) cases were cured without necrosis of the stretched skin edges.Conclusions Ultrasonic debridement combined with continuous skin stretching is an appropriate technique for repairing the refractory wound bed in the patients who are older,in poor general condition,or poor condition of local skin and soft tissue,or have poor postoperative effect,or surgical contraindication or at higher risk of surgery.
Matrix metalloproteinase 9, blood brain barrier and tuberculous meningitis
Chinese Journal of Infection and Chemotherapy.2017;17(4):463-467. doi:10.16718/j.1009-7708.2017.04.022
Country
China
Publisher
复旦大学医学院
ElectronicLinks
http://www.cjic.com.cnEditor-in-chief
cjic@fudan.edu.cn
Abbreviation
Chinese Journal of Infection and Chemotherapy
Vernacular Journal Title
中国感染与化疗杂志
ISSN
1009-7708
EISSN
Year Approved
2009
Current Indexing Status
Currently Indexed
Start Year
2001
Description
历史沿革【现用刊名：中国感染与化疗杂志;曾用刊名：中国抗感染化疗杂志;创刊时间：2001】，期刊荣誉【Caj-cd规范获奖期刊】。
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